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| 1 | Mechanisms of intrahepatic triglyceride accumulation显示文摘Hepatic steatosis defined as lipid accumulation in hepatocytes is very frequently found in adults and obese adolescents in the Western World. Etiologically, obesity and associated insulin resistance or excess alcohol intake are the most frequent causes of hepatic steatosis. However, steatosis also often occurs with chronic hepatitis C virus(HCV) infection and is also found in rare but potentially life-threatening liver diseases of pregnancy. Clinical significance and outcome of hepatic triglyceride accumulation are highly dependent on etiology and histological pattern of steatosis. This review summarizes current concepts of pathophysiology of common causes of hepatic steatosis, including non-alcoholic fatty liver disease(NAFLD), alcoholic fatty liver disease, chronic HCV infections, drug-induced forms of hepatic steatosis, and acute fatty liver of pregnancy. Regarding the pathophysiology of NAFLD, this work focuses on the close correlation between insulin resistance and hepatic triglyceride accumulation, highlighting the potential harmful effects of systemic insulin resistance on hepatic metabolism of fatty acids on the one side and the role of lipid intermediates on insulin signalling on the other side. Current studies on lipid droplet morphogenesis have identified novel candidate proteins and enzymes in NAFLD. | Claudia Ress Susanne Kaser | 2016 | World Journal of Gastroenterology2016，22，4： | 10 |
| 2 | Liver resections can be performed safely without Pringle maneuver: A prospective study显示文摘AIM To evaluate liver resections without Pringle maneuver, i.e., clamping of the portal triad. METHODS Between 9/2002 and 7/2013, 175 consecutive liver resections(n = 101 major anatomical and n = 74 large atypical > 5 cm) without Pringle maneuver were performed in 127 patients(143 surgeries). Accompanying, 37 wedge resections(specimens < 5 cm) and 43 radiofrequency ablations were performed. Preoperative volumetric calculation of the liver remnant preceeded all anatomical resections. The liver parenchyma was dissected by waterjet. The median central venous pressure was 4 mmH g(range: 5-14). Data was collected prospectively. RESULTS The median age of patients was 60 years(range: 16-85). Preoperative chemotherapy was used in 70 cases(49.0%). Liver cirrhosis was present in 6.3%, and liver steatosis of ≥ 10% in 28.0%. Blood loss was median 400 mL(range 50-5000 mL). Perioperative blood transfusions were given in 22/143 procedures(15%). The median weight of anatomically resected liver specimens was 525 g(range: 51-1850 g). One patient died postoperatively. Biliary leakages(n = 5) were treated conservatively. Temporary liver failure occurred in two patients.CONCLUSION Major liver resections without Pringle maneuver are feasible and safe. The avoidance of liver inflow clamping might reduce liver damage and failure, and shorten the hospital stay. | Christoph A Maurer Mikolaj Walensi Samuel A Kaser Beat M Künzli Rene Lotscher Anne Zuse | 2016 | World Journal of Hepatology2016，8，24： | 6 |
| 3 | Inflammatory Bowel Disease显示文摘 | Arthur Kaser Sebastian Zeissig Richard S. Blumberg | 2010 | Annual Review of Immunology2010，，： | 5 |
| 4 | Inflammatory Bowel Disease Is a Risk Factor for Recurrent Venous Thromboembolism显示文摘 | Gottfried Novacek Ansgar Weltermann Anna Sobala Herbert Tilg Wolfgang Petritsch Walter Reinisch Andreas Mayer Thomas Haas Arthur Kaser Thomas Feichtenschlager Harry Fuchssteiner Peter Knoflach Harald Vogelsang Wolfgang Miehsler Reingard Platzer Wolfgang T | 2010 | Gastroenterology2010，，3： | 4 |
| 5 | European evidence-based Consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease显示文摘 | J.F. Rahier S. Ben-Horin Y. Chowers C. Conlon P. De Munter G. D’Haens E. Domènech R. Eliakim A. Eser J. Frater M. Gassull M. Giladi A. Kaser M. Lémann T. Moreels A. Moschen R. Pollok W. Reinisch M. Schunter E.F. Stange H. Tilg G. Van Assche N. Viget B. Vu | 2009 | Journal of Crohn’s and Colitis2009，，2： | 3 |
| 6 | Survive an innate immune response through XBP1显示文摘 | Arthur Kaser Richard S Blumberg | 2010 | Cell Research2010，20，5： | 3 |
| 7 | Clinical presentation of venous thromboembolism in inflammatory bowel disease显示文摘 | Pavol Papay Wolfgang Miehsler Herbert Tilg Wolfgang Petritsch Walter Reinisch Andreas Mayer Thomas Haas Arthur Kaser Thomas Feichtenschlager Harry Fuchssteiner Peter Knoflach Harald Vogelsang Reingard Platzer Wolfgang Tillinger Bernhard Jaritz Alfons Schm | 2012 | Journal of Crohn’s and Colitis2012，，： | 2 |
| 8 | Inflammatory Bowel Disease显示文摘 | Arthur Kaser Sebastian Zeissig Richard S. Blumberg | 2010 | Annual Review of Immunology2010，，： | 2 |
| 9 | Adiponectin and its receptors in nonalcoholic steatohepatitis显示文摘 | Kaser S Moschen A Cayon A | 2005 | Gut2005，54，1： | 1 |
| 10 | Diagnostic value of sonography,ultrasound-guided fine-needle aspiration cyto-logy,and diffusion-weighted MRI in the characterization of cold thyroid nodules显示文摘 | Schueller-Weidekamm C Schueller G Kaserer K | 2010 | Eur J Radiol2010，73，3： | 1 |
| 11 | Visfatin,an adipocytokine with proinflammatory and immunomodulating properties显示文摘 | Moschen AR Kaser A Enrich B | 2007 | Immunol2007，178，3： | 1 |
| 12 | XBP1links ER stress to in-testinal inflammation and confers genetic risk for human inflam-matory bowel disease显示文摘 | Kaser A Lee AH Franke A | 2008 | Cell2008，134，5： | 1 |
| 13 | Resistin messenger-RNA expression is increased by proinflammatory cytokines in vitro显示文摘 | Kaser S Kaser A Sandhofer A | 2003 | Biochem Biophys Res Commun2003，309，2： | 1 |
| 14 | Obesity and the microbiota显示文摘 | TILG H MOSCHEN A R KASER A | 2009 | Gastroenterology2009，136，5： | 1 |
| 15 | Dosimetry and image quality of four dental cone beam computed tomography scanners compared with multislice computed tomography scanners 显示文摘 | Suomalainen A Kiljunen T Kaser Y | 2009 | Dentomaxillofac Radio:2009，38，6： | 1 |
| 16 | Resistin messenger RNA expression is increased by proinflammatory cytokines in vitro显示文摘 | KASER S KASER A SANDHOFER A | 2003 | Biochem Bio phys Res Commun2003，309，： | 1 |
| 17 | Adiponectin and its receptors in non-alcoholic steatohepatitis 显示文摘 | Kaser S Moschen A Cayon A | 2005 | Gut2005，54，： | 1 |
| 18 | Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria 显示文摘 | Yoshida M Kobayashi K Kuo T T Bry L Glickman J N Claypool S M Kaser A Nagaishi T Higgins D E Mizoguchi E Wakatsuki Y Roopenian D C Mizoguchi A Lencer W I and Blumberg R S | 2006 | The Journal of Clinical Investigation2006，116，： | 1 |
| 19 | Pharmacological and non-pharmacological treatment of non-alcoholic fatty liver disease显示文摘 | Kaser S Ebenbichler C F Tilg H | | 0，，07： | 1 |
| 20 | Resistin messenger RNA expres- sion is increased by proinflammatory cytokines in vitro显示文摘 | Kaser S Kaser A Sandhofer A | 2003 | Bio- chem Biophys Res Commun2003，309，2： | 1 |
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