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| 1 | Promoter methylation status of hMLH1,MGMT,and CDKN2A/p16 in colorectal adenomas显示文摘AIM:To investigate aberrant DNA methylation of CpG islands and subsequent low-or high-level DNA microsatellite instability(MSI)which is assumed to drive colon carcinogenesis. METHODS:DNA of healthy individuals,adenoma(tu-bular or villous/tubulovillous)patients,and colorectal carcinoma patients who underwent colonoscopy was used for assessing the prevalence of aberrant DNA methylation of human DNA mismatch repair gene mutator L homologue 1(hMLH1),Cyclin-dependent kinase inhibitor 2A(CDKN2A/p16),and O-6-methylguanine DNA methyltransferase(MGMT),as well as their rela- tion to MSI. RESULTS:The frequency of promoter methylation for each locus increased in the sequence healthy tissue/adenoma/carcinoma.MGMT showed the highest frequency in each group.MGMT and CDKN2A/p16 presented a statistically significant increase in promoter methylation between the less and more tumorigenic forms of colorectal adenomas(tubular vs tubullovillous and villous adenomas).All patients with tubulovillous/villous adenomas,as well as all colorectal cancer patients,showed promoter methylation in at least one of the examined loci.These findings suggest a potentially crucial role for methylation in the polyp/adenoma to cancer progres- sion in colorectal carcinogenesis.MSI and methylation seem to be interdependent,as simultaneous hMLH1, CDKN2A/p16,and MGMT promoter methylation was present in 8/9 colorectal cancer patients showing the MSI phenotype. CONCLUSION:Methylation analysis of hMLH1,CD- KN2A/p16,and MGMT revealed specific methylation profiles for tubular adenomas,tubulovillous/villous adenomas,and colorectal cancers,supporting the use of these alterations in assessment of colorectal tumorigenesis. | Vasiliki Psofaki Chryssoula Kalogera Nikolaos Tzambouras Dimitrios Stephanou Epameinondas Tsianos Konstantin Seferiadis Georgios Kolios | 2010 | World Journal of Gastroenterology2010，16，28： | 14 |
| 2 | Effects of KRAS, BRAF, NRAS , and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis显示文摘 | Wendy De Roock Bart Claes David Bernasconi Jef De Schutter Bart Biesmans George Fountzilas Konstantine T Kalogeras Vassiliki Kotoula Demetris Papamichael Pierre Laurent-Puig Frédérique Penault-Llorca Philippe Rougier Bruno Vincenzi Daniele Santini Giusepp | 2010 | Lancet Oncology2010，，8： | 6 |
| 3 | Ultrasound-guided transrectal placement of a drainage tube as therapeutic management of patients with prostatic abscess显示文摘 | Aravantinos E Kalogeras N Zygoulakis N | 2008 | J Endourol2008，22，8： | 1 |
| 4 | Promoter methylation status of hMLH1, MGMT, and CDKN2A/pl6 in colorectal adenomas 显示文摘 | Psofaki V Kalogera C Tzambouras N | 2010 | World J Gastroenterol2010，16，28： | 1 |
| 5 | Vertical Integration of Enterprise Industrial Systems Utilizing Web Services显示文摘 | Kalogeras A P Gialelis J V Alexakos C E | 2006 | IEEE Transactions on Industrial Informatics2006，2，2： | 1 |
| 6 | Lowbit-rate coding of image sequences using adaptive regions of interest显示文摘 | Nikolaos Doulamis Anastasios Doulamis Dimitrios Kalogeras Stefanos Kollias | | IEEE Transactions on CSVT0，8，8： | 1 |
| 7 | Correlation of serum HE4 with tumor size and myometrial invasion in endometrial cancer显示文摘 | Eleftheria Kalogera Nathalie Scholler Cecelia Powless Amy Weaver Ronny Drapkin Jinping Li Shi-Wen Jiang Karl Podratz Nicole Urban Sean C. Dowdy | 2011 | Gynecologic Oncology2011，，2： | 1 |
| 8 | Correlation of serum HFA with tumor size and myometrial invasion in endometrial cancer 显示文摘 | Kalogera E Scholler N Powless C | 2012 | Gynecologic Oncology2012，124，2： | 1 |
| 9 | High prevalence of autoimmune thyroiditis in schoolchildren after elimination of iodine deficiency in northwestern Greece显示文摘 | Zois C Stavrou I Kalogera C | 2003 | Thyroid2003，13，： | 1 |
| 10 | Contradicting perturbations of the segmental and secondary relaxation dynamics of polymer strands constrained in nanopores显示文摘 | Kalogeras I M | 2005 | Acta Mater2005，53，： | 1 |
| 11 | Combination of osteo- pontin and activated leukocyte cell adhesion molecule as potent prognostic discriminators in HER2- and ER-negntive breast can- cer 显示文摘 | Ihnen M Wirtz RM Kalogeras KT | 2010 | Br J Cancer2010，103，7： | 1 |
| 12 | Ultrasound - guided transreetal placement of a drainage tube as therapeutic management of patients with prostatic abscess 显示文摘 | Aravantinos E Kalogeras N Zygoulakis N | 2008 | J Endourol2008，22，： | 1 |
| 13 | Biomark- ers as a guide of medical treatment in cardiovascular dis- eases显示文摘 | Avuranakis M Kariori MG Kalogeras KI | 2012 | Curt Med Chem2012，19，16： | 1 |
| 14 | The importance of tumor volume in the prognosis of patients with glioblastoma: comparison of computerized volumetry and geometrical models显示文摘 | Iliadis G Selviaridis P Kalogera Fountzila A | 2009 | Strahlenther Onkol2009，185，11： | 1 |
| 15 | Improved outcome of high-risk early HER2 positive breast cancer with high CXCL13-CXCR5 messenger RNA expression显示文摘 | Razis E Kalogeras KT Kotoula V | 2012 | Clin Breast Cancer2012，12，3： | 1 |
| 16 | Correlation of serum HE4 with tumor size and myometrial invasion in endometrial cancer 显示文摘 | Kalogera E Scholler N Powless C | 2012 | Gynecol Oncol2012，124，2： | 1 |
| 17 | Prognostic utility of β-tubulin isotype III and correlations with other molecular and clinicopathological variables in patients with early breast cancer: a translational Hellenic Cooperative Oncology Group (HeCOG) study显示文摘 | Pentheroudakis G Batistatou A Kalogeras KT | 2011 | Breast Cancer Res Treat2011，127，1： | 1 |
| 18 | XELIRI-bevacizumab versus FOLFIRI-bevacizumab as first-line treatment in patients with metastatic colorectal cancer:a Hellenic Cooperative Oncology Group phase Ⅲ trial with collateral biomarker analysis显示文摘 | PECTASIDES D PAPAXOINIS G KALOGERAS K T | 2012 | BMC Cancer2012，12，： | 1 |
| 19 | The upgraded role of HER3 and HER4 receptors in breast cancer显示文摘 | Koutras A Fountzilas G Kalogeras K | 2010 | Crit Rev Oncol/hematol2010，74，： | 1 |
| 20 | Prognostic significance of angiogenesis in superficial bladder cancer显示文摘 | N. E. Stavropoulos C. Bouropoulos I. E. Ioachim M. Michael K. Hastazeris I. Tsimaris D. Kalogeras Z. Liamis S. Stefanaki N. I. Agnantis | 2004 | International Urology and Nephrology2004，，2： | 1 |
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