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| 1 | Potassium Channels: A Potential Therapeutic Target for Parkinson's Disease显示文摘The pathogenesis of the second major neurodegenerative disorder, Parkinson's disease(PD), is closely associated with the dysfunction of potassium(K^+ ) channels. Therefore, PD is also considered to be an ion channel disease or neuronal channelopathy. Mounting evidence has shown that K^+ channels play crucial roles in the regulations of neurotransmitter release, neuronal excitability, and cell volume. Inhibition of K^+ channels enhances the spontaneous firing frequency of nigral dopamine(DA)neurons, induces a transition from tonic firing to burst discharge, and promotes the release of DA in the striatum.Recently, three K^+ channels have been identified to protect DA neurons and to improve the motor and non-motor symptoms in PD animal models: small conductance(SK)channels, A-type K^+ channels, and KV7/KCNQ channels.In this review, we summarize the physiological and pharmacological effects of the three K^+ channels. We also describe in detail the laboratory investigations regarding K^+ channels as a potential therapeutic target for PD. | Xiaoyan Chen Bao Xue Jun Wang Haixia Liu Limin Shi Junxia Xie | 2018 | Neuroscience Bulletin2018，34，2： | 13 |
| 2 | The transmission link of CAPS navigation and communication system显示文摘The Chinese Area Positioning System (CAPS) is based on communication satellites with integrated capability, which is different from the Global Positioning System (GPS), the International Maritime Satellite Organization (Inmarsat) and so on. CAPS works at C-band, and its navigation information is not directly generated from the satellite, but from the master control station on the ground and transmitted to users via the satellite. The slightly inclined geostationary-satellite orbit (SIGSO) satellites are adopted in CAPS. All of these increase the difficulty in the design of the system and terminals. In this paper, the authors study the CAPS configuration parameters of the navigation master control station, information transmission capability, and the selection of the antenna aperture of the communication center station, as well as the impact of satellite parameters on the whole communication system from the perspective of the transmission link budget. The conclusion of availability of the CAPS navigation system is achieved. The results show that the CAPS inbound communication system forms a new low-data-rate satellite communication system, which can accommodate mass communication terminals with the transmission rate of no more than 1 kbps for every terminal. The communication center station should be configured with a large-aperture antenna (about 10-15 m); spread spectrum com- munication technology should be used with the spreading gain as high as about 40 dB; reduction of the satellite transponder gain attenuation is beneficial to improving the signal-to-noise ratio of the system, with the attenuation value of 0 or 2 dB as the best choice. The fact that the CAPS navigation system has been checked and accepted by the experts and the operation is stable till now clarifies the rationality of the analysis results. The fact that a variety of experiments and applications of the satellite communication system designed according to the findings in this paper have been successfully carried out confirms the correctness of the study results. | CUI JunXia SHI HuLi CHEN JiBin PEI Jun | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，3： | 6 |
| 3 | An HDR Imaging Method With DTDI Technology for Push-Broom Cameras显示文摘通常,高动态范围(HDR ) 成像基于拿二或有不同暴露的一样的景色的更多的图画。由于在照相机和景色之间的一个高速度的相对运动,然而,要用于推扫帚遥感照相机,为这种技术是难的。为在推扫帚遥感应用的 HDR 成像的缘故,现在的纸建议没有冗余的图象传感器或光部件,能产生 HDR 图象的一个创新方法。明确地,这份报纸与数字领域 time-delay-integration (DTDI ) 采用一个区域数组互补金属氧化物半导体(互补金属氧化物半导体) 为成像的技术而不是多于一个排图象传感器采用,从而与不同暴露拍摄超过一张照片。然后由与一个简单算法熔化二幅原来的图象的一幅新 HDR 图象能被完成。由进行实验,图象的动态范围(医生) 由 26.02 dB 增加。建议方法被证明有效并且在在照相机和场面之间有一个相对运动的另外的成像应用有潜力。 | Wu SUN Chengshan HAN Xucheng XUE Hengyi LV Junxia SHI Changhong HU Xiangzhi LI Yao FU Xiaonan JIANG Liang HUANG Hongyin HAN | 2018 | Photonic Sensors2018，8，1： | 4 |
| 4 | Ghrelin Reduces A-Type Potassium Currents in Dopaminergic Nigral Neurons via the PLC/PKCδPathway显示文摘Dear Editor,Ghrelin,an endogenous ligand of growth hormone secretagogue receptor 1a(GHS-R1a),is a 28-amino-acid peptide that regulates growth hormone secretion,metabolism,food intake,mood,cognition,memory,and neuroprotection[1-3]. | Bao Xue Chen Li Xiaoli Chang Hong Jiang Limin Shi Junxia Xie | 2020 | Neuroscience Bulletin2020，36，8： | 3 |
| 5 | Electrochemical incineration of high concentration azo dye wastewater on the in situ activated platinum electrode with sustained microwave radiation显示文摘 | Guohua Zhao Junxia Gao Wei Shi | 2009 | Chemosphere2009，77，2： | 1 |
| 6 | ACIMMYR2, an Inhib- itor of Dicer-Mediated Biogenesis of Oncomir miR-21, Reverses Epithelial- Mesenchymal Transition and Suppresses Tumor Growth and Progression显示文摘 | Zhendong Shi Junxia Zhang Xiaomin Qian | 2013 | Cancer Res2013，73，17： | 1 |
| 7 | High-resolution linkage and quantitative trait locus mapping using an interspecific cross between Argopecten irradians irradians(♀) and A. purpuratus (♂)显示文摘The bay scallop and Peruvian scallop are economically important species.Interspecific hybrids of these two scallops outperformed both of their parent species in multiple growth traits but exhibited decreased fertility,which provides good models for the study of heterosis and species divergence.Genetic mapping serves as a chromosomal-level framework to investigate the molecular mechanisms of hybridization and introgression.In this study,high-resolution linkage maps were constructed for the bay and Peruvian scallops with an interspecific hybrid family.The linkage map of the bay scallop covered over 98.9% of the whole genome with 2994 mapped markers and the average marker interval of 0.32 cM.For the Peruvian scallop,1585 markers were mapped with the average maker interval of 0.51 cM,covering 97.7% of the genome.Both the two linkage maps have 16 linkage groups,corresponding to the haploid chromosome number of the two species.Approximately,54.5% of markers exhibited significant deviation from the expected Mendelian ratio of segregation,lending in sights into the intrinsic incompatibility between the two species.QTLs related to growth and shell coloration were detected,which could explain 13.1%and 74.9% of the phenotypic variance,respectively.This represents important information for further evaluation.These findings are an important addition to the genomic resources for scallop genetic studies,and are especially useful for investigations on genomic incompatibility for hybridization,genome evolution of closely related species,and genetic enhancement programs in aquaculture. | Junxia Mao Qifan Zeng Zujing Yang Haoyuan Pan Lijie Yao Zhenmin Bao Chunde Wang Shi Wang | 2020 | Marine Life Science & Technology2020，2，2： | 1 |
| 8 | 显示文摘 | Gao Junxia Zhao Guohua Shi Wei | 2009 | Chemo- sphere2009，75，4： | 1 |
| 9 | SNPs and haplotypes in the S100B gene reveal association with schizophrenia显示文摘 | Jixia Liu Yongyong Shi Junxia Tang | 2005 | Biothem Biophys Res Commun2005，328，1： | 1 |
| 10 | Microwave activated electrochemical degradation of 2,4-dichlorophenoxyacetic acid at boron-doped diamond electrode显示文摘 | GAO Junxia ZHAO Guohua SHI Wei | 2009 | Chemosphere2009，75，4： | 1 |
| 11 | Diverse communities of arbuscular mycorrhizal fungi inhabit sites with very high alti- tude in Tibet Plateau显示文摘 | Liu Yongjun He Junxia Shi Guoxi etal | 2011 | FEMS Microbiology Ecology2011，78，2： | 1 |
| 12 | Up regulated expression of peroxisome proliferator activated receptor γ in the hypothalamic-pituitary adrenal axis of weaned pigs after Eseherichia eoli lipopolysaecharide ehallenge显示文摘 | Liu Yulan Shi Junxia Lu Jing | 2010 | The Veterinary Journal2010，184，2： | 1 |
| 13 | Leucine-rich glioma-inactivated protein 1 antibody-mediated autoimmune encephalitis in a 4-year-old girl:a case report显示文摘Background:Leucine-rich glioma-inactivated protein 1(LGI1)antibody-mediated encephalitis is a rare subtype of autoimmune encephalopathy,which is associated with autoimmunity against the neuronal plasma membrane proteins.The characteristic symptoms of this disease are memory dysfunction,seizures,faciobrachial dystonic seizures,cognitive deficits,neuropsychiatric disturbances,and intractable hyponatremia.The diagnosis of this disease mainly depends on the presence of anti-LGI1 antibody in serum or cerebrospinal fluid of patients.LGI1 antibody encephalitis has been reported mostly in adults,with rare occurrences in children.Case presentation:In this report,we described a 4-year-old girl with typical seizures.Seizure types included focal seizures and generalized tonic-clonic seizures.The electroencephalogram findings showed focal discharges.Brain magnetic resonance imaging(MRI)showed normal.The cerebrospinal fluid(CSF)levels of cells,glucose,and chloride were within the normal range,and the culture did not reveal growth of any pathogen.Test of serum LGI1-Ab was positive,while the tests for autoimmune encephalitis antibody series in CSF were negative.The seizures of the patient were completely controlled after the therapy of immunoglobulin,methylprednisolone and antiepileptic drugs(AEDs),and the mental state almost returned to normal.Conclusion:To our knowledge,the patient described here may be the youngest case of LGI1 antibody encephalitis reported to date.Children with the LGI1 antibody-associated encephalitis may present only with single symptoms such as epileptic seizures and have good response to the therapy of immunoglobulin,methylprednisolone and antiepileptic drugs.Our case report will provide hints for pediatricians in the diagnosis and treatment of LGI1-antibody encephalitis. | Junxia Luo Jianguo Shi Yehong Chen Wandong Hu Yujie Guo Guangshun Hou Zaifen Gao | 2021 | Acta Epileptologica2021，3，1： | 1 |
| 14 | hsa-mir-181a and hsa-mir-181b function as tumor suppressors in human glioma cells显示文摘 | Lei Shi Zihao Cheng Junxia Zhang Rui Li Peng Zhao Zhen Fu Yongping You | 2008 | Brain Research2008，，： | 1 |
| 15 | Trends in the Beijing cesarean section rate and reasons for the fluctuations显示文摘To the Editor:Cesarean section(CS)resolves dystocia and serious pregnancy-related complications but also has adverse outcomes such as long recovery time,uterine rupture,and dangerous placenta previa in future pregnancies.The increase in cesarean section rates(CsRs)worldwide has drawn the attention of international scholars. | Ruifen Zhao Li Zhou Weiyuan Zhang Moning Guo Xiaohong Deng Chenghong Yin Jianxia Wei Junxia Shi Xueying Wang Yi Feng | 2022 | Chinese Medical Journal2022，，12： | 0 |
| 16 | Correction to:Leucine-rich gliomainactivated protein 1 antibody-mediated autoimmune encephalitis in a 4-year-old girl:a case report显示文摘Correction to:Acta Epileptologica 3,4(2021)http://gffzzd3cc09b8251d45dfsv0pw69ww5c6u6xpp.ffgz.tsg.suse.edu.cn/10.1186/s42494-021-00039-z After publication of this article[1],it is reported the below corrections need to be made with it.1.The following sentence need to be added to the end of‘Background’section:“This study was approved by the Institutional Ethics Committee of Qilu Children’s Hospital of Shandong University and informed consent has been obtained from the guardian of patient prior to analysis.” | Junxia Luo Jianguo Shi Yehong Chen Wandong Hu Yujie Guo Guangshun Hou Zaifen Gao | 2021 | Acta Epileptologica2021，3，1： | 0 |
| 17 | 6-9 CW Beam Test of the Injector II RFQ for ADS Project显示文摘As one of the main components of the injector II of China ADS LINAC project, an RFQ working at 162.5 MHzis used to accelerate proton beams of 15 mA from 30 keV to 2.1 MeV. The four vane RFQ has been designed incollaboration with Lawrence Berkeley National Laboratory and built at the workshop of the Institute of ModernPhysics, Chinese Academy of Sciences (IMP, CAS). | Zhang Zhouli He Yuan Shi Aimin Sun Liepen Zhang Bin Jia Huan Wang Jing Pan Gang Shi Longbo Xu Xianbo Li Chenxing Wang Wenbin Wang Xianwu Wu Junxia Wu Qi Zhang Junhui Zhu Tieming Guo Yuhui Zhao Hongwei Liu Yong D. Li S. Virostek M. Hoff A. Lambert J. Staples | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 18 | Effect of carboxymethyl konjac glucomannan coating on curcumin-loaded multilayered emulsion:stability evaluation显示文摘The stability against various environmental stresses of the curcumin-loaded secondary and tertiary emulsions that was emulsified by whey protein isolate(WPI)and coated by chitosan(CHI),carboxymethyl konjac glucomannan(CMKGM),or their combination through layer-by-layer assembly was investigated.Generally,the multilayered emulsions were destabilized in high Na Cl concentrations or medium p H that could interrupt the electrostatic interaction between the three polyelectrolytes or deprotonate CHI,indicating that electrostatic interaction played an important role in the stability of emulsions.Compared with the primary emulsion that was solely stabilized by WPI,extra coating with CHI and CMKGM generally increased the stability of the emulsion against repeated freezing-thawing,improved the retention of curcumin against heating,UV irradiation,and long-term storage,and the effects were more remarkable in the tertiary emulsion with CMKGM locating in the outmost layer.Since CMKGM has shown the colon-targeted delivery potency,the multilayered emulsions assembled by layer-by-layer deposition,especially the tertiary emulsion,could be used as an effective carrier for the targeted delivery of curcumin. | Luhui Wang Xinru Zhang Junxia Xiao Jiayi Shi | 2023 | Food Science and Human Wellness2023，12，2： | 0 |
| 19 | Natural variations of OsAUX5,a target gene of OsWRKY78,control the neutral essential amino acid content in rice grains显示文摘Grain essential amino acid(EAA)levels contribute to rice nutritional quality.However,the molecular mechanisms underlying EAA accumulation and natural variation in rice grains remain unclear.Here we report the identification of a previously unrecognized auxin influx carrier subfamily gene,OsAUX5,which encodes an amino acid transporter that functions in uptake of multiple amino acids.We identified an elite haplotype of Pro::OsAUX5^(Hap2) that enhances grain EAA accumulation without an apparent negative effect on agronomic traits.Natural variations of OsAUX5 occur in the cis elements of its promoter,which are differentially activated because of the different binding affinity between OsWRKY78 and the W-box,contributing to grain EAA variation among rice varieties.The two distinct haplotypes were shown to have originated from different Oryza rufipogon progenitors,which contributed to the divergence between japonica and indica.Introduction of the indica-type Pro::OsAUX5^(Hap2) genotype into japonica could significantly increase EAA levels,indicating that indica-type Pro::OsAUX5^(Hap2) can be utilized to increase grain EAAs of japonica varieties.Collectively,our study uncovers an WRKY78–OsAUX5-based regulatory mechanism controlling grain EAA accumulation and provides a potential target for breeding EAA-rich rice. | Yuheng Shi Yuanyuan Zhang Yangyang Sun Ziyang Xie Yu Luo Qiyuan Long Jiahui Feng Xueqing Liu Bi Wang Dujun He Junxia Ren Peizhen Guo Junwei Xing Liqiang He Alisdair RFernie Wei Chen Xianqing Liu Yuehua Luo Cheng Jin Jie Luo | 2023 | Molecular Plant2023，16，2： | 0 |
| 20 | LEAF项目建设状态报告显示文摘LEAF or the Low Energy heavy ion Accelerator Facility is a multidiscipline heavy ion research platform under construction at IMP.It is a 5 year National Major Instruments Research Program supported by National Science Foundation of China(NSFC)started in 2015.Oriented to the frontier research in Material Sciences,Astrophysics,Atomic Physics and Highly Charged Ion Physics,LEAF has been designed and constructed with the state of the art technologies for low energy heavy ion acceleration.This facility features a 45 GHz ECR ion source FECR,a heavy ion CW 4-vane radio frequency quadruple accelerator LRFQ,300 kV HV platform,LEBT,MEBT and several dedicated experimental terminals. | Sun Liangting Yang Yao Lu Liang Guo Yuhui Liu Xiaojun Jing Long Li Libin Sun Liepeng Gao Zheng Ma Hongyi Jin Xiaofeng Zhai Yuhan Xu Xianbo Shi Longbo Xing Chaochao Liu Yuting Zhu Tieming Hu Qiang Zhang Peng Zhang Xuezhen Fang Xing Jia Huan Zhang Bin Liu Chaodong Ma Yingming Zhao Bo Wu Beimin Zhu Li Li Jiaqing Lu Wang Guo Junwei Li Chenxing Wang Zhijun Dou Weiping Wu Junxia Zhang Zimin Yao Qinggao Wu Wei Zhou Zhongzu Zhang Junhui Ma Lizhen He Yuan Zhao Hongwei | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
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