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| 1 | Cytoreductive surgery and intraperitoneal chemotherapy for colorectal peritoneal metastases显示文摘AIM:To systematically review the available evidence regarding cytoreductive surgery(CRS) and intraperitoneal chemotherapy(IPC) for colorectal peritoneal metastases(CPM).METHODS:An electronic literature search was carried out to identify publications reporting oncological outcome data(overall survival and/or disease free survival and/or recurrence rates)following CRS and IPC for treatment of CPM.Studies reporting outcomes following CRS and IPC for cancer subtypes other than colorectal were only included if data were reported independently for colorectal cancer-associated cases;in addition studies reporting outcomes for peritoneal carcinomatosis of appendiceal origin were excluded.RESULTS:Twenty seven studies,published between1999 and 2013 with a combined population of 2838patients met the predefined inclusion criteria.Included studies comprised 21 case series,5 case-control studies and 1 randomised controlled trial.Four studies provided comparative oncological outcome data for patients undergoing CRS in combination with IPC vs systemic chemotherapy alone.The primary indication for treatment was CPM in 96%of cases(2714/2838)and recurrent CPM(rCPM)in the remaining 4%(124/2838).In the majority of included studies(20/27)CRS was combined with hyperthermic intraperitoneal chemotherapy(HIPEC).In 3 studies HIPEC was used in combination with early post-operative intraperitoneal chemotherapy(EPIC),and 2 studies used EPIC only,following CRS.Two studies evaluated comparative outcomes with CRS+HIPEC vs CRS+EPIC for treatment of CPM.The delivery of IPC was performed using an'open'or'closed'abdomen approach in the included studies.CONCLUSION:The available evidence presented in this review indicates that enhanced survival times can be achieved for CPM after combined treatment with CRS and IPC. | Reza Mirnezami Brendan J Moran Kate Harvey Tom Cecil Kandiah Chandrakumaran Norman Carr Faheez Mohamed Alexander H Mirnezami | 2014 | World Journal of Gastroenterology2014，20，38： | 6 |
| 2 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019，25，48： | 3 |
| 3 | Nutrient cycling and distribution in different-aged plantations of Chinese fir in southern China显示文摘 | Ma X Q Kate V H Liu A Q | 2007 | Forest Ecology and Management2007，243，： | 1 |
| 4 | A fine-grained analysis of facial expression processing in high-functioning adults with autism显示文摘 | Kate H Nancy M Grace LL | | 0，，04： | 1 |
| 5 | Effects of herbivory on the reproductive effort of 4 prairie显示文摘 | Erica S Kate L B Johannes M H K | 2002 | BMC Ecology2002，2，： | 1 |
| 6 | Genetic determinants of volatile-thiol release by Saccharomyces cerevisiae during wine fermentation 显示文摘 | Kate S Howell Mathias Klein Jan H Swiegers | 2005 | Appl Environ Microbiol2005，71，9： | 1 |
| 7 | Gonadotrophin regimens and oocyte quality in women with polycystic ovaries显示文摘 | Stephen F Ruth R Kate H | 2002 | RBM online2002，6，2： | 1 |
| 8 | Efficient Hidden Surface Removal for Objects with Small Union Size显示文摘 | KATE M J OVERMARS M H SHARIR M | 1992 | Computational Geometry Theory Application1992，2，： | 1 |
| 9 | Brain natriuretic peptide in hemodialysis patients: predictive value for hemodynamic change during hemodialysis and cardiac function 显示文摘 | Matayoshi T Kate T Nakahama H | 2008 | Am J Nephrel2008，28，： | 1 |
| 10 | Multichannel dynamic- range compression using digital frequency warping 显示文摘 | KATES J M AREHART K H | 2005 | EURASIP Journal on Applied Signal Processing2005，18，： | 1 |
| 11 | Stimulation, inhibi- tion, or stabilization of Na, K- ATPase caused by specific lipid interactions at distinct sites 显示文摘 | HABECK M HAVIV H KATE A | 2015 | J Biol Chem2015，2908，： | 1 |
| 12 | Toward an accurate scaling relation for the critical current in niobium-tin conductors 显示文摘 | Godeke A Haken B T Ten Kate H H J | 2002 | IEEE Transactions on Applied Superconductivity2002，12，： | 1 |
| 13 | Ulva, Umbraulva and Gemina: genetic survey of New Zealand taxa reveals diversity and introduced species 显示文摘 | SVENJA H JUDY E S B KATE F N | 2009 | European Journal of Phycology2009，44，2： | 1 |
| 14 | MRI parcellation of the frontal lobe in boys with attention deficit hyperactivity disorder or Tourette syndrome 显示文摘 | Kates WR Frederikse M Moslofsky Stewart H | 2002 | Psychiatry Research Neuroimaging2002，116，： | 1 |
| 15 | The Role of Manufacture in Consumers' Attributions of Blame in an Ambiguous Product-Harm Crisis 显示文摘 | Daniel Laufer Kate Gillespie David H Silvera | 2009 | Journal of International Consumer Marketing2009，21，3： | 1 |
| 16 | Postoperative incision hernia in patients with abdominal aortic aneurysm and aortoiliac occlusive disease: a systematic review 显示文摘 | Takagi H Sugimoto M Kate T | 2007 | Eur J Vasc Endovascular Surg2007，33，2： | 1 |
| 17 | The green initiative: improving quality and competitiveness for European SMEs显示文摘 | Kate G Paul H Ronan M | 1997 | European Business Review1997，97，5： | 1 |
| 18 | 显示文摘 | Kuiper H Ten Kate FJ | 1999 | Eur J Gastroenterol Hepatol1999，11，7： | 1 |
| 19 | Escape of methane gas from the seabed along the West Spitsbergen continental margin显示文摘 | Westbrook Graham K. Thatcher Kate E. Rohling Eelco J. Piotrowski Alexander M. P?like Heiko Osborne Anne H. Nisbet Euan G. Minshull Tim A. Lanoisellé Mathias James Rachael H. Hühnerbach Veit Green Darryl Fisher Rebecca E. Crocker Anya J. Chab | 2009 | Geophysical Research Letters2009，，15： | 1 |
| 20 | Automatic age estimation basedfaeial aging patterns 显示文摘 | Geng X Zhou Z H Kate S M | 2007 | IEEE Transactions on Pattern Analysis and Machine Intelligence2007，29，12： | 1 |
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