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| 1 | Driving vascular endothelial cell fate of human multipotent Isl1 heart progenitors with VEGF modified mRNA显示文摘multipotent 心祖先的不同家庭在哺乳动物的 cardiogenesis 期间在多样的心脏的、光滑的肌肉和 endothelial 房间系的产生起一个中央作用。驾驶这些 multipotent 祖先的房间命运决定的精确 paracrine 信号的鉴定,和小说的开发来临在 vivo 交付这些信号,是向开他们的再生治疗学的潜力的关键步。此处,我们识别了位于早人的胎儿的心(OFT-ECs ) 的流出道的人的心脏的 endothelial 中介的一个家庭,由 Isl1 和 CD144/vWF 的 coexpression 描绘了。由比较人的 OFT-ECs 和非心脏的 EC 表示的 angiocrine 因素,脉管的 endothelial 生长因素( VEGF ) A 作为最富有地表示的因素被识别,并且同种细胞的试金记录了它的能力驱使人的胚胎的干细胞(转换字符)的 endothelial 说明以一种 VEGF 受体依赖者方式导出 Isl1 +祖先。人的 Isl1-ECs (区分开来与导出 hESC 的 ISL1 + 祖先的 endothelial 房间) 以心脏的 endothelial 祖先的表示类似于 OFT-ECs -- 并且 endocardial 房间特定的基因,证实他们的机关特性。决定是否 VEGF -- A 可能是服务一在里面为人的导出转换字符的 Isl1-ECs 的 vivo 房间命运开关,我们证实化学上使用的一条新奇途径作为一个平台修改了 mRNA 为短暂,还在心血管的祖先的 paracrine 因素的高度有效的表示。VEGF 的 Overexpression -- A 支持在 vivo 的人的 Isl1 + 祖先的不仅 endothelial 说明而且嫁接,增长和幸存(减少的 apoptosis ) 。从人的 pluripotent 干细胞的心脏特定的人的 Isl1-ECs 的大规模推导,结合了能力驾驶跟随移植的 endothelial 说明,嫁接,和幸存,在心为脉管的新生建议新奇策略。 | Kathy O Lui Llor Lang Eduardo A Silva Lei Bu Makoto Sahara Ronald A Li David J Mooney Kenneth R Chien | 2013 | Cell Research2013，23，10： | 6 |
| 2 | Relationship Quality in Services Selling:An Interpersonal Influence Perspective显示文摘 | CROSBY LAWRENCE A KENNETH R EVANS DEBORAH COWLES | 1990 | Journal of Marketing1990，，54： | 1 |
| 3 | Direct dating of sulfides by Rb-Sr:Acritical test using the Polaris Mississippi Valley-type Zn-Pb deposit显示文摘 | Christensen J N Halliday A N Kenneth E L Roderick N R and Stephen E K | | 0，，： | 1 |
| 4 | Evaluation of SiO2 and TiO2 coated BaFeO4 cathode ma- terials for zinc alkaline and lithium non-aqueous primary bat- teries显示文摘 | Kenneth A Walz Aaron Handrick Jeannine R Szczech | 2007 | J Power Sources2007，167，2： | 1 |
| 5 | Hot blast stove process model and model-based controller显示文摘 | Kenneth R Muske James W Howse Glen A Hansen | 1999 | Iron and Steel Engineer1999，76，6： | 1 |
| 6 | RUSLE Revised universal soil loss equation 显示文摘 | KENNETH G R GEORGE R F GLENN A W | 1991 | Journal of soil and water conservation1991，46，： | 1 |
| 7 | Late relapses in patients successfully treated for thrombotic thrembocytopenic purpura显示文摘 | Kenneth H S Gail A R Rama C | 1995 | Ann Intern Med1995，122，8： | 1 |
| 8 | Renal outcomes with different fixed-dose combination therapies in patients with hypertension at high risk for cardiovascular events (ACCOMPLISH): a prespecified secondary analysis of a randomised controlled trial显示文摘 | George L Bakris Pantelis A Sarafidis Matthew R Weir Bj?rn Dahl?f Bertram Pitt Kenneth Jamerson Eric J Velazquez Linda Staikos-Byrne Roxzana Y Kelly Victor Shi Yann-Tong Chiang Michael A Weber | 2010 | The Lancet2010，，9721： | 1 |
| 9 | Reduced Amygdala Response to Fearful Expressions in Children and Adolescents With Callous-Unemotional Traits and Disruptive Behavior Disorders显示文摘 | Marsh Abigail A Finger Elizabeth C Mitchell Derek G V Reid Marguerite E Sims Courtney Kosson David S Towbin Kenneth E Leibenluft Ellen Pine Daniel S Blair R J R | 2008 | The American Journal of Psychiatry2008，，6： | 1 |
| 10 | 显示文摘 | Lu W J Kenneth A D Andrew R | 2002 | J Appl Polym Sci2002，40，： | 1 |
| 11 | Solving Inductive Reasoning Problems in Mathematics: Not-so-Trivial Pursuit 显示文摘 | Lisa A Haverty Kenneth R Koedinger David Klahr | 2000 | Cognitive Science2000，，24： | 1 |
| 12 | Physiological responses of cabbage to incipient copper toxicity显示文摘 | Penelope A R Helen C H Kenneth L S | 1989 | J Amer Soc Hor Sci1989，114，1： | 1 |
| 13 | Hot blast stove process model and model-based controller显示文摘 | Muske Kenneth R Howse James W Hansen Glen A | 1999 | Iron and Steel Engineer1999，76，6： | 1 |
| 14 | Manganesedependent cleavage of nonphenolic lignin structures byceriporiopsis subvermispora in the absence of ligninperox idase显示文摘 | Kenneth A Jensen J R Bao W L | 1996 | Applied and Environmental Microbiology1996，62，10： | 1 |
| 15 | Universal infant hearing screening by automated auditory brainstem response measurement显示文摘 | Judith A Mason Kenneth R Herrmann | 1998 | Pediatrics1998，101，： | 1 |
| 16 | Multi-section CT scanning techniques and clinical applications 显示文摘 | Jonas R Kenneth A Buckwalter | 2000 | RSNA2000，20，6： | 1 |
| 17 | Ophidiacerebrosides - cytotoxic glycosphingolipids containing a novel sphingosine from a sea star 显示文摘 | Jin W Z Kenneth L R Elizabeth A | 1994 | Journal of Organic Chemistry1994，59，： | 1 |
| 18 | Effects of feeding practical diets containing various protein levels on growth, survival, body composition, and processing traits of australian red claw crayfish (cherax quadricarinatus) and on pond water quality显示文摘 | Thompson Kenneth R Muzinic Laura A Engler Linda S | 2004 | Aquaculture Research2004，35，： | 1 |
| 19 | Technetium-99m galactosyl-neoglycoalbumin: preparation and preclinical studies显示文摘 | David R Robert C Kenneth A | 1985 | J Nucl Med1985，26，10： | 1 |
| 20 | Ligand design and metal-ion recognition interaction of nikel ( Ⅱ ) with 17- to 19-membered macrocycles containing O2N3 donor and O3N2 donor sets and X-ray structure of the parent 17-membered macrocyclic ligand显示文摘 | KENNETH R A ATHONY J L LEONARD F L | 1983 | J Amer Chem Soc1983，105，4： | 1 |
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