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| 1 | Combined resection and radiofrequency ablation for multifocal hepatocellular carcinoma: Prognosis and outcomes显示文摘AIM: To analyze the combined treatment of resection and intraoperative radiofrequency ablation (RFA) for multifocal hepatocellular carcinoma in terms of prognosis and surgical outcomes.METHODS: This study was a retrospective case comparison study using prospectively collected data. The study covered the period from April 2001 to December 2006. The data of 200 patients with histologically confirmed hepatocellular carcinoma were reviewed. Nineteen patients (17 men and 2 women) having received resection in combination with RFA were chosen as subjects of the study (the combination group). Fiftyfour patients (43 men and 11 women) having received resection alone were selected for comparison (the resection group). The two groups matched tumor number and tumor size, and all the patients in the two groups displayed no tumor rupture, major vascular involvement and distant metastasis. Their demographics, preoperative assessment, disease recurrence patterns, overall survival and diseasefree survival were compared.RESULTS: In the combination group, the medianage was 65 years (range, 3477 years), the median tumor number was 3 (range, 29), and the median tumor size was 6 cm (range, 1.214 cm). In the resection group, the median age was 51.5 years (range, 2780 years, P = 0.003), the median tumor number was 3 (range, 29, P = 0.574), and the median tumor size was 6 cm (range, 114 cm, P = 0.782). The two groups were similar in characteristics of tumors and comorbidities, and had comparable results in preoperative liver function tests. All patients had ChildPugh class A status. Bilobar involvement occurred in 14 patients (73.6%) in the combination group and 3 patients (5.5%) in the resection group (P = 0.04). Six patients (32%) in the combination group and 35 patients (65%) in the resection group underwent major hepatectomy. Thirteen patients (68%) in the combination group and 19 patients (35%) in the resection group underwent minor hepatectomy (P = 0.012). The combination group had fewer major resections (32% vs 65%, P = 0.012), less blood loss (400 vs 657 mL, P = 0.007), shorter operation time (270 vs 400 min, P = 0.001), and shorter hospital stay (7 vs 8.5 d, P = 0.042). The two groups displayed no major differences in surgical complications (15.8% vs 31.5%, P = 0.24), disease recurrence (63.2% vs 50%, P = 0.673), hospital mortality (5.3% vs 5.6%, P = 1), and overall survival (53 vs 44.5 mo, P = 0.496).CONCLUSION: Safe and effective for selected patients with multifocal hepatocellular carcinoma, the combination of resection and intraoperative RFA widens the applicability of surgical intervention for the disease. | Tan To Cheung Kelvin K Ng Kenneth S Chok See Ching Chan Ronnie T Poon Chung Mau Lo Sheung Tat Fan | 2010 | World Journal of Gastroenterology2010，16，24： | 14 |
| 2 | Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors显示文摘组合指向的治疗在由堵住治疗癌症是更有效的绕过机制或导致的合成致命性。然而,他们的临床的申请被抵抗和毒性妨碍。遇见这重要挑战,我们用 ErbB2-overexpressing/PTEN-low 开发了并且测试各种各样的指向的治疗的指导 biomarker 的顺序的应用程序的一个新奇概念,高度好攻击的乳癌作为我们的模型。惊人地,从遗传上设计的鼠标与 intratumoral 异质从病人和乳房的肿瘤在两 PTEN-low/trastuzumab-resistant 乳癌支撑了 ErbB2 和下游的小径驱动器 trastuzumab 抵抗的激活。尽管 lapatinib 开始禁止了 trastuzumab 抵抗的鼠标肿瘤,肿瘤由激活表明由量的蛋白质数组出现的网络的 PI3K/mTOR 绕过抑制。有趣地,小径也是的 mTOR 的激活在 neoadjuvant 观察了表明 lapatinib 抵抗的对待 lapatinib 的病人。Trastuzumab + lapatinib 抵抗被一个 PI3K/mTOR 双 kinase 禁止者(BEZ235 ) 的顺序的申请有效地没有重要毒性克服。然而,我们的 p-RTK 数组分析证明 BEZ235 治疗在遗传上设计的老鼠肿瘤导致了增加的 ErbB2 表示和 phosphorylation,导致 BEZ235 抵抗并且在 3-D,然而并非 2-D,文化。机械学地,我们作为 BEZ235 抵抗的新奇机制识别了 ErbB2 蛋白质稳定和激活,它被随后的治疗与 lapatinib + BEZ235 联合颠倒。显著地, biomarker 指导的指向的治疗的这个顺序的应用程序在很快发展加倍的抵抗的肿瘤改变忍受极其好攻击的肿瘤的鼠标的寿命。使用的这条根本上新奇的途径有效地在一个顺序的顺序罐头指向了治疗目标和改编在在治疗期间发展抵抗的癌症的发信号的网络。 | Ozgur Sahin Qingfei Wang Samuel W Brady Kenneth Ellis Hai Wang Chia-Chi Chang Qingling Zhang Preety Priya Rui Zhu Stephen T Wong Melissa D Landis William J Muller Francisco J Esteva Jenny Chang Dihua Yu | 2014 | Cell Research2014，24，5： | 2 |
| 3 | In vitro alterations of intestinal bacterial microbiota in fecal samples during storage显示文摘 | Stephan J O Meike M Kenneth N T | 2004 | Diagnostic Microbiology and Infectious Disease2004，50，： | 1 |
| 4 | Amphiphilic templating of magnesium hydroxide显示文摘 | Ranjit K T Kenneth K J | 2005 | Langmuir2005，21，12： | 1 |
| 5 | Amphiphilic Templating of Magnesiu Hydroxide 显示文摘 | Ranjit K T Kenneth K J | 2005 | Langmuir2005，21，12： | 1 |
| 6 | Deoxybenzoin-based polyarylates as halogen-free fire-resistant polymers 显示文摘 | Kenneth E A Ranganathan T | 2006 | Macromolecules2006，，39： | 1 |
| 7 | An investigation of correlation factors linking footing resistance on sand with cone penetration test results显示文摘 | KENNETH G: ALI T | 2012 | Computers and Geoteehnies2012，46，： | 1 |
| 8 | Pectic acids in the production of wood-containing paper显示文摘 | Kenneth E S Anna C S Jeffrey W T | 1998 | TAPPI J1998，81，7： | 1 |
| 9 | Suicidal overdoses of psychotropic drugs by elderly in New York City:comparison with younger adults显示文摘 | Robert A Andrew L Kenneth T | 2011 | Psychiatry Research2011，188，3： | 1 |
| 10 | Cefalu, Streptozotocin-Induced Diabetes Mellitusin Cynomolgus Monkeys: Changes in Carbohydrate Metabolism, Skin Glycation and Pancreatic Islets 显示文摘 | Kenneth N Litwak William T | 1998 | Lab Anim Sei1998，48，2： | 1 |
| 11 | Circumvention of multi-drugresistance of cancer cells by Chinese herbal medicines 显示文摘 | STELLA C KENNETH T LIN G | 2010 | ChinMed2010，5，26： | 1 |
| 12 | The impact of heterogeneity correction on dosimetric parameters that predict for radiation pneumonitis显示文摘 | Daniel T Kenneth R Christopher G | 2006 | Int J Radiat Oncol Biol Phys2006，65，1： | 1 |
| 13 | IFN-γ activated primary murine astrocytes express B7 costimulatory molecules and prime naive antigene-specific T cells显示文摘 | Kelly MN Kenneth BG Litjen T | 1997 | J Immunol1997，158，： | 1 |
| 14 | Present Sta- tus of Aeroelasticity of Wind Turbines 显示文摘 | Flemming R Morten H H Kenneth T | 2003 | Wind Energy2003，6，： | 1 |
| 15 | Condition monitoring approaches applied to the polychloroprene cable jacketing material 显示文摘 | Kenneth T G Roger A A Robert B | 2004 | Polymer Degradation and Stability2004，84，4： | 1 |
| 16 | A macro-model of smoking and lung cancer:examining aggregate trends in lung cancer rates using the CPS-I and CPS-Ⅱ and two- stage clonal expansion models显示文摘 | David T Levy C Kenneth B | 2012 | Risk Analysis2012，32，1： | 1 |
| 17 | Reversal of P-glycoprotein (P-gp) mediated multidrug resistance in colon cancer cells by cryptotanshinone and dihydrotanshinone of salvia miltiorrhiza 显示文摘 | TAO H KENNETH K W T LIN Z | 2014 | Phytomed Inter J Phytother Phytopharmacol2014，21，11： | 1 |
| 18 | Specific emitter identiilcation (SEI) and classical parameter fusion technology显示文摘 | Kenneth I T Paul R D Martin H H | 2000 | IEEE Transactions on Aerospace and Electronic Systems2000，36，2： | 1 |
| 19 | Agar like polysaccharide produced by a Pseudomonas species production and basic properties显示文摘 | Kenneth S Kang George T Veeder Peter J Mirrasoul | 1982 | Applied and Environment Microbiology1982，43，5： | 1 |
| 20 | Appraisal Trends显示文摘 | LOCHER A KENNETH T | 1988 | Personal Journal1988，9，2： | 1 |
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