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| 1 | 乳腺癌组织中TP和TS及DPD mRNA表达与预后的关系显示文摘目的 探讨乳腺癌组织中胸苷酸化酶 (TP)、胸苷酸合成酶 (TS)和二氢嘧啶脱氢酶(DPD)mRNA表达水平及其与预后的关系。方法 采用real time定量PCR技术检测经过微选的 9例正常乳腺组织和 86例乳腺癌组织TP、TS和DPD的mRNA表达水平。结果 肿瘤组织中TP、TS和DPDmRNA表达水平中位数分别为 16 .5 4 ,0 .38和 2 .74 ,正常乳腺组织分别为 11.75 ,0 .2 5和 8.33,差异均无显著性 (P >0 .0 5 )。除年龄与DPD表达呈负相关外 ,TP、TS和DPDmRNA表达与肿瘤体积、淋巴结转移、组织学分级、临床分期均无相关性。TP、DPD高表达组和低表达组之间 ,无瘤生存期和总生存期差异均无显著性。TS高表达组和低表达组无瘤生存期差异无显著性 (P =0 .0 6 9) ;平均总生存期分别为 5 9.0 0和 70 .30个月 ,差异有显著性 (P =0 .0 4 96 )。结论 仅检测TSmRNA对判断乳腺癌预后有参考价值 ,同时检测TP、TS和DPD具有更好的预测价值。 | 李惠翔 Suo ZH 张云汉 Bjrn Risberg Mats G Karlsson Jahn M Nesland | 2004 | 中华肿瘤杂志2004，26，11： | 9 |
| 2 | 糖类生物学:药物设计的新领域显示文摘生理和病理过程中蛋白质与糖类分子相互作用的新发现,提示糖类是药物设计的新领域。本文综述了糖类生物学研究的新进展,确证了糖类作为蛋白质结合受体的重要功能,主要简述了糖类在免疫调控、肿瘤细胞抗原成分以及在病原微生物受体结合中的作用。 | Karlsson KA 杨彬 | 1992 | 国外医学(药学分册)1992，19，4： | 8 |
| 3 | 大学创业生态系统的架构与构建路径显示文摘大学创业生态系统是促进学术创业和创业教育实现良性可持续发展的基石,但构建大学创业生态系统仍缺乏理论指导。兼顾组织和制度层面,采用一个双元分析框架,对芬兰阿尔托大学和瑞典隆德大学两所大学案例进行深入分析,在理论上提出大学创业生态系统的架构与构建路径,深化大学创业生态系统的研究。 | 翟庆华 苏靖 Tomas Karlsson | 2016 | 科技管理研究2016，36，21： | 7 |
| 4 | Acromioclavicular dislocations treated by coracoacromial ligament transfer显示文摘 | J. Karlsson H. árnarson K. Sigurjónsson | 1986 | Archives of Orthopaedic and Traumatic Surgery1986，，1： | 6 |
| 5 | Evaluating the Ryman-Laikre effect for marine stock enhancement and aquaculture显示文摘 | Robin S. WAPLES Kjetil HINDAR Sten KARLSSON Jeffrey J. HARD | 2016 | Current Zoology2016，62，6： | 5 |
| 6 | Direct generation of linearly polarized photon emission with designated orientations from site-controlled InGaN quantum dots显示文摘Semiconductor quantum dots(QDs)have been demonstrated viable for efficient light emission applications,in particular for the emission of single photons on demand.However,the preparation of QDs emitting photons with predefined and deterministic polarization vectors has proven arduous.Access to linearly polarized photons is essential for various applications.In this report,a novel concept to directly generate linearly-polarized photons is presented.This concept is based on InGaN QDs grown on top of elongated GaN hexagonal pyramids,by which the predefined elongation determines the polarization vectors of the emitted photons from the QDs.This growth scheme should allow fabrication of ultracompact arrays of photon emitters,with a controlled polarization direction for each individual emitter. | Anders Lundskog Chih-Wei Hsu K Fredrik Karlsson Supaluck Amloy Daniel Nilsson Urban Forsberg Per Olof Holtz Erik Janzen | 2014 | Light(Science & Applications)2014，3，1： | 4 |
| 7 | 瑞典隆德大学的专科护士教育与启示显示文摘介绍瑞典隆德大学护理学院专科护士教育的学习周期、学分、学员入学要求、培养目标、课程内容、教学结构、教学形式、考核和质量的评估与反馈等。提出瑞典的专科护士教育对我国专科护士教育在学员入学资格、课程内容的设置、教学模式的转变、教学质量的评估和反馈等方面具有重要的借鉴、指导作用。 | 徐静娟 Ingalill Rahm Hallberg Staffan Karlsson | 2010 | 护理学杂志(综合版)2010，25，4： | 3 |
| 8 | Marginal zone B cells are naturally reactive to collagen type II and are involved in the initiation of the immune response in collagen-induced arthritis显示文摘Antibodies against type II collagen(CII)are essential for development of collagen-induced arthritis(CIA),but how and where the B-cell response to CII is initiated is not fully known.We show here that naive DBA/1 mice display naturally reactive IgM and IgG anti-CII producing B cells prior to immunization.The CII-reactive B cells were observed in the spleen and recognized as marginal zone(MZ)B cells.After CII immunization,CII-specific B cells expanded rapidly in the spleen,in contrast to the lymph nodes,with the initial response derived from MZ B cells and later by follicular(FO)B cells.This was evident despite that the MZ B cells were subject to stringent tolerance mechanisms by having a greater Fc gamma receptor IIb expression than the FO B cells.Further,the MZ B cells migrated to the FO areas upon immunization,possibly providing antigen and activating FO T cells and subsequently FO B cells.Thus,around CIA onset increased numbers of IgG anti-CII producing FO B cells was seen in the spleen,which was dominated by IgG2a-and IgG2b-positive cells.These data demonstrate that CII-reactive MZ B cells are present before and expand after CII immunization,suggesting an initiating role of MZ B cells in the development of CIA. | Cecilia Carnrot Kajsa E Prokopec Kristina Rasbo Mikael CI Karlsson Sandra Kleinau | 2011 | Cellular & Molecular Immunology2011，8，4： | 3 |
| 9 | Serum lipids, lipoprtein(a) level, and apolipoprotein(a) isoforms as prognostic markers in patients with coronary heart disease显示文摘 | LUNDSTAM U HERLITZ J KARLSSON T | 2002 | J Intern Med2002，251，2： | 2 |
| 10 | 小型腐殖质湖泊的碳收支:湖泊对北方集水区有机物质循环重要性的一个实例显示文摘由于通常是大范围的细菌呼吸作用和沉积物中有机碳的有效埋藏,湖泊在北方景观有机物质循环中发挥着重要作用。为了评估碳收支对与有机物有关的放射性核素在环境中迁移的潜在影响,我们基于一种质量平衡方法,计算了瑞典的一个小腐殖质湖的碳收支,该湖位于一个放射性废料潜在最后埋藏点的附近。我们发现该湖是一个净异养的生态系统,从集水区和现有大型植物生产物中补充得到有机碳输入。有机碳最大的汇点是水生细菌的呼吸作用和随后向大气释放CO_2。虽然每年埋藏在沉积物中的有机碳是一个比较小的汇,但它却导致湖中最大碳库的形成。因此,湖泊也许同时分散和聚集从最后埋藏点中泄漏的有机伴生的放射性核素。 | Sebastian Sobek Bjrn Sderbck Sara Karlsson Eva Andersson Anna Kristina Brunberg 李四海 | 2006 | AMBIO-人类环境杂志2006，35，8： | 2 |
| 11 | Comparative study of low-field NMR relaxation measurements and two traditional methods in the determination of water holding capacity of pork显示文摘 | Hanne C Bertram Henrik J Andersen Anders H Karlsson | 2000 | Meat Science2000，，2： | 2 |
| 12 | Pilot Study of Sentinel-Node-Based Adoptive Immunotherapy in Advanced Colorectal Cancer显示文摘 | Mona Karlsson PhD Per Marits PhD Kjell Dahl PhD Tobias Dag?? MD Sven Enerb?ck Magnus Th?rn Ola Winqvist | 2010 | Annals of Surgical Oncology2010，，7： | 2 |
| 13 | 热浸镀锌超高强钢板钒微合金化技术研究显示文摘对超高强度钢板进行热处理,模拟热浸镀锌和合金化镀锌工艺的热循环,并考察获得的力学性能和微观组织。研究用钢含有适量的碳(~0.2%)、锰(1.2%)和铬(0.4%),保证钢板在奥氏体化后在镀锌前的连续退火线上进行快速冷却时能够完全转变成马氏体。采用不同的钒含量(0~0.1%)和氮含量(0.002%~0.012%),研究这些微合金化元素对回火马氏体强度的影响。尤其与高氮相配合情况下,钒有助于抵抗回火效应,因此在镀锌后大部分原始强化贡献被保留下来,使得钢的抗拉强度超过1 000 MPa。使用铝或硅进行不同脱氧试验,发现在同一碳含量下两者具有相同的强度水平,但是Si镇静钢的弯曲性能明显优异。对退火钢板进行微观组织观察,但是钒产生有益作用的原因还未完全掌握。通过研究得出这样结论:钒微合金化对耐腐蚀超高强度钢板的开发而言是一种极具前景的途径。 | Hutchinson B Martin D Karlsson O Lindberg F Thoors H Marceau R K W Taylor A S | 2016 | 钢铁钒钛2016，37，6： | 2 |
| 14 | The ostrich effect: Selective attention to information显示文摘 | Niklas Karlsson George Loewenstein Duane Seppi | 2009 | Journal of Risk and Uncertainty2009，，2： | 2 |
| 15 | Acromioclavicular dislocations treated by coracoacromial ligament transfer显示文摘 | J. Karlsson H. árnarson K. Sigurjónsson | 1986 | Archives of Orthopaedic and Traumatic Surgery1986，，1： | 2 |
| 16 | On the determination of residual stress and mechanical properties by indentation显示文摘 | Xi Chen Jin Yan Anette M. Karlsson | 2005 | Materials Science & Engineering A2005，，1： | 2 |
| 17 | The significance of cooling rate on water dynamics in porcine muscle from heterozygote carriers and non-carriers of the halothane gene—a low-field NMR relaxation study显示文摘 | Hanne Christine Bertram Anders Hans Karlsson Henrik J?rgen Andersen | 2003 | Meat Science2003，，4： | 2 |
| 18 | Nonsubmerged implants in the treatment of the edentulous lower jaw:a prospective longitudinal study of ITI hollow screws 显示文摘 | Hellem S Karlsson U Almfeldt I | 2001 | Clin Implant Dent Relat Res2001，3，1： | 1 |
| 19 | The absence of stereo selective P-glycoprotein-mediated transport of R/Sverapamil across the rat jejunum 显示文摘 | SANDSTROM R KARLSSON A LENNERNAS H | 1998 | J Pharm Pharmacol1998，50，7： | 1 |
| 20 | Determination of formic-acid and acetic acid concentrations formed during hydrothermal of birch wood and its relation to colour, strength and hardness显示文摘 | Bror Sundqvist Olov Karlsson Una Westermark | 2006 | Wood Sci Technol2006，40，： | 1 |
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