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| 1 | Patients with primary biliary cirrhosis have increased serum total antioxidant capacity measured with the crocin bleaching assay显示文摘AIM: The balance between oxidants and antioxidants can play an important role in the initiation and development of liver diseases. Recently, we have described a new automated method for the determination of total antioxidant capacity (TAC) in human serum and plasma.METHODS: We measured TAC and corrected TAC (CTAC -abstraction of interactions due to endogenous uric acid,bilirubin and albumin) in 52 patients with chronic liver diseases (41 patients with primary biliary cirrhosis (PBC),10 patients with chronic hepatitis C and 13 patients with viral HCV cirrhosis) as well as in 10 healthy controls. In 23 PBC patients measurement were also done 6 mo after treatment with ursodeoxycholic acid (UDCA). The TAC assay was based on a modification of the crocin bleaching assay. The results were correlated with routine laboratory measurements and the histological stage of PBC.RESULTS: There were no significant differences in TAC between the various groups. However, CTAC was considerably increased in the PBC group compared to controls and cirrhotics. Analysis of these patients according to disease stages showed that this increase was an early phenomenon observed only in stages Ⅰ and Ⅱ compared to controls, cirrhotics and patients with chronic hepatitis C).After 6 mo of treatment with UDCA, levels of CTAC decreased to those similar to that of controls.CONCLUSION: Patients in the early stages of PBC present with high levels of corrected total antioxidant capacity and this maybe related to the pathophysiology of the disease. UDCA treatment restores the levels of CTAC to control levels. | George Notas Niki Miliaraki Marilena Kampa Fillipos Dimoulios Erminia Matrella Adam Hatzidakis Elias Castanas Elias Kouroumalis | 2005 | World Journal of Gastroenterology2005，11，27： | 13 |
| 2 | Pathogenesis of primary biliary cirrhosis: A unifying model显示文摘主要胆汁性肝硬变(PBC ) 是导致小肝内胆汁管并且最后的进步破坏到肝肝硬化和失败的未知病原学的疾病。它被女优势和浆液自身抗体描述到指向 2-oxoacid 脱氢酶建筑群的 E2 部件的 mitochondrial 抗原。尽管他们与疾病致病被联系,没有具体证据到目前为止被介绍了。流行病学的数据显示盒子和可能的环境因素的一个地理聚类在致病被含有。很多个基因因素在决定疾病危险性或前进起一个作用,尽管没有权威的结论到目前为止被得出了。到有免疫力的致病的一个关键因素被认为是有免疫力的忍耐的故障,通过分子的模仿或通过所谓的决定因素,密度当模特儿。在这评论,关于主要胆汁性肝硬变的致病的可得到的数据被描述并且讨论。一个新统一假设基于在主要胆汁性肝硬变(PBC ) 的早 endothelin 生产过剩被介绍并且讨论。 | Elias Kouroumalis George Notas | 2006 | World Journal of Gastroenterology2006，12，15： | 10 |
| 3 | Increased ΤGF-β3 in primary biliary cirrhosis: An abnormality related to pathogenesis?显示文摘AIM: To investigate the transforming growth factor-β (TGF-β) isoforms in the peripheral and hepatic venous blood of primary biliary cirrhosis (PBC) patients. METHODS: We examined TGF-β1, TGF-β2 and TGF-β3 (enzyme-linked immunosorbent assay), in 27 stage Ⅳ PBC patients (27 peripheral and 15 hepatic vein sera), 35 early (Ⅰ-Ⅱ) PBC and 60 healthy controls. As disease controls 28 hepatitis C virus (HCV) cirrhosis (28 peripheral and 17 hepatic vein serum), 44 chronic HCV hepatitis and 38 HCV-related hepatocellular carcinomas were included. We also tested liver tissue by immunohistochemistry to identify localization of TGF isoforms. RESULTS: TGF-β1 was significantly decreased in all cirrhotics (PBC Ⅲ-Ⅳ: median 13.4 ng/mL; range, 7.4-26.2, HCV cirrhosis: 11.6 ng/mL; range, 5.0-33.8), compared to controls (30.9 ng/mL; range, 20.9-37.8). TGF-β2 was increased in viral cirrhosis but not in PBC and chronic hepatitis. TGF-β3 (47.2 pg/mL; range, 27.0-79.7 in healthy controls) was increased in early and late PBC (Ⅰ-Ⅱ: 94.3 pg/mL; range, 41.5-358.6; Ⅲ-Ⅳ: 152.8 pg/mL; range, 60.4-361.2; P < 0.001) and decreased in viral cirrhosis (37.4 pg/mL; range, 13.3-84.0; P < 0.05). Hepatic vein TGF-β levels were analogous to those in peripheral blood. Immunohistochemistry identified all isoforms in portal tract lymphocytes, sinusoidal cells and cholangiocytes. TGF-β3 was additionally overexpressed in hepatocytes in PBC patients. CONCLUSION: The serum profile of TGF-β isoforms is different in cirrhotics. Increased TGF-β3 is characteristic of PBC. These findings may be related to the immunological abnormalities of PBC. | Argyro Voumvouraki Mairi Koulentaki Maria Tzardi Ourania Sfakianaki Penelope Manousou George Notas Elias Kouroumalis | 2010 | World Journal of Gastroenterology2010，16，40： | 4 |
| 4 | Octreotide modulates the effects on fibrosis of TNF-α, TGF-β and PDGF in activated rat hepatic stellate cells显示文摘 | Stefanos Klironomos George Notas Ourania Sfakianaki Foteini Kiagiadaki Costas Xidakis Elias Kouroumalis | 2014 | Regulatory Peptides2014，，： | 2 |
| 5 | Safety and efficacy of adenotonsillectomy for obstructive sleep apnea in infants,toddlers and preschool children显示文摘 | Hamada M Iida M Nota J | 2015 | Auris Nasus Larynx2015，42，3： | 1 |
| 6 | Prevalence of tuberculosis, HIV and respiratory symptoms in two Zambian communities: implications for tuberculosis control in the era of HIV显示文摘 | Ayles H Schaap A Nota A | 2009 | Plos One2009，4，5： | 1 |
| 7 | Production of Pro- and Anti-fibrotic Agents by Rat Kupffer Cells; The Effect of Octreotide显示文摘 | Costas Xidakis Dushanka Ljumovic Pinelopi Manousou George Notas Vassilis Valatas George Kolios Elias Kouroumalis | 2005 | Digestive Diseases and Sciences2005，，5： | 1 |
| 8 | Resveratrol exerts its antiproliferative effect on HepG2 hepatocellular carcinoma cells, by inducing cell cycle arrest,and NOS activation显示文摘 | Notas G Nifli A P Kampa M | 2006 | Biochim Biophys Acta2006，1760，11： | 1 |
| 9 | Polyphenols and cancer cell growth显示文摘 | Kampa M Nifli AP Notas G | 2007 | Rev Physiol Biochem Pharmacol2007，159，： | 1 |
| 10 | Transcriptomics reveals extensive inducible biotransformation in the soil-dwelling invertebrate Folsomia camdida exposed to phenanthrene显示文摘 | Nota B Bosse M Ylstra B van Straalen NM Roolofs D | | 0，，1： | 1 |
| 11 | Pre-hospital/emergencydepartment handover in Italy显示文摘 | Do jmi Di Delupis F Mancini N di Nota T | 2015 | Intern Emerg Med2015，10，1： | 1 |
| 12 | Comparison of a mul- tiplex, bead-based fluorescent assay and immunofluorescence meth ods for the detection of ANA and ANCA autoantibodies in human serum显示文摘 | Nifli AP Notas G Mamoulaki M et ol | 2006 | J Immunol Methods2006，311，12： | 1 |
| 13 | A bone-conduction system for audito-ry stimulation in MRI显示文摘 | Yukiko Nota Tatsuya Kitaura | 2007 | Acoust Sci&Tech2007，28，1： | 1 |
| 14 | Complement activation determines the therapeutic activity of rituximab in vivo显示文摘 | Di Gaetano N Cittera E Nota R | 2003 | J Immunol2003，171，3： | 1 |
| 15 | Estradiol and progesterone receptors in malignant gastrointestinal tumors显示文摘 | Nota E Contieri E | 1984 | Cancer Res1984，44，10： | 1 |
| 16 | Apoptosis and apoptosis related proteins in chronic viral liver disease显示文摘 | Tzardi M Valatas V Kanavaros P Karydi E Notas G Xidakis C Kouroumalis E | 2002 | Apoptosis2002，7，2： | 1 |
| 17 | NK and NKT cells in liver injury and fi brosis显示文摘 | Notas G Kisseleva T Brenner D | 2009 | Clin Immunol2009，130，： | 1 |
| 18 | Resveratrol exerts its antiproliferative effect on HepG2 hepatocellular carcinoma cells,by inducing cell cycle arrest,and NOS activation显示文摘 | Notas G Nifli AP Kampa M | 2006 | Biochim Biophys Acta2006，1760，11： | 1 |
| 19 | Nitric oxide and pro-inflammatory cytokines in acute hepatitis B显示文摘 | Koulentaki M Notas G Petinaki E | 2004 | Eur J Intern Med2004，15，： | 1 |
| 20 | Gene expression analysis reveals a gene set discriminatory to different metals in soil 显示文摘 | Nota B Verweij RA Molenaar D | 2010 | Toxicol Sci2010，115，1： | 1 |
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