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| 1 | Expression of interleukin-2 receptor on blood lymphocytes stimulated with allogeneic lymphocytes or autologous tumor cells显示文摘 | G. Stuber F. Vánky E. Pócsik M. Benczúr E. Klein | 1990 | Cancer Immunology Immunotherapy1990，，2： | 4 |
| 2 | Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales显示文摘 | C.P Wilkinson Frederick L Ferris Ronald E Klein Paul P Lee Carl David Agardh Matthew Davis Diana Dills Anselm Kampik R Pararajasegaram Juan T Verdaguer | 2003 | Ophthalmology2003，，9： | 4 |
| 3 | Meeting report:a hard look at the state of enamel research显示文摘The Encouraging Novel Amelogenesis Models and Ex vivo cell Lines(ENAMEL) Development workshop was held on 23 June 2017 at the Bethesda headquarters of the National Institute of Dental and Craniofacial Research(NIDCR). Discussion topics included model organisms, stem cells/cell lines, and tissues/3 D cell culture/organoids. Scientists from a number of disciplines,representing institutions from across the United States, gathered to discuss advances in our understanding of enamel, as well as future directions for the field. | ophir d klein olivier duverger wendy shaw rodrigo s lacruz derk joester janet moradian-oldak megan k pugach j timothy wright sarah e millar ashok b kulkarni john d bartlett thomas gh diekwisch pamela den besten james p simmer | 2017 | International Journal of Oral Science2017，9，4： | 3 |
| 4 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 5 | Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales显示文摘 | C.P Wilkinson Frederick L Ferris Ronald E Klein Paul P Lee Carl David Agardh Matthew Davis Diana Dills Anselm Kampik R Pararajasegaram Juan T Verdaguer | 2003 | Ophthalmology2003，，9： | 2 |
| 6 | Effect of donor–recipient HLA matching at HLA A, B, C, and DRB1 on outcomes after umbilical-cord blood transplantation for leukaemia and myelodysplastic syndrome: a retrospective analysis显示文摘 | Mary Eapen John P Klein Guillermo F Sanz Stephen Spellman Annalisa Ruggeri Claudio Anasetti Maria Brown Richard E Champlin Joan Garcia-Lopez Gareth Hattersely Gesine Koegler Mary J Laughlin Gerard Michel Samir K Nabhan Franklin O Smith Mary M Horowitz Eli | 2011 | Lancet Oncology2011，，13： | 2 |
| 7 | Empagliflozin alleviates podocytopathy and enhances glomerular nephrin expression in db/db diabetic mice显示文摘BACKGROUND Modern guidelines recommend sodium-glucose cotransporter-2(SGLT2)inhibitors as the preferred antihyperglycemic agents for patients with type 2 diabetes and chronic kidney disease.However,the mechanisms underlying the renal protective effect of SGLT2 inhibitors are not fully understood.structure of podocytes and nephrin expression in glomeruli in db/db diabetic mice.METHODS We treated 8-wk-old male db/db mice with EMPA(10 mg/kg/d)or vehicle for 8 wk.Age-matched male db/+mice were included as non-diabetic controls.Parameters of body composition,glycemic and lipid control,and plasma concentrations of leptin,insulin and glucagon were assessed.We evaluated renal hypertrophy as kidney weight adjusted to lean mass,renal function as plasma levels of creatinine,and albuminuria as the urinary albumin-to-creatinine ratio(UACR).Renal structures were studied by light and transmission electron microscopy with a focus on mesangial volume and podocyte structure,respectively.Glomerular nephrin and transforming growth factor beta(TGF-β)were assessed by immunohistochemistry.RESULTS Severe obesity and hyperglycemia developed in db/db mice prior to the start of the experiment;increased plasma concentrations of fructosamine,glycated albumin,cholesterol,leptin,and insulin,and elevated UACR were detected.Mesangial expansion,glomerular basement membrane thickening,and increased area of TGF-βstaining in glomeruli were revealed in vehicle-treated mice.Podocytopathy was manifested by effacement of foot processes;nephrin-positive areas in glomeruli were reduced.EMPA decreased the levels of glucose,fructosamine and glycated albumin,UACR,kidney hypertrophy,mesangial expansion,glomerular basement membrane thickening,and glomerular TGF-βstaining,alleviated podocytopathy and restored glomerular staining of nephrin.CONCLUSION These data indicate that EMPA attenuates podocytopathy in experimental diabetic kidney disease.The anti-albuminuric effect of EMPA could be attributed to mitigation of podocyte injury and enhancement of nephrin expression. | Vadim V Klimontov Anton I Korbut Iuliia S Taskaeva Nataliya P Bgatova Maksim V Dashkin Nikolai BOrlov Anna S Khotskina Evgenii L Zavyalov Thomas Klein | 2020 | World Journal of Diabetes2020，11，12： | 2 |
| 8 | Shaping the future of biomarker research in breast caneer to ensure clinical relevance显示文摘 | Hinestrosa MC Dickersin K Klein P | 2007 | Nat Rev Caneer2007，7，4： | 1 |
| 9 | Polyurethanepolysiloxane interpenetrating polymer networks ( 1 ) : A polyether urethane-poly ( dimethyl siloxane ) system 显示文摘 | EBDON J R HOURSTON D J KLEIN P G | 1984 | Polymer1984，25，11： | 1 |
| 10 | Numerical simulation of crack growth in an isotropic solid with randomized internal cohesive bonds 显示文摘 | Gao H Klein P | 1998 | Journal of the Mechanics and Physics of Solids1998，46，2： | 1 |
| 11 | Zero forcing and minimum mean-square-error equalization for multiuser detection in code-division multiple-access channels 显示文摘 | KLEIN A KALEH G BAIER P | 1996 | IEEE Transactions on Vehicular Technology1996，45，： | 1 |
| 12 | Zero forcing and minimum mean-square-error equalization for multiuser detection in code-division multiple-access channels显示文摘 | KLEIN A KALEH G K BAIER P W | 1996 | IEEE Transactions on Vehicular Technology1996，45，2： | 1 |
| 13 | Wnt-frizzled signaling in neural crest formation显示文摘 | Wu J Saint-Jeannet J P Klein P S | 2003 | Trends Neurosci2003，26，1： | 1 |
| 14 | Immunological study of lactate dehydrogenase from Streptococcus mutans and evi- dence of common antigenic domains with lactate dehydroge- nases from lactic bacteria显示文摘 | Sommer P Klein JP Ogier JA | 1986 | Infect Immun1986，51，1： | 1 |
| 15 | Valuation of European options subject to financial distress and interest rate risk显示文摘 | Klein P Inglis M | 1999 | Journal of Derivatives1999，6，3： | 1 |
| 16 | Microbial ecology: Hu- man gut microbes associated with obesity显示文摘 | Ley R E Turnbaugh P J Klein S | 2006 | Nature2006，7122，444： | 1 |
| 17 | BiOhemical factors underlying the age - related sensitivity of turkeys to aflatoxin B1显示文摘 | Klein P J Van - Vleet T R Hall J O | | 0，，： | 1 |
| 18 | Antibodies in HIV-1 vaccine development and therapy显示文摘 | Klein F Mouquet H Dosenovic P | 2013 | Science2013，341，6151： | 1 |
| 19 | Lo- cal and systemic risk factors influencing the long-term success of angular stable alloplastic reconstruction plates of the mandi- ble显示文摘 | KAMMERER P W KLEIN M O MOERGEL M | 2014 | Journal of Cranio-maxillo-facial Surgery: Official Pub- lication of the European Association for Cranio-Maxillo-Facial Surgery2014，42，5： | 1 |
| 20 | Diversification, Organization, and Efficiency: Evidence from Bank Holding Companies 显示文摘 | Klein P G Saidenberg M R | 1998 | Organization and Efficien- cy1998，5，1： | 1 |
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