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| 1 | 左氧氟沙星三联疗法治疗顽固性Hp感染优于铋剂四联疗法显示文摘 | Saad RJ Schoenfeld P Kim HM | 2006 | 中国处方药2006，5，5： | 40 |
| 2 | Insulin glargine versus NPH insulin therapy in Asian Type 2 diabetes patients显示文摘 | Pan, CY Sinnassamy, P Chung, KD Kim, KW | 2007 | 中国生物学文摘2007，21，11： | 17 |
| 3 | 孕前血压及其到妊娠早期的变化:先兆子痫和妊娠期高血压的早期危险因素显示文摘先兆子痫和妊娠期高血压是常见的妊娠并发症,与母婴发病率显著相关。尽管对怀孕期间的危险因素进行了广泛的研究,但大多数患妊娠期高血压疾病的妇女并不被认为是高风险的,预防措施仍不清楚。研究者评估了妊娠前的血压及其到妊娠早期的变化,将其作为妊娠高血压疾病发展新的危险标志。 | 刘青(译) 刘莉(摘/审校) Nobles CJ Mendola P Mumford SL Silver RM Kim K Andriessen VC Connell M Sjaarda L Perkins NJ Schisterman EF | 2020 | 中华高血压杂志2020，28，12： | 12 |
| 4 | 用RFLP方法研究陕西省主要小麦品种遗传多样性及其演变显示文摘研究用RFLP方法,对我国主要小麦产区,陕西省40年代以来广为种植的小麦品种的遗传多样性进行了研究,结果表明,占总带数26.2%的HINDII酶的RFLP带具有遗传多态性。24个小麦品种平均遗传相似系数为0.948。53.8%的探针显示了多态性。平均多态性信息含量指数为0.252。陕西省小麦品种遗传多样性以70年代为最高,之后开始降低。 | 朱列层 唐国顺 HAZEN S P KIM H S WARD R W | 1999 | 西北植物学报1999，19，2： | 11 |
| 5 | Magnetic resonance imaging in rectal cancer:A surgeon's perspective显示文摘Magnetic resonance imaging(MRI)in rectal cancer was first investigated in 1999 and has become almost mandatory in planning rectal cancer treatment.MRI has a high accuracy in predicting circumferential resection margin involvement and is used to plan neoadjuvant therapy.The accuracy of MRI in assessing mesorectal lymph nodes remains moderate,as there are no reliable criteria to assess nodal involvement.MRI seems to be good in assessing peritoneal involvement in upper rectal cancer;this however has been assessed in only a few studies and needs further research.For low rectal cancers,mesorectum is thin at the level of levator ani especially in relation to prostate;so predicting circumferential resection margin involvement is not easy.However high spatial resolution coronal imaging shows levator muscles,sphincter complex and intersphincteric plane accurately.This is used to stage low rectal tumors and plan plane of surgery(standard surgery,intersphincteric resection,Extralevator abdominoperineal resection).While most centres perform MRI post chemoradiotherapy,its role in accurate staging post neoadjuvant therapy remains debatable.THe role of Diffusion weighted MRI post neoadjuvant therapy is being evaluated in research settings. | Avanish P Saklani Sung Uk Bae Amy Clayton Nam Kyu Kim | 2014 | World Journal of Gastroenterology2014，20，8： | 11 |
| 6 | Updates in the management of cranial dural arteriovenous fistula显示文摘Dural arteriovenous fistula(dAVF)accounts for approximately 10%of all intracranial vascular malformations.While they can be benign lesions,the presence of retrograde venous drainage and cortical venous reflux makes the natural course of these lesions aggressive high risk of haemorrhage,neurological injury and mortality.Endovascular treatment is often the first line of treatment for dAVF.Both transarterial and transvenous approaches are used to cure dAVF.The selection of treatment approach depends on the angioarchitecture of the dAVF,the location,the direction of venous flow.Surgery and,to a lesser extent,stereotactic radiosurgery are used when endovascular approaches are impossible or unsuccessful. | Humain Baharvahdat Yinn Cher Ooi Wi Jin Kim Ashkan Mowla Alexander L Coon Geoffrey P Colby | 2020 | Stroke & Vascular Neurology2020，5，1： | 10 |
| 7 | 室内TDR试验监测石灰矿渣加固粘性土的物理化学反应过程(英文)显示文摘石灰矿渣和水泥矿渣常用于加固道路基层的粘性土。目前现场一般采用未加固土的最大干密度和最优含水率来评价加固土的压实施工质量。但是粘性土掺加了石灰后,发生了复杂的物理化学反应,使得其压实特性与未加固土有很大的不同。采用时域反射计监测石灰加固土内的物理化学反应过程。试验时将不同石灰矿渣掺和量和含水率的Orchard粘土通过标准击实试验夯实于击实筒中,用TDR监测其中的物理化学反应,针式贯入仪监测强度的增长。试验发现,电导率和介电常数的变化反应了土中的离子交换和硬化反应的过程。初始电导率(1d之内)的减小揭示了石灰矿渣的掺和量的大小,而长期电导率的减小揭示了强度的增长。试验表明,时域反射计技术可用于评价石灰加固土的施工质量。 | 陈仁朋 DAITA R K DRNEVICH V P KIM D H | 2006 | 岩土工程学报2006，28，2： | 7 |
| 8 | 如何设计高质量针刺临床研究:基于证据的专家共识显示文摘本针刺随机对照试验(Randomised controlled trials, RCT)专家共识是基于目前针刺试验面临的最普遍、最关键问题,由临床医生、研究人员、从事针灸和外科的临床试验专家、统计专家、临床流行病学和方法学专家以及患者组成的国际临床研究小组联合制订。该共识将有助于临床试验资助者、注册者以及期刊编辑等评估针刺RCT方案及研究结果的相关性、重要性和质量。 | 张誉清 焦睿珉 Claudia M Witt 劳力行 刘建平 Lehana Thabane Karen J Sherman Mike Cummings Dawn P Richards Eun-Kyung Anna Kim Tae-Hun Kim Myeong Soo Lee Michael E Wechsler Benno Brinkhaus Jun J Mao Caroline A Smith 岗卫娟 刘保延 刘志顺 刘岩 郑晖 吴佳霓 AloBSO Carrasco-Labra Mohit Bhandari Philip J Devereaux 景向红 Gordon Guyatt | 2022 | 英国医学杂志中文版2022，25，6： | 7 |
| 9 | Colonoscopic yield of colorectal neoplasia in daily clinical practice显示文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients. | Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 10 | Long-term irritable bowel syndrome symptom control with reintroduction of selected FODMAPs显示文摘AIM To investigate the long-term effect of dietary education on a low fermentable oligosaccharide, disaccharide and polyol(FODMAP) diet on irritable bowel syndrome(IBS) symptoms and quality of life(Qo L).METHODS Participants with IBS(Rome III) were randomized to two groups. Group I commenced a low FODMAP diet at baseline. At three months, group II, so far a comparator group, crossed over to a low FODMAP diet while group I started re-challenging foods. All patients completed the IBS SSS(IBS symptom severity scoring system, 0-500 points increasing with severity), IBS Qo L questionnaire(0-100 increasing with Qo L), a FODMAP specific food frequency questionnaire and provided a stool sample at baseline, three and six months for microbiome analysis.RESULTS Fifty participants were enrolled into group I(n = 23) or group II(n = 27). Participants in both groups were similar in baseline values but with more men in group I. There was a significantly lower IBS SSS(275.6 ± 63.6 to 128.8 ± 82.5 vs 246.8 ± 71.1 to 203.6 ± 70.1)(P < 0.0002) and increased Qo L(68.5 ± 18.0 to 83 ± 13.4 vs 72.9 ± 12.8 to 73.3 ± 14.4)(P < 0.0001) in group I vs group II at 3 mo. The reduced IBS SSS was sustained at 6 mo in group I(160 ± 102) and replicated in group II(124 ± 76). Fiber intake decreased on the low FODMAP diet(33 ± 17 g/d to 21 ± 8 g/d)(P < 0.01) and after re-introducing FODMAP containing foods increased again to 27 ± 9 g/d. There was no change seen in the intestinal microbiome when participants adopted a low FODMAP diet.CONCLUSION This study demonstrated that a reduction in FODMAPs improves symptoms in IBS and this improvement can be maintained while reintroducing FODMAPs. | Ruth M Harvie Alexandra W Chisholm Jordan E Bisanz Jeremy P Burton Peter Herbison Kim Schultz Michael Schultz | 2017 | World Journal of Gastroenterology2017，23，25： | 5 |
| 11 | 心率作为冠心病与左室收缩障碍患者的预后危险因素(BEAUTIFUL):一项随机、对照试验的一个亚组分析显示文摘背景BEAUTIFUL研究对降心率药物伊伐布雷定的发病率与病死率收益进行了评估。BEAUTIFUL试验中的安慰剂组是由稳定型冠心病与左室收缩功能障碍的大型患者队列组成。我们对该安慰剂组进行了亚组分析,旨在检验这样一种假设,即基线静息心率升高是心血管疾病发病与死亡的标志。
方法采用Cox比例风险模型,对心率≥70次/min患者(2693例)以及〈70次/min患者(2745例)进行对比,分析基线静息心率与心血管结局之间的关系。将心率作为一个连续变量,并采用更为精细的心率分类进行其他分析。
结果在对基线特征进行校正后,心率≥70次/min患者的心血管疾病死亡(34%,P=0.0041)、心力衰竭入院(53%,P=0.0001)、心肌梗死入院(46%,P=0.0066)及冠状动脉血运重建(38%,P=0.037)风险升高。心率每升高5次/min,患者的心血管疾病死亡(8%,P=0.0005)、心力衰竭入院(16%.P〈0.0001)、心肌梗死入院(7%,P=0.052)及冠状动脉血运重建(8%,P=0.034)风险亦升高。对心率精细分组的分析表明,心率〉70次/min患者的病死率与心力衰竭发生率持续升高,但这种相关性在冠状动脉结局方面并不显著。对于心力衰竭结局而言,静息心率对早期事件的预测价值较晚期事件的预测价值更强。
结论在冠心病和左室收缩功能障碍的患者中,心率升高(≥70次/min)意味着心血管疾病结局风险升高,同时对心力衰竭相关性结局与冠状动脉事件相关性结局有着不同的影响。 | Kim Fox Ian Ford P Gabriel Steg Michal Tendera Michele Robertson Roberto Ferrari 罗亮(译) | 2008 | 世界临床医学2008，2，6： | 5 |
| 12 | Mitochondrial H2O2 generated from electron transport chain complex I stimulates muscle differentiation显示文摘Mitochondrial 反应的氧种类(mROS ) 被认为有害到房间。然而,他们的生理的角色一直不作为表明调停人是彻底地探索了。这里,我们调查了 mROS 是否从 mitochondrial 电子运输链(mETC ) 产生了复杂我刺激了肌肉区别。我们的结果证明 mROS 的数量被增加并且锰 superoxide dismutase (MnSOD ) 在肌肉区别期间经由 NF-B 激活被导致。指向线粒体的抗氧化剂(MitoQ 和 MitoTEMPOL ) 和指向线粒体的过氧化氢酶减少了没有影响 ATP 的数量的 mROS 数量和压制的肌肉区别。Mitochondrial 改变包括在线粒体的数字和尺寸的 mitochondrial 抄写因素 A 和增加的正式就职,并且功能的激活在肌肉区别期间被观察。特别地,增加了 mETC 建筑群的表示层次我子单元和建筑群的一项更高的活动我比另外的建筑群被观察。毒鱼藤素, mETC 建筑群的一个禁止者我,减少 mitochondrial NADH/NAD+ 比率和 mROS 层次在肌肉区别期间。mROS 铺平的我用小介入 RNA 和毒鱼藤素减少了的建筑群的抑制,压制的肌肉区别,和有伴随物的弄空的 ATP 层次在 glycolysis 增加。从这些结果,我们结束那复杂我导出 | Seonmin Lee Eunyoung Tak Jisun Lee MA Rashid Michael P Murphy Joohun Ha Sung Soo Kim | 2011 | Cell Research2011，21，5： | 4 |
| 13 | Effects of the nitrification inhibitor nitrapyrin and tillage practices on yield-scaled nitrous oxide emission from a maize field in Iran显示文摘Nitrification inhibitors can effectively decrease nitrification rates and nitrous oxide(N_(2)O)emission while increasing crop yield under certain conditions.However,there is no information available on the effects of nitrification inhibitors and tillage practices on N_(2)O emissions from maize cropping in Iran.To study how tillage practices and nitrapyrin(a nitrification inhibitor)affect N_(2)O emission,a split factorial experiment using a completely randomized block design with three replications was carried out in Northeast Iran,which has a cold semiarid climate.Two main plots were created with conventional tillage and minimum tillage levels,and two nitrogen(N)fertilizer(urea)management systems(with and without nitrapyrin application)were created as subplots.Tillage level did not have any significant effect on soil ammonium(NH_(4)^(+))and nitrate(NO_(3)^(-))concentrations,cumulative amount and yield-scaled N_(2)O emission,and aboveground biomass of maize,whereas nitrapyrin application showed significant effect.Nitrapyrin application significantly reduced the cumulative amount of N_(2)O emission by 41%and 32%in conventional tillage and minimum tillage practices,respectively.A reduction in soil NO_(3)^(-)concentration by nitrapyrin was also observed.The average yield-scaled N_(2)O emission was 13.6 g N_(2)O-N kg^(-1)N uptake in both tillage systems without nitrapyrin application and was significantly reduced to 7.9 and 8.2 g N_(2)O-N kg^(-1)N uptake upon the application of nitrapyrin in minimum tillage and conventional tillage practices,respectively.Additionally,nitrapyrin application increased maize biomass yield by 4%and 13%in the minimum tillage and conventional tillage systems,respectively.Our results indicate that nitrapyrin has a potential role in reducing N_(2)O emission from agricultural systems where urea fertilizers are broadcasted,which is common in Iran due to the practice of traditional farming. | Azam BORZOUEI Ulo MANDER Alar TEEMUSK Alberto SANZ-COBENA Mohammad ZAMAN Dong-Gill KIM Christoph MÜLLER Ali Askary KELESTANIE Parvaneh SAYYAD AMIN Ebrahim MOGHISEH Khadim DAWAR Ana Gabriela PÉREZ-CASTILLO | 2021 | Pedosphere2021，31，2： | 4 |
| 14 | Power management unit chip design for automobile active-matrix organic light-emitting diode display module显示文摘A power management unit (PMU) chip supplying dual panel supply voltage, which has a low electro-magnetic interference (EMI) characteristic and is favorable for miniaturization, is designed. A two-phase charge pump circuit using external pumping capacitor increases its pumping current and works out the charge-loss problem by using bulk-potential biasing circuit. A low-power start-up circuit is also proposed to reduce the power consumption of the band-gap reference voltage generator. And the ring oscillator used in the ELVSS power circuit is designed with logic devices by supplying the logic power supply to reduce the layout area. The PMU chip is designed with MagnaChip’s 0.25 μm high-voltage process. The driving currents of ELVDD and ELVSS are more than 50 mA when a SPICE simulation is done. | KIM J H PARK J H KIM J H CAO T V LEE T Y BAN H J YANG K KIM H G HA P B KIM Y H | 2009 | Journal of Central South University2009，16，4： | 4 |
| 15 | Diagnosing, planning and evaluating osteochondral ankle defects with imaging modalities显示文摘This current concepts review outlines the role of diffe-rent imaging modalities in the diagnosis, preoperative planning, and follow-up of osteochondral ankle defects. An osteochondral ankle defect involves the articular cartilage and subchondral bone(usually of the talus) and is mostly caused by an ankle supination trauma. Conventional radiographs are useful as an initial imaging tool in the diagnostic process, but have only moderate sensitivity for the detection of osteochondral defects. Computed tomography(CT) and magnetic resonance imaging(MRI) are more accurate imaging modalities. Recently, ultrasonography and single photon emission CT have been described for the evaluation of osteochondral talar defects. CT is the most valuable modality for assessing the exact location and size of bony lesions. Cartilage and subchondral bone damage can be visualized using MRI, but the defect size tends to be overestimated due to bone edema. CT with the ankle in full plantar flexion has been shown a reliable tool for preoperative planning of the surgical approach. Postoperative imaging is useful for objective assessment of repair tissue or degenerative changes of the ankle joint. Plain radiography, CT and MRI have been used in outcome studies, and different scoring systems are available. | Christiaan JA van Bergen Rogier M Gerards Kim TM Opdam Maaike P Terra Gino MMJ Kerkhoffs | 2015 | World Journal of Orthopedics2015，6，11： | 3 |
| 16 | Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study显示文摘 | Mark S Pearce Jane A Salotti Mark P Little Kieran McHugh Choonsik Lee Kwang Pyo Kim Nicola L Howe Cecile M Ronckers Preetha Rajaraman Alan W Craft Louise Parker Amy Berrington de González | 2012 | The Lancet . 2012 (9840)2012，，： | 3 |
| 17 | Computational Study of Performance Characteristics for Truncated Conical Aerospike Nozzles显示文摘Aerospike nozzles are advanced rocket nozzles that can maintain its aerodynamic efficiency over a wide range of altitudes. It belongs to class of altitude compensating nozzles. A vehicle with an aerospike nozzle uses less fuel at low altitudes due to its altitude adaptability,where most missions have the greatest need for thrust. Aerospike nozzles are better suited to Single Stage to Orbit(SSTO) missions compared to conventional nozzles. In the current study, the flow through 20% and 40% aerospike nozzle is analyzed in detail using computational fluid dynamics technique. Steady state analysis with implicit formulation is carried out. Reynolds averaged Navier-Stokes equations are solved with the Spalart-Allmaras turbulence model. The results are compared with experimental results from previous work. The transition from open wake to closed wake happens in lower Nozzle Pressure Ratio for 20% as compared to 40% aerospike nozzle. | Prasanth P Nair Abhilash Suryan Heuy Dong Kim | 2017 | Journal of Thermal Science2017，26，6： | 2 |
| 18 | Axitinib versus sorafenib as first-line therapy in patients with metastatic renal-cell carcinoma: a randomised open-label phase 3 trial显示文摘 | Thomas E Hutson Vladimir Lesovoy Salman Al-Shukri Viktor P Stus Oleg N Lipatov Angel H Bair Brad Rosbrook Connie Chen Sinil Kim Nicholas J Vogelzang | 2013 | Lancet Oncology2013，，13： | 2 |
| 19 | High-resolution magnetic resonance imaging of normal porcine cartilaginous epiphyseal maturation显示文摘 | Babyn P Kim H Lemaire C | 1996 | JMRI1996，1，1： | 2 |
| 20 | Anaerobic bacteria and intrahepatic stones: detections of Clostridium sp. and Bacteroides fragilis显示文摘To detect anaerobic bacteria Clostridium sp . and Bacteroides fragilis in intrahepatic stones by molecular genetic method Methods DNA was extracted from 59 stone samples and subjected to polymerase chain reaction (PCR) amplification targeting the 16S rRNA gene of Clostridium sp . and the glutamine synthetase gene of Bacteroides fragilis Single-strand conformational polymorphism (SSCP) analysis was performed to identify the Clostridium sp Results 16S rRNA gene sequences for Clostridium sp. were identified in 49 stones (83%, 49/59) The two most common groups were detected in 19 (41%) and 17 (37%) of the 46 samples using SSPC analysis, and 25/59 (42%) stones were tested positive for Bacteroides fragilis Conclusions Anaerobes such as Clostridium sp and Bacteroides fragilis present in intrahepatic stones and may play a role in stone formation PCR is a useful technique to detect fastidious pathogens, which are difficult to culture SSCP of PCR products is a rapid method in differentiating bacterial | LIU Yanlei Kan Lam Yajarayma J Tang Paul H Gumerlock Dong Ki Lee Myung Hwa Kim Sum P Lee Joseph SilvaJr Joseph W Leung | 2000 | Chinese Medical Journal2000，，9： | 2 |
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