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| 1 | Calcium-dependent modulation and plasma membrane targeting of the AKT2 potassium channel by the CBL4/ ClPK6 calcium sensor/protein kinase complex显示文摘 | Katrin Held Franqois Pascaud Christian Eckert Pawel Gajdanowicz Kenji Hashimoto Claire Corratge-Faillie Jan Niklas Offenborn Benoit Lacombe Ingo Dreyer Jean-Baptiste Thibaud Jorg Kudla | 2011 | Cell Research2011，21，7： | 23 |
| 2 | The role of mechanotransduction versus hypoxia during simulated orthodontic compressive strain——an in vitro study of human periodontal ligament fibroblasts显示文摘During orthodontic tooth movement(OTM)mechanical forces trigger pseudo-inflammatory,osteoclastogenic and remodelling processes in the periodontal ligament(PDL)that are mediated by PDL fibroblasts via the expression of various signalling molecules.Thus far,it is unknown whether these processes are mainly induced by mechanical cellular deformation(mechanotransduction)or by concomitant hypoxic conditions via the compression of periodontal blood vessels.Human primary PDL fibroblasts were randomly seeded in conventional six-well cell culture plates with O2-impermeable polystyrene membranes and in special plates with gas-permeable membranes(Lumox?,Sarstedt),enabling the experimental separation of mechanotransducive and hypoxic effects that occur concomitantly during OTM.To simulate physiological orthodontic compressive forces,PDL fibroblasts were stimulated mechanically at 2 g·cm?2 for 48 h after 24 h of pre-incubation.We quantified the cell viability by MTT assay,gene expression by quantitative real-time polymerase chain reaction(RT-qPCR)and protein expression by western blot/enzyme-linked immunosorbent assays(ELISA).In addition,PDL-fibroblast-mediated osteoclastogenesis(TRAP+cells)was measured in a 72-h coculture with RAW264.7 cells.The expression of HIF-1α,COX-2,PGE2,VEGF,COL1A2,collagen and ALPL,and the RANKL/OPG ratios at the mRNA/protein levels during PDL-fibroblast-mediated osteoclastogenesis were significantly elevated by mechanical loading irrespective of the oxygen supply,whereas hypoxic conditions had no significant additional effects.The cellular–molecular mediation of OTM by PDL fibroblasts via the expression of various signalling molecules is expected to be predominantly controlled by the application of force(mechanotransduction),whereas hypoxic effects seem to play only a minor role.In the context of OTM,the hypoxic marker HIF-1αdoes not appear to be primarily stabilized by a reduced O2 supply but is rather stabilised mechanically. | Niklas Ullrich Agnes Schroder Jonathan Jantsch Gerrit Spanier Peter Proff Christian Kirschneck | 2019 | International Journal of Oral Science2019，11，4： | 5 |
| 3 | Bone mineral density in lifelong trained male football players compared with young and elderly untrained men显示文摘Purpose: The purpose of the present controlled cross-sectional study was to investigate proximal femur and whole-body bone mineral density(BMD), as well as bone turnover profile, in lifelong trained elderly male football players and young elite football players compared with untrained age-matched men.Methods: One hundred and forty healthy, non-smoking men participated in the study, including lifelong trained football players(FTE, n = 35)aged 65—80 years, elite football players(FTY, n = 35) aged 18—30 years, as well as untrained age-matched elderly(UE, n = 35) and young(UY,n = 35) men. All participants underwent a regional dual-energy X-ray Absorptiometry(DXA) scan of the proximal femur and a whole-body DXA scan to determine BMD. From a resting blood sample, the bone turnover markers(BTMs) osteocalcin, carboxy-terminal type-1 collagen crosslinks(CTX-1), procollagen type-1 amino-terminal propeptide(P1NP), and sclerostin were measured.Results: FTE had 7.3%—12.9% higher(p < 0.05) BMD of the femoral neck, wards, shaft, and total proximal femur in both legs compared to UE,and 9.3%—9.7% higher(p < 0.05) BMD in femoral trochanter in both legs compared to UY. FTY had 24.3%—37.4% higher(p < 0.001) BMD in all femoral regions and total proximal femur in both legs compared to UY. The whole-body DXA scan confirmed these results, with FTE showing similar whole-body BMD and 7.9% higher(p < 0.05) leg BMD compared to UY, and with FTY having 9.6% higher(p < 0.001) wholebody BMD and 18.2% higher(p < 0.001) leg BMD compared to UY. The plasma concentration of osteocalcin, CTX-1, and P1NP were 29%,53%, and 52% higher(p < 0.01), respectively, in FTY compared to UY.Conclusion: BMD of the proximal femur and whole-body BMD are markedly higher in lifelong trained male football players aged 65—80 years and young elite football players aged 18—30 years compared to age-matched untrained men. Elderly football players even show higher BMD in femoral trochanter and leg BMD than untrained young despite an age difference of 47 years. | Marie Hagman Eva Wulff Helge Therese Hornstrup Bjorn Fristrup Jens Jung Nielsen Niklas Rye Jorgensen Jesper Lovind Andersen Jorn Wulff Helge Peter Krustrup | 2018 | Journal of Sport and Health Science2018，7，2： | 5 |
| 4 | 木焦油污染土壤中微生物特性的空间变异性研究显示文摘运用地统计学方法研究了木焦油污染土壤中微生物量、微生物群落结构、微生物活性等的空间变异特征.分别采用26种主要磷脂类脂肪酸(PLFA)的总含量(totPLFA)、PLFA的第一主成分和第二主成分(PLFAPC1和PC2)以及土壤培养过程中CO2C的累积释放量(Cre)来表征土壤中的微生物量、微生物群落结构以及微生物活性.结果表明,多数微生物特性指标均存在不同程度的空间自相关性,其半变异函数曲线可用带块金效应的球状模型进行拟合.变量的空间相关距离在2.50~16.60m之间.PLFAPC1、totPLFA和Cre均具有较强的空间依赖性,其相对结构变差(由结构性因素引起的空间变异)分别为82.3%、79.6%和64.7%,而PLFAPC2不存在明显的空间依赖性.克立格空间插值图表明,样地中存在几处微生物相对密集分布且代谢活性较高的区域,其中优势微生物菌群是由PLFAs16:1ω7t,cy17:0,18:1ω7和cy19:0所表征的革兰氏阴性细菌.土壤中主要污染物多环芳烃含量和空间分布是影响微生物特性空间分布格局的重要因素之一. | 杨秀虹 李适宇 Gran Bengtsson Niklas Trneman | 2005 | 应用生态学报2005，16，5： | 2 |
| 5 | The ostrich effect: Selective attention to information显示文摘 | Niklas Karlsson George Loewenstein Duane Seppi | 2009 | Journal of Risk and Uncertainty2009，，2： | 2 |
| 6 | 原发性高血压患者血清和尿液中肿瘤坏死因子浓度与早期器官损害的关系显示文摘高血压被认为是一种低度炎症性疾病。因此,炎症细胞因子浓度可能在高血压患者体内升高,包括肿瘤坏死因子(tumor necrosis factor,TNF)„该研究由年龄18-65岁的参与者96人组成:原发性高血压患者76例和20名健康对照人群。用诊室和动态血压监测(ambulatory blood pressure monitoring,ABPM)测量血压,采集血液进行实验室检查[TNF,TNF受体(TNF receptor 1,TNFR1)],收集24h尿以评估蛋白尿和TNF浓度。 | 陈嘉睿(译) 叶鹏(审校) Puszkarska A Niklas A Giuszek J Lipski D Niklas K | 2019 | 中华高血压杂志2019，27，11： | 2 |
| 7 | Left ventricular concentric remodeling rather than left ventricular hypertrophy is related to the insulin resistance syndrome in elderly men显示文摘 | Sundstrom J Lind L Niklas N | 2000 | Circulation2000，101，： | 1 |
| 8 | Biomass allocation to leaves, stems and roots : recta-analyses of interspecific variation and environmental control 显示文摘 | POORTER H NIKLAS K J REICH P B | 2012 | New Phytologist2012，193，1： | 1 |
| 9 | Photochemistry on metal nanoparticles显示文摘 | DIETRICH M NIKLAS N | 2006 | Chemical Reviews2006，106，10： | 1 |
| 10 | Cyclooxygenase-2, prostaglandin synthase, and prostaglandin H2 metabolism in traumatic brain injury in the rat 显示文摘 | Kunz T Niklas Marklund Lara H | 2002 | Neurotrauma2002，9，19： | 1 |
| 11 | Modelling below-and above-ground biomass for non-woody and woody plants显示文摘 | Niklas K J | 2005 | Annals of Botany2005，95，2： | 1 |
| 12 | Plant allometryis there a grand unifying theory?显示文摘 | Niklas K J | 2004 | Cambridge Philosophical Society2004，79，： | 1 |
| 13 | In vivo ionizing irradiations produce deletions in the hprt gene of human T-lymphocytes显示文摘 | Janice A Niklas J Patrick O' Neill Timothy C Hunter | 1991 | Mutat Res1991，250，： | 1 |
| 14 | Invariant scaling relationships for interspecific plant biomass production rates and body size显示文摘 | Niklas K J Enquist B J | 2001 | PNAS2001，98，5： | 1 |
| 15 | Biomass allocation to leaves, stems and roots: Meta-analyses of interspecific variation and environmental control 显示文摘 | POORTER H NIKLAS K J REICH P B OLEKSYN J POOT P MOMMER L | 2012 | New Phytologist2012，193，1： | 1 |
| 16 | Impact of decision goal on escalation显示文摘 | Karlsson Niklas Juliusson sgeir Grankvist Gunne | 2002 | Acta Psychologica2002，111，3： | 1 |
| 17 | A mechanical perspective on foliage leaf form and function显示文摘 | Niklas K J | 1999 | New Phytologist1999，143，1： | 1 |
| 18 | Global allocation rules for patterns of biomass partitioning in seed plants显示文摘 | Enquist B J Niklas K J | 2002 | Science2002，295，： | 1 |
| 19 | Enhanced NaCI stress tolerance in transgenic tobacco expressing bacteria] choline dehydrogenase显示文摘 | G6sta Lilius Niklas Ho]mberg Leif Billow | 1996 | Nature Biotecno]ogy1996，14，： | 1 |
| 20 | Evidence for digenic inheritance of nonsyndromic hereditary hearing loss in a Swedish Family 显示文摘 | JORUNE BALCIUNIENE NIKLAS DAHL ERIK BORG | 1998 | Am J Hum Genet1998，63，3： | 1 |
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