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| 1 | Coordinated peak expression of MMP-26 and TIMP-4 in preinvasive human prostate tumor显示文摘因为早察觉和治疗为病人的医药管理是批评的,为早前列腺癌症诊断的新奇简历标记的鉴定是高度重要的。在基础房间层和地下室膜的连续性的混乱为高级职业人员静电干扰 intraepithelial 瘤形成(HGPIN ) 的前进是必要的到在人的前列腺的侵略腺癌。涉及变换到侵略显型的分子是强烈审查的题目。我们以前报导了矩阵 metalloproteinase-26 (MMP-26 ) 经由地下室膜蛋白质并且由激活 MMP-9 的酶原形式的劈开支持人的前列腺癌症房间的侵略。而且,我们发现了 metalloproteinases-4 (TIMP-4 ) 的那个织物禁止者是大多数有势力 MMP-26 的内长的禁止者。这里,我们更高示威(p<0.0001 ) 在 HGPIN 和癌症的 MMP-26 和 TIMP-4 表示,与非肿瘤的 acini 相比。他们的表示层次在 HGPIN 是最高的,但是在一样的纸巾在侵略癌症(为各个的 p<0.001 ) 衰退。连续前列腺癌症织物节染色的 Immunohistochemical 建议 MMP-26 和 TIMP-4 的 colocalization。现在的学习显示 MMP-26 和 TIMP-4 可以在 HGPIN 的变换期间起一个不可分的作用到侵略癌症并且可以也为早前列腺癌症诊断用作标记。房间研究(2006 ) 16:750-758。做 i:10.1038/sj .cr.7310089;出版联机 2006 年 8 月 29 日。 | Seakwoo Lee Kevin K Desai Kenneth A Iczkowski Robert G Newcomer Kevin J WU Yun-Ge Zhao Winston W Tan Mark D Roycik Qing-Xiang Amy Sang | 2006 | Cell Research2006，16，9： | 18 |
| 2 | Treatment responses in Asians and Caucasians with chronic hepatitis C infection显示文摘AIM:To conduct a multicentre retrospective review of virological response rates in Asians infected with genotype 1 chronic hepatitis C(CHC) treated with combination interferon and ribavirin and then to compare their responses to that among Caucasians.METHODS:Asian patients infected with genotype 1 CHC treated at 4 Australian centres between 2001 to 2005 were identified through hospital databases.Baseline demographic characteristics,biochemical,virological and histological data and details of treatment were collected.Sustained virological responses(SVR) in this cohort were then compared to that in Caucasian subjects,matched by genotype,age,gender and the stage of hepatic fibrosis.RESULTS:A total of 108 Asians with genotype 1 CHC were identified.The end of treatment response(ETR) for the cohort was 79% while the SVR was 67%.Due to the relatively advanced age of the Asian cohort,only sixty-four subjects could be matched with Caucasians.The ETR among matched Asians and Caucasians was 81% and 56% respectively(P=0.003),while the SVR rates were 73% and 36%(P <0.001) respectively.This difference remained significant after adjusting for other predictive variables. | Kenneth K Yan Marianne Guirgis Amany Zekry Thuy Dinh Anouk Dev Jacob George Alice Lee | 2008 | World Journal of Gastroenterology2008，14，21： | 12 |
| 3 | 特应性皮炎动物模型表皮分化蛋白表达的改变显示文摘目的观察特应性皮炎(AD)除真皮T细胞浸润和皮肤增厚外,是否有表皮细胞的分化和增生异常。方法利用反复外涂半抗原的方法制作AD动物模型。在观察该模型皮肤生理学改变的同时,利用免疫组化的方法对表皮分化蛋白的表达和角质形成细胞的增生进行观察。结果AD组角质层的水分含量明显降低;皮肤水分丢失量及pH明显增高。与对照组相比,AD组表皮兜甲蛋白(loricrin)的表达明显减少;在角质层,中间丝相关蛋白(Filaggrin)和外皮蛋白(involucrin)的表达强度稍微减低,但表达部位有明显地改变。正常时仅表达在角质层,而在AD组其颗粒层和棘细胞层均有较强的染色。抗增生细胞核抗体染色显示,AD的表皮增生极其活跃。HE染色显示AD的表皮明显增厚。结论利用反复外涂半抗原的方法可成功制作AD动物模型,AD除皮肤生理的异常外,还伴有表皮增生和分化的异常。 | 杨军 Seung Hun Lee 黄晓波 Kenneth R.Feingold Peter M.Elias 史月君 蔄茂強 | 2006 | 中国皮肤性病学杂志2006，20，12： | 5 |
| 4 | 社区步行通达性对独栋住宅房价的效益评估--美国德克萨斯州奥斯丁市空间特征分析显示文摘通过分析美国德克萨斯州奥斯丁市2010—2012年独栋住宅的销售价格,以街道智慧步行指数(Street Smart Walk Score)和人行道密度(Sidewalk Density)作为衡量指标,研究社区步行通达性对房价的影响。使用Cliff-Ord空间特征模型(即广义空间模型,General Spatial Model,或者SAC)控制空间自相关影响。结果表明:在依赖小汽车的社区通过增加设施可达性来提升步行通达性的举措并不能提高房价;增加人行道也只能最小限度地提高房价。投资社区便利设施和人行道对适宜步行社区的房价提升效果比依赖小汽车的社区显著。 | 李威 Kenneth Joh Chanam Lee Jun-Hyun Kim Han Park Ayoung Woo 张斯阳(译) | 2016 | 城市交通2016，14，4： | 5 |
| 5 | A review of silicon-based wafer bonding processes,an approach to realize the monolithic integration of Si-CMOS and III-V-on-Si wafers显示文摘The heterogeneous integration of III-V devices with Si-CMOS on a common Si platform has shown great promise in the new generations of electrical and optical systems for novel applications,such as HEMT or LED with integrated control circuitry.For heterogeneous integration,direct wafer bonding(DWB)techniques can overcome the materials and thermal mismatch issues by directly bonding dissimilar materials systems and device structures together.In addition,DWB can perform at wafer-level,which eases the requirements for integration alignment and increases the scalability for volume production.In this paper,a brief review of the different bonding technologies is discussed.After that,three main DWB techniques of single-,double-and multi-bonding are presented with the demonstrations of various heterogeneous integration applications.Meanwhile,the integration challenges,such as micro-defects,surface roughness and bonding yield are discussed in detail. | Shuyu Bao Yue Wang Khaw Lina Li Zhang Bing Wang Wardhana Aji Sasangka Kenneth Eng Kian Lee Soo Jin Chua Jurgen Michel Eugene Fitzgerald Chuan Seng Tan Kwang Hong Lee | 2021 | Journal of Semiconductors2021，42，2： | 5 |
| 6 | Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration显示文摘Heart regeneration occurs by dedifferentiation and proliferation of pre-existing cardiomyocytes(CMs).However,the signaling mechanisms by which injury induces CM renewal remain incompletely understood.Here,we find that cardiac injury in zebrafish induces expression of the secreted Wnt inhibitors,including Dickkopf 1(Dkkl),Dkk3,secreted Frizzled-related protein 1(sFrpl),and sFrp2,in cardiac tissue adjacent to injury sites.Experimental blocking of Wnt activity via Dkkl overexpression enhances CM proliferation and heart regeneration,whereas ectopic activation of Wnt8 signaling blunts injury-induced CM dedifferentiation and proliferation.Although Wnt signaling is dampened upon injury,the cytoplasmic β-catenin is unexpectedly increased at disarrayed CM sarcomeres in myocardial wound edges.Our analyses indicated that p21-activated kinase 2(Pak2)is induced at regenerating CMs,where it phosphorylates cytoplasmic β-catenin at Ser 675 and increases its stability at disassembled sarcomeres.Myocardial-specific induction of the phospho-mimeticβ-catenin(S675E)enhances CM dedifferentiation and sarcomere disassembly in response to injury.Conversely,inactivation of Pak2 kinase activity reduces the Ser 675-phosphorylatedβ-catenin(pS675-β-catenin)and attenuates CM sarcomere disorganization and dedifferentiation・Taken together,these findings demonstrate that coordination of Wnt signaling inhibition and Pak2/pS675-βYatenin signaling enhances zebrafish heart regeneration by supporting CM dedifferentiation and proliferation. | Xiangwen Peng Kaa Seng Lai Peilu She Junsu Kang Tingting Wang Guobao Li Yating Zhou jianjian Sun Daqing Jin Xiaolei Xu Lujian Liao Jiandong Liu Ethan Lee Kenneth D.Poss Tao P.Zhong | 2021 | Journal of Molecular Cell Biology2021，13，1： | 3 |
| 7 | Recurrence and Outcomes Following Hepatic Resection, Radiofrequency Ablation, and Combined Resection/Ablation for Colorectal Liver Metastases显示文摘 | Eddie K. Abdalla Jean-Nicolas Vauthey Lee M. Ellis Vickie Ellis Raphael Pollock Kristine R. Broglio Kenneth Hess Steven A. Curley | 2004 | Annals of Surgery2004，，6： | 3 |
| 8 | The Effects of Attitudinal and Demographic Factors on Intention to Buy Pirated CDs: The Case of Chinese Consumers显示文摘 | Kenneth K. Kwong Oliver H. M. Yau Jenny S. Y. Lee Leo Y. M. Sin Alan C. B. Tse | 2003 | Journal of Business Ethics2003，，3： | 2 |
| 9 | Bone morphogenetic protein 2 improves patellar tendon healing by promoting migration and proliferation of tenocytes显示文摘The repair of injured tendons remains a great challenge because of the poor intrinsic healing capacity of tendons. In this study, we examined the spatiotemporal expression pattern of the bone morphogenetic protein 2 (bmp-2) gene in normal and experimentally injured rat patellar tendons. We also investigated the ability of exogenously applied BMP-2 to promote patellar tendon healing. In situ hybridization with bmp-2 and alk-6 (bmp-2 receptor) antisense riboprobes revealed that both genes were normally expressed at low levels in intact rat tendons. However, bmp-2 expression was significantly upregulated in tenocytes found in the wound site at 7 d and later following tendon injury. In addition, it was found that bmp-2 was expressed in cultured patellar tenocytes. Appli- cation of exogenous BMP-2 to the tendon wound site significantly enhanced tendon repair. Moreover, in vitro and in vivo studies further demonstrated that BMP-2 enhanced tenocyte proliferation and migration to the wound site. The detectable amount of BMP-2 in normal tendons suggests that a basal level of bmp-2 expression was likely present to maintain the normal functions of the patellar tendon. Injury to the tendon induced increased bmp-2 expression intrinsically, but the expression level was insufficient for proper tendon repair. Our findings indicate that it is possible to significantly improve tendon healing by applying exogenous BMP-2 to the wound site, inferring that this protein could be developed as a potential therapeutic reagent for the treatment of damaged tendons. | TANG MeiKuen LEE Kenneth K | 2011 | Chinese Science Bulletin2011，56，13： | 2 |
| 10 | Gastrointestinal Kaposi's sarcoma: Case report and review of the literature显示文摘Kaposi's sarcoma(KS) of the gastrointestinal tract is not an uncommon disease among individuals with acquired immunodeficiency syndrome(AIDS). The majority is asymptomatic, and for this reason, gastrointestinal KS(GI-KS) remains undiagnosed. With continued tumor growth, considerable variation in clinical presentation occurs including abdominal pain, nausea, vomiting, iron deficiency anemia(either chronic or frank gastrointestinal bleeding), and rarely mechanical obstruction alone or combined with bowel perforation. Endoscopy with biopsy allows for histological and immunohistochemical testing to confirm the diagnosis of GI-KS among those with clinical symptoms. In previous studies, dual treatment with highly active antiretroviral therapy and systemic chemotherapy have been associated with improved morbidity and mortality in individuals with visceral KS. Therefore, investigators have suggested performing screening endoscopies in select patients for early detection and treatment to improve outcome. In this review, we describe a 44 years old man with AIDS and cutaneous KS who presented for evaluation of postprandial abdominal pain, vomiting, and weight loss. On upper endoscopy, an extensive, infiltrative,circumferential, reddish mass involving the entire body and antrum of the stomach was seen. Histologic examination later revealed spindle cell proliferation, and confirmatory immunohistochemical testing revealed human herpes virus 8 latent nuclear antigen expression consistent with a diagnosis of gastric KS. Following this, we present a comprehensive review of literature on KS with emphasis on gastrointestinal tract involvement and management. | Ann Joo Lee Lacie Brenner Bashar Mourad Carmela Monteiro Kenneth J Vega Juan Carlos Munoz | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，3： | 2 |
| 11 | Adverse Effect of Ventricular Pacing on Heart Failure and Atrial Fibrillation Among Patients With Normal Baseline QRS Duration in a Clinical Trial of Pacemaker Therapy for Sinus Node Dysfunction显示文摘 | Michael O. Sweeney Anne S. Hellkamp Kenneth A. Ellenbogen Arnold J. Greenspon Roger A. Freedman Kerry L. Lee Gervasio A. Lamas | 2003 | Circulation2003，，23： | 2 |
| 12 | Development of a Core Set from a Large Rice Collection using a Modified Heuristic Algorithm to Retain Maximum Diversity显示文摘A new heuristic approach was undertaken for the establishment of a core set for the diversity research of rice. As a result, 107 entries were selected from the 10 368 characterized accessions. The core set derived using this new approach provided a good representation of the characterized accessions present in the entire collection. No significant differences for the mean, range, standard deviation and coefficient of variation of each trait were observed between the core and existing collections. We also compared the diversity of core sets established using this Heuristic Core Collection (HCC) approach with those of core sets established using the conventional clustering methods. This modified heuristic algorithm can also be used to select genotype data with allelic richness and reduced redundancy, and to facilitate management and use of large collections of plant genetic resources in a more efficient way. | Hun-Ki Chung Kyu-Won Kim Jong-Wook Chung Jung-Ro Lee Sok-Young Lee Anupam Dixit Hee-Kyoung Kang Weiguo Zhao Kenneth L. McNally Ruraidh S. Hamilton Jae-Gyun Gwag Yong-Jin Park | 2009 | Journal of Integrative Plant Biology2009，51，12： | 2 |
| 13 | Adverse Effect of Ventricular Pacing on Heart Failure and Atrial Fibrillation Among Patients With Normal Baseline QRS Duration in a Clinical Trial of Pacemaker Therapy for Sinus Node Dysfunction显示文摘 | Michael O. Sweeney Anne S. Hellkamp Kenneth A. Ellenbogen Arnold J. Greenspon Roger A. Freedman Kerry L. Lee Gervasio A. Lamas | 2003 | Circulation2003，，23： | 1 |
| 14 | Fibroblast Growth Factor 23, Bone Mineral Density, and Risk of Hip Fracture Among Older Adults: The Cardiovascular Health Study显示文摘 | Anna Jovanovich Petra Bù?ková Michel Chonchol John Robbins Howard A. Fink Ian H. de Boer Bryan Kestenbaum Ronit Katz Laura Carbone Jennifer Lee Gail A. Laughlin Kenneth J. Mukamal Linda F. Fried Michael G. Shlipak Joachim H. Ix | 2013 | The Journal of Clinical Endocrinology & Metabolism2013，，8： | 1 |
| 15 | Quantive determination of the elemental,ferrous,ferric,souble,and complexed iron in foods显示文摘 | Kenneth Lee FMClydesdale | 1979 | Food Science1979，，2： | 1 |
| 16 | Pain in Chronic Pancreatitis and Pancreatic Cancer显示文摘 | Kenneth E. Fasanella Brian Davis John Lyons Zongfu Chen Kenneth K. Lee Adam Slivka David C. Whitcomb | 2007 | Gastroenterology Clinics of North America2007，，2： | 1 |
| 17 | Quantive determination of the elemental,ferrous, ferric, souble,and complexed iron in foods显示文摘 | Kenneth Lee Clydesdale F M | 1979 | J Food Science1979，44，2： | 1 |
| 18 | Effects of in situ light reduction on the maintenance, growth and partitioning of carbon resources in Thalassia testudinum Banks ex Konig显示文摘 | LEE K KENNETH H | 1997 | J Exp Mar Biol Ecol1997，210，1： | 1 |
| 19 | Targeted ablation of the histidine-rich Ca 2+ -binding protein (HRC) gene is associated with abnormal SR Ca 2+ -cycling and severe pathology under pressure-overload stress显示文摘 | Chang Sik Park Shan Chen Hoyong Lee Hyeseon Cha Jae Gyun Oh Sunghee Hong Peidong Han Kenneth S. Ginsburg Sora Jin Inju Park Vivek P. Singh Hong-Sheng Wang Clara Franzini-Armstrong Woo Jin Park Donald M. Bers Evangelia G. Kranias Chunghee Cho Do Han Kim | 2013 | Basic Research in Cardiology2013，，3： | 1 |
| 20 | Antitumor agents. Part 218: Cappamensin A, a new In vitro anticancer principle, from Capparis sikkimensis显示文摘 | Jiu-Hong Wu Fang-Rong Chang Ken-ichiro Hayashi Hiroaki Shiraki Chih-Chuang Liaw Yuka Nakanishi Kenneth F. Bastow Donglei Yu Ih-Sheng Chen Kuo-Hsiung Lee | 2003 | Bioorganic & Medicinal Chemistry Letters2003，，13： | 1 |
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