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| 1 | SNPs and haplotypes in the S100B gene reveal association with schizophrenia显示文摘 | Jixia Liu Yongyong Shi Junxia Tang | 2005 | Biothem Biophys Res Commun2005，328，1： | 1 |
| 2 | Rewiring ERBB3 and ERK signaling confers resistance to FGFR1 inhibition in gastrointestinal cancer harbored an ERBB3-E928G mutation显示文摘Dear Editor,Recently,a large number of studies found that activation of ERBB3(Erb-B2 receptor tyrosine kinase 3,also known as HER3)may be one of the major mechanisms underlying resistance to therapies that target the EGFR(epidermal growth factor receptor),HER2,and other receptor tyrosine kinases(RTKs)(Chen et al.,2011;Choi et al.,2012;Ross et al.,2018).Interestingly,mutations in ERBB3 are commonly reported in gastrointestinal(Gl)cancer,with mutations identified in approximately 12%of stomach and colorectal cancer cases(Jaiswal et al.,2013). | Xiang Yang Hongxiao Wang Enjun Xie Biyao Tang Qingdian Mu Zijun Song Junyi Chen Fudi Wang Junxia Min | 2020 | Protein & Cell2020，11，12： | 1 |
| 3 | Monitoring the morphology evolution of LiNi_(0.8)Mn_(0.1)Co_(0.1)O_(2)during high-temperature solid state synthesis via in situ SEM显示文摘The particle morphology determined by the sintering process is the director factor affecting the electrochemical performance of Ni-rich NMC cathode materials.To prepare the ideal NMC particles,it is of great significance to understand the morphological changes during sintering process.In this work,the morphology evolution of LiNi_(0.8)Mn_(0.1)Co_(0.1)O_(2)(NMC811)synthesis at temperature ranging from 300–1080℃were observed by in situ SEM.The uniform mixture of spherical Ni_(0.8)Mn_(0.1)Co_(0.1)(OH)_(2)precursor and lithium sources(LiOH)was employed by high temperature solid-state process inside the SEM,which enables us to observe morphology changes in real time.The results show that synthetic reaction of LiNi_(0.8)Mn_(0.1)Co_(0.1)O_(2)usually includes three processes:the raw materials’dehydration,oxidation,and combination,accompanied by a significant reduction in particle size,which is important reference to control the synthesis temperature.As heating temperature rise,the morphology of mixture also changed from flake to brick-shaped.However,Ni nanoparticle formation is apparent at higher temperature~1000℃,suggesting a structural transformation from a layered to a rock-salt-like structure.Combining the in-situ observed changes in size and morphology,and with the premise of ensuring the morphology change from flakes to bricks,reducing the sintering temperature as much as possible to prevent excessive reduction in particle size and layered to a rock-salt structure transformation is recommended for prepare ideal NMC particles. | Liang Tang Xiaopeng Cheng Rui Wu Tianci Cao Junxia Lu Yuefei Zhang Ze Zhang | 2022 | Journal of Energy Chemistry2022，31，3： | 1 |
| 4 | Thermally assisted switching in FePt single-domain particles with a Gaussian distribution of temperature显示文摘Magnetic nanoscale systems,including nanodots,nanofibers,nanowires and nanoparticles,are currently attracting great interest due to their interesting physical and promising applications in various fields,such as magnetic recording,sensors,target drugs and catalysts,as well as others.To achieve ultrahigh recording density,the method of heat assisted magnetic recording(HAMR) has been introduced.In this work,with the help of a Monte Carlo method,the mechanisms of thermally assisted magnetization switching in FePt single-domain particles driven by an external magnetic field are investigated,where the temperature in the particles is assumed to follow a Gaussian distribution.Two nucleation modes are observed for different distributions of temperature.One is initiated by many droplets,which join each other at the boundary of the system;the other is ini-tiated by many droplets at the boundary,but in growth tending toward the inner part of the system.An inverse proportional relationship between the metastable lifetime and the distribution is also found. | TANG Ke YANG HongJie CAO LinHong YU HongTao LIU JinSong WANG JunXia | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，7： | 1 |
| 5 | Taming quantum dots’nucleation and growth enables stable and efficient blue-light-emitting devices显示文摘Controlling quantum dots’emission,nanostructure,and energy level alignment to achieve stable and efficient blue emission is of great significance for electroluminescence devices but remains a challenge.Here,a series of blue ZnCdSeS/ZnS quantum dots was optimized in preparation by taming their nucleation and growth kinetics.Controlling anion precursor reactive properties to modulate quantum dots’nucleation and growth tailors their alloy core and continuous gradient energy band nanostructure.These results not only elevate the thermal stability of blue quantum dots but also further enhance the injection/transportation of carriers and improve the radiative recombination efficiency in the device.The blue ZnCdSeS/ZnS quantum dots applied in light-emitting devices show superior performance,including maximum current efficiency and external quantum efficiency of,respectively,8.2 cd/A and 15.8%for blue,2.6 cd/A and 10.0%for blue-violet,and 10.9 cd/A and 13.4%for sky-blue devices.The blue and sky-blue devices exhibit lifetimes of more than 10,000 h.The proposed methodology for tailoring quantum dots is expected to pave new guidelines for further facilitating visible optoelectronic device exploration. | ZHIWEI MA JUNXIA HU LIPING TANG BINGBING LYU | 2022 | Photonics Research2022，10，10： | 0 |
| 6 | Targeting the LSD1-G9a-ER Stress Pathway as a Novel Therapeutic Strategy for Esophageal Squamous Cell Carcinoma显示文摘Despite recent advances in the management and treatment of esophageal squamous cell carcinoma(ESCC),the prognosis remains extremely poor,and current nonsurgical treatment options are limited.To identify new therapeutic targets,we screened a curated library of epigenetic compounds using a panel of cancer cell lines and found that coinhibiting the histone demethylase LSD1 and the histone methyltransferase G9a potently suppresses cell growth;similar results were obtained by knocking down both LSD1 and G9a expression.Importantly,we also found that inhibiting LSD1 and G9a significantly decreased tumor growth in a xenograft mouse model with ESCC cell lines.To examine the clinical relevance of these findings,we performed immunohistochemical analyses of microarray profiling data obtained from human esophageal squamous cancer tissues and found that both LSD1 and G9a are upregulated in cancer tissues compared to healthy tissues,and this increased expression was significantly correlated with poor prognosis.Mechanistically,we discovered that inhibiting LSD1 and G9a induces cell death via S-phase arrest and apoptosis,and cotargeting ER stress pathways increased this effect both in vitro and in vivo.Taken together,these findings provide compelling evidence that targeting LSD1,G9a,and ER stress-related pathways may serve as a viable therapeutic strategy for ESCC. | Hongxiao Wang Zijun Song Enjun Xie Junyi Chen Biyao Tang Fudi Wang Junxia Min | 2022 | Research2022，，3： | 0 |
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