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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 3 | Rimximabin combina-tion with platinum-containig chemotherapy in patients with relapsed or primary refractory diffuse large B-cell lymphoma显示文摘 | Kessler T Berdel W E | 2003 | Oncol Rep2003，10，6： | 1 |
| 4 | In situ poly- (urea- formaldehyde) microencapsulation of dicyclopentadiene 显示文摘 | Brown E N Kesslers M R Sottost N T | 2003 | Journal of Microencapsulation2003，20，6： | 1 |
| 5 | Pulmonary hyper- tension in chronic obstructive pulmonary disease 显示文摘 | Weitzenblum E Chaouat A Kessler R | 2013 | Pneu- monologia i alergologia polska2013，81，： | 1 |
| 6 | In situ poly (urea-formaldehyde) microencapsulation of dicyclopentadiene显示文摘 | Brown E N Kessler M R Sottos N R | 2003 | Journal of Microencapsulation2003，20，6： | 1 |
| 7 | Sleep-related O2 desaturation and daytime pulmonary haemodynamies in COPD patients with mild hypoxaemia显示文摘 | Chaouat A Weitzenblum E Kessler R | 1997 | Eur Respir J1997，10，： | 1 |
| 8 | The natural history of calf vein thrombosis : lysis of thrombi and develop- ment of reflux 显示文摘 | Masuda E M Kessler D M Kistner R L | 1998 | J Vase Surg1998，28，1： | 1 |
| 9 | Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the national comorbidity survey replication显示文摘 | Kessler R C Berglund P Demler O Jin R Merikangas K R Walters E E | | 0，，62： | 1 |
| 10 | Pulmonary hypertension in the obstructive sleep apnoea syndrome: prevalence, causes and therapeutic consequences 显示文摘 | Kessler R ChaouatA Weitzenblum E | 1996 | Eur Respir J1996，9，： | 1 |
| 11 | Daytime hypoventilation in obstructive sleep apnea syndrome 显示文摘 | Weitzenblum E Chaouat A Kessler R | 1999 | Sleep Med Rev1999，3，： | 1 |
| 12 | Prevalence of and risk factors for lifetime suicide attempts in the National Comorbidity Survey 显示文摘 | KESSLER R C BORGES G WALTERS E E | 1999 | Arch Gen Psychia1999，56，7： | 1 |
| 13 | Patient understanding,detection,and experience of COPD exacerbations:an observational,interview-based study显示文摘 | Kessler R Stahl E Vogelmeier C | 2006 | Chest2006，130，1： | 1 |
| 14 | Posttraumatic stress disorder in the national eomorbidity survey显示文摘 | Kessler R C Sonnega Bromet E | 1995 | Arch Gen Psychiatry1995，52，： | 1 |
| 15 | 'Natural history'of pulmonary hypertension in a series of 131 patientswith chronic obstructive lung disease显示文摘 | Kessler R Faller M Weitzenblum E | 2001 | Am J Respir Crit Care Med2001，164，2： | 1 |
| 16 | A randomized trial ofnocturnal oxygen therapy in chronic obstructive pulmonary disease pa-tients显示文摘 | Chaouat A Weitzenblum E Kessler R | 1999 | Eur Respir J1999，14，5： | 1 |
| 17 | Metachronous renal cell carcinoma metastasis to the contralateral adrenal gland显示文摘 | Kessler O J Mukamel E Weinstein R | 1998 | Urology1998，51，： | 1 |
| 18 | Evaluation of unattended automated titration to determine therapeutic continuous positive airway pressure in patients with obstructive sleep apnea 显示文摘 | Kessler R Weitzenblum E Chaouat A | 2003 | Chest2003，123，3： | 1 |
| 19 | Pulmonary hypertension in the obstructive sleep apnoea syndrome: prevalence, causes and therapeutic consequences显示文摘 | Kessler R Chaouat A Weitzenblum E | 1996 | Eur Respir J1996，9，4： | 1 |
| 20 | Metachronous renal cell carcinoma metastasis to the contralateral adrenal gland显示文摘 | KESSLER OJ MUKAMEL E WEINSTEIN R | 1998 | Urology1998，51，4： | 1 |
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