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| 1 | Octreotide induces caspase activation and apoptosis in human hepatoma HepG2 cells显示文摘AIM: To investigate the role of octreotide on cellular proliferation and apoptosis of human hepatoma (HepG2) cells. METHODS: We studied cellular proliferation, apoptosis and the possible internal caspase-mediated apoptosis pathway involved, after treatment of HepG2 carcinoma cells with octreotide in comparison with the apoptosis caused by tumor necrosis factor-α (TNF-α). Activities of caspase-3, caspase-9, caspase-8 and caspase-2 were studied, while apoptosis was investigated through detection of DNA fragmentation and through identification of apoptotic cells with the annexin-V/propidium iodide flow cytometric method. RESULTS: After an initial increase in HepG2 cellular proliferation, a significant inhibition was observed with 10-8 mol/L octreotide, while TNF-α dose-dependently decreased proliferation. Early and late apoptosis was significantly increased with both substances. Octreotide significantly increased caspase-3, caspase-8 and caspase-2 activity. TNF-α signifi cantly increased only caspase-2. Cellular proliferation was decreased after treatment with octreotide or TNF-α alone but, in contrast to TNF-α, octreotide decreased proliferation only at concentrations of 10-8 mol/L, while lower concentrations increased proliferation. CONCLUSION: Our findings are suggestive of caspasemediated signaling pathways of octreotide antitumor activity in HepG2 cells, and indicate that measurements of serum octreotide levels may be important, at least in clinical trials, to verify optimal therapeutic drug concentrations. | Nikos J Tsagarakis Ioannis Drygiannakis Antonis G Batistakis George Kolios Elias A Kouroumalis | 2011 | World Journal of Gastroenterology2011，17，3： | 5 |
| 2 | Gastroscopic findingsin Mediterranean Kaposi's sarcoma(non-AIDS)显示文摘 | Kolios G Kaloterakis A Filiotou A | 1995 | Gastroint-est Endosc1995，42，4： | 1 |
| 3 | Vitamin D status as related to race and feeding type in pretema infants during the frist year of life显示文摘 | Giapros VI Kolios G Pantou C | 2012 | Eur J Clin Nutr2012，66，2： | 1 |
| 4 | Expression of functional CXCR4 chemokine receptors on human colonic epithelial cells 显示文摘 | Jordan NJ Kolios G Abbot SE | 1999 | J Clin Invest1999，104，： | 1 |
| 5 | Effect of octreotide on apoptosis-related proteins in rat Kupffer cells a possible antitumour mechanism显示文摘 | Xidakis C Kolios G Valatas V | 2004 | Anticancer Res2004，24，2： | 1 |
| 6 | Oxidative stress due to anesthesia and surgical trauma:Importance of early entera! nutrition显示文摘 | Kotzampassi K Kolios G Manousou P | 2009 | Mol Nutr Food Res2009，53，6： | 1 |
| 7 | 显示文摘 | Kolios G Frauhammer J Eigenberger G | 2000 | Chemical Engineering Science2000，55，24： | 1 |
| 8 | n economic comparison of surgical and medical therapy in patients with secondary hyper- paratbyrnidism - the German perspective 显示文摘 | Schneider R Kolios G Koch BM | 2010 | Surgery2010，148，6： | 1 |
| 9 | Modulation of T cell responses by IL-2 and IL-2 complexes显示文摘 | BOYMAN O KOLIOS A G RAEBER M E | 2015 | Clin Exp Rheumatol2015，33，492： | 1 |
| 10 | An economic compa- rison of surgical and medical therapy in patients with secondary hyperparathyroidism--the German perspective 显示文摘 | Schneider R Kolios G Koch BM | 2010 | Surgery2010，148，6： | 1 |
| 11 | Bone infections and bone graft substitutes for local antibiotic therapy显示文摘 | Lalidou F Kolios G and Drosos GI | 2014 | Surg Technol Int2014，124，： | 1 |
| 12 | The value of experimental mod- els of colitis in predicting efficacy of biological therapies for inflammatory bowel diseases显示文摘 | Valatas V Vakas M Kolios G | 2013 | American Journal of Physiology Gastrointestinal and Liver Physiology2013，305，11： | 1 |
| 13 | Immunomodulatory cytokines suppress epithelial nitric oxide production in inflammatory bowel disease by acting on mononuclear cells 显示文摘 | Linehan J D Kolios G Valatas V | 2005 | Free Radic Biol Med2005，39，12： | 1 |
| 14 | Stem cells in liver regeneration and their potential clinical applications显示文摘 | DROSOS I KOLIOS G | 2013 | Stem Cell Reviews and Report2013，9，5： | 1 |
| 15 | Increased expression of chemokine receptor CCR3 and its ligands in ulcerative colitis:the role of colonic epithelial cells in in vitro studies显示文摘 | Manousou P Kolios G Valatas V | | 0，，2： | 1 |
| 16 | Role of cytokines in the pathogensis of anemia of chronic disease in rhenmatoid arthritis显示文摘 | Voulgari PV kolios G Papadopoulos GK | 1999 | Clin Immurol1999，92，2： | 1 |
| 17 | Expression of in- ducible nitric oxide synthase activity in human colon epithe- lial cells:modulation by T lymphpcyte derived cytokines 显示文摘 | Kolios G Rooney N Murphy CT | 1998 | Gut1998，43，1： | 1 |
| 18 | New aspects on the metabolic role of intestinal microbiota in the development of athcrosclerosis显示文摘 | Drosos I Tavridou A Kolios G | 2015 | Metabolism2015，64，47： | 1 |
| 19 | Role of cytokines in the pathogenesis of anemia of chronic disease in rheumatoid arthritis显示文摘 | Voulgari PV Kolios G Papadopoulos G K | 1999 | Clin Immunol1999，92，2： | 1 |
| 20 | Role of cytokines in the pathogenesis of anemia of chronic disease in rheumatoidarthritis 显示文摘 | Voulgari PV Kolios G Papadoupulos GK | 1999 | Clin Immunol1999，92，： | 1 |
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