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| 1 | The Genome Sequence Archive Family: Toward Explosive Data Growth and Diverse Data Types显示文摘The Genome Sequence Archive(GSA)is a data repository for archiving raw sequence data,which provides data storage and sharing services for worldwide scientific communities.Considering explosive data growth with diverse data types,here we present the GSA family by expanding into a set of resources for raw data archive with different purposes,namely,GSA(http://gffzz77e3413bc06540eds0qkkq05fccup6vwx.ffgz.tsg.suse.edu.cn/gsa/),GSA for Human(GSA-Human,http://gffzz77e3413bc06540eds0qkkq05fccup6vwx.ffgz.tsg.suse.edu.cn/gsa-human/),and Open Archive for Miscellaneous Data(OMIX,http://gffzz77e3413bc06540eds0qkkq05fccup6vwx.ffgz.tsg.suse.edu.cn/omix/).Compared with the 2017 version,GSA has been significantly updated in data model,online functionalities,and web interfaces.GSA-Human,as a new partner of GSA,is a data repository specialized in human genetics-related data with controlled access and security.OMIX,as a critical complement to the two resources mentioned above,is an open archive for miscellaneous data.Together,all these resources form a family of resources dedicated to archiving explosive data with diverse types,accepting data submissions from all over the world,and providing free open access to all publicly available data in support of worldwide research activities. | Tingting Chen Xu Chen Sisi Zhang Junwei Zhu Bixia Tang Anke Wang Lili Dong Zhewen Zhang Caixia Yu Yanling Sun Lianjiang Chi Huanxin Chen Shuang Zhai Yubin Sun Li Lan Xin Zhang Jingfa Xiao Yiming Bao Yanqing Wang Zhang Zhang Wenming Zhao | 2021 | Genomics, Proteomics & Bioinformatics2021，19，4： | 38 |
| 2 | Downstaging and resection of hepatocellular carcinoma in patients with extrahepatic metastases after stereotactic therapy显示文摘Background:A combination of tyrosine kinase inhibitors(TKIs)and anti-PD-1 antibodies with local regional therapy has elicited yield substantial clinical benefits in patients who have hepatocellular carcinoma(HCC)with extrahepatic metastases.Using this treatment strategy to convert HCC patients with extrahepatic metastases from unresectable to resectable has not yet been reported.Methods:Consecutive hepatocellular carcinoma patients with extrahepatic metastases who received first-line therapy with a combination of TKIs and anti-PD-1 antibodies and at least one local regional therapy were analysed.Results:Nine patients with localized disease who received first-line systemic therapy were enrolled.At baseline,all of them had oligometastatic disease,namely,Barcelona Clinic Liver Cancer stage C(or Chinese Liver Cancer stage IIIB).The most common treatment administered was lenvatinib plus anti-PD-1 antibody and transarterial chemoembolization,and the median time span from systemic therapy to surgery was 3.2(IQR,2.8-6.2)months.Three patients achieved a pathological complete response.Six patients underwent laparoscopic surgery,and the other 3 patients underwent open surgery.After a median follow-up of 10.2(IQR,8.6-20.0)months,7 patients survived without disease recurrence,and 2 experienced tumour recurrence.All patients had any-grade AEs,and 55.6%of the patients experienced grade 3 AEs.Fatigue was the most common AE,followed by elevated aminotransferase levels and hypertension.Conclusions:Stereotactic therapy is a feasible conversion therapy for HCC patients with extrahepatic metastases to become resectable.This is the first study to analyse therapeutic outcomes of patients receiving these therapies for HCC with extrahepatic metastases. | Xiaobo Yang Haifeng Xu Bangyou Zuo Xu Yang Jin Bian Junyu Long Dongxu Wang Junwei Zhang Cong Ning Yanyu Wang Ziyu Xun Yunchao Wang Xin Lu Yilei Mao Xinting Sang Haitao Zhao | 2021 | Hepatobiliary Surgery and Nutrition2021，10，4： | 17 |
| 3 | Rice MtN3/saliva/SWEET gene family: Evolution,expression profiling, and sugar transport显示文摘The rice MtN3/saliva/SWEET gene family consists of21 paralogs. However, their functions in physiological processes are largely unknown, although at least three of the 21 paralogs are used by pathogenic bacteria to infect rice.Here, we report the evolutionary features, transcriptional characteristics, and putative functions in sugar transport of this gene family. The wild rice accessions in this study included those with AA, BB, CC, BBCC, CCDD, EE, and GG genomes,which appeared approximately 0.58–14.6 million years ago.The structures, chromosomal locations, phylogenetic relationships, and homologous distribution among the accessions suggest that the number of rice MtN3/saliva/SWEET paralogs gradually increased as the Oryza genus evolved, and one third of the paralogs may have originated recently. These paralogs are differentially expressed in vegetative and reproductive tissues, in the leaf senescence process, and in signaling dependent on gibberellic acid, cytokinin, or 1-naphthalene acetic acid(an analog of auxin), suggesting that they may be associated with multiple physiological processes. Four paral ogs could transport galactose in yeast, which suggests tha they may have a similar function in rice. These results will help to elucidate their roles and biochemical functions in rice development, adaptation to environment, host-pathogen interaction, and so forth. | Meng Yuan Junwei Zhao Renyan Huang Xianghua Li Jinghua Xiao Shiping Wang | 2014 | Journal of Integrative Plant Biology2014，56，6： | 14 |
| 4 | GSA:Genome Sequence Archive显示文摘With the rapid development of sequencing technologies towards higher throughput and lower cost, sequence data are generated at an unprecedentedly explosive rate. To provide an efficient and easy-to-use platform for managing huge sequence data, here we present Genome Sequence Archive(GSA; http://gffzzdbc7b6aaae734bddh0qkkq05fccup6vwx.ffgz.tsg.suse.edu.cn/gsa or http://gffzz4eaf941a184140e3h0qkkq05fccup6vwx.ffgz.tsg.suse.edu.cn), a data repository for archiving raw sequence data. In compliance with data standards and structures of the International Nucleotide Sequence Database Collaboration(INSDC), GSA adopts four data objects(Bio Project, Bio Sample,Experiment, and Run) for data organization, accepts raw sequence reads produced by a variety of sequencing platforms, stores both sequence reads and metadata submitted from all over the world,and makes all these data publicly available to worldwide scientific communities. In the era of big data, GSA is not only an important complement to existing INSDC members by alleviating the increasing burdens of handling sequence data deluge, but also takes the significant responsibility for global big data archive and provides free unrestricted access to all publicly available data in support of research activities throughout the world. | Yanqing Wang Fuhai Song Junwei Zhu Sisi Zhang Yadong Yang Tingting Chen Bixia Tang Lili Dong Nan Ding Qian Zhang Zhouxian Bai Xunong Dong Huanxin Chen Mingyuan Sun Shuang Zhai Yubin Sun Lei Yu Li Lan Jingfa Xiao Xiangdong Fang Hongxing Lei Zhang Zhang Wenming Zhao | 2017 | Genomics, Proteomics & Bioinformatics2017，15，1： | 13 |
| 5 | Early Permian–Late Triassic Magmatism in the Tuotuohe Region of the Qinghai–Tibet Plateau: Constraints on the Tectonic evolution of the Western Segment of the Jinshajiang Suture显示文摘In this paper we present new zircon U–Pb ages, whole-rock major and trace element analyses, and zircon Hf isotopic data for magmatic rocks in the Tuotuohe region of the western segment of the Jinshajiang suture. Our aim is to constrain the Early Permian–Late Triassic tectonic evolution of the region. Zircons from the magmatic rocks of the Tuotuohe region are euhedral–subhedral in shape and display fine-scale oscillatory zoning as well as high Th/U ratios(0.4–4.6), indicating a magmatic origin. The zircon U–Pb ages obtained using LA–ICP–MS are 281 ± 1 Ma, 258 ± 1 Ma, 244 ± 1 Ma, and 216 ± 1 Ma, which indicate magmatism in the Early Permian–Late Triassic. A diorite from Bashihubei(BSHN) has SiO2 = 57.18–59.97 wt%, Al2O3 = 15.70–16.53 wt%, and total alkalis(Na2O + K2O) = 4.46–6.34 wt%, typical of calc-alkaline and metaluminous series. A gabbro from Bashibadaoban(BSBDB) belongs to the alkaline series, and is poor in SiO2(45.46–54.03 wt%) but rich in Al2O3(16.19–17.39 wt%) and total alkalis(Na2O + K2O = 5.48–6.26 wt%). The BSHN diorite and the BSBDB gabbro both display an enrichment of LREEs and LILEs and depletion of HFSEs, and they have no obvious Eu anomaly; they have relatively low MgO contents(2.54–4.93 wt%), Mg# values of 43 to 52, and low Cr and Ni contents(8.07–33.6 ppm and 4.41–14.2 ppm, respectively), indicating they differentiated from primitive mantle magmas. They have low Nb/U, Ta/U, and Ce/Pb ratios(1.3–9.6, 0.2–0.8, and 0.1–18.1, respectively), and their initial Hf isotopic ratios range from +9.6 to +16.9(BSHN diorite) and +6.5 to +12.6(BSBDB gabbro), suggesting their primary magmas were derived mainly from the partial melting of a mantle wedge that had been metasomatized by subduction fluids. Taking all the new data together, we conclude that the western and eastern segment of the Jinshajiang suture regions underwent identical processes of evolution in the Early Permian–Late Triassic: oceanic crust subduction before the Early Permian, continental collision during the Early–Middle Triassic, and post-collisional extension from the Late Triassic. | QIAN Ye SUN Fengyue LI Bile LI Shijin ZHAO Junwei | 2014 | Acta Geologica Sinica(English Edition)2014，88，2： | 12 |
| 6 | Analysis of CVC roll contour and determination of roll crown显示文摘Mathematical analysis of continuous variable crown (CVC) roll contour used in CSP production line was conducted and the roll contour function of CVC roll was obtained. The validation with actual CVC roll contour shows that the calculation values of the roll contour function and the actual roll contour parameters given by equipment provider are the same, which proves that the roll contour function of CVC rolls given in this article is correct. The nonlinear relationship between the roll crown of CVC rolls and roll shift amounts was deduced. The concept of crown extremum was given. | Guang Xu Xianjun Liu Jiarong Zhao Junwei Xiong | 2007 | Journal of University of Science and Technology Beijing2007，14，4： | 7 |
| 7 | A new unconventional HLA-A2-restricted epitope from HBV core protein elicits antiviral cytotoxic T lymphocytes显示文摘细胞毒素的 T 房间(CTL ) 在肝炎 B 的控制起一个关键作用病毒(HBV ) 感染和病毒的清理。然而,大多数识别 CTL epitopes 从遗传型 A 和 D 的 HBV 被导出,并且很少在在亚洲更流行的遗传型 B 和 C 的病毒被定义。因为 HBV 核心蛋白质(HBc ) 是最保守、产生免疫性的部件,在这研究,我们使用了盖住 HBc 屏蔽并且识别特定的 CTL epitopes 的一个重叠 9-mer 肽水池。异乎寻常的 HLA-A2-restricted epitope HBc141149 被结晶化分析发现,在结构上描绘了。immunogenicity 和 anti-HBV 活动进一步在 HBV 和 HLA-A2 被决定转基因的老鼠。最后,我们证明在 HBc141149 epitope 的变化与病毒的参数被联系,在 HBV 的疾病前进感染了病人。我们的数据因此提供卓见进这异乎寻常的 epitope 绑定的结构特征给 MHC-I 分子,以及 epitope 特定的 CTL 活动在 HBV 安排 T 房间反应和有免疫力的避免感染的病人。 | Lu Sun Yu Zhang Bao Zhao Mengmeng Deng Jun Liu Xin Li Junwei Hou Mingming Gui Shuijun Zhang Xiaodong Li George F. Gao Songdong Meng | 2014 | Protein & Cell2014，5，4： | 7 |
| 8 | Development of the triazole-fused pyrimidine derivatives as highly potent and reversible inhibitors of histone lysine specific demethylase1(LSD1/KDM1A)显示文摘Histone lysine specific demethylase 1(LSD1) has been recognized as an important modulator in post-translational process in epigenetics. Dysregulation of LSD1 has been implicated in the development of various cancers. Herein, we report the discovery of the hit compound 8 a(IC50=3.93 μmol/L) and further medicinal chemistry efforts, leading to the generation of compound 15 u(IC50=49 nmol/L, and Ki= 16 nmol/L), which inhibited LSD1 reversibly and competitively with H3 K4 me2, and was selective to LSD1 over MAO-A/B. Docking studies were performed to rationalize the potency ofcompound 15 u. Compound 15 u also showed strong antiproliferative activity against four leukemia cell lines(OCL-AML3, K562, THP-1 and U937) as well as the lymphoma cell line Raji with the IC50 values of 1.79, 1.30, 0.45, 1.22 and 1.40 μmol/L, respectively. In THP-1 cell line, 15 u significantly inhibited colony formation and caused remarkable morphological changes. Compound 15 u induced expression of CD86 and CD11 b in THP-1 cells, confirming its cellular activity and ability of inducing differentiation.The findings further indicate that targeting LSD1 is a promising strategy for AML treatment, the triazolefused pyrimidine derivatives are new scaffolds for the development of LSD1/KDM1 A inhibitors. | Zhonghua Li Lina Ding Zhongrui Li Zhizheng Wang Fengzhi Suo Dandan Shen Taoqian Zhao Xudong Sun Junwei Wang Ying Liu Liying Ma Bing Zhao Pengfei Geng Bin Yu Yichao Zheng Hongmin Liu | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 6 |
| 9 | Recent developments in multimodality fluorescence imaging probes显示文摘Multimodality optical imaging probes have emerged as powerful tools that improve detection sensitivity and accuracy, important in disease diagnosis and treatment. In this review, we focus on recent developments of optical fluorescence imaging(OFI) probe integration with other imaging modalities such as X-ray computed tomography(CT), magnetic resonance imaging(MRI), positron emission tomography(PET), single-photon emission computed tomography(SPECT), and photoacoustic imaging(PAI). The imaging technologies are briefly described in order to introduce the strengths and limitations of each techniques and the need for further multimodality optical imaging probe development. The emphasis of this account is placed on how design strategies are currently implemented to afford physicochemically and biologically compatible multimodality optical fluorescence imaging probes. We also present studies that overcame intrinsic disadvantages of each imaging technique by multimodality approach with improved detection sensitivity and accuracy. | Jianhong Zhao Junwei Chen Shengnan Ma Qianqian Liu Lixian Huang Xiani Chen Kaiyan Lou Wei Wang | 2018 | Acta Pharmaceutica Sinica B2018，8，3： | 6 |
| 10 | Ambient volatile organic compounds at a receptor site in the Pearl River Delta region:Variations,source apportionment and effects on ozone formation显示文摘We present the continuously measurements of volatile organic compounds(VOCs)at a receptor site(Wan Qing Sha,WQS)in the Pearl River Delta(PRD)region from September to November of 2017.The average mixing ratios of total VOCs(TVOCs)was 36.3±27.9 ppbv with the dominant contribution from alkanes(55.5%),followed by aromatics(33.3%).The diurnal variation of TVOCs showed a strong photochemical consumption during daytime,resulting in the formation of ozone(O_(3)).Five VOC sources were resolved by the positive matrix factorization(PMF)model,including solvent usage(28.6%),liquid petroleum gas(LPG)usage(24.4%),vehicle exhaust(21.0%),industrial emissions(13.2%)and gasoline evaporation(12.9%).The regional transport air masses from the upwind cities of south China can result in the elevated concentrations of TVOCs.Low ratios of TVOCs/NO_(x)(1.53±0.88)suggested that the O_(3) formation regime at WQS site was VOC-limited,which also confirmed by a photochemical box model with the master chemical mechanism(PBM-MCM).Furthermore,the observation on high-O_(3) episode days revealed that frequent O_(3) outbreaks at WQS were mainly caused by the regional transport of anthropogenic VOCs especially for aromatics and the subsequent photochemical reactions.This study provides valuable information for policymakers to propose the effective control strategies on photochemical pollution in a regional perspective. | Yao Meng Junwei Song Lewei Zeng Yingyi Zhang Yan Zhao Xufei Liu Hai Guo Liuju Zhong Yubo Ou Yan Zhou Tao Zhang Dingli Yue Senchao Lai | 2022 | Journal of Environmental Sciences2022，34，1： | 5 |
| 11 | Melanin nanoparticles alleviate sepsis-induced myocardial injury by suppressing ferroptosis and inflammation显示文摘Myocardial injury as one of the severe complications leads to the increasing morbidity and mortality in patients with sepsis.Recent studies reported that reactive oxygen species(ROS)-mediated ferroptosis plays a critical role in the development of heart diseases.Therefore,we hypothesized that anti-ferroptosis agent might be a novel potential therapeutic strategy for sepsis-induced cardiac injury.Herein,we demonstrated that a small biocompatible and MRI-visible melanin nanoparticles(MMPP)improves myocardial function by inhibiting ROS-related ferroptosis signaling pathway.In LPS-induced murine sepsis model,after a single dose intravenously injection of MMPP treatment,MMPP markedly alleviated the myocardial injury including cardiac function and heart structure disorder through suppressing iron-accumulation induced ferroptosis.In vitro,MMPP inhibited cardiomyocyte death by attenuating oxidative stress,inflammation and maintaining mitochondrial homeostasis.Collectively,our findings demonstrated that MMPP protected heart against sepsis-induced myocardial injury via inhibiting ferroptosis and inflammation,which might be a novel therapeutic approach in future. | Chang Liu Quan Zou Huixin Tang Jia Liu Shiqi Zhang Caihong Fan Junwei Zhang Ruiqing Liu Yashan Liu Ruiyan Liu Yan Zhao Qiang Wu Zhi Qi Yanna Shen | 2023 | Bioactive Materials2023，，6： | 5 |
| 12 | Microstructure and mechanical properties of C_(x)Hf_(0.25)NbTaW_(0.5) refractory high-entropy alloys at room and high temperatures显示文摘The microstructure and mechanical properties of as-cast and isothermally annealed C_(x)Hf_(0.25)NbTaW_(0.5)(x=0,0.05,0.15,0.25)refractory high-entropy alloys(RHEAs)were studied.Both the as-cast and annealed RHEAs consisted of disordered body-centered cubic solid solution phase and metal carbide(MC)phase with a face-centered cubic crystal structure(Fm-3 m space group).The primary carbides were enriched with Hf and C elements and tended to form lamellar eutectic-like microstructure in the interdendrites.The lamellar eutectic-like structure in the interdendrites would be formed from the decomposition of sub-carbide M_(2)C under the influence of Hf element.After isothermal annealing,slatted carbides were precipitated on the matrix,and the distribution became more uniform with high C content.The formation of carbides strongly influenced the mechanical properties both at room and high temperatures.The yield strength values of C_(x)Hf_(0.25)NbTaW_(0.5) RHEA at 1473 and 1673 K were 792 and 749 MPa,respectively.The result had exceeded the high temperature mechanical properties of currently known RHEAs.Moreover,this RHEA exhibited high-temperature performance stability and excellent plasticity,exceeding 30 and 50%at room and elevated temperatures(above 1273 K),respectively.During thermal deformation,carbon-containing RHEAs obtained more severe work hardening than that of ACHO RHEAs,and required greater dynamic recrystallization to achieve the dynamic equilibrium. | Shiyu Wu Dongxu Qiao Haitao Zhang Junwei Miao Hongliang Zhao Jun Wang Yiping Lu Tongmin Wang Tingju Li | 2022 | Journal of Materials Science & Technology2022，，2： | 4 |
| 13 | eGPS 1.0: comprehensive software for multi-omic and evolutionary analyses显示文摘It has become increasingly challenging for researchers to analyze the exponentially expanding amount of multi-omic data.Here,we describe multi-functional software named evolutionary GenotypePhenotype Systems(eGPS)that enables users to perform comprehensive multiomic and evolutionary analyses.The eGPS combines the power of cloud computing and the advantage of desktop application,has a user-friendly graphic interface and is highly interactive. | Dalang Yu Lili Dong Fangqi Yan Hailong Mu Bixia Tang Xiao Yang Tao Zeng Qing Zhou Feng Gao Zhonghuang Wang Ziqian Hao Hongen Kang Yi Zheng Hongwei Huang Yuzhang Wei Wei Pan Yaochen Xu Junwei Zhu Shilei Zhao Ciran Wang Pengyu Wang Long Dai Mushan Li Li Lan Yiwei Wang Hua Chen Yi-Xue Li Yun-Xin Fu Zhen Shao Yiming Bao Fangqing Zhao Luo-Nan Chen Guo-Qing Zhang Wenming Zhao Haipeng Li | 2019 | National Science Review2019，6，5： | 4 |
| 14 | The Global Landscape of SARS-CoV-2 Genomes, Variants, and Haplotypes in 2019nCoVR显示文摘On January 22,2020,China National Center for Bioinformation(CNCB)released the 2019 Novel Coronavirus Resource(2019nCoVR),an open-access information resource for the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).2019nCoVR features a comprehensive integration of sequence and clinical information for all publicly available SARS-CoV-2 isolates,which are manually curated with value-added annotations and quality evaluated by an automated in-house pipeline.Of particular note,2019nCoVR offers systematic analyses to generate a dynamic landscape of SARS-CoV-2 genomic variations at a global scale.It provides all identified variants and their detailed statistics for each virus isolate,and congregates the quality score,functional annotation,and population frequency for each variant.Spatiotemporal change for each variant can be visualized and historical viral haplotype network maps for the course of the outbreak are also generated based on all complete and high-quality genomes available.Moreover,2019nCoVR provides a full collection of SARS-CoV-2 relevant literature on the coronavirus disease 2019(COVID-19),including published papers from PubMed as well as preprints from services such as bioRxiv and medRxiv through Europe PMC.Furthermore,by linking with relevant databases in CNCB,2019nCoVR offers data submission services for raw sequence reads and assembled genomes,and data sharing with NCBI.Collectively,SARS-CoV-2 is updated daily to collect the latest information on genome sequences,variants,haplotypes,and literature for a timely reflection,making 2019nCoVR a valuable resource for the global research community.2019nCoVR is accessible at http://gffzzdbc7b6aaae734bdds0qkkq05fccup6vwx.ffgz.tsg.suse.edu.cn/ncov/. | Shuhui Song Lina Ma Dong Zou Dongmei Tian Cuiping Li Junwei Zhu Meili Chen Anke Wang Yingke Ma Mengwei Li Xufei Teng Ying Cui Guangya Duan Mochen Zhang Tong Jin Chengmin Shi Zhenglin Du Yadong Zhang Chuandong Liu Rujiao Li Jingyao Zeng Lili Hao Shuai Jiang Hua Chen Dali Han Jingfa Xiao Zhang Zhang Wenming Zhao Yongbiao Xue Yiming Bao | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 4 |
| 15 | Cloning of Porcine Lactoferrin Gene and Construction of Expression System in Recombinant Lactobacillus显示文摘Lactobacillus was selected as a bacterial carrier for expression of N-lobe of porcine lactoferrin(PLF N) . A pair of primers was designed with Oligo6.0 and used to amplify PLF N gene. It was in accordance with the characters of translational fusions from gene and expression vector plasmid. A 1 077 bp fragment of the gene from PLF was cloned from mammary gland tissue of the lactating sow on the third day by RT-PCR;the gene was connected with the vector plasmid pPG612.1 and transformed into the host strain JM109. The recombinant expression vector plasmid pPG612-PLF N was created and identified by using plasmid extraction,PCR,restriction enzyme digestion and sequence analysis. The recombinant plasmid was transformed into Lactobacillus casei ATCC393,Lactobacillus plantarum KLDS 1.0344,Lactobacillus paracasei KLDS 1.0652 and Lactobacillus pentosus KLDS1.0413 by electroporation,and produced the recombinant strains of pPG612-PLF N /L. casei,pPG612-PLF N /L. plantarum,pPG612-PLF N /L. paracasei and pPG612-PLF N /L. pentosus,respectively. The results indicated that PLF N gene had inserted into the expression vectors and achieved multiple Lactobacillus expression systems. It electes the base for the expression and production of recombinant porcine lactoferrin in Lactobacillus. | ZONG Xiaolin HA Zhuo ZHAO Lili LIU Diqiu QIAO Xinyuan JIANG Yanping GE Junwei LI Yijing TANG Lijie | 2011 | Journal of Northeast Agricultural University(English Edition)2011，18，4： | 3 |
| 16 | Simultaneously optimizing pore morphology and enhancing mechanical properties of Al-Si alloy composite foams by graphene nanosheets显示文摘The integrity and regularity of pore morphology play an important role in determining the mechanical properties of the metallic foam materials.The conventional methods on refining pore morphology are mainly focused on the optimization of fabrication techniques,however,they are usually inconvenient and complicated.Recently,incorporating nano reinforcement is considered to be a suitable way to fabricate metallic composite foams accompanied by optimized pore morphology and enhanced mechanical properties.In this work,through a facile and rapid powder metallurgy foaming method,the aluminum-silicon(Al-Si)alloy composite foams reinforced by graphene nanosheets(GNSs)are successfully fabricated.The microstructure analyses reveal that,for the Al-Si alloy foams incorporating the GNSs(GNSs/Al-Si composite foams),the pore size is transformed to be smaller,the pore size distributions become more homogeneous and the pore shape is also refined to a regular and roundish state.Meanwhile,the shape of Si precipitates is found transforming from an irregular long strip(length of~20μm,width of~5μm)to a fine particle state(diameter of~5μm).Moreover,the compressive testing results show that,the 0.4wt%GNSs/Al-Si composite foams own the optimal compression stress of 11.7±0.5 MPa,plateau stress of 10.0±1.0 MPa and energy absorption capacity of 6.8±0.7 MJ/m^(3),which have improvement of 58.1%,53.8%and 51.1%in comparison with the Al-Si alloy foams counterpart,respectively.The present findings may pave a new way for developing new generation of metallic composite foams that with stable microstructure and excellent mechanical performance. | Weiting Li Xudong Yang Kunming Yang Chunnian He Junwei Sha Chunsheng Shi Yunhui Mei Jiajun Li Naiqin Zhao | 2022 | Journal of Materials Science & Technology2022，，6： | 3 |
| 17 | Cell viability and dopamine secretion of 6-hydroxydopamine-treated PC12 cells co-cultured with bone marrow-derived mesenchymal stem cells显示文摘In the present study, PC12 cells induced by 6-hydroxydopamine as a model of Parkinson's Disease, were used to investigate the protective effects of bone marrow-derived mesenchymal stem cells bone marrow-derived mesenchymal stem cells against 6-hydroxydopamine-induced neurotoxicity and to verify whether the mechanism of action relates to abnormal α-synuclein accumulation in cells. Results showed that co-culture with bone marrow-derived mesenchymal stem cells enhanced PC12 cell viability and dopamine secretion in a cell dose-dependent manner. MitoLight staining was used to confirm that PC12 cells co-cultured with bone marrow-derived mesenchymal stem cells demonstrate reduced levels of cell apoptosis. Immunocytochemistry and western blot analysis found the quantity of α-synuclein accumulation was significantly reduced in PC12 cell and bone marrow-derived mesenchymal stem cell co-cultures. These results indicate that bone marrow-derived mesenchymal stem cells can attenuate 6-hydroxydopamine-induced cytotoxicity by reducing abnormal α-synuclein accumulation in PC12 cells. | Yue Tang Yongchun Cui Fuliang Luo Xiaopeng Liu Xiaojuan Wang Aili Wu Junwei Zhao Zhong Tian Like Wu | 2012 | Neural Regeneration Research2012，7，14： | 3 |
| 18 | Early Cretaceous Climate Changes Recorded in Magnetic Susceptibility and Color Index Variations of the Lower Liupanshan Group, Central China显示文摘This study carried out comprehensive analysis on sedimentology, magnetic susceptibility(χlf) and color data of the continental sediments of the Liupanshan Group in Central China so as to obtain climatic change information during the 129.14–122.98 Ma interval. Based on the results of the ?lf and of the redness(a*), the section can be divided into two segments:(1) 129.14–126.3 Ma, with the lowest ?lf values and strongly variable relatively high values of redness and(2) 126.3–122.98 Ma, with high ?lf values and relatively low redness. Analysis of the lithology and facies as well as the magnetic minerals and their contents points to a detrital origin of the magnetic minerals and this allow us to interpret the relationship between magnetic susceptibility variations and climate changes. Our study shows that the climate was significantly dry and hot during the whole studied interval although the interval between 126.3 Ma and 122.98 was a little bit cooler with increased humidity. | DAI Shuang ZHU Qiang HUANG Yongbo DA SILVA Anne-Christine ZHAO Jie LIU Junwei KONG Li PENG Dongxiang LUO Lingling YAN Ningyun WANG Wenjie ZHANG Xiang | 2016 | Acta Geologica Sinica(English Edition)2016，90，3： | 3 |
| 19 | Effects of fruit thinning on ascorbate–glutathione cycle metabolism in black currants(Ribes nigrum L.)显示文摘To elucidate mechanisms regulating ascorbic acid(AsA) biosynthesis and accumulation in the fruit and leaves of black currants,As A and the activities of key enzymes in the ascorbate–glutathione(As A–GSH) cycle were measured from fruit set to fruit ripening during fruit thinning treatments of three common commercial black currant cultivars that differed in their As A levels:'Risager'(low),'Brodtrop'(medium) and 'Adelinia'(high).Treatments were 50% fruit reduction(50% of total fruit set) by hand,control was no thinning.Fruit thinning treatment significantly increased As A content in fruit of all three cultivars from weeks 2 to 8,significantly decreased As A content in leaves from weeks 3 to 8.Dehydroascorbate reductase and monodehydroascorbate reductase activities in fruit and leaves had a similar pattern,increasing during week 2,rose until they peaked in week 4.Ascorbate peroxidase activity in fruit in the thinning treatment was slightly lower than in the control.Fruit thinning was shown to be a good model to test As A biosynthesis regulation and accumulation in black currants.The results from our study provided strong evidence that As A–GSH cycle involved in As A synthesis and accumulation in fruit. | Dong Qin Lijuan Zhao Yu Gary Gao Fangxiao Li Shulei Li Junwei Huo Shuang Lou Peng Liu | 2017 | Journal of Forestry Research2017，28，5： | 3 |
| 20 | Synthesis,structural characterization and properties of a 3D infinitely extended structural rare earth coordination compound of K_3{[Sm(H_2O)_7]_2Na[α-SiW_(11)O_(39)Sm(H_2O)_4]_2}·14 H_2O显示文摘A 3D infinitely extended structural rare earth coordination compound with a formula of K3{[Sm(H2O)7]2Na[a-SiW11O39Sm(H2O)4]2}·14H2O has been synthesized by reaction of Sm2O3,HClO4,NaOH with a-K8SiW11O39·nH2O,and characterized by IR,UV spectra,ICP,TG-DTA,cyclic voltammetry,variable-temperature magnetic susceptibility and X-ray single-crystal diffrac-tion.X-ray single-crystal diffraction indicates that the title compound crystallizes in a triclinic lat-tice,Pi space group,with a = 1.2462(3) nm,b = 1.2652(3) nm,c = 1.8420(4) nm,α = 87.45(3)°,β = 79.91(3)°,γ = 82.57(3)°,Z = 1,R1 = 0.0778,wR2 = 0.1610.Structural analysis reveals that Sm3+(1) coordination cation has incorporated into the vacant site of [α-SiW11O39]8? entity,forming the [α-SiW11O39Sm(H2O)4]5? subunit.The two adjacent [a-SiW11O39Sm(H2O)4]5? subunits are combined with each other through two Sm(1)-O-W bridges accompanying the formation of dim-mer structural unit [α-SiW11O39Sm(H2O)4]210? of the title compound.The neighboring dimmer structural units [α-SiW11O39Sm(H2O)4]210? are linked to form the 1D chainlike structure by means of two Sm3+(2) and a Na+(1) coordination cations.The K+(1) cations connect the 1D packing chains constructing the 2D netlike structure,and adjacent netlike layers are also grafted by K+(2) cations to build the novel 3D infinitely extended structure.The result of TG-DTA curves manifests that the decomposition temperature of the title polyanionic framework is 554℃.The cyclic volt-ammetry measurements show that the title polyanion has the two-step redox processes in aqueous solution with pH = 3.1.Variable temperature magnetic susceptibility indicates the title compound obeys the Cruie-Weiss Law in the higher temperature range from 110 to 300 K,while in the lower temperature range from 2 to 110 K the comparatively strong antiferromagnetism in-teractions can be observed. | WANG Jingping ZHAO Junwei NIU Jingyang | 2005 | Science China Chemistry2005，48，4： | 2 |
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