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| 1 | 家庭参与式管理模式对早产儿18月龄生长发育的影响显示文摘目的 了解新生儿重症监护病房(NICU)的家庭参与式管理模式(FIC)对早产儿18月龄生长发育的影响.方法 为前瞻性病例平行对照研究.2015至2016年在中南大学湘雅三医院儿童保健部进行18月龄生长发育随访的早产儿为研究对象.FIC组婴儿为出生胎龄28~35周、出生时被纳入FIC的早产儿,对照组为根据性别、出生体重、胎龄和随访时日龄进行条件匹配(1:1比例)但未参加FIC的早产儿.分析指标包括母亲受教育年限、根据Graffar法进行的家庭社会分层(SES)、婴儿家庭环境测评(HOME)量表评分、婴幼儿智力行为发育贝利量表的智力发育指数(MDI)和精神运动发育指数(PDI).选用x2检验、t检验、Pearson相关系数、Spearman相关系数进行组间比较及相关性检验.结果 HC组与对照组各纳入67名早产儿,男早产儿比例分别为52%(35名)和51%(34名),出生胎龄(32.4±1.7)和(32.2±1.6)周,出生体重(1 690±415)和(1 719 ±412)g,两组婴儿具有可比性.18月龄时随访平均体重分别为(10±1)和(10±1)kg,母亲受教育年限(15±2)和(15±2)年,SES评分(42±6)和(41±6)分,HOME评分(31±5)和(32±5)分,两组之间各数据差异均无统计学意义(P均>0.05),FIC组18月龄贝利量表MDI及PDI均明显高于对照组[(95±9)比(86±9),(87 ±9)比(80±8)分,t=5.506、4.502,均P=0.000].全部婴儿的MDI、PDI与胎龄均正相关(r=0.398、0.272,P=0.000、0.001),但各胎龄阶段FIC组与对照组的MDI、PDI之差与胎龄无相关关系(r=0.679、-0.393,P=0.094、0.383).结论 在NICU中开展FIC可促进早产儿18月龄的生长发育,FIC值得在中国的NICU中进行推广。 | 李颖 高翔羽 向希盈 戴红梅 杨刘 Shoo K.Lee 黑明燕 | 2016 | 中华儿科杂志2016，54，12： | 78 |
| 2 | 2015至2018年中国25家医院新生儿重症监护室早产儿中心导管相关性血流感染发生率的横断面调查显示文摘目的调查中国25家NICU中早产儿中心导管(CLs)置管率、CLs相关血流感染(CLABSI)的发生率及病原菌分布,为临床防治CLABSI提供基线数据。方法本研究数据来源于整群随机对照研究'应用以循证为基础的质量改进方法降低新生儿重症监护病房感染发生率(REIN-EPIQ)'建立的早产儿临床数据库。研究人群为2015年5月至2018年4月中国25家医院NICU收治的出生胎龄<34周的所有早产儿(排除自动出院)。结果共纳入24 884例早产儿,其中9 537例(38.3%)至少留置一根置管,经外周静脉穿刺中心静脉置管(PICC)7 532例(79.0%)。CLABSI总发生率为2.4/1 000(0.0~9.8/1 000)导管日,CLABSI相关病死率为6.7%(35/526)。CLABSI的发生率随着胎龄和出生体重的上升呈下降趋势。CLABSI的主要病原菌为革兰阴性菌(46.2%),其中肺炎克雷伯菌占49.8%,其次为革兰阳性菌(33.9%),真菌占19.9%。结论我国NICU早产儿中心静脉导管置管率高,CLABSI发生率存在显著单位间差异,CLABSI病原菌以革兰阴性菌为主,真菌占比高。需要采取针对性质量改进措施以缩小单位间差异、降低真菌CLABSI发生率。 | 无 卞一丁 蒋思远 冀涌 韩树萍 王三南 李占魁 夏世文 杨长仪 杨传忠 陈玲 单若冰 刘玲 易彬 林振浪 王杨 刘江勤 何玲 李明霞 潘新年 郭艳 刘翠青 周勤 李晓莺 孙慧清 齐宇洁 黑明燕 Shoo K.Lee 杨毅 严卫丽 曹云 | 2019 | 中国循证儿科杂志2019，14，4： | 45 |
| 3 | 家庭参与式护理对早产儿体格生长及随访影响的多中心群组随机对照研究显示文摘目的探讨新生儿重症监护病房(neonatal intensive care unit,NICU)家庭参与式护理(family integrated care,FICare)对早产儿体格生长的影响。方法采用前瞻性群组随机对照研究,将来自国内8个省11家三级甲等医院的NICU随机分为FICare组(6家)和对照组(5家),比较两组患儿一般临床资料及随访时间点(校正年龄1月、3月、6月、12月、18月)的身长、体重、头围情况。结果FICare组共纳入298例,对照组共纳入303例。FICare组和对照组早产儿胎龄分别为(31.0±1.9)周、(31.7±1.8)周,出生体重分别为(1553±378)g、(1653±348)g,差异有统计学意义(P<0.05);两组患儿的性别比例、分娩方式及孕母情况等临床资料比较差异均无统计学意义(P>0.05)。FICare组、对照组的平均住院时间分别为(35.0±20.2)d、(34.3±17.4)d,差异无统计学意义(P>0.05);两组患儿出院时全母乳喂养率分别为36.6%、17.8%,差异有统计学意义(P<0.001)。FICare组校正年龄6月、12月、18月时的随访率高于对照组(90.9%比74.3%、82.6%比40.6%、60.7%比32.0%),差异有统计学意义(P<0.001);整个随访期间,除12月龄时体重外,FICare组患儿体重、头围大于对照组,差异有统计学意义(P<0.05);校正年龄1月、3月时FICare组患儿身长大于对照组,差异有统计学意义(P<0.05)。结论对NICU住院早产儿实施FICare可促进早产儿出院后的体格发育,提高家长对出院后随访的依从性。 | 向希盈 高翔羽 高喜容 李占魁 夏世文 张谦慎 韩树萍 高红霞 农绍汉 张爱民 李佳 李颖 Shoo K.Lee 黑明燕 | 2020 | 中华新生儿科杂志(中英文)2020，35，6： | 16 |
| 4 | 中国新生儿重症监护病房极早及超早产儿非红细胞血制品使用现况显示文摘目的分析2019年中国新生儿协作网(CHNN)新生儿重症监护病房住院的极早及超早产儿非红细胞血制品的使用现状及单位间差异,为探讨输注合理性与规范性提供证据。方法基于CHNN大规模极早产儿队列数据库进行横断面研究,纳入2019年生后24 h内收入CHNN 57家NICU治疗、出生胎龄<32周且接受完整治疗的6598例早产儿。收集患儿一般情况,描述不同出生胎龄、不同病情危重程度早产儿非红细胞血制品(血小板、血浆、人免疫球蛋白、白蛋白、冷沉淀和凝血酶原复合物)的使用率及次数。输注过至少1种非红细胞血制品即为输注组。采用两独立样本t检验、秩和检验或χ^(2)检验进行输注组和非输注组组间比较。使用线性回归模型对单位间输注率和单位特征进行相关性分析。结果6598例早产儿出生胎龄为30.0(28.7,31.0)周,出生体重为(1353±312)g,女2877例(43.6%)。2816例(42.7%)早产儿为输注组,输注次数为3(1,6)次。与未输注组相比,输注组患儿出生胎龄更小(Z=17.62,P<0.01),出生体重更低(t=18.64,P<0.01),小于胎龄、多胎以及产房高级复苏比例均更高(χ^(2)=31.06、12.82、287.52,均P<0.01),女婴比例以及本院出生比例则均更低(χ^(2)=10.68、78.23,均P<0.01)。总研究人群中,使用率高的非红细胞血制品依次为白蛋白25.4%(1674例)、人免疫球蛋白21.5%(1417例)、血浆18.9%(1245例)。901例超早产儿中,60.4%(544例)输注过非红细胞血制品,使用次数4(2,8)次;5697例极早产儿中,39.9%(2272例)输注过非红细胞血制品,使用次数3(1,6)次。病情危重和非危重组中非红细胞血制品输注率分别达62.2%(1693/2723)和29.0%(1123/3875),输注次数分别为4(2,7)次和2(1,4)次。57家NICU中,调整与非红细胞血制品输注相关的因素后,各单位间极早及超早产儿非红细胞血制品输注率差异有统计学意义(校正χ^(2)=153.48,P<0.01)。结论2019年中国NICU救治的极早及超早产儿中,接近半数曾接受非红细胞血制品输注,各单位非红细胞血制品使用率存在巨大差异。 | 赵璞 顾昕玥 蒋思远 王延辰 曹云 周文浩 Shoo K.Lee 张勤 王瑾 中国新生儿协作网 | 2022 | 中华儿科杂志2022，60，2： | 4 |
| 5 | Macrophage depletion and Schwann cell transplantation reduce cyst size after rat contusive spinal cord injury显示文摘Schwann cell transplantation is a promising therapy for the treatment of spinal cord injury(SCI) and is currently in clinical trials.In our continuing efforts to improve Schwann cell transplantation strategies,we sought to determine the combined effects of Schwann cell transplantation with macrophage depletion.Since macrophages are major inflammatory contributors to the acute spinal cord injury,and are the major phagocytic cells,we hypothesized that transplanting Schwann cells after macrophage depletion will improve cell survival and integration with host tissue after SCI.To test this hypothesis,rat models of contusive SCI at thoracic level 8 were randomly subjected to macrophage depletion or not.In rat subjected to macrophage depletion,liposomes filled with clodronate were intraperitoneally injected at 1,3,6,11,and 18 days post injury.Rats not subjected to macrophage depletion were intraperitoneally injected with liposomes filled with phosphate buffered saline.Schwann cells were transplanted 1 week post injury in all rats.Biotinylated dextran amine(BDA) was injected at thoracic level 5 to evalute axon regeneration.The Basso,Beattie,and Bresnahan locomotor test,Gridwalk test,and sensory test using von Frey filaments were performed to assess functional recovery.Immunohistochemistry was used to detect glial fibrillary acidic protein,neurofilament,and green fluorescent protein(GFP),and also to visulize BDA-labelled axons.The GFP labeled Schwann cell and cyst and lesion volumes were quantified using stained slides.The numbers of BDA-positive axons were also quantified.At 8 weeks after Schwann cell transplantation,there was a significant reduction in cyst and lesion volumes in the combined treatment group compared to Schwann cell transplantation alone.These changes were not associated,however,with improved Schwann cell survival,axon growth,or locomotor recovery.Although combining Schwann cell transplantation with macrophage depletion does improve histopathology of the injury site,the effect on axon growth and behavioral recovery appears no better than what can be achieved with Schwann cell transplants alone. | Yee-Shuan Lee Lucy H.Funk Jae K.Lee Mary Bartlett Bunge | 2018 | Neural Regeneration Research2018，13，4： | 4 |
| 6 | Surgical management of uveitis-glaucoma-hyphema syndrome显示文摘AIM:To report outcomes of patients after intraocular lens(IOL)repositioning or exchange for the version of the uveitisglaucoma-hyphema(UGH)syndrome that does not include closed loop anterior chamber IOL(nUGH).METHODS:Chart review of patients with nUGH who underwent IOL repositioning or exchange by one surgeon were reviewed.The main outcome measures were best corrected visual acuity(BCVA)as a decimal fraction preoperatively and postoperatively after IOL repositioning or exchange.Clinical findings evaluated included the presence of uveitis,hyphema,elevated intraocular pressure(IOP),and other complications such as pigment dispersion or vitreous hemorrhage.The number of anti-inflammatory and glaucoma medications were assessed before and after IOL repositioning or exchange.RESULTS:The study included 14 pseudophakic eyes.The median time at the onset of contemporary UGH after cataract extraction and IOL implantation(CE/IOL)was7.5 y.IOL repositioning or exchange was performed at a mean duration of 8.1±4.7 mo(median:4 mo)after onset of UGH.The mean BCVA was improved from 0.45±0.26 preoperatively after onset of UGH syndrome to 0.76±0.22(P=0.016)after IOL repositioning or exchange.Among the14 eyes,uveitis,elevated IOP,and hyphema were present preoperatively in 13,13,and 6 eyes,respectively.Uveitis and hyphema resolved in all cases after IOL surgery.The mean IOP was reduced from 26.4±4.5 mm Hg preoperatively to 14.7±4.9 postoperatively(P=0.01).The mean number of glaucoma medications used was reduced from 1.7±1.1 medications preoperatively to 0.8±1.08(P=0.04)postoperatively.CONCLUSION:IOL repositioning or exchange is an effective treatment in many cases for medically resistant contemporary UGH syndrome. | Abdelrahman M.Elhusseiny Richard K.Lee William E.Smiddy | 2020 | International Journal of Ophthalmology(English edition)2020，13，6： | 3 |
| 7 | The association of cerebrospinal fluid pressure with optic nerve head and macular vessel density显示文摘The present study aims to investigate the effect of temporary cerebrospinal fluid pressure(CSFP) reduction on optic nerve head(ONH) and macular vessel density(VD) using optical coherence tomography angiography.Forty-four eyes of 44 adults with diagnostic lumbar puncture and CSFP reduction were recruited.Thirty-two eyes of 32 healthy volunteers were controls.ONH and macular VD images were evaluated differences between baseline and after CSFP reduction.The results showed that the mean CSFP decreased from(11.6±2.1) mm Hg to(8.2±3.4) mm Hg(P<0.001).VD in the macular regions decreased significantly after CSFP reduction in the study group(all P<0.05).The control group showed no significant changes in macular VD(all P>0.05).In the study group,decreased VD in the macular parainferior region was associated with CSFP reduction(R^(2)=0.192,P=0.003),the reduction of macular VD in parafoveal(R^(2)=0.098,P=0.018),parainferior(R^(2)=0.104,P=0.021),parasuperior(R^(2)=0.059,P=0.058),paranasal(R^(2)=0.057,P=0.042),paratemporal(R^(2)=0.079,P=0.026) was associated with mean ocular perfusion pressure decrease following CSFP reduction.ONH vessel density did not differ after CSFP reduction(all P>0.05).In conclusion,macular vessel density decreased in association with CSFP reduction.Retinal vessel density in the macular region is more sensitive than that in peripapillary region after CSFP reduction. | Xiangxiang Liu Mohamed M.Khodeiry Danting Lin Yunxiao Sun Qing Zhang Jiawei Wang Richard K.Lee Ningli Wang | 2022 | Science China(Life Sciences)2022，65，6： | 3 |
| 8 | Prospective randomized, double‐blind, placebo‐controlled study of pre‐ and postoperative administration of a COX‐2‐specific inhibitor as opioid‐sparing analgesia in major colorectal surgery显示文摘 | R.Sim D. M.Cheong K. S.Wong B. M. K.Lee Q. Y.Liew | 2006 | Colorectal Disease2006，，1： | 2 |
| 9 | 中国极早产儿动脉导管未闭的治疗现状显示文摘目的总结2019—2021年中国新生儿协作网(CHNN)各单位收治的极早产儿中动脉导管未闭(PDA)的治疗现状和变化趋势以及单位间治疗差异。方法横断面研究基于CHNN极早产儿队列,纳入2019—2021年CHNN 79家三级新生儿重症监护病房(NICU)收治的所有入院≤3日龄的22525例极早产儿(出生胎龄<32周)。描述所有极早产儿以及不同出生胎龄(≤26、27~28、29~31周)组的PDA治疗率以及药物和手术治疗情况。PDA定义为住院期间通过心脏超声诊断的PDA;PDA治疗率为接受过PDA药物和(或)手术治疗的极早产儿人数/所有极早产儿人数。使用Logistic回归检验分析研究3年间及不同出生胎龄组PDA治疗率的变化趋势。建立多元Logistic回归模型计算不同单位PDA治疗的标准化比率(SR),以比较调整人群特征后单位间PDA治疗率的差异。结果22525例极早产儿中男12615例(56.0%),出生胎龄30.0(28.6,31.0)周,出生体重1310(1100,1540)g,经超声心动图诊断的PDA 49.7%(11186/22525),所有极早产儿PDA治疗率为16.8%(3795/22525)。在3762例接受了药物治疗的极早产儿中,首次药物治疗以布洛芬为主[93.4%(3515例)],首次药物治疗的年龄为6(4,10)日龄;59.3%(2231例)的极早产儿在首次药物治疗时已经撤离了有创呼吸支持,82.2%(3092例)的极早产儿仅接受1个疗程药物治疗。在143例接受了手术治疗的极早产儿中,手术治疗的年龄为32(22,46)日龄。2019—2021年3年间,极早产儿PDA治疗率差异无统计学意义(P=0.650)。PDA治疗率随着出生胎龄的增加而降低(P<0.001)。出生胎龄≤26、27~28、29~31周极早产儿PDA治疗率分别为39.6%(688/1737)、25.9%(1319/5098)、11.4%(1788/15690)。极早产儿总数≥100例的单位共61家,这些单位的极早产儿PDA治疗率范围为0(0/116)~47.4%(376/793)。在调整患儿基本特征后,61家单位极早产儿PDA治疗的SR范围为0(95%CI 0~0.3)~3.4(95%CI 3.1~3.8)。结论2019—2021年中国新生儿协作单位收治极早产儿中,小出生胎龄患儿PDA治疗率低于发达国家,大出生胎龄患儿治疗率则偏高,不同单位间PDA治疗率差异显著。 | 钱爱民 程锐 顾昕玥 殷荣 白瑞苗 杜娟 孙梦雅 程萍 Shoo K.Lee 杜立中 曹云 周文浩 赵幽燕 蒋思远 无 | 2023 | 中华儿科杂志2023，61，10： | 2 |
| 10 | Designing and implementing a case-based learning environment for enhancing ill-structured problem solving:classroom management problems for prospective teachers显示文摘 | Choi I K.Lee | | 0，，01： | 1 |
| 11 | Prevalence and specificity of clinically significant red cell alloantibodies in Chinese women during pregnancy – a review of cases from 1997 to 2001显示文摘 | C. K.Lee E. S. K.Ma M.Tang C. C. K.Lam C. K.Lin L. C.Chan | 2003 | Transfusion Medicine2003，，： | 1 |
| 12 | Generation of dynamically perfused functional vascular network system within hydrogel using3D bio-printing technology显示文摘Introduction:3D bio-printing technology[1-3](Figure 1)capable of dispensing live cells,soluble factors,and phase-changing hydrogel in a desired pattern,has great potential in creating 3D tissue.However,maintaining the viability of a thick tissue structure during tissue growth and maturation is challenging due to lack of adequate vascular perfusion.In a simple tissue model with | Vivian K.Lee Seung-Schik Yoo Peter Vincent Guohao Dai | 2013 | 医用生物力学2013，28，S1： | 1 |
| 13 | Cell transplantation to replace retinal ganglion cells faces challenges-the Switchboard Dilemma显示文摘The mammalian retina displays incomplete intrinsic regenerative capacities;therefore,retina degeneration is a major cause of irreversible blindness such as glaucoma,agerelated macular degeneration and diabetic retinopathy.These diseases lead to the loss of retinal cells and serious vision loss in the late stage.Stem cell transplantation is a great promising novel treatment for these incurable retinal degenerative diseases and represents an exciting area of regenerative neurotherapy.Several suitable stem cell sources for transplantation including human embryonic stem cells,induced pluripotent stem cells and adult stem cells have been identified as promising target populations.However,the retina is an elegant neuronal complex composed of various types of cells with different functions.The replacement of these different types of cells by transplantation should be addressed separately.So far,retinal pigment epithelium transplantation has achieved the most advanced stage of clinical trials,while transplantation of retinal neurons such as retinal ganglion cells and photoreceptors has been mostly studied in pre-clinical animal models.In this review,we opine on the key problems that need to be addressed before stem cells transplantation,especially for replacing injured retinal ganglion cells,may be used practically for treatment.A key problem we have called the Switchboard Dilemma is a major block to have functional retinal ganglion cell replacement.We use the public switchboard telephone network as an example to illustrate different difficulties for replacing damaged components in the retina that allow for visual signaling.Retinal ganglion cell transplantation is confronted by significant hurdles,because retinal ganglion cells receive signals from different interneurons,integrate and send signals to the correct targets of the visual system,which functions similar to the switchboard in a telephone network-therefore the Switchboard Dilemma. | Yuan Liu Richard K.Lee | 2021 | Neural Regeneration Research2021，16，6： | 1 |
| 14 | Sensitive detection and accurate monitoring of Plasmodium vivax parasites on routine complete blood count using automatic blood cell analyzer (DxH800TM)显示文摘 | H. K.LEE S. I.KIM H.CHAE M.KIM J.LIM E. J.OH Y.KIM Y. J.PARK W.LEE K.HAN | 2012 | International Journal of Laboratory Hematology2012，，： | 1 |
| 15 | 5‐HT2B receptors modulate visceral hypersensitivity in a stress‐sensitive animal model of brain‐gut axis dysfunction显示文摘 | S. M.O’mahony D. C.Bulmer A.‐m.Coelho P.Fitzgerald C.Bongiovanni K.Lee W.Winchester T. G.Dinan J. F.Cryan | 2010 | Neurogastroenterology & Motility2010，，5： | 1 |
| 16 | Deep‐vein thrombosis rates after major orthopedic surgery in Asia. An epidemiological study based on postoperative screening with centrally adjudicated bilateral venography显示文摘 | F.PIOVELLA C‐J.WANG H.LU K.LEE L. H.LEE W. C.LEE A. G. G.TURPIE A. S.GALLUS A.PLANèS R.PASSERA A.ROUILLON | 2005 | Journal of Thrombosis and Haemostasis2005，，12： | 1 |
| 17 | 查看详情显示文摘 | T.Zhao A.Scholl F.Zavaliche K.Lee M.Barry A.Doran M.P.Cruz Y.H.Chu C.Ederer N.A.Spaldin R.R.Das D.M.Kim S.H.Baek C.B.Eom and R.Ramesh | | 0，，10： | 1 |
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