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| 1 | Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer. | Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki | 2006 | World Journal of Gastroenterology2006，12，40： | 3 |
| 2 | Climate Change Vulnerability Assessments: An Evolution of Conceptual Thinking显示文摘 | Hans-Martin Füssel Richard J. T. Klein | 2006 | Climatic Change2006，，3： | 2 |
| 3 | Effect of donor–recipient HLA matching at HLA A, B, C, and DRB1 on outcomes after umbilical-cord blood transplantation for leukaemia and myelodysplastic syndrome: a retrospective analysis显示文摘 | Mary Eapen John P Klein Guillermo F Sanz Stephen Spellman Annalisa Ruggeri Claudio Anasetti Maria Brown Richard E Champlin Joan Garcia-Lopez Gareth Hattersely Gesine Koegler Mary J Laughlin Gerard Michel Samir K Nabhan Franklin O Smith Mary M Horowitz Eli | 2011 | Lancet Oncology2011，，13： | 2 |
| 4 | Sonographic signs of neutropenic enterocolitis显示文摘瞄准:与 neutropenic 小肠结肠炎在病人在诊断和后续的时间调查 sonographic 特征。方法:在有 neutropenic 小肠结肠炎的 14 个病人的 sonographic 调查结果被描述并且评估了考虑症状和临床的结果。结果:在有 neutropenic 小肠结肠炎的所有病人, ileocoecal 区域涉及墙变厚 >10 公里。一个透壁的煽动性的模式,变厚的肠墙的亢奋的由脉管形成和免费腹的液体是普通调查结果。肠墙的 sonographically 揭示的厚度与致命的结果(P<0.03 ) 被联系。在 11 个幸存病人,临床的症状的改进被肠的墙厚度的进步减小伴随。结论:肠的高端 sonography 是为诊断的一个有用工具,对预后的评价和有 neutropenic 小肠结肠炎的病人的后续。ultrasonographically 揭示的肠厚度反映严厉和疾病的功课,并且似乎为临床的结果预兆。 | Christoph F Dietrich Stella Hermann Stefan Klein Barbara Braden | 2006 | World Journal of Gastroenterology2006，12，9： | 2 |
| 5 | Influence of Motoneuron Firing Synchronization on sEMG Characteristics in Dependence of Electrode Position显示文摘 | KLEINE B U STEGEMAN D F MUND D A | 2001 | J Appl Physiol2001，91，： | 1 |
| 6 | Role of fiberoptic bronchosco- py in conjunction with the use of double-lumen tubes for thoracic anesthesia : a prospective study显示文摘 | Klein U Karzai W Bloos F | 1998 | Anesthesiology1998，88，2： | 1 |
| 7 | Antibodies in HIV-1 vaccine development and therapy显示文摘 | Klein F Mouquet H Dosenovic P | 2013 | Science2013，341，6151： | 1 |
| 8 | Placental growth factor contributes to micro-vascular abnormalization and blood-retinal barrier breakdown in diabetic retinopathy 显示文摘 | KOWALCZUK L TOUCHARD E OMRI S JONET L KLEIN C VALAMANES F | 2011 | PLoS One2011，6，17： | 1 |
| 9 | Resilience to natural hazards: how useful is this concept 显示文摘 | Klein R J T Nicholls R J Thomalla F | 2003 | Global Environmental Change Part B: Environmental Hazards2003，5，12： | 1 |
| 10 | Leptin production during early starvation in lean and obese women 显示文摘 | KLEIN S HOROWITZ J F LANDT M | 2000 | Am J Physiol Endocrinol Metab2000，278，2： | 1 |
| 11 | Staphylococcus saprophyticus ATCC 15305 is internalized into human urinary bladder carcinoma cell line 5637显示文摘 | Szabados F Kleine B Anders A | 2008 | FEMS Microbiol Lett2008，285，2： | 1 |
| 12 | Lipid metabolism during endurance exercise显示文摘 | Jeffrey F Horowitz and Samuel Klein | 2000 | American Journal of Clinical Nutrition2000，72，2： | 1 |
| 13 | The incidence and spatial patterns of wheat plants infectd by Fusariym graminearum group land the effect of crown roton yield显示文摘 | Klein T A Burgess L W Ellison F W | 1991 | Australian Journal of Agricultural Research1991，42，3： | 1 |
| 14 | 显示文摘 | Bervas M Badway F Klein L C | 2005 | Electrochemical and Solid State Letters2005，8，4： | 1 |
| 15 | Evaluation of the efficacy and dose-response relationship of dexibuprofen in patients with osteoarthritis of the hip and comparison with racemic ibuprofen using the WOMAC osteoarthritis index显示文摘 | Mayrhofer F Klein G | 2000 | Int J Clin Pharmacol Ther2000，38，1： | 1 |
| 16 | A new continuous catheter delivery system显示文摘 | STEELE S M KLEIN S M D'ERCOLE F J | 1998 | Anesth Analg1998，87，1： | 1 |
| 17 | Localization of Xhol repetitive sequences on autosomes in addition to the W chromosome in chickens and its relevance for sex diagnosis 显示文摘 | Klein S Ellendorff F | 2000 | Anim Genet2000，31，10： | 1 |
| 18 | Chemistry, petrology and origin of banded iron-formation Iithologies from the 3 800 Ma Isua supracrustal belt, West Greenland显示文摘 | Dymek R F Klein C | 1988 | Precambrian Research1988，39，： | 1 |
| 19 | Is moderate atherosclerotic stenosis in the middle cerebral artery a cause of or a coincidental finding in ischemic stroke显示文摘 | Klein I F Labreuche J Lavallée P C | | 0，，2： | 1 |
| 20 | Effects of amino acid supplementation on left ventricular remodeling in patients with chronic heart failure with decreased systolic function and diabetes mellitus: rationale and design of a magnetic resonance imaging study显示文摘 | Klein L Gattis WA Borrello F | 2004 | Am J Cardiol2004，93，8： | 1 |
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