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| 1 | SHP2 regulates skeletal cell fate by modifying SOX9 expression and transcriptional activity显示文摘Chondrocytes and osteoblasts differentiate from a common mesenchymal precursor, the osteochondroprogenitor(OCP), and help build the vertebrate skeleton. The signaling pathways that control lineage commitment for OCPs are incompletely understood. We asked whether the ubiquitously expressed protein-tyrosine phosphatase SHP2(encoded by Ptpn11) affects skeletal lineage commitment by conditionally deleting Ptpn11 in mouse limb and head mesenchyme using 'Cre-lox P'-mediated gene excision.SHP2-deficient mice have increased cartilage mass and deficient ossification, suggesting that SHP2-deficient OCPs become chondrocytes and not osteoblasts. Consistent with these observations, the expression of the master chondrogenic transcription factor SOX9 and its target genes Acan, Col2a1, and Col10a1 were increased in SHP2-deficient chondrocytes, as revealed by gene expression arrays, q RT-PCR, in situ hybridization, and immunostaining. Mechanistic studies demonstrate that SHP2 regulates OCP fate determination via the phosphorylation and SUMOylation of SOX9, mediated at least in part via the PKA signaling pathway. Our data indicate that SHP2 is critical for skeletal cell lineage differentiation and could thus be a pharmacologic target for bone and cartilage regeneration. | Chunlin Zuo Lijun Wang Raghavendra M.Kamalesh Margot E.Bowen Douglas C.Moore Mark S.Dooner Anthony M.Reginato Qian Wu Christoph Schorl Yueming Song Matthew L.Warman Benjamin G.Neel Michael G.Ehrlich Wentian Yang | 2018 | Bone Research2018，6，2： | 3 |
| 2 | Targeted Ptpn11 deletion in mice reveals the essential role of SHP2 in osteoblast differentiation and skeletal homeostasis显示文摘The maturation and function of osteoblasts(OBs)rely heavily on the reversible phosphorylation of signaling proteins.To date,most of the work in OBs has focused on phosphorylation by tyrosyl kinases,but little has been revealed about dephosphorylation by protein tyrosine phosphatases(PTPases).SHP2(encoded by PTPN11)is a ubiquitously expressed PTPase.PTPN11 mutations are associated with both bone and cartilage manifestations in patients with Noonan syndrome(NS)and metachondromatosis(MC),although the underlying mechanisms remain elusive.Here,we report that SHP2 deletion in bone gamma-carboxyglutamate protein-expressing(Bglap+)bone cells leads to massive osteopenia in both trabecular and cortical bones due to the failure of bone cell maturation and enhanced osteoclast activity,and its deletion in Bglap+chondrocytes results in the onset of enchondroma and osteochondroma in aged mice with increased tubular bone length.Mechanistically,SHP2 was found to be required for osteoblastic differentiation by promoting RUNX2/OSTERIX signaling and for the suppression of osteoclastogenesis by inhibiting STAT3-mediated RANKL production by osteoblasts and osteocytes.These findings are likely to explain the compromised skeletal system in NS and MC patients and to inform the development of novel therapeutics to combat skeletal disorders. | Lijun Wang Huiliang Yang Jiahui Huang Shaopeng Pei Liyun Wang Jian Q.Feng Dian Jing Hu Zhao Henry M.Kronenberg Douglas C.Moore Wentian Yang | 2021 | Bone Research2021，9，1： | 3 |
| 3 | Primary cytomegalovirus ileitis complicated by massive gastrointestinal haemorrhage in a patient with steroid refractory Crohn’s disease显示文摘 | S. T. T.Le S. S. K.Lee L.Prideaux A. A.Block G. T. C.Moore | 2010 | Internal Medicine Journal2010，，11： | 1 |
| 4 | Posthatching development of Alligator mississippiensis ovary and testis显示文摘 | Brandon C.Moore Heather J.Hamlin Nicole L.Botteri Ashley N.Lawler Ketan K.Mathavan Louis J.Guillette | 2010 | Morphol2010，，5： | 1 |
| 5 | Posthatching development of Alligator mississippiensis ovary and testis显示文摘 | Brandon C.Moore Heather J.Hamlin Nicole L.Botteri Ashley N.Lawler Ketan K.Mathavan Louis J.Guillette | 2010 | J Morphol2010，，5： | 1 |
| 6 | Potential genotoxicity of wastewater‐contaminated pore waters with comparison to sediment toxicity and macrobenthic community composition*显示文摘 | Michael A.Lewis Carol B.Daniels James C.Moore ThomasChen | 2002 | Environ. Toxicol2002，，1： | 1 |
| 7 | Spatial variation in vehicle-derived metal pollution identified by magnetic and elemental analysis of roadsidetree leaves显示文摘 | B.A.Maher C.Moore | | 0，，02： | 1 |
| 8 | Delayed Antarctic melt season reduces albedo feedback显示文摘Antarctica’s response to climate change varies greatly both spatially and temporally.Surface melting impacts mass balance and also lowers surface albedo.We use a 43-year record(from 1978 to 2020)of Antarctic snow melt seasons from space-borne microwave radiometers with a machine-learning algorithm to show that both the onset and the end of the melt season are being delayed.Granger-causality analysis shows that melt end is delayed due to increased heat flux from the ocean to the atmosphere at minimum sea-ice extent from warming oceans.Melt onset is Granger-caused primarily by the turbulent heat flux from ocean to atmosphere that is in turn driven by sea-ice variability.Delayed snowmelt season leads to a net decrease in the absorption of solar irradiance,as a delayed summer means that higher albedo occurs after the period of maximum solar radiation,which changes Antarctica’s radiation balance more than sea-ice cover. | Lei Liang Huadong Guo Shuang Liang Xichen Li John C.Moore Xinwu Li Xiao Cheng Wenjin Wu Yan Liu Annette Rinke Gensuo Jia Feifei Pan Chen Gong | 2023 | National Science Review2023，10，9： | 0 |
| 9 | Atmospheric feedbacks on Arctic summer sea-ice anomalies in ensemble simulations of a coupled regional climate model显示文摘Ensemble simulations with the Arctic coupled regional climate model HIRHAM-NAOSIM have been analyzed to investigate atmospheric feedbacks to September sea-ice anomalies in the Arctic in autumn and the following winter. Different 'low minus high ice' composites have been calculated using selected model runs and different periods. This approach allows us to investigate the robustness of the simulated regional atmospheric feedbacks to detected sea-ice anomalies. Since the position and strength of the September sea-ice anomaly varies between the different 'low minus high ice' composites, the related simulated atmospheric patterns in autumn differ depending on the specific surface heat flux forcing through the ocean-atmosphere interface. However, irrespective of those autumn differences, the regional atmospheric feedback in the following winter is rather insensitive to the applied compositing. Neither the selection of simulations nor the considered period impacts the results. The simulated consistent large-scale atmospheric circulation pattern shows a wave-like pattern with positive pressure anomaly over the region of the Barents/Kara Seas and Scandinavia/western Russia('Scandinavian-Ural blocking') and negative pressure anomaly over the East Siberian/Laptev Seas. | Annette RINKE Dorthe HANDORF Wolfgang DORN Klaus DETHLOFF John C.MOORE Xiangdong ZHANG | 2018 | Advances in Polar Science2018，29，3： | 0 |
| 10 | 冷冻造型的“冷硬”工艺方法显示文摘1.引言“冷硬”工艺方法有如下突出的优点:清洁而便宜的粘结剂;砂子易於操作;随冷冻过程砂子透气性增加。烧注后,无烟、无臭、无灰尘,落砂容易。 | F.H.Hoult C.Moore 范芷芳 | 1991 | 铸造设备研究1991，，1： | 0 |
| 11 | Arctic sea ice and atmospheric circulation under the abrupt4xCO2 scenario显示文摘We analyze sea ice changes from eight different earth system models that have conducted experiment abrupt4xCO2 of the Coupled Model Intercomparison Project Phase 5(CMIP5). In response to abrupt quadrupling of CO2 from preindustrial levels, Arctic temperatures dramatically rise by about 10°C—16°C in winter and the seasonal sea ice cycle and sea ice concentration are significantly changed compared with the pre-industrial control simulations(pi Control). Changes of Arctic sea ice concentration are spatially correlated with temperature patterns in all seasons and highest in autumn. Changes in sea ice are associated with changes in atmospheric circulation patterns at heights up to the jet stream. While the pattern of sea level pressure changes is generally similar to the surface air temperature change pattern, the wintertime 500 h Pa circulation displays a positive Pacific North America(PNA) anomaly under abrupt4xCO2-pi Control. This large scale teleconnection may contribute to, or feedback on, the simulated sea ice cover change and is associated with an intensification of the jet stream over East Asia and the north Pacific in winter. | YU Xiaoyong Annette Rinke JI Duoying CUI Xuefeng John C.Moore | 2014 | Advances in Polar Science2014，25，4： | 0 |
| 12 | Glacier geoengineering to address sea-level rise:A geotechnical approach显示文摘It is remarkable that the high-end sea level rise threat over the next few hundred years comes almost entirely from only a handful of ice streams and large glaciers.These occupy a few percent of ice sheets’coastline.Accordingly,spatially limited interventions at source may provide globally-equitable mitigation from rising seas.Ice streams control draining of ice sheets;glacier retreat or acceleration serves to greatly increase potential sea level rise.While various climatic geoengineering approaches have been considered,serious consideration of geotechnical approaches has been limited e particularly regarding glaciers.This study summarises novel and extant geotechnical techniques for glacier restraint,identifying candidates for further research.These include draining or freezing the bed;altering surface albedo;creating obstacles:retaining snow;stiffening shear margins with ice;blocking warm sea water entry;thickening ice shelves(increasing buttressing,and strengthening fractured shelves against disintegration);as well as using regional climate engineering or local cloud seeding to cool the glacier or add snow.Not all of these ideas are judged reasonable or feasible,and even fewer are likely to be found to be advisable after further consideration.By describing and evaluating the potential and risks of a large menu of responses e even apparently hopeless ones e we can increase the chances of finding one that works in times of need. | Andrew LOCKLEY Michael WOLOVICK Bowie KEEFER Rupert GLADSTONE Li-Yun ZHAO John C.MOORE | 2020 | Advances in Climate Change Research2020，11，4： | 0 |
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