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| 1 | Prevalence of Nontraumatic Osteonecrosis of the Femoral Head and its Associated Risk Factors in the Chinese Population: Results from a Nationally Representative Survey显示文摘 | De-Wei Zhao Mang Yu Kai Hu Wei Wang Lei Yang Ben-Jie Wang Xiao-Hong Gao Yong-Ming Guo Yong-Qing Xu Yu-Shan Wei Si-Miao Tian Fan Yang Nan Wang Shi-Bo Huang Hui Xie Xiao-Wei Wei Hai-Shen Jiang Yu-Qiang Zang Jun Ai Yuan-Liang Chen Guang-Hua Lei Yu-Jin Li Geng Tia Zong-Sheng Li Yong Cao Li Ma | 2015 | Chinese Medical Journal2015，，21： | 151 |
| 2 | An insoluble polysaccharide from the sclerotium of Poria cocos improves hyperglycemia, hyperlipidemia and hepatic steatosis in ob/ob mice via modulation of gut microbiota显示文摘Metabolic syndrome characterized by obesity, hyperglycemia and liver steatosis is becoming prevalent all over the world. Herein, a water insoluble polysaccharide(WIP) was isolated and identified from the sclerotium of Poria cocos, a widely used Traditional Chinese Medicine. WIP was confirmed to be a(1-3)-β-D-glucan with an average Mw of 4.486 × 10~6 Da by NMR and SEC-RI-MALLS analyses. Furthermore, oral treatment with WIP from P. cocos significantly improved glucose and lipid metabolism and alleviated hepatic steatosis in ob/ob mice. 16 S DNA sequencing analysis of cecum content from WIP-treated mice indicated the increase of butyrate-producing bacteria Lachnospiracea, Clostridium. It was also observed that WIP treatment elevated the level of butyrate in gut, improved the gut mucosal integrity and activated the intestinal PPAR-γ pathway. Fecal transplantation experiments definitely confirmed the causative role of gut microbiota in mediating the benefits of WIP. It is the first report that the water insoluble polysaccharide from the sclerotium of P. cocos modulates gut microbiota to improve hyperglycemia and hyperlipidemia. Thereby, WIP from P. cocos, as a prebiotic, has the potential for the prevention or cure of metabolic diseases and may elucidate new mechanism for the efficacies of this traditional herbal medicine on the regulation of lipid and glucose metabolism. | SUN Shan-Shan WANG Kai MA Ke BAO Li LIU Hong-Wei | 2019 | Chinese Journal of Natural Medicines2019，17，1： | 60 |
| 3 | Effects of Duhuojisheng Tang and combined therapies on prolapse of lumbar intervertebral disc:a systematic review of randomized control trails显示文摘OBJECTIVE:A systematic review of the literature was conducted to evaluate the curative effect and safety of Duhuojisheng Tang on prolapse of the lumbar intervertebral disc.METHODS:The databases of PubMed,China National Knowledge Infrastructure(CNKI),Chinese Scientific Journals Database(VIP),Chinese Biomedical Literature Database(CBM) and Chinese Medical Citation Index(CMCI) were searched up to January 30,2012.Randomized controlled trials were selected to compare Duhuojisheng Tang with one or more of the following treatments:traction,acupuncture,massage,cupping and Western medical treatment.The quality-evaluating standard and the software RevMan 5.1 in Cochrane coordinative net were used to analyze the data.The effective indexes of the results were clinical curative rate,effectiveness of alleviating clinical symptoms and adverse reaction.RESULTS:Thirty-one randomized controlled trials of low quality,involving 3915 patients were systematically evaluated.Statistical analyses showed that good curative effect was achieved in both the group using Duhuojisheng Tang alone and with combined therapies.CONCLUSION:Using Duhuojisheng Tang alone or combined with other therapies can effectively improve pain,leg-raising height and other clinical symptoms of patients with prolapse of lumbar intervertebral disc.Due to low methodological quality of the articles,no exact recommendations can be made. | Yanxu Ma Minghua Huang Jingyan Cui Kai Meng Yuhao Zhao | 2013 | Journal of Traditional Chinese Medicine2013，33，2： | 27 |
| 4 | Validation of quantitative computed tomography-derived areal bone mineral density with dual energy X-ray absorptiometry in an elderly Chinese population显示文摘 | Cheng Xiaoguang Wang Ling Wang Qianqian Ma Yimin Su Yongbin Li Kai | 2014 | Chinese Medical Journal2014，，8： | 22 |
| 5 | Left posterior fascicular block: a new endpoint of ablation for verapamil-sensitive idiopathic ventricular tachycardia显示文摘Background Verapamil-sensitive, idiopathic left ventricular tachycardia (ILVT) with right bundle branch block configuration and left-axis deviation is known to be due to re-entry mechanism but the exact nature of reentrant circuit in ILVT is not fully elucidated. Radiofrequency (RF) ablation was applied during ventricular tachycardia (VT) and termination of the VT or abolishing the inducibility of the tachycardia was used as an endpoint for successful RF. In this study, the left posterior fascicular block in surface electrocardiogram (ECG) was used as a new endpoint of ablation to cure ILVT. Methods Electrophysiological studies and radiofrequency ablation were performed in 39 consecutive patients [30 men, 9 women; age ranging from 10 to 64 years, mean (29±16) years] with verapamil-sensitive ILVT and structurally normal hearts. VT could be terminated by the intravenous administration of verapamil in all patients. The target site was the midseptum of LV where the earliest Purkinje potentials were recorded during VT. RF current was applied to the target site with or without late diastolic potential (LDP) during sinus rhythm in 37 patients and during VT in 2 patients to meet the ablation endpoint: the left posterior fascicular block in the surface ECG. Results Thirty-seven patients with ILVT had been treated by RF ablation during sinus rhythm and two had been treated during VT. All of them met the endpoint of the left posterior fascicular block. Thirty-eight cases were symptom-free without medications during the follow-up period (range from 3 to 95 months, median 17 months). One patient developed a clinical recurrence and the left posterior fascicular block in surface ECG disappeared. The patient received another treatment. The endpoint was met and the procedure was successful. Conclusions The left posterior fascicular block in surface ECG used as an endpoint of RF ablation to treat ILVT is effective. It is important especially in those patients whose VT can not be induced or the inducible condition is unstable. The effective endpoint implied that the left posterior fascicle might be a critical part of the re-entrant circuit. | MA Fu-sheng MA Jian TANG Kai HAN Hao JIAYu-he FANG Pi-hua CHU Jian-min PU Jie-lin ZHANG Shu | 2006 | Chinese Medical Journal2006，，5： | 21 |
| 6 | An economic and low-carbon day-ahead Pareto-optimal scheduling for wind farm integrated power systems with demand response显示文摘Demand response(DR)and wind power are beneficial to low-carbon electricity to deal with energy and environmental problems.However,the uncertain wind power generation(WG)which has anti-peaking characteristic would be hard to exert its ability in carbon reduction.This paper introduces DR into traditional unit commitment(UC)strategy and proposes a multi-objective day-ahead optimal scheduling model for wind farm integrated power systems,since incentive-based DR can accommodate excess wind power and can be used as a source of system spinning reserve to alleviate generation side reserve pressure during both peak and valley load periods.Firstly,net load curve is obtained by forecasting load and wind power output.Then,considering the behavior of DR,a day-ahead optimal dispatching scheme is proposed with objectives of minimum generating cost and carbon emission.Non-dominated sorting genetic algorithm-II(NSGA-II)and satisfaction-maximizing method are adopted to solve the multi-objective model with Pareto fronts and eclectic decision obtained.Finally,a case study is carried out to demonstrate that the approach can achieve economic and environmental aims and DR can help to accommodate the wind power. | Rui MA Kai LI Xuan LI Zeyu QIN | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，3： | 20 |
| 7 | Sexual and reproductive health service needs of university/ college students: updates from a survey in Shanghai, China显示文摘瞄准:由在上海探索大学学生的态度和感觉支持为年轻人的繁殖健康服务的预备,中国,向繁殖健康。方法:从 2004 年 7 月到 2006 年 5 月,在上海的 14 所大学的 5 243 个学生参加了我们的调查。话题在性健康上并且性用性,到色情材料的暴露,和知识盖住繁殖保健服务,对的态度和经验的要求播送感染(STI )/AIDS。结果:提供了有效答案表的 5 067 个学生, 50.05% 是女性, 49.95% 是男性的, 14.86% 是医学院的学生,并且 85.14% 有非医学的背景。38.4% 回答者的一个总数以前收到了繁殖卫生教育。学生的多数支持了基于学校的繁殖卫生教育,并且也从书,同学,和因特网主要关于性获得了信息。婚前的性行为被 17.7% 调查参加者反对,并且 37.5% 能识别在问询表列出的 STI 的所有三种类型。尽管 83.7% 知道了 HIV 怎么被播送,仅仅, 55.7% 知道了什么时候使用避孕套, 57.8% 知道避孕套的使用能减少 HIV 感染的风险。结论:繁殖健康服务正在落后于大学学生的当前的态度和要求。尽管学生对性事的态度是开明的,他们繁殖健康和 STIs/AIDS 的知识仍然是有限的。提供有效、机密的繁殖健康服务给年轻人因此是必要的。 | Bin Chen Yong-Ning Lu Hong-Xiang Wang Qing-Liang Ma Xiao-Ming Zhao Jian-Hua Guo Kai Hu Yi-Xin Wang Yi-Ran Huang Pei Chen | 2008 | Asian Journal of Andrology2008，10，4： | 20 |
| 8 | Holocene high lake-levels and pan-lake period on Badain Jaran Desert显示文摘Many lakes exist in southeastern Badain Jaran Desert and its hinterland, including 110 perennial lakes and some seasonal or extinct lakes. Geomorphological, sedimentological, and bioglyph evidence obtained from field investigations on Badain Jaran Desert lake group, alongside measurements and dating performed on lake relic, prove that these lakes expanded while the climate was relatively wet during early and middle Holocene. The dating results suggest that the pan-lake period of the Badain Jaran Desert began at 10 cal kyr BP, before which the limnic peat period occurred(11–10 cal kyr BP). Many lakes reached their maximal water-level during 8.6–6.3 cal kyr BP and retreated or dried up in the late Holocene(about 3.5–0 cal kyr BP). During that period, the precipitation at Badain Jaran Desert may have reached 200 mm yr^(-1) for 7.7–5.3 cal kyr BP, inferred from both the age and precipitation rate of calcareous root tubes. The water balance calculation shows that wetter and warmer climate and the increase of underground water recharge were key factors in maintaining and developing the lake group at both centennial and millennial time scales. Furthermore, lake surface expansion and the increasing fresh water availability set the background for the prosperous prehistoric culture. | WANG NaiAng NING Kai LI ZhuoLun WANG YiXin JIA Peng MA Ling | 2016 | Science China Earth Sciences2016，59，8： | 19 |
| 9 | Perspectives on the Application of Genome-Editing Technologies in Crop Breeding显示文摘Most conventional and modern crop-improvement methods exploit natural or artificially induced genetic variations and require laborious characterization of the progenies of multiple generations derived from time-consuming genetic crosses.Genome-editing systems,in contrast,provide the means to rapidly modify genomes in a precise and predictable way,making it possible to introduce improvements directly into elite varieties.Here,we describe the range of applications available to agricultural researchers using existing genome-editing tools.In addition to providing examples of genome-editing applications in crop breeding,we discuss the technical and social challenges faced by breeders using genome-editing tools for crop improvement. | Kai Hua Jinshan Zhang Jose Ramon Botella Changle Ma Fanjiang Kong Baohui Liu Jian-Kang Zhu | 2019 | Molecular Plant2019，12，8： | 19 |
| 10 | Value of radiofrequency ablation in the treatment of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is a malignant disease that substantially affects public health worldwide.It is especially prevalent in east Asia and sub-Saharan Africa,where the main etiology is the endemic status of chronic hepatitis B.Effective treatments with curative intent for early HCC include liver transplantation,liver resection(LR),and radiofrequency ablation(RFA).RFA has become the most widely used local thermal ablation method in recent years because of its technical ease,safety,satisfactory local tumor control,and minimally invasive nature.This technique has also emerged as an important treatment strategy for HCC in recent years.RFA,liver transplantation,and hepatectomy can be complementary to one another in the treatment of HCC,and the outcome benefits have been demonstrated by numerous clinical studies.As a pretransplantation bridge therapy,RFA extends the average waiting time without increasing the risk of dropout or death.In contrast to LR,RFA causes almost no intraabdominal adhesion,thus producing favorable conditions for subsequent liver transplantation.Many studieshave demonstrated mutual interactions between RFA and hepatectomy,effectively expanding the operative indications for patients with HCC and enhancing the efficacy of these approaches.However,treated tumor tissue remains within the body after RFA,and residual tumors or satellite nodules can limit the effectiveness of this treatment.Therefore,future research should focus on this issue. | Kai Feng Kuan-Sheng Ma | 2014 | World Journal of Gastroenterology2014，20，20： | 19 |
| 11 | Evodiamine improves congnitive abilities in SAMP8 and APPswe/PS1△E9 transgenic mouse models of Alzheimer's disease显示文摘 | Shu-min YUAN Kai GAO Dong-mei WANG Xiong-zhi QUAN Jiang-ning LIU Chun-mei MA Chuan QIN Lian-feng ZHANG | 2011 | Acta Pharmacologica Sinica2011，32，3： | 19 |
| 12 | Correlation between coagulation function, tumor stage and metastasis in patients with renal cell carcinoma: a retrospective study显示文摘背景在癌病人的凝结功能是反常的,但是在肾的房间癌,凝结功能的程度和关系仍然保持不清楚。这研究回顾地与 350 个连续病人的一个总数从 2004 ~ 2010 承认了到我们的泌尿学部门的肾的房间 carcinoma.Methods 在病人调查了在凝结功能,临床的阶段和转移之间的关系被 histolopathologic 检查与肾的房间癌诊断并且在这研究被包括。肾的良性的肿瘤的 231 个案例的一个总数被看作控制组。纤维蛋白原,凝血素时间,激活的部分 thromboplastin 时间和国际规范的比率在所有题目被评估。肿瘤尺寸,临床的阶段,淋巴节点转移,和远转移用外科手术前的血浆纤维蛋白原与肾的房间癌病人铺平的放射线学的成像, intraoperative 调查结果,和组织学的 studies.Results 被评估((383.9 朠慥r 吗?? | XIAO Bo MA Lu-lin ZHANG Shu-dong XIAO Chun-lei LU Jian HONG Kai LIAO Hong-yi | 2011 | Chinese Medical Journal2011，，8： | 18 |
| 13 | Surgical strategy for presacral tumors: analysis of 33 cases显示文摘背景 Presacral 肿瘤是位于因为在那里的 presacral 或 retrorectal space.Although 是在有恶意的 presacral 肿瘤的病人的预后的实质的改进,知道的空间的高度很少发生的肿瘤,更新的外科的策略的发展是可能的进一步改进这篇文章的 tumors.The 目的是在 33 种情况中报导我们的经验,并且考察外科的策略,病理学的特征和复杂并发症的预防的恶意的 presacral 的 oncologic 结果复发在外科以后在 18 个月内发生在 teratoma 的一种情况中,由 trans 骶的切除治好;本地复发和肺转移手术后地在 6 个月内在 angiosarcoma 的一种情况中同时发生了,病人一个月以后死于大多数 presacral 肿瘤的主要治疗是的呼吸 failure.Conclusions 外科的途径的外科的 resection.Selection 为 presacral tumors.The 地点的完全的切除术是很重要的,肿瘤,皮的条件和软纸巾和病人的尺寸和怪癖是体型都是限定词 factors. | LI Guo-dong CHEN Kai FU Dong MA Xiao-jun SUN Meng-xiong SUN Wei CAI Zheng-dong | 2011 | Chinese Medical Journal2011，，23： | 16 |
| 14 | Adipose-derived mesenchymal stem cell transplantation promotes adult neurogenesis in the brains of Alzheimer's disease mice显示文摘In the present study,we transplanted adipose-derived mesenchymal stem cells into the hippocampi of APP/PS1 transgenic Alzheimer’s disease model mice.Immunofluorescence staining revealed that the number of newly generated(BrdU+)cells in the subgranular zone of the dentate gyrus in the hippocampus was significantly higher in Alzheimer’s disease mice after adipose-derived mesenchymal stem cell transplantation,and there was also a significant increase in the number of BrdU+/DCX+neuroblasts in these animals.Adipose-derived mesenchymal stem cell transplantation enhanced neurogenic activity in the subventricular zone as well.Furthermore,adipose-derived mesenchymal stem cell transplantation reduced oxidative stress and alleviated cognitive impairment in the mice.Based on these findings,we propose that adipose-derived mesenchymal stem cell transplantation enhances endogenous neurogenesis in both the subgranular and subventricular zones in APP/PS1 transgenic Alzheimer’s disease mice,thereby facilitating functional recovery. | Yufang Yan Tuo Ma Kai Gong Qiang Ao Xiufang Zhang Yao Gong | 2014 | Neural Regeneration Research2014，9，8： | 16 |
| 15 | A Multicenter, Randomized, Double-Blind, and Placebo-Controlled Study of the Effects of Tongxinluo Capsules in Acute Coronary Syndrome Patients with High On-Treatment Platelet Reactivity显示文摘 | Lei Zhang Yi Li Bai-Song Yang Lu Li Xiao-Zeng Wang Mei-Ling Ge Quan-Min Jing Ying-Yan Ma Geng Wang Hai-Wei Liu Xin Zhao Bin Wang Kai Xu Ya-Ling Han | 2018 | Chinese Medical Journal2018，，5： | 16 |
| 16 | Establishment and preliminery use of hepatitis Bvirus preS1/2 antigen assay显示文摘 | CHEN Kun, HAN Bao Guang, MA Xian Kai, ZHANG He Qiu, MENG Li, WANG Guo Hua, XIA Fang, SONG Xiao Guo and LING Shi Gan | 1999 | World Journal of Gastroenterology1999，5，6： | 14 |
| 17 | Vagus Nerve Stimulation for Pediatric and Adult Patients with Pharmaco-resistant Epilepsy显示文摘 | Fan-Gang Meng Fu-Min Jia Xiao-Hui Ren Yan Ge Kai-Liang Wang Yan-Shan Ma Ming Ge Kai Zhang Wen-Han HU Xin Zhang Wei Hu Jian-Guo Zhang | 2015 | Chinese Medical Journal2015，，19： | 13 |
| 18 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 19 | Immunohistochemical study of hepatic oval cells in human chronic viral hepatitis显示文摘AIM To detect immunohistochemically the presence of oval cells in chronic viral hepatitis with antibody against c-kit.METHODS We detected oval cells in paraffin-embedded liver sections of 3 normal controls and 26 liver samples from patients with chronic viral hepatitis, using immunohistochemistry with antibodies against c-kit, π-class glutathione Stransferase ( Tr-GST ) and cytokeratins 19(CK19).RESULTS Oval cells were not observed in normal livers. In chronic viral hepatitis, hepatic oval cells were located predominantly in the periportal . region and fibrosis septa,characterized by an ovoid nucleus, small size,and scant cytoplasm. Antibody against stem cell factor receptor, c-kit, had higher sensitivity and specificity than π-GST and CK19. About 50% -70% of c-kit positive oval cells were stained positively for either π-GST or CK19.CONCLUSION Oval cells are frequently detected in human livers with chronic viral hepatitis, suggesting that oval cell proliferation is associated with the liver regeneration in this condition. | Xiong Ma De Kai Qiu Yan Shen Peng Shanghai Institute of Digestive Diseases, Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China | 2001 | World Journal of Gastroenterology2001，7，2： | 13 |
| 20 | The influence of temperature on rare earth flotation with naphthyl hydroxamic acid显示文摘The influence of temperature on the complex process of Bayan Obo rare earth(RE) ore flotation with a collector of naphthyl hydroxamic acid(LF8#) was investigated. Industrial test data shows that the grade and recovery of RE increase with the temperature. However, the proportion of bastnaesite in the bulk concentrate increases as the RE grade improves. Adsorption mechanism of LF8# on the surfaces of bastnaesite and monazite were confirmed via zeta potential, UV/Vis Spectrophotometer(UV/Vis), Fourier transform infrared(FTIR), and X-ray photoelectron spectroscopy analyses(XPS). Although the results indicate that the total amount of the LF8# adsorption on the surface of bastnaesite and monazite decreases with increasing the temperature, the amount of stable adsorbed predominance of characteristic bonds(-C(=O)N-) from LF8# uptake on bastnaesite surfaces increases significantly at high temperatures. This conclusion indicates that the adsorption stability increases with increasing the temperature.For monazite, the amount of characteristic elements C and N in LF8# does not increase as the temperature increases on the mineral surface, but the proportion of characteristic bonds increases, which shows that the adsorption stability of LF8# on the surface of monazite also increases, but it is not as significant as bastnaesite, which may be one of the reasons that the floatability of bastnaesite is better than those of monazite. Pulp dispersion results show that the temperature improve the dispersions of both the gangue and RE minerals. This improved the flotation selectivity so that it favored RE minerals. The calculated bubble size distribution confirms that higher temperatures generate smaller bubbles, thereby increasing the bubble-particle collision probability and the recovery of RE minerals. | Mei Li Kai Gao Dongliang Zhang Haijun Duan Linlin Ma Lan Huang | 2018 | Journal of Rare Earths2018，36，1： | 13 |
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