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| 1 | Non-small-bowel lesions encountered during double-balloon enteroscopy performed for obscure gastrointestinal bleeding显示文摘AIM:To report the incidence of non-small-bowel bleeding pathologies encountered during double-balloon enteroscopy (DBE) procedures and to analyse their significance.METHODS: A retrospective study of a prospective DBE database conducted in a tertiary-referral center was conducted. A total of 179 patients with obscure gastrointestinal bleeding (OGIB) referred for DBE from June 2004 to November 2008 were analysed looking for the incidence of non-small-bowel lesions (NSBLs; all and newly diagnosed) encountered during DBE.RESULTS: There were 228 (150 antegrade and 78 retrograde) DBE procedures performed in 179 patients. The mean number of DBE procedures was 1.27 per patient. The mean age (SD) of the patients was 62 ± 16 years old. There were 94 females (52.5%). The positive yield for a bleeding lesion was 65.9%. Of the 179 patients, 44 (24.6%) had NSBLs (19 of them had dual pathology with small-bowel lesions and NSBLs); 27 (15.1%) had lesions not detected by previous endoscopies. The most common type of missed lesions were vascular lesions.CONCLUSION: A significant proportion of patients (24.6%) had lesions within reach of conventional endoscopy. Careful repeat examination with gastroscopy and colonoscopy might be required. | Hoi-Poh Tee Arthur J Kaffes | 2010 | World Journal of Gastroenterology2010，16，15： | 21 |
| 2 | Prospective randomized controlled trial evaluating cap-assisted colonoscopy vs standard colonoscopy显示文摘AIM: To study the significance of cap-fitted colonoscopy in improving cecal intubation time and polyp detection rate. METHODS: This study was a prospective randomized controlled trial conducted from March 2008 to February 2009 in a tertiary referral hospital at Sydney. The primary end point was cecal intubation time and the secondary endpoint was polyp detection rate. Consecutive cases of total colonoscopy over a 1-year period were recruited. Randomization into either standard colonoscopy (SC) or cap-assisted colonoscopy (CAC) was performed after consent was obtained. For cases randomized to CAC, one of the three sizes of cap was used: D-201-15004 (with a diameter of 15.3 mm), D-201-14304 (14.6 mm) and D-201-12704 (13.0 mm). All of these caps were produced by Olympus Medical Systems, Japan. Independent predictors for faster cecal time and better polyp detection rate were also determined from this study. RESULTS: There were 200 cases in each group. There was no signif icant difference in terms of demographic characteristics between the two groups. CAC, when compared to the SC group, had no signif icant difference in terms of cecal intubation rate (96.0% vs 97.0%, P = 0.40) and time (9.94 ± 7.05 min vs 10.34 ± 6.82 min, P = 0.21), or polyp detection rate (32.8% vs 31.3%, P = 0.75). On the subgroup analysis, there was no significant difference in terms of cecal intubation time by trainees (88.1% vs 84.8%, P = 0.40), ileal intubation rate (82.5% vs 79.0%, P = 0.38) or total colonoscopy time (23.24 ± 13.95 min vs 22.56 ± 9.94 min, P = 0.88). On multivariate analysis, the independent determinants of faster cecal time were consultant-performed procedures (P < 0.001), male patients (P < 0.001), non-usage of hyoscine (P < 0.001) and better bowel preparation (P = 0.01). The determinants of better polyp detection rate were older age (P < 0.001), no history of previous abdominal surgery (P = 0.04), patients not having esophagogastroduodenoscopy in the same setting (P = 0.003), trainee-performed procedures (P = 0.01), usage of hyoscine (P = 0.01) and procedures performed for polyp follow-up (P = 0.01). The limitations of the study were that it was a single-center experience, no blinding was possible, and there were a large number of endoscopists. CONCLUSION: CAC did not signif icantly different from SC in term of cecal intubation time and polyp detection rate. | Hoi-Poh Tee Crispin Corte Hamdan Al-Ghamdi Emilia Prakoso John Darke Raman Chettiar Wassim Rahman Scott Davison Sean P Griffin Warwick S Selby Arthur J Kaffes | 2010 | World Journal of Gastroenterology2010，16，31： | 10 |
| 3 | Double-balloon enteroscopy-assisted dilatation avoids surgery for small bowel strictures: A systematic review显示文摘AIM To evaluate the therapeutic role of double-balloon enteroscopy(DBE) in small bowel strictures and to propose a standard approach to small bowel strictures.METHODS Systematic review of studies involving DBE in patients with small bowel strictures. Only studies limited to small bowel strictures were included and those with ileo-colonic strictures were excluded. RESULTS In total 13 studies were included,in which 310 patients were dilated. The average follow-up time was 31.8 mo per patient. The complication rate was 4.8% per patient and 2.6% per dilatation. Surgery was avoided in 80% of patients. After the first dilatation,46% were treated with re-dilatation and only 17% required surgery.CONCLUSION DBE-assisted dilatation avoids surgery in 80% of patients with small bowel strictures and is safe and effective. We propose a standardized approach to small bowel strictures. | Judith E Baars Ruben Theyventhiran Patrick Aepli Payal Saxena Arthur J Kaffes | 2017 | World Journal of Gastroenterology2017，23，45： | 6 |
| 4 | Placement of removable metal biliary stent in post-orthotopic liver transplantation anastomotic stricture显示文摘Postoperative biliary strictures are the most common cause of benign biliary stricture in Western countries, secondary to either operative injury or bile duct anastomotic stricture following orthotopic liver transplantation(OLT).Surgery or endoscopic interventions are the mainstay of treatment for benign biliary strictures.We aim to report the outcome of 2 patients with refractory anastomotic biliary stricture post-OLT,who had successful temporary placement of a prototype removable covered self-expandable metal stent(RCSEMS).These 2 patients(both men,aged 44 and 53 years)were given temporary placement of a prototype RCSEMS (8.5 Fr gauge delivery system,8 mm×40 mm stent dimensions)in the common bile duct across the biliary stricture.There was no morbidity associated with stent placement and removal in these 2 cases.Clinical parameters improved after the RCSEMS placement.Longterm biliary patency was achieved in both the patients. No further biliary intervention was required within 14 and 18 mo follow-up after stent removal. | Hoi-Poh Tee Martin W James Arthur J Kaffes | 2010 | World Journal of Gastroenterology2010，16，28： | 4 |
| 5 | 为双汽球 enteroscopy 的学习曲线: 从 282 过程的分析的调查结果显示文摘 AIM: To determine the learning curves for antegrade double-balloon enteroscopy (aDBE) and retrograde DBE (rDBE) by analyzing the technical success rates. METHODS: A retrospective analysis in a tertiary referral center. This study reviewed all cases from June 2006 to April 2011 with a target lesion in the small-bowel identified by either capsule endoscopy or computed tomography scan posted for DBE examinations. Main outcome measurements were: (1) Technical success of aDBE def ined by f inding or excluding a target lesion after achieving suff icient length of small bowel intubation; and (2) Technical success for rDBE was def ined by either f inding the target lesion or achieving stable overtube placement in the ileum. RESULTS: Two hundred and eighty two procedures fulf illed the inclusion criteria and were analyzed. These procedures were analyzed by blocks of 30 cases. Therewas no distinct learning curve for aDBE. Technical success rates for rDBE continued to rise over time, although on logistic regression analysis testing for trend, there was no signif icance (P = 0.09). The odds of success increased by a factor of 1.73 (95% CI: 0.93-3.22) for rDBE. For these data, it was estimated that at least 30-35 cases of rDBE under supervision were needed to achieve a good technical success of more than 75%. CONCLUSION: There was no learning curve for aDBE. Technical success continued to increase over time for rDBE, although a learning curve could not be proven statistically. Approximately 30-35 cases of rDBE will be required for stable overtube intubation in ileum. | Hoi-Poh Tee Soon-Hin How Arthur J Kaffes | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，8： | 4 |
| 6 | Complications of double balloon enteroscopy: a multicenter survey显示文摘 | P. Mensink J. Haringsma T. Kucharzik C. Cellier E. Pérez-Cuadrado K. M?nkemüller A. Gasbarrini A. Kaffes K. Nakamura H. Yen H. Yamamoto | 2007 | Endoscopy2007，，07： | 3 |
| 7 | Needle-knife sphincterotomy: factors predicting its use and the relationship with post-ERCP pancreatitis (with video)显示文摘 | Adam A. Bailey Michael J. Bourke Arthur J. Kaffes Karen Byth Eric Y. Lee Stephen J. Williams | 2010 | Gastrointestinal Endoscopy2010，，2： | 2 |
| 8 | 内镜下胆管插管困难时十二指肠乳头括约肌预切开的早期应用:一项传统技术与改良技术比较的前瞻性研究显示文摘Background: Pre-cutting techniques have been used to gain biliary access at the expense of an increased complication rate. This may be because of the multiple attempts to achieve cannulation by using standard methods before pre-cutting and causing excess edema and papillary trauma. There are limited data on the early use of pre-cutting techniques. Methods: We performed a prospective study of the early introduction of needle-knife techniques in patients with difficult biliary cannulation. Standard biliary cannulation was attempted with a sphincterotome and a guidewire. If this failed within 10 minutes or if there were more than 5 pancreatic cannulations, the needle-knife technique was used. Either a standard method of pre-cutting (below-up-ward) from the papillary orifice or the modified technique of pre-cutting (above-downward), stopping short of the papillary orifice, was adopted, as per the discretion of the endoscopist. If pre-cutting failed, the cannulation was reattempted 24 to 48 hours later. Results: A total of 346 therapeutic biliary ERCP procedures were performed between April and August 2003. Of these, 70 patients (20%) (mean age, 54 years; 38 men) underwent needle-knife pre-cut sphincterotomy (16 with the standard technique). In 58 patients (83%), the procedure was successful with the initial pre-cutting, making the total success at initial ERCP 334/346 (96.5%). Nine patients in whom pre-cut failed, returned for a second-attempt ERCP, with 7 completed successfully. The total success rate of pre-cutting was 65/70 (93%). The overall success rate of biliary cannulation, after two ERCP attempts, was 341/346 (98.5%). Six patients had mild bleeding, and one had mild pancreatitis. There was no difference in these complications between the two types of precut techniques. Conclusions: The early use of needle knife for difficult biliary cannulation is safe and effective, irrespective of the technique used. | Kaffes A.J. Sriram P.V.J. 赵萌 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，0，3： | 2 |
| 9 | SINGLE-01: a randomized, controlled trial comparing the efficacy and depth of insertion of single- and double-balloon enteroscopy by using a novel method to determine insertion depth显示文摘 | Marios Efthymiou Paul V. Desmond Gregor Brown Richard La Nauze Arthur Kaffes Tee Joo Chua Andrew C.F. Taylor | 2012 | Gastrointestinal Endoscopy2012，，5： | 2 |
| 10 | Hyoscine butylbromide administered at the cecum increases polyp detection: a randomized double-blind placebo-controlled trial显示文摘 | C. Corte L. Dahlenburg W. Selby S. Griffin C. Byrne T. Chua A. Kaffes | 2012 | Endoscopy2012，，10： | 1 |
| 11 | Iron deficiency anaemia: a review of diagnosis, investigation and management显示文摘 | Ken Liu Arthur J. Kaffes | 2012 | European Journal of Gastroenterology & Hepatology2012，，2： | 1 |
| 12 | Loss of met- allothionein predisposes mice to diethylnitrosamine - in- duced hepatocarcinogenesis l)y activating NF - kappaB target genes显示文摘 | Majumder S Roy S Kaff enberger T | 2010 | Cancer Res2010，7，10： | 1 |
| 13 | Hyoscine butylbromide administered at the cecum increases polyp detection: a randomized double-blind placebo-controlled trial显示文摘 | C. Corte L. Dahlenburg W. Selby S. Griffin C. Byrne T. Chua A. Kaffes | 2012 | Endoscopy2012，，10： | 1 |
| 14 | A prospective, randomized, placebo-controlled trial of transdermal glyceryl trinitrate in ERCP: effects on technical success and post-ERCP pancreatitis显示文摘 | Arthur John Kaffes Michael John Bourke Stephen Ding Ahmad Alrubaie Vu Kwan Stephen John Williams | 2006 | Gastrointestinal Endoscopy2006，，3： | 1 |
| 15 | Proposed guidelines for diagnosis of chromosome mosaicism in amniocytes based on data derived from chromosome mosaicism and pseudomosaicism studies 显示文摘 | Hsu LY Kaffe S Jenkins EC | 1992 | Prenat Diagu1992，12，7： | 1 |
| 16 | Early institution of pre-cut for difficult biliary cannulation: prospective study comparing conventional vs a modified technique 显示文摘 | Kaffes A J Sriram PV Rao GV | 2005 | Gastrointest Endosc2005，62，5： | 1 |
| 17 | Statistical evaluation of radiologic survey of pulp stones 显示文摘 | Tamse A Kaffe I Littner MM | 1982 | J Endod1982，8，10： | 1 |
| 18 | Meta- analysis of narrow- band imaging versus conventional colonoscopy for adenoma de- tection显示文摘 | Dinesen L Chua TJ Kaffes AJ | 2012 | Gastrointestinal Endoscopy2012，75，： | 1 |
| 19 | Radiological features of central haemangioma of the jaws 显示文摘 | Zlotogorski A Buchner A Kaffe I | 2005 | Dentomaxillofac Radiol2005，34，29： | 1 |
| 20 | Review article: the diagnosis and investigation of obscure gastrointestinal bleeding 显示文摘 | Liu K Kaffes AJ | 2011 | Aliment Pharmacol Ther2011，34，4： | 1 |
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