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| 1 | Langerin在Langerhans细胞组织细胞增生症和非Langerhans细胞组织细胞性疾病中的表达显示文摘 | Lan S K Chu P G Weiss L M 黄文斌(摘译) | 2008 | 临床与实验病理学杂志2008，24，5： | 23 |
| 2 | Management of borderline and locally advanced pancreatic cancer:Where do we stand?显示文摘Many patients with pancreas cancer present with locally advanced pancreatic cancer(LAPC).The principle tools used for diagnosis and staging of LAPC include endoscopic ultrasound,axial imaging with computed tomography and magnetic resonance imaging,and diagnostic laparoscopy.The definition of resectability has historically been vague,as there is considerable debate and controversy as to the definition of LAPC.For the patient with LAPC,there is some level of involvement of the surrounding vascular structures,which include the superior mesenteric artery,celiac axis,hepatic artery,superior mesenteric vein,or portal vein.When feasible,most surgeons would recommend possible surgical resection for patients with borderline LAPC,with the goal of an R0 resection.For initially unresectable LAPC,neoadjuvant should be strongly considered.Specifically,these patients should be offered neoadjuvant therapy,and the tumor should be assessed for possible response and eventual resection.The efficacy of neoadjuvant therapy with this approach as a bridge to potential curative resection is broad,ranging from 3%-79%.The different modalities of neoadjuvant therapy include sin-gle or multi-agent chemotherapy combined with radiation,chemotherapy alone,and chemotherapy followed by chemotherapy with radiation.This review focuses on patients with LAPC and addresses recent advances and controversies in the field. | Jin He Andrew J Page Matthew Weiss Christopher L Wolfgang Joseph M Herman Timothy M Pawlik | 2014 | World Journal of Gastroenterology2014，20，9： | 11 |
| 3 | 非诺贝特治疗与2型糖尿病患者长期心血管病风险的关系显示文摘2型糖尿病患者心血管病风险高,部分原因在于高三酰甘油和低高密度脂蛋白胆固醇血症。而在他汀类药物治疗基础上,加强降低三酰甘油治疗,能否降低这种风险尚不清楚。该研究的目的是在使用他汀类药物治疗的2型糖尿病患者中,确定非诺贝特能否降低心血管病风险。 | 刘莉 叶鹏 Elam MB Ginsberg HN Lovato LC Corson M Largay J Leiter LA Lopez C O'Connor PJ Sweeney ME Weiss D Friedewald WT Buse JB Gerstein HC Probstfield J Grimm R Ismail-Beigi F Goff DC Jr Fleg JL Rosenberg Y Byington RP ACCORDION study investigators | 2017 | 中华高血压杂志2017，25，6： | 7 |
| 4 | Response to endoscopic therapy for biliary anastomotic strictures in deceased versus living donor liver transplantation显示文摘BACKGROUND:Endoscopic therapy has been successful in the management of biliary complications after both deceased donor liver transplantation(DDLT) and living donor liver transplantation(LDLT).LDLT is thought to be associated with higher rates of biliary complications,but there are few studies comparing the success of endoscopic management of anastomotic strictures between the two groups.This study aims to compare our experience in the endoscopic management of anastomotic strictures in DDLT versus LDLT.METHODS:This is a retrospective database review of all liver transplant patients undergoing endoscopic retrograde cholangiopancreatography(ERCP) after liver transplantation.The frequency of anastomotic stricture and the time to develop and to resolve anastomotic stricture were compared between DDLT and LDLT.The response of anastomotic stricture to endoscopic therapy was also analyzed.RESULTS:A total of 362 patients underwent liver transplantation between 2003 and 2011,with 125 requiring ERCP to manage biliary complications.Thirty-three(9.9%) cases of DDLT and 8(27.6%) of LDLT(P=0.01) were found to have anastomotic stricture.When comparing DDLT and LDLT,there was no difference in the mean time to the development of anastomotic strictures(98±17 vs 172±65 days,P=0.11),likelihood of response to ERCP [22(66.7%) vs 6(75.0%),P=0.69],mean time to the resolution of anastomotic strictures(268±77 vs 125±37 days,P=0.34),and the number of ERCPs required to achieve resolution(3.9±0.4 vs 4.7±0.9,P=0.38).CONCLUSIONS:Endoscopic therapy is effective in the majority of biliary complications relating to liver transplantation.Anastomotic strictures occur more frequently in LDLT compared with DDLT,with equivalent endoscopic treatment response and outcomes for both groups. | Calvin HY Chan Fergal Donnellan Michael F Byrne Alan Coss Mazhar Haque Holly Wiesenger Charles H Scudamore Urs P Steinbrecher Alan A Weiss Eric M Yoshida | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，5： | 7 |
| 5 | Toxoplasma gondii : from animals to humans显示文摘 | Astrid M Tenter Anja R Heckeroth Louis M Weiss | 2000 | International Journal for Parasitology2000，，12： | 4 |
| 6 | Socio-cultural determinants of timely and delayed treatment of Buruli ulcer: implications for disease control显示文摘Introduction:Public health programmes recommend timely medical treatment for Buruli ulcer(BU)infection to prevent pre-ulcer conditions from progressing to ulcers,to minimise surgery,disabilities and the socio-economic impact of BU.Clarifying the role of socio-cultural determinants of timely medical treatment may assist in guiding public health programmes to improve treatment outcomes.This study clarified the role of socio-cultural determinants and health system factors affecting timely medical treatment for BU in an endemic area in Ghana.Methods:A semi-structured explanatory model interview based on the explanatory model interview catalogue(EMIC)was administered to 178 BU-affected persons.Based on research evidence,respondents were classified as timely treatment(use of medical treatment 3 months from awareness of disease)and delayed treatment(medical treatment 3 months after onset of disease and failure to use medical treatment).The outcome variable,timely treatment was analysed with cultural epidemiological variables for categories of distress,perceived causes of BU,outside-help and reasons for medical treatment in logistic regression models.The median time for the onset of symptoms to treatment was computed in days.Qualitative phenomenological analysis of respondents’narratives clarified the meaning,context and dynamic features of the relationship of explanatory variables with timely medical treatment.Results:The median time for initiating treatment was 25 days for pre-ulcers,and 204 days for ulcers.Income loss and use of herbalists showed significantly negative associations with timely treatment.Respondents’use of herbalists was often motivated by the desire for quick recovery in order to continue with work and because herbalists were relatives and easily accessible.However,drinking unclean water was significantly associated with timely treatment and access to health services encouraged timely treatment(OR 8.5,p=0.012).Findings show that health system factors of access are responsible for non-compliance to treatment regimes.Conclusions:Findings highlight the importance of an integrated approach to BU control and management considering the social and economic features that influence delayed treatment and factors that encourage timely medical treatment.This approach should consider periodic screening for early case-detection,collaboration with private practitioners and traditional healers,use of mobile services to improve access,adherence and treatment outcomes. | Mercy M Ackumey Margaret Gyapong Matilda Pappoe Cynthia Kwakye Maclean Mitchell G Weiss | 2012 | Infectious Diseases of Poverty2012，1，1： | 3 |
| 7 | 群体药物代谢动力学方法研究伏立康唑的变异度:以优化给药方案显示文摘伏立康唑为广谱抗真菌药物,主要经肝药代谢酶CYP2C19、或CYP3A4和CYP2C9代谢,其药动学特征呈非线性并变异程度大,且该药治疗窗窄,使临床应用复杂。本研究将4项健康受试者研究和2项患者临床研究的数据(包括240名受试者的3352个血药浓度数据)建立非线性混合效应模型分析(NONM EM ),以剂量模拟检验协变量影响效应和据CYP2C19表型分层的伏立康唑浓度(2~5 mg/L )达标情况。结果表明伏立康唑符合滞后时间的一级口服吸收和消除米氏方程的二房室模型。伏立康唑在健康受试者中的最大代谢速率(Vmax )比患者高111%。具有一个或多个CYP2C19功能缺失(LoF)等位基因的受试者的 Vmax较没有上述等位基因缺失的受试者偏低41.2%。合并使用苯妥英钠或利福平,圣约翰草提取物或糖皮质激素可显著增加伏立康唑的消除。口服或静脉注射伏立康唑200 mg ,每日2次,第7天的谷浓度<2 mg/L的概率对无CYP2C19 LoF等位基因的受试者分别为72%和63%;口服或静脉给药300 mg ,每日2次,该概率分别较低,为49%和35%。相反,对于具有CYP2C19 LoF等位基因的受试者,上述给药方案第7天的伏立康唑谷浓度>5 mg/L 的概率分别为29%、39%、57%和77%。因此,目前伏立康唑的给药方案在无CYP2C19 LoF等位基因的受试者中暴露量偏低,需增加给药剂量,但在CYP2C19活性降低的受试者中暴露量则偏高。尽管本研究中伏立康唑生物利用度较高(94%),但个体差异较大(36.7%),且不同研究的结果差异较大(63%~96%),改变给药途径时也需要进行药物浓度监测。本研究表明,为保证伏立康唑的有效性和安全性,需进行治疗药物浓度监测。 | Dolton M J Mikus G Weiss J 赵苗 | 2015 | 中国感染与化疗杂志2015，15，5： | 2 |
| 8 | Chlorofluoromethans in South Atlantic antarctic intermediate water显示文摘 | WARNER M J WEISS R F | 1992 | Deep-Sea Res1992，39，： | 2 |
| 9 | Pharmacologic management of acute attacks of migraine and prevention of migraine headache显示文摘 | Vincenza Snow Kevin Weiss eric M Wall | 2002 | Ann Intern Med2002，137，： | 1 |
| 10 | Radial tunnel syndrome显示文摘 | Mastey RD Weiss AC | 1996 | Hand Clinics1996，12，4： | 1 |
| 11 | Heteronuclear 2D NMR studies of an engineered insulin monomer:assignment and characterization of the receptor-bingding surface by selective 2H and 13C labeling with application to protein design显示文摘 | Hua Q X Lynch C S | 1991 | Biochemistry1991，30，： | 1 |
| 12 | Pathophysiologic features of a pneumoperitoneum at laparoseopy:a swine model显示文摘 | Volz J Koster S Weiss M | 1996 | Am J Obstet Gynecol1996，174，11： | 1 |
| 13 | Evaluation of canopy biophysical variable re- trieval performances from the accumulation of large swath satellite data显示文摘 | Weiss M Baret F | 1999 | Remote Sensing of Environment1999，70，： | 1 |
| 14 | Laboratory study of heavy metal phytoremediation by three wetland macrophytes 显示文摘 | Weiss J Hondzo M Biesboer D | 2006 | International Journal of Phytoremediation2006，8，3： | 1 |
| 15 | Toxoplasma gondii : from animals to humans显示文摘 | Tenter A M Heckeroth A R Weiss L M | 2000 | Int J Parasitol2000，30，1213： | 1 |
| 16 | Electrospinning of food-grade nanofibers from cellulose acetate and egg al- bumen blends显示文摘 | WONGSASULAK S P M WEISS J | 2010 | Jounal of Food Engineering2010，98，3： | 1 |
| 17 | Liver-specific RNA metabolism in hepatoma cells:variations in transcription rates and mRNA levels显示文摘 | Clayton DF Weiss M Darnell JE | 1985 | Molecular Cellular Biology1985，5，： | 1 |
| 18 | Purification and characterization of perlucin and perlustrin, two new proteins from the shell of the mollusc Haliotis laevigata显示文摘 | Weiss I M Kaufmann S Mann K | 2000 | Biochem Biophys Res Commun2000，267，： | 1 |
| 19 | Residual stresses in ceramic plasma - sprayed thermal barrier coatings: Measurement and calculation显示文摘 | Levit M Grimberc I Weiss B Z | 1996 | Materials Science & Engineering A1996，206，1： | 1 |
| 20 | Trends in antibiotic resistance of Staphylococci over an eight-year period: difference in the emergence of resistance between coagulase positive and coagulase negative Staphylococci显示文摘 | Laverdiere M Weiss K Rivest R | 1998 | Miceobial Drug Resistance1998，4，： | 1 |
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