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| 1 | 利用微卫星进行奶牛数量性状基因位点定位的研究显示文摘采用孙女设计法对德国奶牛的3个数量性状——产奶量、乳脂产量及乳蛋白产量进行了数量性状基因位点的定位研究。实验共有20个父系半同胞家系的1 130头种公牛,共测定了30对染色体上的229个微卫星,表型性状的育种值由孙代母牛估计得到。连锁分析采用多重遗传标记回归法,临界F值由置换实验法计算得到。统计检验发现在某些染色体上存在着一些显著的QTL’s区域,特别是14号染色体上某一区域对所有3个产奶性状都有极显著的影响。进一步证实了Coppieters和Ron等人的实验结果。 | 徐宁迎 H Thomsen N Reinsch C Looft E Kalm | 2000 | Acta Genetica Sinica2000，27，9： | 20 |
| 2 | Diagnostic and prognostic potential of tissue and circulating long non-coding RNAs in colorectal tumors显示文摘Long non-coding RNAs(lncRNAs)are members of the non-protein coding RNA family longer than 200 nucleotides.They participate in the regulation of gene and protein expression influencing apoptosis,cell proliferation and immune responses,thereby playing a critical role in the development and progression of various cancers,including colorectal cancer(CRC).As CRC is one of the most frequently diagnosed malignancies worldwide with high mortality,its screening and early detection are crucial,so the identification of disease-specific biomarkers is necessary.LncRNAs are promising candidates as they are involved in carcinogenesis,and certain lncRNAs(e.g.,CCAT1,CRNDE,CRCAL1-4)show altered expression in adenomas,making them potential early diagnostic markers.In addition to being useful as tissue-specific markers,analysis of circulating lncRNAs(e.g.,CCAT1,CCAT2,BLACAT1,CRNDE,NEAT1,UCA1)in peripheral blood offers the possibility to establish minimally invasive,liquid biopsy-based diagnostic tests.This review article aims to describe the origin,structure,and functions of lncRNAs and to discuss their contribution to CRC development.Moreover,our purpose is to summarise lncRNAs showing altered expression levels during tumor formation in both colon tissue and plasma/serum samples and to demonstrate their clinical implications as diagnostic or prognostic biomarkers for CRC. | Orsolya Galamb Barbara K Barták Alexandra Kalmár Zsófia B Nagy Krisztina A Szigeti Zsolt Tulassay Peter Igaz Béla Molnár | 2019 | World Journal of Gastroenterology2019，25，34： | 18 |
| 3 | Epithelial toll-like receptor 9 signaling in colorectal inflammation and cancer: Clinico-pathogenic aspects显示文摘Toll-like receptors (TLRs) recognize specific motifs which are frequently present in bacteria, fungi, prokaryotes and viruses. Amongst TLRs, TLR9 can be activated by such bacterial or viral DNA fragments, immunoglobulin-DNA complexes or synthetic oligonucleotides, which all contain unmethylated cytosineguanine nucleotide sequences (CpGs). Emerging data indicate that TLR9 signaling has a role in, and may influence, colorectal carcinogenesis and colonic inflammation. CpGs are classified into three groups according to their influence on both the antigen-specific humoraland cellular immunity, and the production of type 1 interferons and proinflammatory cytokines. TLR9 activation via CpGs may serve as a new therapeutic target for several cancerous and various inflammatory conditions. Due to its probable anti-cancer effects, the application possibilities of TLR9-signaling modulation may be extremely diverse even in colorectal tumors. In this review we aimed to summarize the current knowledge about TLR-signaling in the pathogenesis and therapy of inflammatory bowel diseases and colorectal cancer. Due to the species-specific differences in TLR9 expression, however, one must be careful in translating the animal model data into the human system, because of the differences between CpG-oligodeoxynucleotide-responsive cells. TLR9 agonist DNA-based immunomodulatory sequences could also represent a promising therapeutic alternative in systemic inflammatory conditions and chronic colonic inflammations as their side effects are not significant. | István Fri Ferenc Sipos Tiana M Germann Alexandra Kalmár Zsolt Tulassay Béla Molnár Gyrgyi Mzes | 2013 | World Journal of Gastroenterology2013，19，26： | 14 |
| 4 | Aging related methylation influences the gene expression of key control genes in colorectal cancer and adenoma显示文摘AIM To analyze colorectal carcinogenesis and age-related DNA methylation alterations of gene sequences associated with epigenetic clock CpG sites. METHODS In silico DNA methylation analysis of 353 epigenetic clock Cp G sites published by Steve Horvath was performed using methylation array data for a set of 123 colonic tissue samples [64 colorectal cancer(CRC), 42 adenoma, 17 normal; GEO accession number: GSE48684]. Among the differentially methylated agerelated genes, secreted frizzled related protein 1(SFRP1) promoter methylation was further investigated in colonic tissue from 8 healthy adults, 19 normal children, 20 adenoma and 8 CRC patients using bisulfite-specific PCR followed by methylation-specific high resolution melting(MS-HRM) analysis. m RNA expression of age-related 'epigenetic clock' genes was studied using Affymetrix HGU133 Plus2.0 whole transcriptome data of 153 colonic biopsy samples(49 healthy adult, 49 adenoma, 49 CRC, 6 healthy children)(GEO accession numbers: GSE37364, GSE10714, GSE4183, GSE37267). Whole promoter methylation analysis of genes showing inverse DNA methylationgene expression data was performed on 30 colonic samples using methyl capture sequencing.RESULTS Fifty-seven age-related Cp G sites including hypermethylated PPP1R16 B, SFRP1, SYNE1 and hypomethylated MGP, PIPOX were differentially methylated between CRC and normal tissues(P < 0.05, ?β≥ 10%). In the adenoma vs normal comparison, 70 CpG sites differed significantly, including hypermethylated DKK3, SDC2, SFRP1, SYNE1 and hypomethylated CEMIP, SPATA18(P < 0.05, ?β≥ 10%). In MS-HRM analysis, the SFRP1 promoter region was significantly hypermethylated in CRC(55.0% ± 8.4 %) and adenoma tissue samples(49.9% ± 18.1%) compared to normal adult(5.2% ± 2.7%) and young(2.2% ± 0.7%) colonic tissue(P < 0.0001). DNA methylation of SFRP1 promoter was slightly, but significantly increased in healthy adults compared to normal young samples(P < 0.02). This correlated with significantly increased SFRP1 m RNA levels in children compared to normal adult samples(P < 0.05). In CRC tissue the mR NA expression of 117 agerelated genes were changed, while in adenoma samples 102 genes showed differential expression compared with normal colonic tissue(P < 0.05, logF C > 0.5). The change of expression for several genes including SYNE1, CLEC3 B, LTBP3 and SFRP1, followed the same pattern in aging and carcinogenesis, though not for all genes(e.g., MGP). CONCLUSION Several age-related DNA methylation alterations can be observed during CRC development and progression affecting the m RNA expression of certain CRC- and adenoma-related key control genes. | Orsolya Galamb Alexandra Kalmár Barbara Kinga Barták árpád V Patai Katalin Leiszter Bálint Péterfia Barnabás Wichmann Gábor Valcz Gábor Veres Zsolt Tulassay Béla Molnár | 2016 | World Journal of Gastroenterology2016，22，47： | 7 |
| 5 | 用商品群作为参考系构建猪的微卫星连锁图谱显示文摘由 19头杂种公猪 [皮特兰× (皮特兰×汉普夏 ) ]、5 2头杂种母猪 [Leicoma× (大约克×长白 ) ]及其 332头后代组成的商品群作为参考系 ,选择 172个微卫星标记和 3个Ⅰ类标记 (RYR1、PIT1、PRKAG3)对参考系的个体进行遗传标记分型 ,应用CRIMAP(2 4 )构建猪的整个基因组微卫星连锁图谱。采用多重PCR方法对微卫星标记进行扩增 ,用ABI 377测序仪进行电泳分离 ,应用Genescan 3 0和Genotyper 2 0软件进行基因型检测。 3个Ⅰ类标记用PCR RFLP技术进行分型。CRIMAP程序分析表明 :所构建的猪常染色体性平均连锁图谱的总长度为 2 36 8 7cM ,X染色体的长度为 14 3 10cM ,遗传标记的平均间距为 16 3cM ,亲本的微卫星标记座位的杂合度平均为 0 70。此连锁图谱的构建将为商品猪群的生长、胴体、肉质以及繁殖性状的QTL扫描打下基础。 | 郭晓令 Looft Christian Reinsch Norbert Kalm Ernst | 2003 | Acta Genetica Sinica2003，30，7： | 5 |
| 6 | Prediction of Dynamic and Aerodynamic Characteristics of the Centrifugal Fan with Forward Curved Blades显示文摘The main aim of this paper is determine the centrifugal fan with forward curved blades aerodynamic characteristics based on numerical modeling. Three variants of geometry were investigated. The first, basic 'A' variant contains 12 blades. The geometry of second 'B' variant contains 12 blades and 12 semi-blades with optimal length[1]. The third, control variant 'C' contains 24 blades without semi-blades. Numerical calculations were performed by CFD Ansys. Another aim of this paper is to compare results of the numerical simulation with results of approximate numerical procedure. Applied approximate numerical procedure [2] is designated to determine characteristics of the turbulent flow in the bladed space of a centrifugal-flow fan impeller. This numerical method is an extension of the hydro-dynamical cascade theory for incompressible and inviscid fluid flow. Paper also partially compares results from the numerical simulation and results from the experimental investigation. Acoustic phenomena observed during experiment, during numerical simulation manifested as deterioration of the calculation stability, residuals oscillation and thus also as a flow field oscillation. Pressure pulsations are evaluated by using frequency analysis for each variant and working condition. | Jií Polansky László Kalmár Roman Gápár | 2013 | Journal of Thermal Science2013，22，6： | 2 |
| 7 | 利用商品猪群定位猪耳型QTL显示文摘由 19头杂种公猪 [皮特兰× (皮特兰×汉普夏 ) ]、5 2头杂种母猪 [Leicoma× (大约克×长白 ) ]及其 332头后代组成的商品群作为参考家系 ,选择 172个微卫星标记和 3个 1类标记 (RYR1、PRKAG3、PIT1)对参考家系的个体进行遗传标记分型 ,构建了猪的整个基因组微卫星连锁图谱。按照线性评分的方法 (竖耳 :1分 ;垂耳 :- 1分 ;半垂耳 :0分 )测定猪的耳型表型值。耳型测定值的平均值为 0 .2 3,标准差为 0 .82。应用最小二乘回归方法对耳型的QTL进行定位 ,结果仅在 6号染色体的末端 (Sw1881和Sw32 2 )之间以 1%基因组显著性水平检测出 1个耳型基因位点 ,而在其他染色体上即使 10 %染色体显著性水平上也没有发现QTL。 | 郭晓令 Looft Christian Reinsch Norbert Kalm Ernst | 2004 | Acta Genetica Sinica2004，31，8： | 2 |
| 8 | Nutritional and life-quality consequences of aboral pouch construction after total gastrectomy:a randomized,controlled study显示文摘 | Horváth OP Kalmár K Cseke L | 2001 | Eur J Surg Oncol2001，27，6： | 1 |
| 9 | Comparative scanning electron microscopy study of oriented till blocks, glacial grains and Devonian sands in Estonia and Latvia 显示文摘 | Mahaney W C Kalm V | 2000 | Boreas2000，29，1： | 1 |
| 10 | Favorable response to high-dose infliximab for refractory childhood uveitis 显示文摘 | Kalm P Weiss M Imundo LF Levy DM | 2006 | Oph- thalmology2006，113，5： | 1 |
| 11 | Metastatic prostate cancercomplicated with chronic disseminated intravascular coagulopa-thy causing acute renal failure,mimicking thrombotic thrombo-cytopenic purpura and hemolytic uremic syndrome:pathomech-anism,differential diagnosis and therapy related to a case显示文摘 | Deme D Ragán M Kalmár K | 2010 | Magy Onkol2010，54，4： | 1 |
| 12 | Comparative scanning electron microscopy study of oriented till blocks, glacial grains and Devo nian sands in Estonia and Latvia 显示文摘 | Mahaney W C Kalm V | 2000 | Boreas2000，29，1： | 1 |
| 13 | A simple and efficient method for PCR amplication DNA extraction from ancient bones显示文摘 | Kalmár T Bachati C Z Marcsik A | 2000 | Nucleic Acids Research2000，28，12： | 1 |
| 14 | Degradation of Orange 3R, mixture of dyes and textile effluent and production of polyhydroxyalkanoates from biomass obtained after degradation显示文摘 | Tamboli DP Gomare SS Kalme SS | 2010 | International Biodeterioration & Biodegradation2010，64，8： | 1 |
| 15 | Rersonal use of hair dyes and risk of bladder cancer: A meta-analysis of epidemiologic data 显示文摘 | Kelsh MA Alexander DD Kalmes RM | 2008 | Cancer Causes Control2008，19，6： | 1 |
| 16 | Bovine β-defensins: Identification and characterization of novel bovine β-defensin genes and their expression in mammarygland tissue显示文摘 | Susanne Roosen Kay Exner Sven Paul Jens-Michael Schr?der Ernst Kalm Christian Looft | 2004 | Mammalian Genome2004，，10： | 1 |
| 17 | Decolourization of azo dye methyl red by Saccharomyces cerevisiae MTCC 463显示文摘 | J.P. Jadhav G.K. Parshetti S.D. Kalme S.P. Govindwar | 2006 | Chemosphere2006，，2： | 1 |
| 18 | Rapid communication : detection and mapping of polymorphisms in the bovine lactoperoxidase (LPO) gene and in the glycosylation - dependent cell adhesion molecule 1 ( GlyCAM1 ) gene using fluorescent single - strand conformation polymorphism analysisl 显示文摘 | KARALL C LOOFT C KALM E | 1997 | J Anim Sci1997，75，： | 1 |
| 19 | One-year lowdose erythromycin treatment of persistent chronic sinusitis after sinus surgery:clinical outcome and effects on mucociliary parameters and nasal nitric oxide显示文摘 | Cervin Anders Kalm O Sandkull P | | Otolaryngol Head Neck Surg0，126，5： | 1 |
| 20 | Biodegradation of benzidine based dye direct blue-6 by pseudomonas desmolyticum NCIM 2112显示文摘 | S D Kalme G K Parshetti S U Jadhav | 2006 | Bioresource Technology2006，1，： | 1 |
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