|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 2 | 波罗的海蓝藻赤潮的历史显示文摘波罗的海所发生的赤潮,主要是由Nodudaria spupmigena和Aphanizomenon sp.这两种蓝藻形成的。有关这些赤潮的长期变化记录可以从过去(1887~1938年)和现代(1974~1998年)出版的浮游植物数据记录中找到。通过各种不同的收集、分析方法已经得到了大量的数据,为了提高这些数据的可比性,人们正在不断地尝试老的、新的采样方式与固定方法。100多年前,浮游生物就做为鱼类的食物来源而引起了人们的兴趣;富营养化问题主要出现在南部的礁湖(haffs)以及大城市附近的海边水域。二战前,很少有关于开阔海域赤潮的报道。在过去的营养环境中,Nodudaria spupmigena和Aphanizomenon sp.的数量还很少,从1887~1938年的137个夏季采样中表明它们的丰度还没有达到过最高峰。在现在的营养环境中,高丰度是非常普遍的,这两个物种的数目范围相对于过去的营养环境来说有了明显的增长。自20世纪60年代以来,蓝藻赤潮在波罗的海本体与芬兰湾的开阔海域是非常常见的,这表明了营养物已经高度丰富。 | Terttu Finni Kaisa Kononen Riitta Olsonen Kerstin Wallstrm 马志华 | 2001 | AMBIO-人类环境杂志2001，30，4： | 2 |
| 3 | Progress in evaluation of risk potential of ionic liquids--basis for all eco-design of sustainable products显示文摘 | BERND J KERSTIN M PETER B | 2005 | Green Chem2005，7，： | 1 |
| 4 | Effects of foliar and soil insecticide applications on the collembolan community of an early set - aside arable field显示文摘 | Kerstin E Schadler M Scheu S | 2006 | Applied Soil Ecology2006，31，： | 1 |
| 5 | Neuroretinal hypoxic signaling in a new preclinical murine model for proliferative diabetic retinopathy显示文摘Diabetic retinopathy(DR)affects approximately one-third of diabetic patients and,if left untreated,progresses to proliferative DR(PDR)with associated vitreous hemorrhage,retinal detachment,iris neovascularization,glaucoma and irreversible blindness.In vitreous samples of human patients with PDR,we found elevated levels of hypoxia inducible factor 1 alpha(HIF1α).HIFs are transcription factors that promote hypoxia adaptation and have important functional roles in a wide range of ischemic and inflammatory diseases.To recreate the human PDR phenotype for a preclinical animal model,we generated a mouse with neuroretinal-specific loss of the von Hippel Lindau tumor suppressor protein,a protein that targets HIF1αfor ubiquitination.We found that the neuroretinal cells in these mice overexpressed HIF1αand developed severe,irreversible ischemic retinopathy that has features of human PDR.Rapid progression of retinopathy in these mutant mice should facilitate the evaluation of therapeutic agents for ischemic and inflammatory blinding disorders.In addition,this model system can be used to manipulate the modulation of the hypoxia signaling pathways,for the treatment of non-ocular ischemic and inflammatory disorders. | Katherine J Wert Vinit B Mahajan Lijuan Zhang Yuanqing Yan Yao Li Joaquin Tosi Chun Wei Hsu Takayuki Nagasaki Kerstin M Janisch Maria B Grant MaryAnn Mahajan Alexander G Bassuk Stephen H Tsang | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 1 |
| 6 | Engelmann Spruce (Picea engelmannii) as a biological monitor of changes in soil metal loading related to past mining activity 显示文摘 | Kerstin M Witte Richard B Wanty Ian Ridley W | 2004 | Applied Geochemistry2004，，： | 1 |
| 7 | Pelvic suspension improves quality characteristics in M. semimembranosus from Swedish dual purpose young bulls显示文摘 | Maria Lundesj? Ahnstr?m Ann-Charlotte Enf?lt Ingemar Hansson Kerstin Lundstr?m | 2005 | Meat Science2005，，3： | 1 |
| 8 | Response of bone and periodontal ligament cells to biodegradable polymer scaffolds in vitro显示文摘 | Kerstin S Kristina A Kamal M | | 0，，06： | 1 |
| 9 | A model of quality assessment in patients on long-term oxygen therapy显示文摘 | Torbj?rn Gustafson Kerstin L?fdahl Kerstin Str?m | 2008 | Respiratory Medicine2008，，2： | 1 |
| 10 | Response of enzyme activities to nitrogen addition in forest floors of different C-to-N ratios显示文摘 | KERSTIN M EGBERT M | 2003 | Biol Fertil Soils2003，38，2： | 1 |
| 11 | Alterations of β-adrenergic signaling and cardiac hypertrophy in transgenic mice overexpressing TGF-β1显示文摘 | ROSENKRANZ S FLESCH M KERSTIN A K | 2002 | American Journal of Physiology2002，283，3： | 1 |
| 12 | The next-generation sphingosine-1 receptor modulator BAF312(siponimod) improves cortical network functionality in focal autoimmune encephalomyelitis显示文摘Autoimmune diseases of the central nervous system(CNS) like multiple sclerosis(MS) are characterized by inflammation and demyelinated lesions in white and grey matter regions. While inflammation is present at all stages of MS, it is more pronounced in the relapsing forms of the disease, whereas progressive MS(PMS) shows significant neuroaxonal damage and grey and white matter atrophy. Hence, disease-modifying treatments beneficial in patients with relapsing MS have limited success in PMS. BAF312(siponimod) is a novel sphingosine-1-phosphate receptor modulator shown to delay progression in PMS. Besides reducing inflammation by sequestering lymphocytes in lymphoid tissues, BAF312 crosses the blood-brain barrier and binds its receptors on neurons, astrocytes and oligodendrocytes. To evaluate potential direct neuroprotective effects, BAF312 was systemically or locally administered in the CNS of experimental autoimmune encephalomyelitis mice with distinct grey-and white-matter lesions(focal experimental autoimmune encephalomyelitis using an osmotic mini-pump). Ex-vivo flow cytometry revealed that systemic but not local BAF312 administration lowered immune cell infiltration in animals with both grey and white matter lesions. Ex-vivo voltage-sensitive dye imaging of acute brain slices revealed an altered spatio-temporal pattern of activation in the lesioned cortex compared to controls in response to electrical stimulation of incoming white-matter fiber tracts. Here, BAF312 administration showed partial restore of cortical neuronal circuit function. The data suggest that BAF312 exerts a neuroprotective effect after crossing the blood-brain barrier independently of peripheral effects on immune cells. Experiments were carried out in accordance with German and EU animal protection law and approved by local authorities(Landesamt für Natur, Umwelt und Verbraucherschutz Nordrhein-Westfalen;87-51.04.2010.A331) on December 28, 2010. | Petra Hundehege Manuela Cerina Susann Eichler Christian Thomas Alexander M. Herrmann Kerstin Goel Thomas Müntefering Juncal Fernandez-Orth Stefanie Bock Venu Narayanan Thomas Budde Erwin-Josef Speckmann Heinz Wiendl Anna Schubart Tobias Ruck Sven G. Meuth | 2019 | Neural Regeneration Research2019，14，11： | 1 |
| 13 | Enzymatic degradation and electrospray tandem mass spectrometry as tools for determi- ning the structure of cationic starches prepared by wet and dry methods 显示文摘 | Wiebke T Kerstin W Petra M | 2004 | Carbohydrate Research2004，339，3： | 1 |
| 14 | Determination of the principal path ways of PCDD and PCDF to lolium muhiflorum ( Welsh ray grass)显示文摘 | Kerstin W P Mclachlan M S Umlauf G 1995 | 1995 | Environ Sci Technol1995，29，： | 1 |
| 15 | Soft combination of neural classifiers:a comparative study显示文摘 | Antanas V Arunas L Kerstin M | 1999 | Pattern Recognition Letters1999，20，4： | 1 |
| 16 | Ballast water deoxgenation can prevent aquatic introductions while reducing ship corrosion 显示文摘 | Kerstin W Masayasu M | 2002 | Biological Conservation2002，103，： | 1 |
| 17 | Association of polymorphisms of the transforming growth factor-β1 gene with the rate of progression of HCV-induced liver fibrosis显示文摘 | Jan Gewaltig Kerstin Mangasser-Stephan Carsten Gartung Stefan Biesterfeld Axel M Gressner | 2002 | Clinica Chimica Acta2002，，1： | 1 |
| 18 | Transient lesion in the splenium related to antiepileptic drug: case report and new pathophysiological insights 显示文摘 | Kerstin A Stefan E Siawoosh M | 2008 | Seizure2008，17，： | 1 |
| 19 | A fibre Bragg grating refractometer 显示文摘 | KerstinS Wolfgang E Rudolf M | 2001 | Measurement Science and Technology2001，12，7： | 1 |
| 20 | Inhibition of angiogenesis by IL-32: Possible role in asthma显示文摘 | Norbert Meyer Janine Christoph Heidi Makrinioti Philippe Indermitte Claudio Rhyner Michael Soyka Thomas Eiwegger Maciej Chalubinski Kerstin Wanke Hiroyuki Fujita Paulina Wawrzyniak Simone Bürgler Sherrie Zhang Mübeccel Akdis Günter Menz Cezmi Akdis | 2012 | The Journal of Allergy and Clinical Immunology2012，，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员