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| 1 | Is hepatic arterial infusion chemotherapy effective treatment for advanced hepatocellular carcinoma resistant to transarterial chemoembolization?显示文摘AIM:To evaluate the effectiveness of hepatic arterial infusion chemotherapy(HAIC) for advanced hepatocellular carcinoma(HCC) resistant to transarterial chemoembolization(TACE).METHODS:This study was conducted on 42 patients who received HAIC for advanced HCC between 2001and 2010 at our hospital.5-fluorouracil(5-FU) was administered continuously for 24 h from day 1 to day 5 every 2-4 wk via an injection reservoir.Intra-arterial cisplatin or subcutaneous interferon was administered in combination with the 5-FU.The patients enrolled in this retrospective study were divided into two groups according to whether or not they fulfilled the criteria for resistance to TACE proposed by the Japan Society of Hepatology in 2010(written in Japanese);one group of patients who did not fulfill the criteria for TACE resistance(group A,n = 23),and another group who fulfilled the criteria for TACE resistance(group B,n = 19).We compared the outcomes in terms of the response and survival rates between the two groups.RESULTS:Both the response rate and tumor suppression rate following HAIC were significantly superior in group A than in group B(response rate:48% vs 16%,P = 0.028,tumor suppression rate:87% vs 53%,P = 0.014).Furthermore,both the progression-free survival rate and survival time were significantly superior in group A than in group B(3-,6-,12-,and 24-mo = 83%,70%,29% and 20% vs 63%,42%,16% and 0%,respectively,P = 0.040,and 9.8 mo vs 6.2 mo,P = 0.040).A multivariate analysis(Cox proportional hazards regression model) showed that resistance to TACE was an independent predictor of poor survival(P = 0.007).CONCLUSION:HAIC administrating 5-FU was not effective against advanced HCC resistant to TACE.Other tools for treatment,i.e.,molecular-targeting agents may be considered for these cases. | Hiroyuki Kirikoshi Masato Yoneda Hironori Mawatari Koji Fujita Kento Imajo Shingo Kato Kaori Suzuki Noritoshi Kobayashi Kensuke Kubota Shin Maeda Atsushi Nakajima Satoru Saito | 2012 | World Journal of Gastroenterology2012，18，16： | 9 |
| 2 | Gender differences of low-dose aspirin-associated gastroduodenal ulcer in Japanese patients显示文摘AIM:To clarify the gender differences about the clini-cal features and risk factors of low-dose aspirin (LDA) (81-100 mg daily)-associated peptic ulcer in Japanese patients.METHODS: There were 453 patients under treatment with LDA (298 males, 155 females) who underwent esophagogastroduodenoscopy at the Department of Gastroenterology and Hepatology of Hiratsuka City Hospital between January 2003 and December 2007. They had kept taking the LDA or started treatmentduring the study period and kept taking LDA during the whole period of observation. Of these, 119 patients (87 males, 32 females) were diagnosed as having LDA-associated peptic ulcer. We examined the clinical factors associated with LDA-associated peptic ulcer in both sexes.RESULTS: A history of peptic ulcer was found to be the risk factor for LDA-associated peptic ulcer common to both sexes. In female patients, age greater than 70 years (prevalence ORs 8.441, 95% CI: 1.797-33.649, P = 0.0069) was found to be another significant risk fac-tor, and the time to diagnosis as having LDA-associat-ed peptic ulcer by endoscopy was significantly shorter than that in the male patients (P = 0.0050). CONCLUSION: We demonstrated gender differences about the clinical features and risk factors of LDA-asso-ciated peptic ulcer. Special attention should be paid to aged female patients taking LDA. | Kazuhisa Okada Masahiko Inamori Kento Imajyo Hideyuki Chiba Takashi Nonaka Tadahiko Shiba Takashi Sakaguchi Kazuhiko Atsukawa Hisao Takahashi Etsuo Hoshino Atsushi Nakajima | 2010 | World Journal of Gastroenterology2010，16，15： | 4 |
| 3 | Argon plasma coagulation for superficial esophageal squamous-cell carcinoma in high-risk patients显示文摘AIM: To evaluate the usefulness and safety of argon plasma coagulation (APC) for superficial esophageal squamous-cell carcinoma (SESC) in high-risk patients. METHODS: We studied 17 patients (15 men and 2 women, 21 lesions) with SESC in whom endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD), and open surgery were contraindicated from March 1999 through February 2009. None of the patients could tolerate prolonged EMR/ESD or open surgery because of severe concomitant disease (e.g., liver cirrhosis, cerebral infarction, or ischemic heart disease) or scar formation after EMR/ESD and chemoradiotherapy. After conventional endoscopy, an iodine stain was sprayed on the esophageal mucosa to determine the lesion margins. The lesion was then ablated by APC. We retrospectively studied the treatment time, number of APC sessions per site, complications, presence or absence of recurrence, and time to recurrence.RESULTS: The median duration of follow-up was 36 mo (range: 6-120 mo). All of the tumors were macroscopically classified as superficial and slightly depressed type (0-Ⅱc). The preoperative depth of invasion was clinical T1a (mucosal cancer) for 19 lesions and clinical T1b (submucosal cancer) for 2. The median treatment time was 15 min (range: 10-36 min). The median number of treatment sessions per site was 2 (range: 1-4). The median hospital stay was 14 d (range: 5-68 d). Among the 17 patients (21 lesions), 2 (9.5%) had recurrence and underwent additional APC with no subsequent evidence of recurrence. There were no treatment-related complications, such as bleeding or perforation. CONCLUSION: APC is considered to be safe and effective for the management of SESC that cannot be resected endoscopically because of underlying disease, as well as for the control of recurrence after EMR and local recurrence after chemoradiotherapy. | Kumiko Tahara Satoshi Tanabe Kenji Ishido Katsuhiko Higuchi Tohru Sasaki Chikatoshi Katada Mizutomo Azuma Kento Nakatani Akira Naruke Myungchul Kim Wasaburo Koizumi | 2012 | World Journal of Gastroenterology2012，18，38： | 4 |
| 4 | Simple scoring system for predicting cirrhosis in nonalcoholic fatty liver disease显示文摘AIM:To investigate a simple noninvasive scoring system for predicting liver cirrhosis in nonalcoholic fatty liver disease(NAFLD)patients.METHODS:A total of 1048 patients with liver-biopsyconfirmed NAFLD were enrolled from nine hepatology centers in Japan(stage 0,216;stage 1,334;stage 2,270;stage 3,190;stage 4,38).The weight and height of the patients were measured using a calibrated scale after requesting the patients to remove their shoes and any heavy clothing.Venous blood samples were obtained in the morning after the patients had fasted overnight for 12 h.Laboratory evaluation was performed in all patients.Statistical analysis was conducted using SPSS version 12.0.Continuous variables were expressed as mean±SD.RESULTS:The optimal cutoff value of platelet count,serum albumin,and aminotransferase/alanine aminotransferase ratio(AAR)was set at<15.3 104/μL,<4.0g/dL,and>0.9,respectively,by the receiver operating characteristic curve.These three variables were combined in an unweighted sum(platelet count=1 point,serum albumin=1 point,AAR=1 point)to form an easily calculated composite score for predicting cirrhosis in NAFLD patients,called the PLALA(platelet,albumin,AAR)score.The diagnosis of PLALA≥2 had sufficient accuracy for detecting liver cirrhosis in NAFLD patients.CONCLUSION:The PLALA score may be an ideal scoring system for detecting cirrhosis in NAFLD patients with sufficient accuracy and simplicity to be considered for clinical use. | Takaomi Kessoku Yuji Ogawa Masato Yoneda Kento Imajo Yoshio Sumida Yuichiro Eguchi Hideki Fujii Hideyuki Hyogo Masafumi Ono Yasuaki Suzuki Takumi Kawaguchi Kazuaki Chayama Saiyu Tanaka Kazuma Fujimoto Keizo Anzai Toshiji Saibara Michio Sata Yoshito Itoh Atsushi Nakajima Takeshi Okanoue Japan Study Group of NAFLD(JSG-NAFLD) | 2014 | World Journal of Gastroenterology2014，20，29： | 2 |
| 5 | Hyperresponsivity to Low-Dose Endotoxin during Progression to Nonalcoholic Steatohepatitis Is Regulated by Leptin-Mediated Signaling显示文摘 | Kento Imajo Koji Fujita Masato Yoneda Yuichi Nozaki Yuji Ogawa Yoshiyasu Shinohara Shingo Kato Hironori Mawatari Wataru Shibata Hiroshi Kitani Kenichi Ikejima Hiroyuki Kirikoshi Noriko Nakajima Satoru Saito Shiro Maeyama Sumio Watanabe Koichiro Wada Atsus | 2012 | Cell Metabolism2012，，1： | 2 |
| 6 | Emerging drugs for non-alcoholic steatohepatitis显示文摘 | Wataru Tomeno Masato Yoneda Kento Imajo Yuji Ogawa Takaomi Kessoku Satoru Saito Yuichiro Eguchi Atsushi Nakajima | 2013 | Expert Opinion on Emerging Drugs2013，，3： | 2 |
| 7 | Upper gastrointestinal complications associated with gemcitabine-concurrent proton radiotherapy for inoperable pancreatic cancer显示文摘 | Kento Takatori Kazuki Terashima Rihito Yoshida Aya Horai Shinya Satake Takayuki Ose Naoto Kitajima Yoshikazu Kinoshita Yusuke Demizu Nobukazu Fuwa | 2014 | Journal of Gastroenterology2014，，6： | 2 |
| 8 | Non-mechanical scanning laser Doppler velocimetry with sensitivity to direction of transverse velocity component using optical serrodyne frequency shifting显示文摘 | Maru Koichi Watanabe Kento | 2014 | Optics Communications2014，319，： | 1 |
| 9 | Deep-learning-based quality filtering of mechanically exfoliated 2D crystals显示文摘Two-dimensional(2D)crystals are attracting growing interest in various research fields such as engineering,physics,chemistry,pharmacy,and biology owing to their low dimensionality and dramatic change of properties compared to the bulk counter parts.Among the various techniques used to manufacture 2D crystals,mechanical exfoliation has been essential to practical applications and fundamental research.However,mechanically exfoliated crystals on substrates contain relatively thick flakes that must be found and removed manually,limiting high-throughput manufacturing of atomic 2D crystals and van der Waals heterostructures.Here,we present a deep-learning-based method to segment and identify the thickness of atomic layer flakes from optical microscopy images.Through carefully designing a neural network based on U-Net,we found that our neural network based on Unet trained only with the data based on realistically small number of images successfully distinguish monolayer and bilayer MoS2 and graphene with a success rate of 70–80%,which is a practical value in the first screening process for choosing monolayer and bilayer flakes of all flakes on substrates without human eye.The remarkable results highlight the possibility that a large fraction of manual laboratory work can be replaced by AI-based systems,boosting productivity. | Yu Saito Kento Shin Kei Terayama Shaan Desai Masaru Onga Yuji Nakagawa Yuki M.Itahashi Yoshihiro Iwasa Makoto Yamada Koji Tsuda | 2019 | npj Computational Materials2019，，1： | 1 |
| 10 | High-Performance Liquid Chromatographic Determination and Metabolic Study of Sennoside A in Daiokanzoto by Mouse Intestinal Bacteria显示文摘 | KENTO T EMI M TAKESI K | | 0，，： | 1 |
| 11 | Cutaneous involvement by neutrophil-rich,CD30-positive anaplatic large cell lymphoma mimicking deep pustules显示文摘 | Kentos A Renoirte C | 1999 | (letter) Am J Surg Pathol1999，23，： | 1 |
| 12 | GUCCI,FENDIFRADA,SAIMT LAURENT 奢侈品牌LOGO T最强论显示文摘夏天必备的T恤,想要随便一穿就很时尚的奢侈品牌logoT.'只要这件就够了.'我们准备了今年夏天最应该入手的4件奢侈品T恤,快来get一件其中最可爱的吧让人看着就很兴奋的GUCCI logo搭配最潮的网球图案变身最in单品GUCCI由名媛们起头,全世界的潮人们都在穿的GUCCI的logo T真的很可爱今年的设计使用了刺绣带来复古的感觉。 | KENTO MORI | 2019 | 美眉2019，，8： | 1 |
| 13 | Gamma-glutamyl transferase and cardiovascular risk in nonalcoholic fatty liver disease:The Gut and Obesity Asia initiative显示文摘BACKGROUND Gamma-glutamyl transferase(GGT)is associated with the risk of cardiovascular disease(CVD)in the general population.AIM To identify the association of baseline GGT level and QRISK2 score among patients with biopsy-proven nonalcoholic fatty liver disease(NAFLD).METHODS This was a retrospective study involving 1535 biopsy-proven NAFLD patients from 10 Asian centers in 8 countries using data collected by the Gut and Obesity in Asia(referred to as“GO ASIA”)workgroup.All patients with available baseline GGT levels and all 16 variables for the QRISK2 calculation(QRISK2-2017;developed by researchers at the United Kingdom National Health Service;http://gffzz3d3435dbdf8b436dspfccknwq0p9f6nvn.ffgz.tsg.suse.edu.cn/2017/;10-year cardiovascular risk estimation)were included and compared to healthy controls with the same age,sex,and ethnicity.Relative risk was reported.QRISK2 score>10%was defined as the high-CVD-risk group.Fibrosis stages 3 and 4(F3 and F4)were considered advanced fibrosis.RESULTS A total of 1122 patients(73%)had complete data and were included in the final analysis;314(28%)had advanced fibrosis.The median age(interquartile range[IQR])of the study population was 53(44-60)years,532(47.4%)were females,and 492(43.9%)were of Chinese ethnicity.The median 10-year CVD risk(IQR)was 5.9%(2.6-10.9),and the median relative risk of CVD over 10 years(IQR)was 1.65(1.13-2.2)compared to healthy individuals with the same age,sex,and ethnicity.The high-CVD-risk group was significantly older than the low-risk group(median[IQR]:63[59-67]vs 49[41-55]years;P<0.001).Higher fibrosis stages in biopsy-proven NAFLD patients brought a significantly higher CVD risk(P<0.001).Median GGT level was not different between the two groups(GGT[U/L]:Median[IQR],high risk 60[37-113]vs low risk 66[38-103],P=0.56).There was no correlation between baseline GGT level and 10-year CVD risk based on the QRISK2 score(r=0.02).CONCLUSION The CVD risk of NAFLD patients is higher than that of healthy individuals.Baseline GGT level cannot predict CVD risk in NAFLD patients.However,advanced fibrosis is a predictor of a high CVD risk. | Panyavee Pitisuttithum Wah-Kheong Chan George Boon-Bee Goh Jian-Gao Fan Myeong Jun Song Phunchai Charatcharoenwitthaya Ajay Duseja Yock-Young Dan Kento Imajo Atsushi Nakajima Khek-Yu Ho Khean-Lee Goh Vincent Wai-Sun Wong Sombat Treeprasertsuk | 2020 | World Journal of Gastroenterology2020，26，19： | 1 |
| 14 | A quantitative study of peripheral blood stem cell contamination in diffuse large-cell non-Hodgkin's lymphoma: One-half of patients significantly mobilize malignant cells 显示文摘 | Jacquy C Soree A Lambert F Bosly A Ferrant A Andre M Parma J Kentos A Martiat P | 2000 | Br J Haematol2000，110，3： | 1 |
| 15 | 2D Finite Element Computer Analysis of Strength for Brazed Joint of Cemented Carbide and Silver Brazing Filler Metal显示文摘 | Meribe Richard Chukwuma Kazuya MORI Kento Takenouchi Yuki Fijishita Takeshi Eguchi Kazufumi Sakata | 2016 | Journal of Mechanics Engineering and Automation2016，6，4： | 1 |
| 16 | An angiotensin-converting enzyme inhibitor, not an angiotensin II type-1 receptor blocker, prevents β-aminopropionitrile monofumarate-induced aortic dissection in rats显示文摘 | Hirotaka Nagashima Kento Uto Yasunari Sakomura Yoshikazu Aoka Akiko Sakuta Shigeyuki Aomi Nobuhisa Hagiwara Masatoshi Kawana Hiroshi Kasanuki | 2002 | Journal of Vascular Surgery2002，，4： | 1 |
| 17 | Enhancement in the ef- ficiency of an organic-inorganic hybrid solar cell with a dopedP3 HT hole-transporting layer on a void-free perovskite active layer 显示文摘 | Guo Yunlong Liu Chao Kento Inoue | 2014 | J Mater Chem A2014，2，13： | 1 |
| 18 | Distinct pharmacodynamics of insulin glargine and insulin detemir: Crossover comparison in Type 1 and Type 2 diabetic patients on basal-bolus regimen显示文摘 | Tomoko Kato Ichiro Tokubuchi Kazuhisa Muraishi Shuichi Sato Tamotsu Kato Kento Hara Kayo Tanaka Hiroo Kaku Yuji Tajiri Kentaro Yamada | 2010 | Diabetes Research and Clinical Practice2010，，3： | 1 |
| 19 | Association between plasma adiponectin levels and decline in forced expiratory volume in Is in a general japanese population :The Takahata study显示文摘 | Kento Sato Yoko Shibata Shuichi Abe | 2014 | Int J Med Sci2014，11，8： | 1 |
| 20 | Emerging drugs for non-alcoholic steatohepatitis显示文摘 | Wataru Tomeno Masato Yoneda Kento Imajo Yuji Ogawa Takaomi Kessoku Satoru Saito Yuichiro Eguchi Atsushi Nakajima | 2013 | Expert Opinion on Emerging Drugs2013，，3： | 1 |
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