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| 1 | Clinically relevant factors associated with quantitative optical coherence tomography angiography metrics in deep capillary plexus in patients with diabetes显示文摘Background:To test clinically relevant factors associated with quantitative artifact-free deep capillary plexus(DCP)metrics in patients with diabetes mellitus(DM).Methods:563 eligible eyes(221 with no diabetic retinopathy[DR],135 with mild DR,130 with moderate DR,and 77 with severe DR)from 334 subjects underwent optical coherence tomography-angiography(OCT-A)with a swept-source OCT(Triton DRI-OCT,Topcon,Inc.,Tokyo,Japan).Strict criteria were applied to exclude from analysis those DCP images with artifacts and of poor quality,including projection artifacts,motion artifacts,blurriness,signal loss,B-scan segmentation error,or low-quality score.A customized MATLAB program was then used to quantify DCP morphology from the artifact-free DCP images by calculating three metrics:foveal avascular zone(FAZ),vessel density(VD),and fractal dimension(FD).Results:166(29.5%)eyes were excluded after quality control,leaving in the analysis 397 eyes(170 with no DR,101 with mild DR,90 with moderate DR,36 with severe DR)from 250 subjects.In the multiple regression models,larger FAZ area was associated with more severe DR(β=0.687;p=0.037),shorter axial length(AL)(β=−0.171;p=0.003),thinner subfoveal choroid thickness(β=−0.122;p=0.031),and lower body mass index(BMI)(β=−0.090;p=0.047).Lower VD was associated with more severe DR(β=−0.842;p=0.001),shorter AL(β=0.107;p=0.039),and poorer visual acuity(VA)(β=−0.133;p=0.021).Lower FD was associated with more severe DR(β=−0.891;p<0.001)and with older age(β=−0.142;p=0.004).Conclusions:Quantitative artifact-free DCP metrics are associated with VA,DR severity,AL,subfoveal choroidal thickness,age,and BMI in diabetic patients.The effects of ocular and systemic factors should be considered for meaningful interpretations of DCP changes in DM patients. | Fang Yao Tang Erica O.Chan Zihan Sun Raymond Wong Jerry Lok Simon Szeto Jason C.Chan Alexander Lam Clement C.Tham Danny S.Ng Carol Y.Cheung | 2020 | Eye and Vision2020，7，1： | 7 |
| 2 | In vivo imaging of structural,metabolic and functional brain changes in glaucoma显示文摘Glaucoma, the world's leading cause of irreversible blindness, is a condition for which elevated intraocular pressure is currently the only modifiable risk factor. However, the disorder can continue to progress even at reduced intraocular pressure. This indicates additional key factors that contribute to the etiopathogenesis. There has been a growing amount of literature suggesting glaucoma as a neurodegenerative disease of the visual system. However, it remains debatable whether the observed pathophysiological conditions are causes or consequences. This review summarizes recent in vivo imaging studies that helped advance the understanding of early glaucoma involvements and disease progression in the brains of humans and experimental animal models. In particular, we focused on the non-invasive detection of early structural and functional brain changes before substantial clinical visual field loss in glaucoma patients; the eye-brain interactions across disease severity; the metabolic changes occurring in the brain's visual system in glaucoma; and, the widespread brain involvements beyond the visual pathway as well as the potential behavioral relevance. If the mechanisms of glaucomatous brain changes are reliably identified, novel neurotherapeutics that target parameters beyond intraocular pressure lowering can be the promise of the near future, which would lead to reduced prevalence of this irreversible but preventable disease. | Anisha Kasi Muneeb A.Faiq Kevin C.Chan | 2019 | Neural Regeneration Research2019，14，3： | 3 |
| 3 | Neuroendocrine tumor epidemiology显示文摘 | OyvindHauso Bjorn I.Gustafsson MarkKidd Helge L.Waldum IgnatDrozdov Anthony K. C.Chan Irvin M.Modlin | 2008 | Cancer2008，，10： | 3 |
| 4 | Effect of Money Supply on Real Output and Price in China显示文摘在过去的 30 年,中国完成了显著长期的经济生长。用季度的数据,我们在在 1993 和 2008 之间的中国在真实输出和通货膨胀上学习钱供应的效果。到这个目的,我们在滤出钱供应的期望的部件以后使用钱供应震动。我们的调查结果提供在中国在真实输出和通货膨胀上支持积极、否定的钱供应震动的不对称的效果的证据。在中国的也就是说真实的 GDP 生长对否定的钱供应震动然而并非积极的钱供应震动作出回应。另外,通货膨胀对积极的钱供应震动然而并非否定的钱供应震动作出回应。我们断定人们中国稳定的钱的生长的政策的银行看起来适当。我们的学习为中国提供重要政策含意。 | Chih-Hsiang Chang Kam C.Chan Hung-Gay Fung | 2009 | China & World Economy2009，17，2： | 3 |
| 5 | A randomized controlled trial of stage‐matched intervention for smoking cessation in cardiac out‐patients显示文摘 | Sophia S. C.Chan Doris Y. P.Leung David C. N.Wong Chu‐PakLau Vivian T.Wong Tai‐HingLam | 2012 | Addiction2012，，4： | 1 |
| 6 | Prevalence of levator ani muscle injury in Chinese women after first delivery显示文摘 | S. S. C.Chan R. Y. K.Cheung A. K. W.Yiu L. L. L.Lee A. W. L.Pang K. W.Choy T. Y.Leung T. K. H.Chung | 2012 | Ultrasound Obstet Gynecol2012，，6： | 1 |
| 7 | Alleviating the Burden of Small‐for‐Size Graft in Right Liver Living Donor Liver Transplantation Through Accumulation of Experience显示文摘 | S. C.Chan C. M.Lo K. K. C.Ng S. T.Fan | 2010 | American Journal of Transplantation2010，，4： | 1 |
| 8 | One-dismensional steady-state model for damage by vaporization and liquid expulsion due to laser material interaction显示文摘 | C.Chan J.Mazumder | | 0，，11： | 1 |
| 9 | Prevalence and specificity of clinically significant red cell alloantibodies in Chinese women during pregnancy – a review of cases from 1997 to 2001显示文摘 | C. K.Lee E. S. K.Ma M.Tang C. C. K.Lam C. K.Lin L. C.Chan | 2003 | Transfusion Medicine2003，，： | 1 |
| 10 | Neuroendocrine tumor epidemiology显示文摘 | OyvindHauso Bjorn I.Gustafsson MarkKidd Helge L.Waldum IgnatDrozdov Anthony K. C.Chan Irvin M.Modlin | 2008 | Cancer2008，，10： | 1 |
| 11 | Glymphatic imaging and modulation of the optic nerve显示文摘Optic nerve health is essential for proper function of the visual system.However,the pathophysiology of certain neurodegenerative disease processes affecting the optic nerve,such as glaucoma,is not fully understood.Recently,it was hypothesized that a lack of proper clearance of neurotoxins contributes to neurodegenerative diseases.The ability to clear metabolic waste is essential for tissue homeostasis in mammals,including humans.While the brain lacks the traditional lymphatic drainage system identified in other anatomical regions,there is growing evidence of a glymphatic system in the central nervous system,which structurally includes the optic nerve.Named to acknowledge the supportive role of astroglial cells,this perivascular fluid drainage system is essential to remove toxic metabolites from the central nervous system.Herein,we review existing literature describing the physiology and dysfunction of the glymphatic system specifically as it relates to the optic nerve.We summarize key imaging studies demonstrating the existence of a glymphatic system in the optic nerves of wild-type rodents,aquaporin 4-null rodents,and humans;glymphatic imaging studies in diseases where the optic nerve is impaired;and current evidence regarding pharmacological and lifestyle interventions that may help promote glymphatic function to improve optic nerve health.We conclude by highlighting future research directions that could be applied to improve imaging detection and guide therapeutic interventions for diseases affecting the optic nerve. | Anisha Kasi Crystal Liu Muneeb A.Faiq Kevin C.Chan | 2022 | Neural Regeneration Research2022，17，5： | 1 |
| 12 | Recent perspectives in the role of chemotherapy in the management of advanced nasopharyngeal carcinoma显示文摘 | Brigette B. Y.Ma Anthony T. C.Chan | 2004 | Cancer2004，，1： | 1 |
| 13 | The Stock Market Valuation of Research and Development Expenditures显示文摘 | Louis K. C.Chan JosefLakonishok TheodoreSougiannis | 2002 | The Journal of Finance2002，，6： | 1 |
| 14 | Factors Affecting the Quality of Building Projects in Hong Kong显示文摘 | Albert P C.Chan C.M.Tam | | 0，，04： | 1 |
| 15 | The Stock Market Valuation of Research and Development Expenditures显示文摘 | Louis K. C.Chan JosefLakonishok TheodoreSougiannis | 2002 | The Journal of Finance2002，，6： | 1 |
| 16 | The partial availability of zUniversal Grammar in second language acquisition:The “failed functional features hypothesis”显示文摘 | Hawkins R C.Chan | | 0，，13： | 1 |
| 17 | Quality of life in Chinese elderly people with depression显示文摘 | Sally W. C.Chan Helen F. K.Chiu Wai‐tongChien David R.Thompson LindaLam | 2006 | Int J Geriat Psychiatry2006，，4： | 1 |
| 18 | The Level and Persistence of Growth Rates显示文摘 | Louis K. C.Chan JasonKarceski JosefLakonishok | 2003 | The Journal of Finance2003，，2： | 1 |
| 19 | Quantum ghost imaging through turbulence显示文摘 | P.B. Dixon G. Howland C.Chan C.O'Sullivan- Hale B.Rodenburg D.S.Simon J.H.Shapiro A.V.Sergienko R.W.Boyd J.C.Howell | | 0，，： | 1 |
| 20 | Use of sensory substitution devices as a model system for investigating cross-modal neuroplasticity in humans显示文摘Blindness provides an unparalleled opportunity to study plasticity of the nervous system in humans.Seminal work in this area examined the often dramatic modifications to the visual cortex that result when visual input is completely absent from birth or very early in life(Kupers and Ptito,2014).More recent studies explored what happens to the visual pathways in the context of acquired blindness.This is particularly relevant as the majority of | Amy C.Nau Matthew C.Murphy Kevin C.Chan | 2015 | Neural Regeneration Research2015，10，11： | 1 |
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