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| 1 | Role of Kupffer cells in the pathogenesis of liver disease显示文摘Kupffer cells, the resident liver macrophages have long been considered as mostly scavenger cells responsible for removing particulate material from the portal circu- lation. However, evidence derived mostly from animal models, indicates that Kupffer cells may be implicated in the pathogenesis of various liver diseases including viral hepatitis, steatohepatitis, alcoholic liver disease, in- trahepatic cholostasis, activation or rejection of the liver during liver transplantation and liver fibrosis. There is accumulating evidence, reviewed in this paper, suggest- ing that Kupffer cells may act both as effector cells in the destruction of hepatocytes by producing harmful soluble mediators as well as antigen presenting cells during viral infections of the liver. Moreover they may represent a significant source of chemoattractant molecules for cy- totoxic CD8 and regulatory T cells. Their role in fibrosis is well established as they are one of the main sources of TGFβ1 production, which leads to the transformation of stellate cells into myofibroblasts. Whether all these variable functions in the liver are mediated by different Kupffer cell subpopulations remains to be evaluated. In this review we propose a model that demonstrates the role of Kupffer cells in the pathogenesis of liver disease. | George Kolios Vassilis Valatas Elias Kouroumalis | 2006 | World Journal of Gastroenterology2006，12，46： | 74 |
| 2 | Promoter methylation status of hMLH1,MGMT,and CDKN2A/p16 in colorectal adenomas显示文摘AIM:To investigate aberrant DNA methylation of CpG islands and subsequent low-or high-level DNA microsatellite instability(MSI)which is assumed to drive colon carcinogenesis. METHODS:DNA of healthy individuals,adenoma(tu-bular or villous/tubulovillous)patients,and colorectal carcinoma patients who underwent colonoscopy was used for assessing the prevalence of aberrant DNA methylation of human DNA mismatch repair gene mutator L homologue 1(hMLH1),Cyclin-dependent kinase inhibitor 2A(CDKN2A/p16),and O-6-methylguanine DNA methyltransferase(MGMT),as well as their rela- tion to MSI. RESULTS:The frequency of promoter methylation for each locus increased in the sequence healthy tissue/adenoma/carcinoma.MGMT showed the highest frequency in each group.MGMT and CDKN2A/p16 presented a statistically significant increase in promoter methylation between the less and more tumorigenic forms of colorectal adenomas(tubular vs tubullovillous and villous adenomas).All patients with tubulovillous/villous adenomas,as well as all colorectal cancer patients,showed promoter methylation in at least one of the examined loci.These findings suggest a potentially crucial role for methylation in the polyp/adenoma to cancer progres- sion in colorectal carcinogenesis.MSI and methylation seem to be interdependent,as simultaneous hMLH1, CDKN2A/p16,and MGMT promoter methylation was present in 8/9 colorectal cancer patients showing the MSI phenotype. CONCLUSION:Methylation analysis of hMLH1,CD- KN2A/p16,and MGMT revealed specific methylation profiles for tubular adenomas,tubulovillous/villous adenomas,and colorectal cancers,supporting the use of these alterations in assessment of colorectal tumorigenesis. | Vasiliki Psofaki Chryssoula Kalogera Nikolaos Tzambouras Dimitrios Stephanou Epameinondas Tsianos Konstantin Seferiadis Georgios Kolios | 2010 | World Journal of Gastroenterology2010，16，28： | 14 |
| 3 | Octreotide induces caspase activation and apoptosis in human hepatoma HepG2 cells显示文摘AIM: To investigate the role of octreotide on cellular proliferation and apoptosis of human hepatoma (HepG2) cells. METHODS: We studied cellular proliferation, apoptosis and the possible internal caspase-mediated apoptosis pathway involved, after treatment of HepG2 carcinoma cells with octreotide in comparison with the apoptosis caused by tumor necrosis factor-α (TNF-α). Activities of caspase-3, caspase-9, caspase-8 and caspase-2 were studied, while apoptosis was investigated through detection of DNA fragmentation and through identification of apoptotic cells with the annexin-V/propidium iodide flow cytometric method. RESULTS: After an initial increase in HepG2 cellular proliferation, a significant inhibition was observed with 10-8 mol/L octreotide, while TNF-α dose-dependently decreased proliferation. Early and late apoptosis was significantly increased with both substances. Octreotide significantly increased caspase-3, caspase-8 and caspase-2 activity. TNF-α signifi cantly increased only caspase-2. Cellular proliferation was decreased after treatment with octreotide or TNF-α alone but, in contrast to TNF-α, octreotide decreased proliferation only at concentrations of 10-8 mol/L, while lower concentrations increased proliferation. CONCLUSION: Our findings are suggestive of caspasemediated signaling pathways of octreotide antitumor activity in HepG2 cells, and indicate that measurements of serum octreotide levels may be important, at least in clinical trials, to verify optimal therapeutic drug concentrations. | Nikos J Tsagarakis Ioannis Drygiannakis Antonis G Batistakis George Kolios Elias A Kouroumalis | 2011 | World Journal of Gastroenterology2011，17，3： | 5 |
| 4 | Role of exercise in preventing and restoring gut dysbiosis in patients with inflammatory bowel diseases:A review显示文摘Inflammatory bowel diseases(IBD)include a spectrum of chronic inflammatory disorders of the gastrointestinal tract whose pathogenesis is yet to be elucidated.The intestinal microbiome has been studied as a causal component,with certain microbiotic alterations having been observed in subtypes of IBD.Physical exercise is a modulator of the intestinal microbiome,causing shifts in its composition that are partially corrective of those observed in IBD;furthermore,physical exercise may be beneficial in patients with certain IBD subtypes.This review studies the effects of physical exercise on the human gut microbiome while investigating pathophysiologic mechanisms that could explain physical activity’s clinical effects on patients with IBD. | Tilemachos Koutouratsas Anastassios Philippou George Kolios Michael Koutsilieris Maria Gazouli | 2021 | World Journal of Gastroenterology2021，27，30： | 4 |
| 5 | Gastroscopic findingsin Mediterranean Kaposi's sarcoma(non-AIDS)显示文摘 | Kolios G Kaloterakis A Filiotou A | 1995 | Gastroint-est Endosc1995，42，4： | 1 |
| 6 | Effects of Cimicifuga racemosa ( Cimicifuga racemosa) and estrogen on metaphyseal fracture healing in the early stage of osteoporosis in ovariectomized rats 显示文摘 | Kolios L Schumann J Sehmisch S | 2010 | Planta Med2010，76，9： | 1 |
| 7 | Vitamin D status as related to race and feeding type in pretema infants during the frist year of life显示文摘 | Giapros VI Kolios G Pantou C | 2012 | Eur J Clin Nutr2012，66，2： | 1 |
| 8 | Production of Pro- and Anti-fibrotic Agents by Rat Kupffer Cells; The Effect of Octreotide显示文摘 | Costas Xidakis Dushanka Ljumovic Pinelopi Manousou George Notas Vassilis Valatas George Kolios Elias Kouroumalis | 2005 | Digestive Diseases and Sciences2005，，5： | 1 |
| 9 | Expression of functional CXCR4 chemokine receptors on human colonic epithelial cells 显示文摘 | Jordan NJ Kolios G Abbot SE | 1999 | J Clin Invest1999，104，： | 1 |
| 10 | Effect of octreotide on apoptosis-related proteins in rat Kupffer cells a possible antitumour mechanism显示文摘 | Xidakis C Kolios G Valatas V | 2004 | Anticancer Res2004，24，2： | 1 |
| 11 | Oxidative stress due to anesthesia and surgical trauma:Importance of early entera! nutrition显示文摘 | Kotzampassi K Kolios G Manousou P | 2009 | Mol Nutr Food Res2009，53，6： | 1 |
| 12 | Multi-criteria assessment of offshore wind tur- bine support structures显示文摘 | LOZANO-MINGUEZ E KOLIO A J BRENNAN F P | 2011 | Renewable Energy2011，，36： | 1 |
| 13 | 显示文摘 | Kolios G Frauhammer J Eigenberger G | 2000 | Chemical Engineering Science2000，55，24： | 1 |
| 14 | n economic comparison of surgical and medical therapy in patients with secondary hyper- paratbyrnidism - the German perspective 显示文摘 | Schneider R Kolios G Koch BM | 2010 | Surgery2010，148，6： | 1 |
| 15 | Modulation of T cell responses by IL-2 and IL-2 complexes显示文摘 | BOYMAN O KOLIOS A G RAEBER M E | 2015 | Clin Exp Rheumatol2015，33，492： | 1 |
| 16 | An economic compa- rison of surgical and medical therapy in patients with secondary hyperparathyroidism--the German perspective 显示文摘 | Schneider R Kolios G Koch BM | 2010 | Surgery2010，148，6： | 1 |
| 17 | Bone infections and bone graft substitutes for local antibiotic therapy显示文摘 | Lalidou F Kolios G and Drosos GI | 2014 | Surg Technol Int2014，124，： | 1 |
| 18 | The value of experimental mod- els of colitis in predicting efficacy of biological therapies for inflammatory bowel diseases显示文摘 | Valatas V Vakas M Kolios G | 2013 | American Journal of Physiology Gastrointestinal and Liver Physiology2013，305，11： | 1 |
| 19 | Immunomodulatory cytokines suppress epithelial nitric oxide production in inflammatory bowel disease by acting on mononuclear cells 显示文摘 | Linehan J D Kolios G Valatas V | 2005 | Free Radic Biol Med2005，39，12： | 1 |
| 20 | Stem cells in liver regeneration and their potential clinical applications显示文摘 | DROSOS I KOLIOS G | 2013 | Stem Cell Reviews and Report2013，9，5： | 1 |
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