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| 1 | Endoscopic retrograde cholangiopancreatography associated pancreatitis:A 15-year review显示文摘The aim of this article is to review the literature regarding post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis.We searched for and evaluated all articles describing the diagnosis,epidemiology,pathophysiology,morbidity,mortality and prevention of post-ERCP pancreatitis(PEP) in adult patients using the PubMed database.Search terms included endoscopic retrograde cholangiopancreatography,pancreatitis,ampulla of vater,endoscopic sphincterotomy,balloon dilatation,cholangiography,adverse events,standards and utilization.We limited our review of articles to those published between January 1,1994 and August 15,2009 regarding human adults and written in the English language.Publicat ions from the reference sections were reviewed and included if they were salient and fell into the time period of interest.Between the dates queried,seventeen large(> 500 patients) prospective and four large retrospective trials were conducted.PEP occurred in 1-15 in the prospective trials and in 1-4 in the retrospective trials.PEP was also reduced with pancreatic duct stent placement and outcomes were improved with endoscopic sphincterotomy compared to balloon sphincter dilation in the setting of choledocholithiasis.Approximately 34 pharmacologic agents have been evaluated for the prevention of PEP over the last f ifteen years in 63 trials.Although 22 of 63 trials published during our period of review suggested a reduction in PEP,no pharmacologic therapy has been widely accepted in clinical use in decreasing the development of PEP.In conclusion,PEP is a well-recognized complication of ERCP.Medical treatment for prevention has been disappointing.Proper patient selection and pancreatic duct stenting have been shown to reduce the complication rate in randomized clinical trials. | Kevin E Woods Field F Willingham | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，5： | 20 |
| 2 | Controlling light with light using coherent metadevices: all-optical transistor, summator and invertor显示文摘Although vast amounts of information are conveyed by photons in optical fibers,the majority of data processing is performed electronically,creating the infamous‘information bottleneck’and consuming energy at an increasingly unsustainable rate.The potential for photonic devices to directly manipulate light remains unfulfilled due largely to a lack of materials with strong,fast optical nonlinearities.In this paper,we show that small-signal amplifier,summator and invertor functions for optical signals may be realized using a four-port device that exploits the coherent interaction of beams on a planar plasmonic metamaterial,assuming no intrinsic nonlinearity.The redistribution of energy among ports can provide nonlinear input-output signal dependencies and may be coherently controlled at very low intensity levels,with multi-THz bandwidth and without introducing signal distortion,thereby presenting powerful opportunities for novel optical data processing architectures,complexity oracles and the locally coherent networks that are becoming part of the mainstream telecommunications agenda. | Xu Fang Kevin F MacDonald Nikolay I Zheludev | 2015 | Light(Science & Applications)2015，4，1： | 5 |
| 3 | Controlling light-with-light without nonlinearity显示文摘According to the fundamental Huygens superposition principle,light beams traveling in a linear medium will pass though one another without mutual disturbance.Indeed,the field of photonics is based on the premise that controlling light signals with light requires intense laser fields to facilitate beam interactions in nonlinear media,where the superposition principle can be broken.Here we challenge this wisdom and demonstrate that two coherent beams of light of arbitrarily low intensity can interact on a metamaterial layer of nanoscale thickness in such a way that one beam modulates the intensity of the other.We show that the interference of beams can eliminate the plasmonic Joule losses of light energy in the metamaterial or,in contrast,can lead to almost total absorption of light.Applications of this phenomenon may lie in ultrafast all-optical pulse-recovery devices,coherence filters and terahertz-bandwidth light-by-light modulators. | Jianfa Zhang Kevin F MacDonald Nikolay I Zheludev | 2012 | Light(Science & Applications)2012，1，1： | 5 |
| 4 | Gut microbiota mediated molecular events and therapy in liver diseases显示文摘Gut microbiota is a community of microorganisms that reside in the gastrointestinaltract. An increasing number of studies has demonstrated that the gutliveraxis plays a critical role in liver homeostasis. Dysbiosis of gut microbiota cancause liver diseases, including nonalcoholic fatty liver disease and alcoholic liverdisease. Preclinical and clinical investigations have substantiated that themetabolites and other molecules derived from gut microbiota and diet interactionfunction as mediators to cause liver fibrosis, cirrhosis, and final cancer. This effecthas been demonstrated to be associated with dysregulation of intrahepaticimmunity and liver metabolism. Targeting these findings have led to thedevelopment of novel preventive and therapeutic strategies. Here, we review thecellular and molecular mechanisms underlying gut microbiota-mediated impacton liver disease. We also summarize the advancement of gut microbiota-basedtherapeutic strategies in the control of liver diseases. | Xiaoqiang Qi Ming Yang Joseph Stenberg Rahul Dey Leslie Fogwe Muhammad Shawkat Alam Eric TKimchi Kevin F Staveley-O'Carroll Guangfu Li | 2020 | World Journal of Gastroenterology2020，26，48： | 5 |
| 5 | Bone graft substitutes for spine fusion: A brief review显示文摘Bone graft substitutes are widely used in the field of orthopedics and are extensively used to promote vertebral fusion. Fusion is the most common technique in spine surgery and is used to treat morbidities and relieve discomfort. Allograft and autograft bone substitutes are currently the most commonly used bone grafts to promote fusion. These approaches pose limitations and present complications to the patient. Numerous alternative bone graft substitutes are on the market or have been developed and proposed for application. These options have attempted to promote spine fusion by enhancing osteogenic properties. In this review, we reviewed biology of spine fusion and the current advances in biomedical materials and biological strategies for application in surgical spine fusion. Our findings illustrate that, while many bone graft substitutes perform well as bone graft extenders, only osteoinductive proteins(recombinant bone morphogenetic proteins-2 and osteogenic protein-1) provide evidence for use as both bone enhancers and bone substitutes for specific types of spinal fusion. Tissue engineered hydrogels, synthetic polymer composites and viral based gene therapy also holds the potential to be used for spine fusion in future, though warrants further investigation to be used in clinical practice. | Ashim Gupta Nitin Kukkar Kevin Sharif Benjamin J Main Christine E Albers Saadiq F El-Amin Ⅲ | 2015 | World Journal of Orthopedics2015，6，6： | 4 |
| 6 | 人参减少 γ射线照射的淋巴细胞微核量(英文)显示文摘目的 评价中国人参对减少辐射诱导的人周围血 G0 期淋巴细胞 (PBL)微核量的作用。方法 采用细胞因子阻滞的微核法检测健康志愿者的血标本。体外 1 37Cs照射之前 ,每份血标本的单个核细胞培养以不同浓度 (0~ 2 0 0 0μg· m l- 1 )的人参根水提取物孵育 2 4 h。结果 (1)在 0 Gy时 ,每 10 0 0个双核 (BN )细胞的微核量是 11.3± 2 .7,人参水提取物≥ 5 0 0μg· ml- 1 时微核量下降 ,但微核量和人参水提取物的浓度之间的差异是显著的。 (2 )单独射线照射显著增加微核量 ,当暴露于 1Gy的照射时 ,随着培养介质中人参水提取物浓度的增加 ,微核量呈显著的线性降低 (R2 =0 .0 5 ,P =0 .0 0 2 ) ;对暴露于 1Gy辐射诱导的微核量 ,人参水提取物浓度在 15 0 0μg· m l- 1 时减少 4 6 .6 % ,浓度在 2 0 0 0μg·m l- 1时减少 5 7.6 % ;对暴露于 2 Gy辐射诱导的微核量的减少呈更强的线性相关 (R2 =0 .7,P=0 .0 0 0 1) ;(3)微核数据分析的结果呈现出与 Poisson模型相关的过度离散趋势。结果表明 :(1)人参水提取物浓度达 2 0 0 0 μg· ml- 1时 ,对 PBL 细胞毒作用无明显影响 ;(2 )人参水提取物浓度在 5 0 0 μg· ml- 1和 2 0 0 0 μg· ml- 1之间时 ,对抗 1 37Cs照射诱导的 MN发挥保护作用。 | 李同光 Ron R Allison Kevin F O'Brien Prabhaker G Khazanie Larry J Dobbs Jr. Peter J Kragel | 2004 | 新乡医学院学报2004，21，3： | 3 |
| 7 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 8 | Pedicle Morphology In Thoracic Adolescent Idiopathic Scoliosis: Is Pedicle Fixation an Anatomically Viable Technique?显示文摘 | Michael F O’Brien Lawrence G Lenke Steven Mardjetko Thomas G Lowe Yinong Kong Kevin Eck David Smith | 2000 | Spine2000，，18： | 2 |
| 9 | Nonlinear dielectric optomechanical metamaterials显示文摘We introduce a dielectric photonic metamaterial presenting a giant nonlinear optical response driven by resonant optomechanical forces.Being inherently free of Joule losses,it exhibits optical bistability at intensity levels of less than 0.2 mW mm22 and,furthermore,manifests nonlinear asymmetric transmission with a forward:backward optical extinction ratio of more than 30 dB. | Jianfa Zhang Kevin F MacDonald Nikolay I Zheludev | 2013 | Light(Science & Applications)2013，2，1： | 2 |
| 10 | Behavioural and neurochemical effects of post-weaning social isolation in rodents-Relevance to developmental neuropsychiatric disorders显示文摘 | Kevin C F F Veronica M P | 2008 | Neuroscience and Biobehavioral Reviews2008，，32： | 1 |
| 11 | Reactive oxygen species as mediators of cardiac injury and protection:the relevance to anesthesia practice显示文摘 | Kevin L G Novalija E Stowe D F | 2005 | Anesth Analg2005，101，5： | 1 |
| 12 | Selective killing of vaccinia virus by LL-37: Implications for eczema vaccinatum显示文摘 | Howell M D James F Kevin O | 2004 | Immunol2004，172，3： | 1 |
| 13 | Biomarkers in newly diagnosed pediatric extensive chronic graft-versus-host disease: a report from the Children′s Oncology Group显示文摘 | Hisaki F Geoff C Kevin S | 2008 | Blood2008，111，： | 1 |
| 14 | Pyridinyl polythiazole class peptide antiriotic microtic micrococcin pi, Secreted by foodbornh staphylococcus e guorm Ws2733, is biosynthesized nonribosomally显示文摘 | Markus C C Torsten S Kevin P F | 2001 | Eu J Biochem2001，268，： | 1 |
| 15 | Modeling uncertainty reasoning with possibilistic Petri nets显示文摘 | Lee Jonathan Liu Kevin F R Chiang Wei-ling | 2003 | IEEE Trans on Systems Man and Cybernetics-Part B:Cybernetics2003，33，2： | 1 |
| 16 | Regulation of the Rapsyn Promoter by Kaiso and δ-Catenin 显示文摘 | Marianna Rodova Kevin F Kelly Michael VanSaun | 2004 | Molecular and Cellular Biology2004，24，： | 1 |
| 17 | Equivalent time temperature model for physical aging and temperature effects on polymer creep and relaxation显示文摘 | Ever J B Kevin J F | 2004 | Journal of Engineering Materials and Technology2004，126，4： | 1 |
| 18 | New method for quantification of vuggy porosity from digital optical borehole images as applied to the karstic Pleistocene limestone of the Biscayne aquifer, southeastern Florida显示文摘 | Kevin J Cunningham Janine I Carlson Neil F Hurley | 2003 | Journal of Applied Geophysics2003，，1： | 1 |
| 19 | Simulation-based comparisons of Tahoe,Reno,and SACK TCP显示文摘 | KEVIN F FLOYD S | | 0，，03： | 1 |
| 20 | A genetic variant BDNF polymorphism aters extinction learning in both mouse and human 显示文摘 | Soliman F Glatt CE Kevin G | 2010 | Science2010，327，5967： | 1 |
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