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| 1 | Colorectal cancer in patients under 50 years of age:A retrospective analysis of two institutions' experience显示文摘AIM:To investigate the epidemiological characteristics of colorectal cancer(CRC)in patients under 50 years of age across two institutions.METHODS:Records of patients under age 50 years of age who had CRC surgery over a 16 year period were assessed at two institutions.The following documents where reviewed:admission notes,operative notes,and discharge summaries.The main study variables included:age,presenting symptoms,family history,tumor location,operation,stage/differentiation of disease,and post operative complications.Stage of disease was classified according to the American Joint Committee on Cancer TNM staging system:tumor depth;node status;and metastases.RESULTS:CRC was found in 180 patients under age50 years(87 females,93 males;mean age 41.4±6.2years).Young patients accounted for 11.2%of cases during a 6 year period for which the full data set wasavailable.Eight percent had a 1stdegree and 12%a 2nd degree family CRC history.Almost all patients(94%)were symptomatic at diagnosis;common symptoms included:bleeding(59%),obstruction(9%),and abdominal/rectal pain(35%).Evaluation was often delayed and bleeding frequently attributed to hemorrhoids.Advanced stage CRC(Stage 3 or 4)was noted in 53%of patients.Most tumors were distal to the splenic flexure(77%)and 39%involved the rectum.Most patients(95%)had segmental resections;6 patients had subtotal/total colectomy.Poorly differentiated tumors were noted in 12%and mucinous lesions in 19%of patients of which most had Stage 3 or 4 disease.Twenty-two patients(13%)developed recurrence and/or progression of disease to date.Three patients(ages 42,42and 49 years)went on to develop metachronous primary colon cancers within 3 to 4 years of their initial resection.CONCLUSION:CRC was common in young patients with no family history.Young patients with symptoms merit a timely evaluation to avoid presentation with late stage CRC. | Elizabeth A Myers Daniel L Feingold Kenneth A Forde Tracey Arnell Joon Ho Jang Richard L Whelan | 2013 | World Journal of Gastroenterology2013，19，34： | 9 |
| 2 | Direct dating of sulfides by Rb-Sr:Acritical test using the Polaris Mississippi Valley-type Zn-Pb deposit显示文摘 | Christensen J N Halliday A N Kenneth E L Roderick N R and Stephen E K | | 0，，： | 1 |
| 3 | Inhibition of vascular endo- thelial cell growth factor activity by an endogenously encoded soluble receptor显示文摘 | Cichard L Kendall Kenneth A | 1993 | P roc N atl Acad Sci US A1993，90，10： | 1 |
| 4 | Feasible trajectory generation for atmospheric entry guidance显示文摘 | JAMES A L KENNETH D M | 2007 | Journal of Guidance Control and Dynamics2007，30，2： | 1 |
| 5 | Renal outcomes with different fixed-dose combination therapies in patients with hypertension at high risk for cardiovascular events (ACCOMPLISH): a prespecified secondary analysis of a randomised controlled trial显示文摘 | George L Bakris Pantelis A Sarafidis Matthew R Weir Bj?rn Dahl?f Bertram Pitt Kenneth Jamerson Eric J Velazquez Linda Staikos-Byrne Roxzana Y Kelly Victor Shi Yann-Tong Chiang Michael A Weber | 2010 | The Lancet2010，，9721： | 1 |
| 6 | Physiological responses of cabbage to incipient copper toxicity显示文摘 | Penelope A R Helen C H Kenneth L S | 1989 | J Amer Soc Hor Sci1989，114，1： | 1 |
| 7 | Manganesedependent cleavage of nonphenolic lignin structures byceriporiopsis subvermispora in the absence of ligninperox idase显示文摘 | Kenneth A Jensen J R Bao W L | 1996 | Applied and Environmental Microbiology1996，62，10： | 1 |
| 8 | Ophidiacerebrosides - cytotoxic glycosphingolipids containing a novel sphingosine from a sea star 显示文摘 | Jin W Z Kenneth L R Elizabeth A | 1994 | Journal of Organic Chemistry1994，59，： | 1 |
| 9 | Suicidal overdoses of psychotropic drugs by elderly in New York City:comparison with younger adults显示文摘 | Robert A Andrew L Kenneth T | 2011 | Psychiatry Research2011，188，3： | 1 |
| 10 | Ligand design and metal-ion recognition interaction of nikel ( Ⅱ ) with 17- to 19-membered macrocycles containing O2N3 donor and O3N2 donor sets and X-ray structure of the parent 17-membered macrocyclic ligand显示文摘 | KENNETH R A ATHONY J L LEONARD F L | 1983 | J Amer Chem Soc1983，105，4： | 1 |
| 11 | unlocking invisible gold: use of nanosims to evaluate gold, trace elements,and sulfur istopes in pyrite from carlin type gold deposits显示文摘 | Shaun L L B Kenneth A H Jean S C | 2009 | Economic Ge- ology2009，，104： | 1 |
| 12 | Manganesedependent cleavage of nonphenolic lignin structures byceriporiopsis subvermispora in the absence of ligninperox idase显示文摘 | Kenneth A Jensen J R Bao W L | 1996 | Applied and Environmental Microbiology1996，62，10： | 1 |
| 13 | Resource assess- ment methodologies: current status and future direction 显示文摘 | Robert A M Alfred E C Kenneth G L | 2003 | AAPG Bulletin2003，87，4： | 1 |
| 14 | Epidemiology and molecular pathology of glioma显示文摘 | Judith A James L Kenneth D | 2006 | Nat Cli Prac2006，2，9： | 1 |
| 15 | Plasma from patients undergoing major open surgery stimulates in vitro tumor growth: Lower insulin-like growth factor binding protein 3 levels may, in part, account for this change显示文摘 | Irena Kirman Vesna Cekic Natalia Poltaratskaia Zishan Asi Marc Bessler Emina H Huang Kenneth A Forde Richard L Whelan | 2002 | Surgery2002，，2： | 1 |
| 16 | Longevity of granular iron in groundwater treatment processes:corrosion product development显示文摘 | KOHN T KENNETH J T ROBERTS A L | 2005 | Environmental Science & Technology2005，39，8： | 1 |
| 17 | Successful treatment oftype 1 diabetes and seizures with combined ketogenic diet and in-sulin显示文摘 | Roxana L?Castaneda A Kenneth J | 2012 | Pediatrics2012，129，51： | 1 |
| 18 | Feasible trajectory generation for atmospheric entry guidance 显示文摘 | James A L Kenneth D M | 2007 | Journal of Guidance Control and Dynamics2007，30，2： | 1 |
| 19 | Deficit irrigation strategies using midday stem water potential in prune显示文摘 | Bruce D L Kenneth A S Stephen M S | 2001 | Irriga- tion Science2001，20，2： | 1 |
| 20 | Best managemcnt practices for water quality improvement in the Lake Okcechobee Watershed 显示文摘 | Bottcher A B Tremwel Terry K Campbell Kenneth L | 1995 | Ecol Eng1995，，5： | 1 |
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