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| 1 | A virtual experiment showing single particle motion on a linearly vibrating screen-deck显示文摘A virtual sieving experimental simulation system was built using physical simulation principles.The effects of vibration frequency and amplitude,the inclination angle of the screen-deck and the vibration direction angle of screen on single particle kinematics were predicted.Properties such as the average velocity and the average throw height were studied.The results show that the amplitude and the angle of vibration have a great effect on particle average velocity and average height.The vibration frequency and the screen-deck inclination angle appear to have little influence on these responses.For materials that are difficult to screen the vibration frequency and amplitude,the screen-deck inclination angle and the vibration angle should be set to 14 Hz,6.6 mm,6° and 40°,respectively,to obtain optimal particle kinematics.A screening process can be simulated reliably by means of a virtual experiment and these results provide references for both screening theory research and sieving practice. | ZHAO, Lala LIU, Chusheng YAN, Junxia | 2010 | Mining Science and Technology2010，20，2： | 11 |
| 2 | Vertical distribution of aerosol optical properties based on aircraft measurements over the Loess Plateau in China显示文摘Vertical distributions of aerosol optical properties based on aircraft measurements over the Loess Plateau were measured for the first time during a summertime aircraft campaign, 2013 in Shanxi, China. Data from four flights were analyzed. The vertical distributions of aerosol optical properties including aerosol scattering coefficients(σsc), absorption coefficients(σab),Angstr?m exponent(α), single scattering albedo(ω), backscattering ratio(βsc), aerosol mass scattering proficiency(Q sc) and aerosol surface scattering proficiency(Q sc′) were obtained. The mean statistical values of σsc were 77.45 Mm-1(at 450 nm), 50.72 Mm-1(at 550 nm), and32.02 Mm-1(at 700 nm). The mean value of σab was 7.62 Mm-1(at 550 nm). The mean values ofα, βsc and ω were 1.93, 0.15, and 0.91, respectively. Aerosol concentration decreased with altitude. Most effective diameters(ED) of aerosols were less than 0.8 μm. The vertical profiles of σsc,, α, βsc, Q sc and Q sc′ showed that the aerosol scattering properties at lower levels contributed the most to the total aerosol radiative forcing. Both α and βsc had relatively large values, suggesting that most aerosols in the observational region were small particles. The mean values of σsc, α, βsc, Q sc, Q sc′, σab and ω at different height ranges showed that most of the parameters decreased with altitude. The forty-eight hour backward trajectories of air masses during the observation days indicated that the majority of aerosols in the lower level contributed the most to the total aerosol loading, and most of these particles originated from local or regional pollution emissions. | Junxia Li Xingang Liu Liang Yuan Yan Yin Zhanqing Li Peiren Li Gang Ren Lijun Jin Runjun Li Zipeng Dong Yiyu Li Junmei Yang | 2015 | Journal of Environmental Sciences2015，27，8： | 6 |
| 3 | Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms显示文摘Iron homeostasis is essential for health;moreover,hepcidin-deficiency results in iron overload in both hereditary hemochromatosis and iron-loading anemia.Here,we identified iron modulators by functionally screening hepcidin agonists using a library of 640 FDA-approved drugs in human hepatic Huh7 cells.We validated the results in C57BL/6J mice and a mouse model of hemochromatosis(Hfe^(−/−)mice).Our screen revealed that the anti-rheumatoid arthritis drug auranofin(AUR)potently upregulates hepcidin expression.Interestingly,we found that canonical signaling pathways that regulate iron,including the Bmp/Smad and IL-6/Jak2/Stat3 pathways,play indispensable roles in mediating AUR’s effects.In addition,AUR induces IL-6 via the NF-κB pathway.In C57BL/6J mice,acute treatment with 5 mg/kg AUR activated hepatic IL-6/hepcidin signaling and decreased serum iron and transferrin saturation.Whereas chronically treating male Hfe^(−/−)mice with 5 mg/kg AUR activated hepatic IL-6/hepcidin signaling,decreasing systemic iron overload,but less effective in females.Further analyses revealed that estrogen reduced the ability of AUR to induce IL-6/hepcidin signaling in Huh7 cells,providing a mechanistic explanation for ineffectiveness of AUR in female Hfe^(−/−)mice.Notably,high-dose AUR(25 mg/kg)induces ferroptosis and causes lipid peroxidation through inhibition of thioredoxin reductase(TXNRD)activity.We demonstrate the ferroptosis inhibitor ferrostatin significantly protects liver toxicity induced by highdose AUR without comprising its beneficial effect on iron metabolism.In conclusion,our findings provide compelling evidence that TXNRD is a key regulator of ferroptosis,and AUR is a novel activator of hepcidin and ferroptosis via distinct mechanisms,suggesting a promising approach for treating hemochromatosis and hepcidin-deficiency related disorders. | Lei Yang Hao Wang Xiang Yang Qian Wu Peng An Xi Jin Weiwei Liu Xin Huang Yuzhu Li Shiyu Yan Shuying Shen Tingbo Liang Junxia Min Fudi Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 4 | Estimating life-cycle energy payback ratio of overhead transmission line toward low carbon development显示文摘The energy conservation plays an important role for low carbon development.In order to evaluate the energy conservation in the full life-cycle,a scheme to estimate the energy consumption,or alternatively the energy pay,in constructing an overhead transmission line is proposed in this paper.The analysis of a typical projection is given for demonstration.With new additional overhead transmission lines,the energy consumption,known as the power loss in power network,is expected to be decline,which is defined in this paper as the energy payback.In order to estimate this kind of contribution,the scheme that consisted of load forecast,production simulation for generating systems,load flow simulation and power loss calculation has been proposed.Case studies,based on the IEEE 24-bus test system,are given to demonstrate the efficacy of the schemes.Moreover,several presumptive scenarios are deployed and analysed with the presented schemes for comparison. | Xiaoming DONG Chongqing KANG Ning ZHANG Huaguang YAN Junxia MENG Xinsheng NIU Xin TIAN | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，1： | 5 |
| 5 | The structure of erastin-bound xCT-4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis显示文摘Dear Editor,Ferroptosis is an iron-dependent,non-apoptotic form of regulated cell death characterized by an accumulation of lipid.derived reactive oxygen species(ROS).The small-molecule compo und erastin in duces ferroptosis via in hibiti ng the cystineglutamate antiporter system x_(c).which consists of two subunits,namely the light chain xCT and the heavy chain 4F2hc(encoded by the SLC7A11 and SLC3A2 genes,respectively).^(1-4) | Renhong Yan Enjun Xie Yaning Li Jin Li Yuanyuan Zhang Ximin Chi Xueping Hu Lei xu Tingjun Hou Brent R.Stockwell Junxia Min Qiang Zhou Fudi Wang | 2022 | Cell Research2022，32，7： | 4 |
| 6 | The terrestrial locomotion of a mole cricket with foreleg amputation显示文摘Mole cricket is a unique insect, it not only can dig and excavate under ground with its specialized forelimb, but also can achieve terrestrial locomotion. This study focused on the difference of kinematics between mole crickets and normal insects in terrestrial walking. In order to study the function of the specialized foreleg, the adjustments made to the foreleg amputation were discussed by analyzing the motion ability, gait, and body posture of the mole cricket with and without forelegs. The results show that mole crickets walk in terrestrial locomotion by using a special tripod gait, with the clumsy foreleg not as functional as normal hexapods. Mole cricket can make corresponding adjustments for the situation of missing forelegs, and achieve required motion stability with remained four legs. | ZHANG Yan ZHANG JunXia REN LuQuan | 2015 | Science China(Technological Sciences)2015，58，6： | 3 |
| 7 | Synthesis and gelation behaviors of five new dimeric cholesteryl derivatives显示文摘Five new diacid amides of di-cholesteryl L-glycinates were designed and prepared.The compounds with linkers containing 0,1, 2,3,or 4 methylene units are denoted as 1,2,3,4,and 5,respectively.Their gelation behaviors in 25 solvents were tested as novel low-molecular-mass organic gelators(LMOGs).It was shown that the length of the linker connecting the two-cholesteryl residues in a gelator plays a crucial role in the gelation behavior of the compound.1 gels 11 of the 25 solvents tested at a concentration lower than 1.0%,while 2 gels 17 of the solvents tested.4 and 5,however,gel only 2 and 4 of them,respectively. SEM observation reveals that the lengths of the linkers and the identity of the solvents are the main factors affecting the structures of the aggregates in the gels.Experimentally,a clear linker effect on the microstructures of the gels was observed.As example,the aggregates of 1,2 and 3 in benzene or 1-heptanol adopt structures of thin fibers,rods or lamellas,respectively. Furthermore,it was found that the gelation and aggregation behaviors of 2,3,4,and 5 in DMSO showed an even-odd effect. | LIU KaiQiang PENG JunXia XUE Min YAN Ni LIU Jing FANG Yu | 2011 | Science China Chemistry2011，54，3： | 2 |
| 8 | Motion Characteristics of the Appendages of Mole Crickets during Burrowing显示文摘Mole crickets,Gryllotalpa orientalis,have a pair of fully specialized forelegs for burrowing and employ an efficient underground excavating pattern,which provides excellent biological example for design of bionic underground excavation equipment.In this study,the excavating pattern and kinematic features of mole crickets were obtained by using high-speed motion capture system and employing a transparent hydrogel as the analogue for soil.The two-dimensional motion characteristics of the forelegs of mole crickets during burrowing were captured and analyzed.The results show that the forelegs of the mole cricket employ a unique excavating pattern,which consists of foreword digging and horizontal expansion.We label this pattern a digging-expanding mode.An excavating cycle includes the digging and expanding motion of the forelegs,rotation caused by the midlegs and hindlegs,and forward thrust by the hindlegs.The excavating motion of the left and right forelegs is alternately carried out.This study can inspire the design of bionic tunnelling mechanisms and underground excavation equipment. | Yan Zhang Jiafeng Cao Qi Wang Pengfei Wang Yueying Zhu Junxia Zhang | 2019 | Journal of Bionic Engineering2019，16，2： | 1 |
| 9 | The effects of restricting the flexion-extension motion of the first metatarso- phalangeal joint on human walking gait 显示文摘 | ZHANG Junxia SI Ying ZHANG Yan | 2014 | Biomed Mater Eng2014，24，6： | 1 |
| 10 | A reactive molecular dynamics study of n?heptane pyrolysis at high temperature显示文摘 | Ding Junxia Zhang Liang Zhang Yan | 2013 | The Journal of Physical Chemistry2013，117，16： | 1 |
| 11 | Salvianolic Acid B Attenuates Rat Hepatic Fibrosis via Downregulating Angiotensin II Signaling显示文摘 | Shu Li Lina Wang Xiuchuan Yan Qinglan Wang Yanyan Tao Junxia Li Yuan Peng Ping Liu Chenghai Liu Adair Roberto Soares Santos | 2012 | <journal-title>Evidence-Based Complementary and Alternative Medicine2012，，： | 1 |
| 12 | Methane reforming with carbon dioxide to synthesis gas over Co-doped Ni-based magnetoplumbite catalysts显示文摘 | Wang Junxia Liu Yan Cheng Tiexin | 2003 | Applied Catalysis A:General2003，250，： | 1 |
| 13 | Signifi cance of soil temperature and moisture for soil respiration in a Chinese mountain area显示文摘 | Li Hongjian Yan Junxia Yue Xiaofeng | 2008 | Agricultural and Forest Meteorology2008，148，3： | 1 |
| 14 | Haemorrhage risk of brain arteriovenous malformation during pregnancy and puerperium显示文摘Background This study aimed to assess whether pregnancy and puerperium were associated with the risk of brain arteriovenous malformation(bAVM)haemorrhage.Methods A retrospective review was conducted in Xiangya Hospital,Central South University from January 2012 to December 2021.A case-crossover design was adopted to calculate the incidence density of bAVM-related haemorrhage among female patients in risk(pregnancy and puerperium)and control(non-pregnancy and non-puerperium)periods,according to four scenarios observed in different populations scenario I:patients with haemorrhagic bAVM of all ages;scenario II:patients with haemorrhagic bAVM of all ages,with at least one previous pregnancy;scenario III:patients with haemorrhagic bAVM who are of reproductive age(15-45 years);scenario IV:patients with haemorrhagic bAVM of reproductive age(15-45 years),with at least one previous pregnancy.Next,a comprehensive literature aggregation(up to April 2022)was performed for evidence synthesis.Results Among the 311 female patients with haemorrhagic bAVM,a significant haemorrhage risk during pregnancy and puerperium was found in Scenarios I(relative risk[RR],2.08;95%CI,1.28 to 3.39),II(RR,3.21;95%CI,1.95 to 5.31)and IV(RR,2.92;95%CI,1.73 to 4.93);however,a suggestive risk was found in scenario III(RR,1.62;95%CI,0.99 to 2.67).Evidence synthesis revealed a consistent haemorrhage risk among patients of all ages(RR,3.15;95%CI,1.93 to 5.15)and those of reproductive age(RR,1.29;95%CI,0.89 to 1.86).Conclusion Compared with most previous studies,a higher but relatively moderate risk for bAVM-related haemorrhage was identified during pregnancy and puerperium.Individualised prevention and treatment strategies should be preferred when neurosurgeons make clinical decisions. | Junyu Liu Honghao Zhang Chun Luo Yuxin Guo Yifeng Li Dun Yuan Weixi Jiang Junxia Yan | 2023 | Stroke & Vascular Neurology2023，8，4： | 1 |
| 15 | Five‐Year Soil Respiration Reflected Soil Quality Evolution in Different Forest and Grassland Vegetation Types in the Eastern Loess Plateau of China显示文摘 | Junxia Yan Liangfu Chen JunJian Li Hongjian Li | 2013 | Clean Soil Air Water2013，，7： | 1 |
| 16 | Labile and Recalcitrant Organic Matter and Microbial Communities in Soil After Conversion of Abandoned Lands in the Loess Plateau, China显示文摘 | Junjian Li Hongjian Li Xiaomei Zhou Xi Zhao Junxia Yan | 2011 | Soil Science2011，，6： | 1 |
| 17 | EphA3 deficiency in the hypothalamus promotes high-fat diet-induced obesity in mice显示文摘Erythropoietin-producing hepatocellular carcinoma A3(EphA3)is a member of the largest subfamily of tyrosine kinase receptors-Eph receptors.Previous studies have shown that EphA3 is associated with tissue development.Recently,we have found that the expression of EphA3 is elevated in the hypothalamus of mice with diet-induced obesity(DIO).However,the role of EphA3 in hypothalamic-controlled energy metabolism remains unclear.In the current study,we demonstrated that the deletion of EphA3 in the hypothalamus by CRISPR/Cas9-mediated gene editing promotes obesity in male mice with high-fat diet feeding rather than those with normal chow diet feeding.Moreover,the deletion of hypothalamic EphA3 promotes high-fat DIO by increasing food intake and reducing energy expenditure.Knockdown of EphA3 leads to smaller intracellular vesicles in GT1-7 cells.The current study reveals that hypothalamic EphA3 plays important roles in promoting DIO. | Jubiao Zhang Yang Chen Lihong Yan Xin Zhang Xiaoyan Zheng Junxia Qi Fen Yang Juxue Li | 2023 | The Journal of Biomedical Research2023，37，3： | 0 |
| 18 | Junctional and somatic hypermutation-induced CX4C motif is critical for the recognition of a highly conserved epitope on HCV E2 by a human broadly neutralizing antibody显示文摘Induction of broadly neutralizing monoclonal antibodies(bNAbs)that bind to the viral envelope glycoproteins is a major goal of hepatitis C virus(HCV)vaccine research.The study of bNAbs arising in natural infection is essential in this endeavor.We generated a human antibody,8D6,recognizing the E2 protein of HCV isolated from a chronic hepatitis C patient.This antibody shows broadly neutralizing activity,which covers a pan-genotypic panel of cell culture-derived HCV virions(HCVcc).Functional and epitope analyses demonstrated that 8D6 can block the interaction between E2 and CD81 by targeting a highly conserved epitope on E2.We describe how the 8D6 lineage evolved via somatic hypermutation to achieve broad neutralization.We found that the V(D)J recombination-generated junctional and somatic hypermutation-induced disulfide bridge(C-C)motif in the CDRH3 is critical for the broad neutralization and binding activity of 8D6.This motif is conserved among a series of broadly neutralizing HCV antibodies,indicating a common binding model.Next,the 8D6 inferred germline(iGL)was reconstructed and tested for its binding affinity and neutralization activity.Interestingly,8D6 iGL-mediated relatively strong inhibition of the 1b genotype PR79L9 strain,suggesting that PR79L9 may serve as a potential natural viral strain that provides E2 sequences that induce bNAbs.Overall,our detailed epitope mapping and genetic studies of the HCV E2-specific mAb 8D6 have allowed for further refinement of antigenic sites on E2 and reveal a new mechanism to generate a functional CDRH3,while its iGL can serve as a probe to identify potential HCV vaccine strains. | Chunyan Yi Jing Xia Lan He Zhiyang Ling Xuesong Wang Yu Yan Jiangjun Wang Xinhao Zhao Weiguo Fan Xiaoyu Sun Ronghua Zhang Sheng Ye Rongguang Zhang Yongfen Xu Liyan Ma Yaguang Zhang Honglin Zhou Zhong Huang Junqi Niu Gang Long Junxia Lu Jin Zhong Bing Sun | 2021 | Cellular & Molecular Immunology2021，18，3： | 0 |
| 19 | 4 - 5 Observation of Enhanced Schottky Signals of RF-bunched C3+ Ion Beam at the CSRe显示文摘 | Wen Weiqiang Ma Xinwen Wang Hanbing Huang Zhongkui Zhang Dacheng Zhu Xiaolong Zhao Dongmei Li Jie Ma Xiaoming Yan Tailai Mao Ruishi Zhao Tiecheng Wu Junxia Yang Jiancheng Yuan Youjin Xia Jiawen Michael Bussmann | 2013 | IMP & HIRFL Annual Report2013，，1： | 0 |
| 20 | 4 - 10 Test Experimental Results for Laser Cooling of C3+ Ions at CSRe显示文摘 | Wang Hanbing Ma Xinwen Wen W eiqiang Huang Zhongkui Zhang Dacheng Zhu Xiaolong Zhao Dongmei Li Jie Ma Xiaoming Yan Tailai Mao Ruishi Zhao Tiecheng Wu Junxia Yang Jiancheng Yuan Youjin Xia Jiawen Michael Bussmann | 2013 | IMP & HIRFL Annual Report2013，，1： | 0 |
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