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| 1 | Modulators affecting the immune dialogue between human immune and colon cancer cells显示文摘The link between chronic inflammation and colorectal cancer has been well established. The events proceeding along tumorigenesis are complicated and involve cells activated at the cancer microenvironment, tumor infiltrating polymorphonuclears, immune cells including lymphocyte subtypes and peripheral blood mononuclear cells(PBMC), as well as tumor-associated macrophages. The immune cells generate inflammatory cytokines, several of them playing a crucial role in tumorigenesis. Additional factors, such as gene expression regulated by cytokines, assembling of tumor growth- and transforming factors, accelerated angiogenesis, delayed apoptosis, contribute all to initiation, development and migration of tumor cells. Oxygen radical species originating from the inflammatory area promote cell mutation and cancer proliferation. Tumor cells may over-express pro-inflammatory mediators that in turn activate immune cells for inflammatory cytokines production. Consequently, an immune dialogue emerges between immune and cancer cells orchestrated through a number of activated molecular pathways. Cytokines, encompassing migration inhibitory factor, transforming growth factor beta 1, tumor necrosisfactor-α, Interleukin(IL)-6, IL-10, IL-12, IL-17, IL-23 have been reported to be involved in human cancer development. Some cytokines, namely IL-5, IL-6, IL-10, IL-22 and growth factors promote tumor development and metastasis, and inhibit apoptosis via activation of signal transducer activator transcription-3 transcription factor. Colon cancer environment comprises mesenchymal, endothelial and immune cells. Assessment of the interaction between components in the tumor environment and malignant cells requires a reconsideration of a few topics elucidating the role of chronic inflammation in carcinogenesis, the function of the immune cells expressed by inflammatory cytokine production, the immunomodulation of cancer cells and the existence of a cross-talk between immune and malignant cells leading to a balance in cytokine production. It is conceivable that the prevalence of anti-inflammatory cytokine production by PBMC in the affected colonic mucosa will contribute to the delay, or even to halt down malignant expansion. Targeting the interplay between immune and cancer cells by mediators capable to alter cytokine secretion toward increased anti-inflammatory cytokine release by PBMC and tumor associated macrophages, may serve as an additional strategy for treatment of malignant diseases. This review will focus on the inflammatory events preceding tumorigenesis in general, and on a number of modulators capable to affect colon cancer cell-induced production of inflammatory cytokines by PBMC through alteration of the immune crosstalk between PBMC and cancer cells. | Meir Djaldetti Hanna Bessler | 2014 | World Journal of Gastrointestinal Oncology2014，6，5： | 7 |
| 2 | The Effects of Postoperative Pain Management on Immune Response to Surgery显示文摘 | Benzion Beilin Yehuda Shavit Evelyn Trabekin Boris Mordashev Eduard Mayburd Alexander Zeidel and Hanna Bessler | 2003 | Anesthesia & Analgesia2003，，3： | 2 |
| 3 | Transvaginal laparoscopically assisted endoscopic choIecystectomy:a hybrid approach to natural orilice surgery显示文摘 | Bessler M Stevens PD M i lone L | 2007 | Gastrointest Endosc2007，66，6： | 1 |
| 4 | Postoperative immune function varies inversely with the degree of surgical trauma in a murine model 显示文摘 | Allendorf JD Bessler M Whelan RL | 1997 | Surg Endosc1997，11，： | 1 |
| 5 | The lack of toxicity of intravitreally administered triamcinolone acetonide显示文摘 | McCuen B W I I Bessler M Tano Y | 1981 | Am J Ophthalmol1981，91，： | 1 |
| 6 | Effects of preemptive analgesia on pain and cytokine production in the postoperative period显示文摘 | Beilin B Bessler H Mayburd E | 2003 | Anesthesiology2003，98，1： | 1 |
| 7 | Mutations in the PIG-A gene causing partial deficiency of GPI-linked surface proteins(PNHⅡ)in patients with paroxysmal nocturnal haemoglobinuria显示文摘 | Bessler M Mason PJ Hillmen P Luzzatto L | 1994 | Br J Haematol1994，87，4： | 1 |
| 8 | The Structure of Interdependence in International Stock Markets 显示文摘 | Bessler D A Yang Jian | 2003 | Journal of International Money and Finance2003，22，2： | 1 |
| 9 | Nfl +/- mice have increased neointima formation via hyperactivation of a Gleevec sensitive molecular pathway 显示文摘 | Lasater EA Bessler WK Mead LE | 2008 | Hum Mol Genet2008，17，15： | 1 |
| 10 | Trocar site recurrence is unlikely to result from aerosolization of tumor cells显示文摘 | R. L. Whelan M.D. G. J. Sellers M.D. J. D. Allendorf B.A. D. Laird B.A. M. D. Bessler M.D. R. Nowygrod M.D. M. R. Treat M.D | 1996 | Diseases of the Colon & Rectum1996，，10： | 1 |
| 11 | Two-line laser-induced fluorescence imaging of vibrational temperatures in a NO-seeded flame显示文摘 | Bessler W G Hildenbrand F Schulz C | 2001 | Appl Opt2001，40，6： | 1 |
| 12 | The lack of toxicity of intravitreally administered triamcinolone acetonide显示文摘 | McCuen BW 2nd Bessler M Tano Y | 1981 | Am J Ophthalmol1981，91，6： | 1 |
| 13 | 2D and 3D CT imaging correlated to rigid endoscopy in complex laryngo-tracheal stenoses显示文摘 | Gluecker T Lang F Bessler S | 2001 | Eur Radiol2001，11，1： | 1 |
| 14 | IL-1 bcta,IL-2,IL-6 and TNF-alpha production by peripheral blood mononuclear cells from patients with Parkinson's disease显示文摘 | Bessler H Djaldetti R Salman H | 1999 | Biomed Pharmacother1999，53，3： | 1 |
| 15 | Genetic and cellu- lar evidence of vascular inflammation in neurofibromin- deficient mice and humans显示文摘 | Lasater EA Li F Bessler WK | 2010 | J Clin Invest2010，120，3： | 1 |
| 16 | Effect of early ver- sus conventional epidural analgesia during labor on cytokine pro- duction 显示文摘 | Orbach-Zinger S Bessler H Amovetzky R | 2012 | J Matem Fetal Neonatal Med2012，25，3： | 1 |
| 17 | The lack of toxicity of intravitreally administered triamcinolone acetonide 显示文摘 | Mc Guen BW Bessler M Tano Y | 1981 | Am J Ophthalmol1981，91，6： | 1 |
| 18 | Postoperative iramune function varies inversely with the degree of surgical trauma in a murine model 显示文摘 | Allendorf JD Bessler M Whelan RL | 1997 | Surg Endosc1997，11，5： | 1 |
| 19 | Effects of preemptive analgesia on pain and cytokine production in the postoperative period显示文摘 | Bessler H Mayburd E | 2003 | Anesthesiology2003，98，1： | 1 |
| 20 | Transvaginal laparoscopieally assisted endoscopic eholecystectomy:a hybrid approach to natural orifice surgery显示文摘 | Bessler M Stevens PD Milone L | 2007 | Gastrointest Endosc2007，66，6： | 1 |
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