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| 1 | CAR-T疗法及其在肿瘤免疫治疗中的应用进展显示文摘嵌合抗原受体T(chimeric antigen receptor T,TCAR-T)细胞免疫疗法是通过赋予T细胞非HLA依赖性的方式来识别肿瘤抗原能力的,改造的T细胞相较于天然T细胞表面受体TCR能够识别更广泛的靶标。在急性白血病和非霍奇金淋巴瘤的治疗上取得了显著的疗效。最近,包括诺华公司的CTL019在内多个CAR-T产品被FDA批准上市。近几年,CAR-T疗法在脑胶质瘤、前列腺癌、肺癌等实体瘤方面的研究也取得了巨大的进展,被认为是最有前景的肿瘤治疗方式之一。该文主要就CAR-T的发展、临床应用及其面临的挑战与未来的发展方向作一综述。 | 林才瑶 Muhammad Kalim 梁可莹 詹金彪 | 2018 | 中国细胞生物学学报2018，40，3： | 8 |
| 2 | GPC3的结构和功能及其在肝细胞癌诊治中的应用显示文摘磷脂酰肌醇蛋白聚糖3(glypican 3,GPC3)是磷脂酰肌醇蛋白聚糖家族的一员,它主要通过糖基磷脂酰肌醇(glycosylphosphatidylinositol,GPI)锚定在细胞膜外侧。在正常人的肝细胞、良性肝肿瘤和其他成熟体细胞表面几乎不能检测到它的存在,而在原发性肝细胞癌(hepatocellular carcinoma,HCC)呈现高表达。因此,GPC3可以作为标志物用以诊断HCC。此外,GPC3在血清和肝组织中过量表达的HCC病人往往预后较差。研究发现,GPC3主要通过激活经典的Wnt信号通路和其他一些通路来促进HCC的迁移和增殖。针对GPC3靶点的单克隆抗体、抗体偶联药物和对应的细胞疗法,可能成为临床治疗HCC的有力武器。 | 汪胜豪 Muhammad Kalim 詹金彪 | 2018 | 中国细胞生物学学报2018，40，2： | 2 |
| 3 | Impact of temperature on yield and related traits in cotton genotypes显示文摘Cotton growth and development is influenced by various uncontrollable environmental conditions. Temperature variations in the field can be created by planting at different dates. The objective of the present study was to evaluate the effect of planting dates and thermal temperatures(growing degree days) on yield of 4 cotton genotypes, viz., CIM-598, CIM-599, CIM-602 and Ali Akbar-703. Plants were subjected to 6 planting dates during 2013 and 2014 in a trial conducted in randomized complete block design with four replications. For boll number, boll weight and seed cotton yield, cotton genotypes exhibited significant differences, CIM-599 produced the highest seed cotton yield of 2 062 kg ha^(–1) on account of maximum boll number and boll weight. The highest seed cotton yield was recorded in planting dates from 15 th April to 1st May whereas early and delayed planting reduced the yield due to less accumulation of heat units. Regression analysis revealed that increase of one unit(15 days) from early to optimum date(15th March to 15 th April) increased yield by 93.58 kg ha^(–1). Delay in planting also decreased the seed cotton yield with the same ratio. Thus it is concluded that cotton must be sown from 15 th April to 1st May to have good productivity in this kind of environment. | Kalim Ullah Niamatullah Khan Zahid Usman Rehmat Ullah Fazal Yazdan Saleem Syed Asif Imran Shah Muhammad Salman | 2016 | Journal of Integrative Agriculture2016，15，3： | 1 |
| 4 | Evaluation of different formulations of IGRs against Aedes albopictus and Culex quinquefasciatus(Diptera:Culicidae)显示文摘Objective: To test the relative efficacy of pyriproxyfen and methoprene on mortality,deformity, inhibition and emergence to adult stages of Culex quinquefasciatus and Aedes albopictus.Methods: Serial dilutions(0.01–0.05 mg/L) of methoprene, pyriproxyfen 0.5 water dispersible granules(WDG) and pyriproxyfen 1.0 WDG were used to assess mortality and inhibition of 3rd instar larvae of Aedes albopictus and Culex quinquefasciatus. Each concentration and control was replicated four times in completely randomized design.Data on larval mortality, growth inhibition, deformities and adult's emergence was recorded weekly. On the basis of best comparative performance, the efficacy of pyriproxyfen 1.0 WDG at 0.1 g/m3 was also tested in the field by collecting treated water samples monthly for 1–6 months after field application. Twenty five 3rd instar larvae of Aedes and Culex spp. of the same cohorts were used for bioassays and compared with larvae in control cups containing 1 L of untreated tap water.Results: Results revealed variations in fatality of different insect growth regulators(IGRs) to the 3rd instar larvae of Culex and Aedes mosquitoes. Among the IGRs, pyriproxyfen 1.0 WDG was found best that exhibited significantly high emergence inhibition against Culex and Aedes spp. Based on the results, the IGRs were classified in terms of the tested parameters in order of pyriproxyfen 1.0 WDG > pyriproxyfen 0.5WDG > methoprene. In case of field studies, pyriproxyfen 1.0 WDG, pool data of the entire target treated sites showed minimum adult emergence from water sampled of habitats treated with 0.1 g/m3 of pyriproxyfen 1.0 WDG.Conclusions: It is thus concluded that IGRs can be utilized as environment friendly control measures for Culex and Aedes spp. of mosquitoes on small and large scale. This will reduce the use of conventional insecticides by the public health authorities and help in reducing selection pressure of insecticides. | Gul Zamin Khan Inamullah Khan Imtiaz Ali Khan Alamzeb Muhammad Salman Kalim Ullah | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，6： | 0 |
| 5 | Determinants of corporate cash holdings in tranquil and turbulent period:evidence from an emerging economy显示文摘Using a sample of 280 firms listed on the Pakistan Stock Exchange,we empirically investigate factors that determine corporate cash holdings in different periods from 2005 to 2014.We divide the sample into three sub-periods—pre-crisis,crisis,and post-crisis—and apply a panel data model to estimate the results.The results suggest that financial crises affect firms’cash holdings policies.Further,findings show that financial crisis has influenced the relationship of size and leverage with cash holdings.In particular,cash flow,liquidity,and tangibility are major determinants of cash holdings in the sub-periods.We present important implications for corporate managers,academicians,and policymakers. | Khalil Jebran Amjad Iqbal Kalim Ullah Bhat Muhammad Arif Khan Mustansar Hayat | 2019 | Financial Innovation2019，5，1： | 0 |
| 6 | On global behavior for complex soliton solutions of the perturbed nonlinear Schrödinger equation in nonlinear optical fibers显示文摘In this research article,the perturbed nonlinear Schrödinger equation(P-NLSE)is examined by utilizing two analytical methods,namely the extended modified auxiliary equation mapping and the generalized Riccati equation mapping methods.Consequently,we establish several sorts of new families of complex soliton wave solutions such as hyperbolic functions,trigonometric functions,dark and bright solitons,periodic solitons,singular solitons,and kink-type solitons wave solutions of the P-NLSE.Using the mentioned methods,the results are displayed in 3D and 2D contours for specific values of the open parameters.The obtained findings demonstrate that the implemented techniques are capable of identifying the exact solutions of the other complex nonlinear evolution equations(C-NLEEs)that arise in a range of applied disciplines. | M.S.Osman Hassan Almusawa Kalim U.Tariq Sadia Anwar Sachin Kumar Muhammad Younis Wen-Xiu Ma | 2022 | Journal of Ocean Engineering and Science2022，7，5： | 0 |
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