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| 1 | 一次新疆伊犁河谷特大暴雨过程的环境场及不稳定条件分析显示文摘伊犁河谷是新疆地区暴雨多发且暴雨强度最强的地区。本文以该地区的一次特大暴雨过程为例,利用观测资料以及WRF高分辨率数值模拟结果对该次暴雨过程的环流背景及不稳定条件进行了分析。结果表明:(1)此次降水过程发生在对流层高层南亚高压'双体型',中层中高纬度'两脊一槽'以及两个中亚低涡发展移动的环流形势下。在伊犁河谷特殊的向西开口的喇叭口地形作用下,中心位于哈萨克斯坦的中亚低涡导致伊犁河谷低层为偏西风,中心位于塔里木盆地的中亚低涡使得伊犁河谷中层为偏东风,导致伊犁河谷内中低层水平风的垂直切变增强;伊犁河谷内,地形及哈萨克斯坦中亚低涡环流的共同作用形成了低空辐合线,辐合线附近形成的辐合区正好与高空急流辐散区垂直叠加,引发河谷内的上升运动增强。低层西风将水汽输送进河谷,并在河谷内迎风坡附近堆积,上升运动增强后导致河谷内堆积的水汽得以抬升。(2)WRF模拟结果分析显示,散度分布、垂直风切变、水汽及热力层结分布等对降水产生均有重要贡献。通过对湿位涡垂直及水平分量的分析得出热力层结影响的对流不稳定对前期降水的产生有影响,同时,垂直风切变影响的对称不稳定对降水增强维持有重要作用。位势散度分析进一步指示出整个降水区低层的对流不稳定主要是由于位势散度的垂直切变部分造成,而位势散度的散度部分能加强河谷内小地形背风坡处的对流不稳定,说明整个降水演变过程中,动热力因子的相互作用共同影响了降水强度和落区。 | 黄昕 周玉淑 冉令坤 KALIM Ullah 曾勇 | 2021 | 大气科学2021，45，1： | 14 |
| 2 | CAR-T疗法及其在肿瘤免疫治疗中的应用进展显示文摘嵌合抗原受体T(chimeric antigen receptor T,TCAR-T)细胞免疫疗法是通过赋予T细胞非HLA依赖性的方式来识别肿瘤抗原能力的,改造的T细胞相较于天然T细胞表面受体TCR能够识别更广泛的靶标。在急性白血病和非霍奇金淋巴瘤的治疗上取得了显著的疗效。最近,包括诺华公司的CTL019在内多个CAR-T产品被FDA批准上市。近几年,CAR-T疗法在脑胶质瘤、前列腺癌、肺癌等实体瘤方面的研究也取得了巨大的进展,被认为是最有前景的肿瘤治疗方式之一。该文主要就CAR-T的发展、临床应用及其面临的挑战与未来的发展方向作一综述。 | 林才瑶 Muhammad Kalim 梁可莹 詹金彪 | 2018 | 中国细胞生物学学报2018，40，3： | 8 |
| 3 | Meteorological impacts on evapotranspiration in different climatic zones of Pakistan显示文摘Arid regions are highly vulnerable and sensitive to drought. The crops cultivated in arid zones are at high risk due to the high evapotranspiration and water demands. This study analyzed the changes in seasonal and annual evapotranspiration(ET) during 1951–2016 at 50 meteorological stations located in the extremely arid, arid, and semi-arid zones of Pakistan using the Penman Monteith(PM) method. The results show that ET is highly sensitive and positively correlated to temperature, solar radiation, and wind speed whereas vapor pressure is negatively correlated to ET. The study also identifies the relationship of ET with the meteorological parameters in different climatic zones of Pakistan. The significant trend analysis of precipitation and temperature(maximum and minimum) are conducted at 95% confidence level to determine the behaviors of these parameters in the extremely arid, arid, and semi-arid zones. The mean annual precipitation and annual mean maximum temperature significantly increased by 0.828 mm/a and 0.014℃/a in the arid and extremely arid zones, respectively. The annual mean minimum temperature increased by 0.017℃/a in the extremely arid zone and 0.019℃/a in the arid zone, whereas a significant decrease of 0.007℃/a was observed in the semi-arid zone. This study provides probabilistic future scenarios that would be helpful for policy-makers, agriculturists to plan effective irrigation measures towards the sustainable development in Pakistan. | Shahzada ADNAN Kalim ULLAH Azmat H KHAN GAO Shouting | 2017 | Journal of Arid Land2017，9，6： | 2 |
| 4 | Moisture Transport over the Arabian Sea Associated with Summer Rainfall over Pakistan in 1994 and 2002显示文摘In this study,we aimed to elucidate the critical role of moisture transport affecting monsoon activity in two contrasting summers over the Arabian Sea during the years 1994,a relatively wet year,and 2002,a relatively dry year.A comprehensive diagnostic evaluation and comparisons of the moisture fields were conducted;we focused on the precipitation and evaporation as well as the moisture transport and its divergence or convergence in the atmosphere.Monthly mean reanalysis data were obtained from the National Centers for Environmental Prediction(NCEP-I and-II).A detailed evaluation of the moisture budgets over Pakistan during these two years was made by calculating the latent energy flux at the surface(E P) from the divergence of the total moisture transport.Our results confirm the moisture supply over the Arabian Sea to be the major source of rainfall in Pakistan and neighboring regions.In 1994,Pakistan received more rainfall compared to 2002 during the summer monsoon.Moisture flow deepens and strengthens over Arabian Sea during the peak summer monsoon months of July and August.Our analysis shows that vertically integrated moisture transport flux have a significant role in supplying moisture to the convective centers over Pakistan and neighboring regions from the divergent regions of the Arabian Sea and the Bay of Bengal.Moreover,in 1994,a deeper vertically integrated moisture convergence progression occurred over Pakistan compared to that in 2002.Perhaps that deeper convergence resulted in a more intense moisture depression over Pakistan and also caused more rainfall in 1994 during the summer monsoon.Finally,from the water budget analysis,it has been surmised that the water budget was larger in 1994 than in 2002 during the summer monsoon. | Kalim ULLAH 高守亭 | 2012 | Advances in Atmospheric Sciences2012，29，3： | 2 |
| 5 | Characterization of Drought and Its Assessment over Sindh,Pakistan During 1951-2010显示文摘Drought is one of the complex meteorological disasters affecting water resources,agriculture,livestock,and socioeconomic patterns of a region.Although drought prediction is difficult,it can be monitored based on climatological information.In this study,we provide high spatiotemporal resolution drought climatology,using observational,gridded precipitation data(0.5°×0.5°) from the Global Precipitation Climatological Center and soil moisture data from the Climate Prediction Center for the 60-yr period 1951-2010.The standardized precipitation index(SPI) based on a fitted Gamma distribution and Run method has been calculated from the regional drought identification model(ReDIM) for 3,6,9,12,and 24 months.The results show strong temporal correlations among anomalies of precipitation,soil moisture,and SPI.Analysis of long-term precipitation data reveals that the drought vulnerability concentrates on monsoon season(JulySeptember),which contributes 72.4%and 82.1%of the annual precipitation in northern and southern Sindh,respectively.Annual and seasonal analyses show no significant changes in the observed precipitation.The category classification criteria are defined to monitor/forecast drought in the selected area.Further analysis identifies two longest episodes of drought,i.e.,1972-1974 and 2000-2002,while 1969,1974,1987,and 2002 are found to be the most severe historical drought years.A drought hazard map of Sindh was developed,in which 10 districts are recognized as highly vulnerable to drought.This study helps to explain the time,duration,intensity,and frequency of meteorological droughts over Sindh as well as its neighboring regions,and provides useful information to disaster management agencies and forecasters for assessing both the regional vulnerability of drought and its seasonal predictability in Pakistan. | Shahzada ADNAN Kalim ULLAH 高守亭 | 2015 | Journal of Meteorological Research2015，29，5： | 2 |
| 6 | GPC3的结构和功能及其在肝细胞癌诊治中的应用显示文摘磷脂酰肌醇蛋白聚糖3(glypican 3,GPC3)是磷脂酰肌醇蛋白聚糖家族的一员,它主要通过糖基磷脂酰肌醇(glycosylphosphatidylinositol,GPI)锚定在细胞膜外侧。在正常人的肝细胞、良性肝肿瘤和其他成熟体细胞表面几乎不能检测到它的存在,而在原发性肝细胞癌(hepatocellular carcinoma,HCC)呈现高表达。因此,GPC3可以作为标志物用以诊断HCC。此外,GPC3在血清和肝组织中过量表达的HCC病人往往预后较差。研究发现,GPC3主要通过激活经典的Wnt信号通路和其他一些通路来促进HCC的迁移和增殖。针对GPC3靶点的单克隆抗体、抗体偶联药物和对应的细胞疗法,可能成为临床治疗HCC的有力武器。 | 汪胜豪 Muhammad Kalim 詹金彪 | 2018 | 中国细胞生物学学报2018，40，2： | 2 |
| 7 | Induction of membranous nephropathy in rabbits by administration of an exogenous cationic antigen显示文摘 | Border WA Ward HJ Kalim ES | 1982 | J Clin Invest1982，69，2： | 1 |
| 8 | Impact of temperature on yield and related traits in cotton genotypes显示文摘Cotton growth and development is influenced by various uncontrollable environmental conditions. Temperature variations in the field can be created by planting at different dates. The objective of the present study was to evaluate the effect of planting dates and thermal temperatures(growing degree days) on yield of 4 cotton genotypes, viz., CIM-598, CIM-599, CIM-602 and Ali Akbar-703. Plants were subjected to 6 planting dates during 2013 and 2014 in a trial conducted in randomized complete block design with four replications. For boll number, boll weight and seed cotton yield, cotton genotypes exhibited significant differences, CIM-599 produced the highest seed cotton yield of 2 062 kg ha^(–1) on account of maximum boll number and boll weight. The highest seed cotton yield was recorded in planting dates from 15 th April to 1st May whereas early and delayed planting reduced the yield due to less accumulation of heat units. Regression analysis revealed that increase of one unit(15 days) from early to optimum date(15th March to 15 th April) increased yield by 93.58 kg ha^(–1). Delay in planting also decreased the seed cotton yield with the same ratio. Thus it is concluded that cotton must be sown from 15 th April to 1st May to have good productivity in this kind of environment. | Kalim Ullah Niamatullah Khan Zahid Usman Rehmat Ullah Fazal Yazdan Saleem Syed Asif Imran Shah Muhammad Salman | 2016 | Journal of Integrative Agriculture2016，15，3： | 1 |
| 9 | Prostaglandin E2 inhibits IL-23 and IL - 12 production by human monocytes through downregulation of their common p40 subunit 显示文摘 | Kalim KW Groettrup M | 2013 | Mol Immunol2013，53，3： | 1 |
| 10 | Molecular interactions on microarrays显示文摘 | Edwin S Kalim M Mikhail S | 1999 | Nat Genet1999，21，： | 1 |
| 11 | Robust chaos in neural networks显示文摘 | POTA POVE A KALIM | 2000 | Physics Letters A2000，277，6： | 1 |
| 12 | Prostaglandin E2 inhibits IL -23 and IL - 12production by human monocytes through down - regulation of their common p40 subunit显示文摘 | Kalim KW Groettrup M | 2012 | Molecular Immunology2012，53，3： | 1 |
| 13 | Closure of a nonhealing gaslrocutanous fistula using argon plasma coagulation anti endoscopic hemoclips 显示文摘 | Hameed H Kalim S Khan YI | 2009 | Can J Gastroenterol2009，23，3： | 1 |
| 14 | Pulmonary artery occlusion pressure and central venous pressure fail to predict ventricular filling volume, cardiac performance, or the response to volume infusion in normal subjects显示文摘 | Anand Kumar Ramon Anel Eugene Bunnell Kalim Habet Sergio Zanotti Stephanie Marshall Alex Neumann Amjad Ali Mary Cheang Clifford Kavinsky Joseph E. Parrillo | 2004 | Critical Care Medicine2004，，3： | 1 |
| 15 | Understanding livelihood vulnerability to climate change: Applying the livelihood vulnerability index in Trinidad and Tobago显示文摘 | Kalim U. Shah Hari Bansha Dulal Craig Johnson April Baptiste | 2013 | Geoforum2013，，： | 1 |
| 16 | Use of computed tomographic pulmonary angiography for the diagnosis of pulmonary embolism; are we overdoing it? 显示文摘 | Kalim S Akhtar MS | 2014 | Journal of Ayub Medical College Abbottabad: JAMC2014，26，1： | 1 |
| 17 | Protein carbamylation is associatedwith heart failure and mortality in diabetic patients with end -stage renal d ise ase显示文摘 | Drechsler C Kalim S Wenger JB | | Kidney Int0，87，6： | 1 |
| 18 | Immunoproteasome subunit LMP7 deficiency and inhibition suppresses Thl and Thl7 but enhances regulatory T cell differentiation显示文摘 | Kalim KW Basler M Kirk CJ | 2012 | J Immunol2012，189，8： | 1 |
| 19 | Molecular interctions on microarrays显示文摘 | Kalim M Mikhail S | 1999 | Nature Genetics Supplement1999，21，： | 1 |
| 20 | Does vitamin D modulate blood pressure?显示文摘 | Hector Tamez Sahir Kalim Ravi I. Thadhani | 2013 | Current Opinion in Nephrology and Hypertension2013，，2： | 1 |
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