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| 1 | Role of Kupffer cells in the pathogenesis of liver disease显示文摘Kupffer cells, the resident liver macrophages have long been considered as mostly scavenger cells responsible for removing particulate material from the portal circu- lation. However, evidence derived mostly from animal models, indicates that Kupffer cells may be implicated in the pathogenesis of various liver diseases including viral hepatitis, steatohepatitis, alcoholic liver disease, in- trahepatic cholostasis, activation or rejection of the liver during liver transplantation and liver fibrosis. There is accumulating evidence, reviewed in this paper, suggest- ing that Kupffer cells may act both as effector cells in the destruction of hepatocytes by producing harmful soluble mediators as well as antigen presenting cells during viral infections of the liver. Moreover they may represent a significant source of chemoattractant molecules for cy- totoxic CD8 and regulatory T cells. Their role in fibrosis is well established as they are one of the main sources of TGFβ1 production, which leads to the transformation of stellate cells into myofibroblasts. Whether all these variable functions in the liver are mediated by different Kupffer cell subpopulations remains to be evaluated. In this review we propose a model that demonstrates the role of Kupffer cells in the pathogenesis of liver disease. | George Kolios Vassilis Valatas Elias Kouroumalis | 2006 | World Journal of Gastroenterology2006，12，46： | 74 |
| 2 | Matrix metalloproteinases and their inhibitors in acute viral hepatitis显示文摘 | KOULENTAKI M VALATAS V XIDAKIS K | 2002 | J Viral Hepat2002，9，3： | 1 |
| 3 | Apoptosis and apoptosis related proteins in chronic viral liver disease显示文摘 | Papakyriakou P Tzardi M Valatas V | 2002 | Apoptosis2002，7，： | 1 |
| 4 | Anemia of chronic disease in rheumatoid arthritis is associated with increased apoptosis of bone marrow erythroid cells:improvemen following anti-tumor necrosis factor alpha α antibody therapy显示文摘 | Papadaki HA Kritikos HD Valatas V | 2002 | Blood2002，100，2： | 1 |
| 5 | Production of Pro- and Anti-fibrotic Agents by Rat Kupffer Cells; The Effect of Octreotide显示文摘 | Costas Xidakis Dushanka Ljumovic Pinelopi Manousou George Notas Vassilis Valatas George Kolios Elias Kouroumalis | 2005 | Digestive Diseases and Sciences2005，，5： | 1 |
| 6 | Effect of octreotide on apoptosis-related proteins in rat Kupffer cells a possible antitumour mechanism显示文摘 | Xidakis C Kolios G Valatas V | 2004 | Anticancer Res2004，24，2： | 1 |
| 7 | Isolation of rat Kupffer cells: a combined methodology for highly purified primary cultures显示文摘 | Valatas V Xidakis C Roumpaki H | 2003 | Cell Biol Int2003，27，1： | 1 |
| 8 | Matrix metallopmteinases and their inhibitors in acute viral hepatitis显示文摘 | Koulentaki M Valatas V Xidakis K | 2002 | J Viral Hepat2002，9，3： | 1 |
| 9 | Apoptosis and apoptosis related proteins in chronic viral liver disease显示文摘 | Tzardi M Valatas V Kanavaros P Karydi E Notas G Xidakis C Kouroumalis E | 2002 | Apoptosis2002，7，2： | 1 |
| 10 | The value of experimental mod- els of colitis in predicting efficacy of biological therapies for inflammatory bowel diseases显示文摘 | Valatas V Vakas M Kolios G | 2013 | American Journal of Physiology Gastrointestinal and Liver Physiology2013，305，11： | 1 |
| 11 | Immunomodulatory cytokines suppress epithelial nitric oxide production in inflammatory bowel disease by acting on mononuclear cells 显示文摘 | Linehan J D Kolios G Valatas V | 2005 | Free Radic Biol Med2005，39，12： | 1 |
| 12 | Increased expression of chemokine receptor CCR3 and its ligands in ulcerative colitis:the role of colonic epithelial cells in in vitro studies显示文摘 | Manousou P Kolios G Valatas V | | 0，，2： | 1 |
| 13 | Isolation of rat kupffer cells :a combined methodology for highly purified primary cultures显示文摘 | Valatas V Xidakis C Roumpaki H | 2003 | Cell Biology international2003，27，1： | 1 |
| 14 | Isolation of rat Kuper's cells:a combined methodology for highly purified primary cultures显示文摘 | Valatas V Xidakis C Roumpaki H | 2003 | Cell Biol Int2003，27，1： | 1 |
| 15 | Anemia of chronic disease in rheumatoid arthritis is associated with increased apoptosis of bone marrow erythroid cells: Improvement following anti - tumor necrosis factor - alpha antibody therapy 显示文摘 | Papadakl HA Kritikos HD Valatas V | 2002 | Blood2002，100，2： | 1 |
| 16 | Immunomodulatory cytokines suppress epithelial nitric oxide production in inflammatory bowel disease by acting on mononuclear cells显示文摘 | Linehan JD Kolios G Valatas V | 2005 | Free Radic Biol Med2005，39，12： | 1 |
| 17 | Anemia of chronic disease in rheumatoid arthritis is associated with increased apoptosis of bone marrow erythroid cells:im-provement following anti–tumor necrosis factor-αanti-body therapy显示文摘 | Papadaki HA Kritikos HD Valatas V | | 0，，02： | 1 |
| 18 | Bolus somatostatin but not oct- reotide reduces hepatic sinusoidal pressure by a NO - independent mechanism in chronic liver disease 显示文摘 | Matrella E Valatas V Notas G | 2001 | Aliment Pharmacol Ther2001，15，6： | 1 |
| 19 | Isolation of rat Kupffer cells:a combined methodology for highly purified primary cultures显示文摘 | Valatas V Xidakis C Roumpaki H | 2003 | Cell Biol Int2003，27，1： | 1 |
| 20 | Isolation of rat Kupffer ceils: a combined methodology for highly purified primary cul- tures显示文摘 | Valatas V Xidakis C Roumpaki H | 2003 | Cell Biol Int2003，27，1： | 1 |
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