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| 1 | Carbonaceous particles in the atmosphere and precipitation of the Nam Co region, central Tibet显示文摘A continuous air and precipitation sampling for carbonaceous particles was conducted in a field observatory beside Nam Co, Central Tibetan Plateau during July of 2006 through January of 2007. Organic carbon (OC) was the dominant composition of the carbonaceous particles both in the atmosphere (1660 ng/m 3 ) and precipitation (476 ng/g) in this area, while the average elemental carbon (BC) concentrations in the atmosphere and precipitation were only 82 ng/m 3 and 8 ng/g, respectively. Very high OC/BC ratio suggested local secondary organic carbon could be a dominant contribution to OC over the Nam Co region, while BC could be mainly originated from Southern Asia, as indicated by trajectory analysis and aerosol optical depth. Comparison between the BC concentrations measured in Lhasa, those at 'Nepal Climate Observatory at Pyramid (NCO-P)' site on the southern slope of the Himalayas, and Nam Co suggested BC in the Nam Co region reflected a background with weak anthropogenic disturbances and the emissions from Lhasa might have little impact on the atmospheric environment here, while the pollutants from the Indo-Gangetic Basin of Southern Asia could be transported to the Nam Co region by both the summer monsoon and the westerly. | Jing Ming Cunde Xiao Junying Sun Shichang Kang Paolo Bonasoni | 2010 | Journal of Environmental Sciences2010，22，11： | 7 |
| 2 | SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation显示文摘Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is the ongoing global pandemic that poses substantial challenges to public health worldwide.A subset of COVID-19 patients experience systemic inflammatory response,known as cytokine storm,which may lead to death.Receptor-interacting serine/threonine-protein kinase 1(RIPK1)is an important mediator of inflammation and cell death.Here,we examined the interaction of RIPK1-mediated innate immunity with SARS-CoV-2 infection.We found evidence of RIPK1 activation in human COVID-19 lung pathological samples,and cultured human lung organoids and ACE2 transgenic mice infected by SARS-CoV-2.Inhibition of RIPK1 using multiple smallmolecule inhibitors reduced the viral load of SARS-CoV-2 in human lung organoids.Furthermore,therapeutic dosing of the RIPK1 inhibitor Nec-1s reduced mortality and lung viral load,and blocked the CNS manifestation of SARS-CoV-2 in ACE2 transgenic mice.Mechanistically,we found that the RNA-dependent RNA polymerase of SARS-CoV-2,NSP12,a highly conserved central component of coronaviral replication and transcription machinery,promoted the activation of RIPK1.Furthermore,NSP12323L variant,encoded by the SARS-CoV-2 C14408T variant first detected in Lombardy,Italy,that carries a Pro323Leu amino acid substitution in NSP12,showed increased ability to activate RIPK1.Inhibition of RIPK1 downregulated the transcriptional induction of proinflammatory cytokines and host factors including ACE2 and EGFR that promote viral entry into cells.Our results suggest that SARS-CoV-2 may have an unexpected and unusual ability to hijack the RIPK1-mediated host defense response to promote its own propagation and that inhibition of RIPK1 may provide a therapeutic option for the treatment of COVID-19. | Gang Xu Ying Li Shengyuan Zhang Haoran Peng Yunyun Wang Dekang Li Taijie Jin Zhuohao He Yilun Tong Chunting Qi Guowei Wu Kangyun Dong Jizhou Gou Yang Liu Tongyang Xiao Jing Qu Liang Li Liang Liu Ping Zhao Zheng Zhang Junying Yuan | 2021 | Cell Research2021，31，12： | 6 |
| 3 | Highly efficient catalytic scavenging of oxygen free radicals with graphene-encapsulated metal nanoshields显示文摘 | Junying Wang Xiaoju Cui Haobo Li Jianping Xiao Jiang Yang Xiaoyu Mu Haixia Liu Yuan-Ming Sun Xuhui Xue Changlong Liu Xiao-Dong Zhang Dehui Deng Xinhe Bao | 2018 | Nano Research2018，11，5： | 4 |
| 4 | Molecular identification of Echinococcus species from eastern and southern Qinghai, China, based on the mitochondrial cox1 gene显示文摘 | Junying Ma Hu Wang Gonghua Lin Philip S. Craig Akira Ito Zhenyuan Cai Tongzuo Zhang Xiumin Han Xiao Ma Jingxiao Zhang Yufang Liu Yanmei Zhao Yongshun Wang | 2012 | Parasitology Research2012，，1： | 2 |
| 5 | Chromosome G-banding in SituHybridization of RFLP Marker umc58 Linked with the Gene hm1 Dictating Helminthosporium carbonum Susceptibility1 in Maize显示文摘ChromosomeG┐bandinginSituHybridizationofRFLPMarkerumc58LinkedwiththeGenehm1DictatingHelminthosporiumcarbonumSusceptibility1in... | Deng Fengjiao Feng Xiaorong Zheng Junying Liu Ting Yi Qingming Zhang Xiyuan Xiao Hanbing Xue Zhigang | 1997 | Wuhan University Journal of Natural Sciences1997，2，2： | 2 |
| 6 | National Alveolar Echinococcosis Distribution--China, 2012−2016显示文摘What is already known about this topic?Both alveolar echinococcosis(AE)and cystic echinococcosis are endemic in China,among which alveolar echinococcosis has a very high mortality rate.What is added by this report?The survey results showed the prevalence and scope of AE in China and identified high-risk groups including children,monks,herdsmen and illiterate people.At the same time,all the cases found in the survey(more than 90%of the patients did not go to the hospital for diagnosis and treatment before survey)were promptly diagnosed and treated.What are the implications for public health practice?This study provides information for the development of a plan for AE prevention and control and for the implementation of interventions targeted to high-risk populations. | Canjun Zheng Chuizhao Xue Shuai Han Zhongjie Li Hu Wang Liying Wang Ying Wang Qian Wang Yu Feng Yanyan Hou Xiao Ma Junying Ma Xiumin Han Gongsang Quzhen Xiaofeng Jiang Weidong Guo Xianglin Wu Yaming Yang Lei Cao Fanka Li Weiqi Chen Xinliu Yan Shicheng Yu Meihua Fu Qing Yu Ning Xiao Jiangping Cao Jun Yan Weiping Wu Xiao-nong Zhou | 2020 | China CDC weekly2020，2，1： | 2 |
| 7 | Effect of organic additives on characterization of electrodeposited Co-W thin films显示文摘 | Guoying Wei Hongliang Ge Xiao Zhu Qiong Wu Junying Yu Baoyan Wang | 2007 | Applied Surface Science2007，，18： | 1 |
| 8 | Programmed albumin nanoparticles regulate immunosuppressive pivot to potentiate checkpoint blockade cancer immunotherapy显示文摘The therapeutic efficacy of programmed cell death protein 1/programmed cell death-ligand 1(PD-1/PD-L1)blockade immunotherapy is extremely dampened by complex immunosuppressive mechanisms including regulatory T cells(Treg),M2 macrophages(M2),and prostaglandin E2(PGE2).The pivotal roles of PGE2 have been recognized by directly inactivating CD8+T cells and indirectly inducing Treg and M2.Therefore,PGE2 abolishment through inactivating cyclooxygenase-2(COX-2)could be robust to sensitize tumour toward anti-PD-1/PD-L1 immunotherapy,which has gone into clinical trials.However,exploring this promising strategy in nanomedicine to enhance immunotherapy remains unrevealed.The key challenge to synergistically combine COX-2 inhibition and anti-PD-1/PD-L1 lies in the different pharmacokinetic profiles and the spatial obstacles since PD-1/PD-L1 interaction occurs extracellularly and COX-2 locates intracellularly.Thus,the programmed release nanoparticles(termed as Cele-BMS-NPs)are rationally designed,which are composed of pH-sensitive human serum albumin derivative,BMS-202 compound as PD-1/PD-L1 inhibitor,glutathione(GSH)-activatable prodrug of celecoxib(COX-2 inhibitor).The in vitro experiments demonstrate that this smart Cele-BMS-NPs could extracellularly release BMS-202 under the acidic tumour microenvironment,and the intracellularly release of celecoxib in response to the elevated GSH concentration inside tumour cells.After systemic administration,the intratumoral infiltration of CD8+T cells is significantly enhanced and meanwhile immunosuppressive M2,Treg,and PGE2 are reduced,thereby eliciting the anti-tumour immune responses toward low immunogenic tumours and postsurgical tumour recurrences. | Liandong Feng Li Yang Longjie Li Junying Xiao Nana Bie Chao Xu Jun Zhou Hongmei Liu Lu Gan Yuzhou Wu | 2022 | Nano Research2022，15，1： | 1 |
| 9 | Mapping QTLs for Phosphorus-Deficiency Tolerance at Wheat Seedling Stage显示文摘 | Junying Su Yanmei Xiao Ming Li Quanyou Liu Bin Li Yiping Tong Jizeng Jia Zhensheng Li | 2006 | Plant and Soil2006，，1： | 1 |
| 10 | Mapping QTLs for Phosphorus-Deficiency Tolerance at Wheat Seedling Stage显示文摘 | Junying Su Yanmei Xiao Ming Li Quanyou Liu Bin Li Yiping Tong Jizeng Jia Zhensheng Li | 2006 | Plant and Soil (-)2006，，1： | 1 |
| 11 | Reducing Canine Echinococcus Infection with Smart Deworming Collars--Tibet,China,June-November,2020显示文摘What is already known about this topic?Existing manual deworming programs launched have made great progress in reducing the Echinococcus infection rate of domestic dogs,but significant challenges remain in scattered nomadic communities inhabiting the Tibetan Plateau.The low deworming frequency and low levels of coverage were responsible for the high infection rate of Echinococcus spp.among dogs.What is added by this report?Smart deworming collars controlled by a remote management system(RMS)was found to increase the deworming frequency and coverage and subsequently reduce the canine infection rates with Echinococcus spp..What are the implications for public health practice?As an innovative tool,smart deworming collars may drive the paradigm shift from manual deworming to smart deworming and stop the transmission of echinococcosis. | Shijie Yang Ning Xiao Jingzhong Li Gongsang Quzhen Junying Ma Qing Yu Zhaohui Luo Huasheng Pang Danzeng Quzhen Suolang Wangjie Xiao-nong Zhou | 2020 | China CDC weekly2020，2，51： | 1 |
| 12 | Mapping QTLs for phosphorus-deficiency tolerance at wheat seedling stage显示文摘 | Su JunYing Xiao YanMei Li Ming | 2006 | Plant and S0il2006，281，： | 1 |
| 13 | Mapping QTLs for Phosphorus-Deficiency Tolerance at Wheat Seedling Stage显示文摘 | Junying Su Yanmei Xiao Ming Li Quanyou Liu Bin Li Yiping Tong Jizeng Jia Zhensheng Li | 2006 | Plant and Soil (-)2006，，1： | 1 |
| 14 | PML–LRIF1 interactions form a novel link between promyelocytic leukemia bodies and centromeres显示文摘Dear Editor,Promyelocytic leukemia(PML)is the scaffold protein that organizes PML bod-ies,which are nuclear membraneless organelles involved in various biologi-cal processes,including tumor suppres-sion and antiviral responses(Ugge et al.,2022).Early electron microscopic analy-ses revealed contacts between the sur-face of PML bodies and chromatin struc-ture(Corpet et al.,2020).In fact,sev-eral chromatin and cell cycle regulators,such as TIP60,P300,and heterochro-matin protein 1(HP1),are localized in PML bodies in interphase cells(Corpet et al.,2020). | Junying Li Xiao Yuan Fengrui Yang Jun Cao Chunyue Wang Saima Akram Peng Zou Felix Aikhionbare Xuejun Li Yong Chen Liangyu Zhang Chuanhai Fu Zhikai Wang Xing Liu Xuebiao Yao | 2023 | Journal of Molecular Cell Biology2023，15，6： | 0 |
| 15 | 2 - 21 Progress Report on Lanzhou Penning Trap (LPT)显示文摘 | HuangWenxue Tian Yulin Wang Junying Wang Yongsheng Sun Yuliang Zhao Jianmin Wang Yue Wu Wei He Yuan Ma Lizhen Xu Hushan Xiao Guoqing | 2012 | IMP & HIRFL Annual Report2012，，1： | 0 |
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