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| 1 | Current and future pharmacological therapies for managing cirrhosis and its complications显示文摘Due to the restrictions of liver transplantation,complication-guided pharmacological therapy has become the mainstay of long-term management of cirrhosis.This article aims to provide a complete overview of pharmacotherapy options that may be commenced in the outpatient setting which are available for managing cirrhosis and its complications,together with discussion of current controversies and potential future directions.PubMed/Medline/Cochrane Library were electronically searched up to December 2018 to identify studies evaluating safety,efficacy and therapeutic mechanisms of pharmacological agents in cirrhotic adults and animal models of cirrhosis.Non-selective betablockers effectively reduce variceal re-bleeding risk in cirrhotic patients with moderate/large varices,but appear ineffective for primary prevention of variceal development and may compromise renal function and haemodynamic stability in advanced decompensation.Recent observational studies suggest protective,haemodynamically-independent effects of beta-blockers relating to reduced bacterial translocation.The gut-selective antibiotic rifaximin is effective for secondary prophylaxis of hepatic encephalopathy;recent small trials also indicate its potential superiority to norfloxacin for secondary prevention of spontaneous bacterial peritonitis.Diuretics remain the mainstay of uncomplicated ascites treatment,and early trials suggest alpha-adrenergic receptor agonists may improve diuretic response in refractory ascites.Vaptans have not demonstrated clinical effectiveness in treating refractory ascites and may cause detrimental complications.Despite initial hepatotoxicity concerns,safety of statin administration has been demonstrated in compensated cirrhosis.Furthermore,statins are suggested to have protective effects upon fibrosis progression,decompensation and mortality.Evidence as to whether proton pump inhibitors cause gut-liver-brain axis dysfunction is conflicting.Emerging evidence indicates that anticoagulation therapy reduces incidence and increases recanalisation rates of non-malignant portal vein thrombosis,and may impede hepatic fibrogenesis and decompensation.Pharmacotherapy for cirrhosis should be implemented in accordance with up-to-date guidelines and in conjunction with aetiology management,nutritional optimisation and patient education. | David Kockerling Rooshi Nathwani Roberta Forlano Pinelopi Manousou Benjamin H Mullish Ameet Dhar | 2019 | World Journal of Gastroenterology2019，25，8： | 16 |
| 2 | Increased ΤGF-β3 in primary biliary cirrhosis: An abnormality related to pathogenesis?显示文摘AIM: To investigate the transforming growth factor-β (TGF-β) isoforms in the peripheral and hepatic venous blood of primary biliary cirrhosis (PBC) patients. METHODS: We examined TGF-β1, TGF-β2 and TGF-β3 (enzyme-linked immunosorbent assay), in 27 stage Ⅳ PBC patients (27 peripheral and 15 hepatic vein sera), 35 early (Ⅰ-Ⅱ) PBC and 60 healthy controls. As disease controls 28 hepatitis C virus (HCV) cirrhosis (28 peripheral and 17 hepatic vein serum), 44 chronic HCV hepatitis and 38 HCV-related hepatocellular carcinomas were included. We also tested liver tissue by immunohistochemistry to identify localization of TGF isoforms. RESULTS: TGF-β1 was significantly decreased in all cirrhotics (PBC Ⅲ-Ⅳ: median 13.4 ng/mL; range, 7.4-26.2, HCV cirrhosis: 11.6 ng/mL; range, 5.0-33.8), compared to controls (30.9 ng/mL; range, 20.9-37.8). TGF-β2 was increased in viral cirrhosis but not in PBC and chronic hepatitis. TGF-β3 (47.2 pg/mL; range, 27.0-79.7 in healthy controls) was increased in early and late PBC (Ⅰ-Ⅱ: 94.3 pg/mL; range, 41.5-358.6; Ⅲ-Ⅳ: 152.8 pg/mL; range, 60.4-361.2; P < 0.001) and decreased in viral cirrhosis (37.4 pg/mL; range, 13.3-84.0; P < 0.05). Hepatic vein TGF-β levels were analogous to those in peripheral blood. Immunohistochemistry identified all isoforms in portal tract lymphocytes, sinusoidal cells and cholangiocytes. TGF-β3 was additionally overexpressed in hepatocytes in PBC patients. CONCLUSION: The serum profile of TGF-β isoforms is different in cirrhotics. Increased TGF-β3 is characteristic of PBC. These findings may be related to the immunological abnormalities of PBC. | Argyro Voumvouraki Mairi Koulentaki Maria Tzardi Ourania Sfakianaki Penelope Manousou George Notas Elias Kouroumalis | 2010 | World Journal of Gastroenterology2010，16，40： | 4 |
| 3 | Production of Pro- and Anti-fibrotic Agents by Rat Kupffer Cells; The Effect of Octreotide显示文摘 | Costas Xidakis Dushanka Ljumovic Pinelopi Manousou George Notas Vassilis Valatas George Kolios Elias Kouroumalis | 2005 | Digestive Diseases and Sciences2005，，5： | 1 |
| 4 | Context- aware recommender systems for learning: a survey and future challenges 显示文摘 | VERBERT K MANOUSELIS N OCHOA X | 2012 | Learning Technologies IEEE Transactions on2012，5，4： | 1 |
| 5 | Oxidative stress due to anesthesia and surgical trauma:Importance of early entera! nutrition显示文摘 | Kotzampassi K Kolios G Manousou P | 2009 | Mol Nutr Food Res2009，53，6： | 1 |
| 6 | Serum ferritin is a discriminant marker for both fibrosis and inflammation in histologi- cally proven non -alcoholic fatty liver disease patients 显示文摘 | Manousou P Kalambokis G Grillo F | 2011 | Liver Int2011，31，5： | 1 |
| 7 | Increased expression of chemokine receptor CCR3 and its ligands in ulcerative colitis:the role of colonic epithelial cells in in vitro studies显示文摘 | Manousou P Kolios G Valatas V | | 0，，2： | 1 |
| 8 | Analysis and Classification of Multi-Criteria Recommender Systems显示文摘 | Nikos Manouselis Constantina Costopoulou | 2007 | World Wide Web2007，00，： | 1 |
| 9 | Context-aware Rec-ommender Systems for Learning : a Survey and Future Challen-ges显示文摘 | Verbert K Manouselis N Ochoa X | 2012 | Learning Technologies IEEE Transactions on2012，5，4： | 1 |
| 10 | Collagen proportionate area is superior to other histological methods for sub-classifying cirrhosis and determining prognosis显示文摘 | Emmanuel Tsochatzis Sara Bruno Graziella Isgro Andrew Hall Eleni Theocharidou Pinelopi Manousou Amar P. Dhillon Andrew K. Burroughs Tu Vinh Luong | 2013 | Journal of Hepatology2013，，： | 1 |
| 11 | Modeling an E-Government Observatory for Rural SMEs Using UML with RUP 显示文摘 | KARETSOS S MANOUSELIS | 2011 | Operational Research2011，11，1： | 1 |
| 12 | Collaborative recommendation of e-learning resources: an experimental investigation 显示文摘 | Manouselis N Vuorikari R Van Assche F | 2010 | Journal of Computer Assisted Learning2010，26，4： | 1 |
| 13 | Context-aware recommender systems for learning: A survey and future challenges 显示文摘 | Verbert K Manouselis N Ochoa X | 2012 | IEEE Transactions on Learning Technologies2012，5，4： | 1 |
| 14 | Analysis and classification of multi-criteria recommender systems显示文摘 | Manouselis N Costopoulou C | 2007 | World Wide Web2007，10，41： | 1 |
| 15 | Computer assisted image analysis of liver collagen at one year biopsy can predict clinical outcome in HCV post LT patients显示文摘 | Manousou P Burroughs AK Isgro G | 2009 | Hepatology2009，，： | 1 |
| 16 | Liver collagen proportionate area predicts decompensation in patients with recurrent hepatitis C virus cirrhosis after liver transplantation显示文摘 | Vincenza Calvaruso Amar Paul Dhillon Emanuel Tsochatzis Pinelopi Manousou Federica Grillo Giacomo Germani David Patch James O’Beirne Andrew Kenneth Burroughs | 2012 | Journal of Gastroenterology and Hepatology2012，，7： | 1 |
| 17 | Analysis and Classifi-cation of Multi-Criteria Recommender Systems 显示文摘 | MANOUSELIS N COSTOPOULOU C | 2007 | World Wide Web2007，10，4： | 1 |
| 18 | Dataset-driven research to support learning and knowledge analyties显示文摘 | VERBERT K MANOUSELIS N DRACHSLER H | 2012 | Educational Technology &Soeiety2012，15，3： | 1 |
| 19 | Analysis and classificationof multi-criteria recommender systems显示文摘 | Manouselis N Costopoulou C | 2007 | World WideWeb2007，10，4： | 1 |
| 20 | Secretion of inflammatory mediators by isolated rat Kupffer cells:the effect of octreotide显示文摘 | Valatas V Kolios G Manousou P Xidakis C Notas G Ljumovic D Kouroumalis EA | | 0，，： | 1 |
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