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| 1 | Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death显示文摘混合的系 kinase 像域的蛋白质(MLKL ) 被识别受体交往下游地工作蛋白质 3 (RIP3 ) 在肿瘤坏死 factor-α(TNF ) 导致了坏死(也叫的 necroptosis ) 。然而, MLKL 怎么工作调停 necroptosis 是未知的。由在 MLKL 大美人房间的 MLKL 功能的宪法,我们证明 MLKL 的 N 终点在 necroptosis 为它的功能被要求。在对待 TNF 的房间的 MLKL 的 oligomerization 为 necroptosis 是必要的,当人工地由使用荷尔蒙绑定领域一起强迫 MLKL (HBD*) 扳机 necroptosis。尤其是,一起强迫 N 终端领域(ND ) 然而并非 MLKL 的 C 终端 kinase 领域引起 necroptosis。进一步的删除分析证明 four-α MLKL (1-130 氨基酸) 的螺旋捆是足够的触发 necroptosis。两 HBD*调停并且 MLKL (ND ) 或 MLKL 的导致 TNF 的建筑群是到血浆膜的类脂化合物椽子的这些建筑群的 tetramers,和 translocation 先于房间死亡。homo-oligomerization 为 MLKL translocation 被要求,为血浆膜地点的信号顺序位于第一和第二 α 的连接; MLKL 的 -helices。MLKL 或 MLKL (ND ) 的血浆膜 translocation 导致钠流入,并且从房间文化媒介的钠的弄空禁止 necroptosis。上述所有现象没在 apoptosis 被看见。因此, MLKL oligomerization 导致 MLKL 的 translocation 到血浆膜,和血浆膜的类脂化合物椽子由自己或经由到增加的另外的蛋白质的 MLKL 复杂行为任何一个钠流入,增加渗透的压力,最后导致膜破裂。 | Xin Chen Wenjuan Li Junming Ren Deli Huang Wan-ting He Yunlong Song Chao Yang Wanyun Li Xinru Zheng PengdaChen Jiahuai Han | 2014 | Cell Research2014，24，1： | 67 |
| 2 | Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis显示文摘像域的蛋白质(Mlkl ) 最近被发现与受体交往交往的混合的系 kinase 蛋白质 3 (Rip3 ) 并且导致的坏死因素(TNF ) 在有教养的房间线规划了坏死(necroptosis ) 为肿瘤必要。我们由抄写产生了 Mlkl 缺乏的老鼠像使活跃之物的受动器核酸酶(TALEN ) 调停了基因混乱和发现 Mlkl 到为象有免疫力的房间开发一样的正常老鼠开发非必需。胚胎的成纤维细胞(MEF ) 和巨噬细胞两个都显示出的 Mlkl 缺乏的老鼠抵抗到坏死然而并非 apoptotic 刺激。Mlkl 缺乏的 MEF 和巨噬细胞与处于他们激活 NF-κ 的能力的野类型的房间难区分;响应 TNF 和 lipopolysaccharides (LPS ) 的 B,英皇家空军之阶级最低之兵, JNK,和 p38 分别地。一致地, Mlkl 缺乏的巨噬细胞和老鼠展出了正常 interleukin-1β(IL-1β) ,在 LPS 处理以后的 IL-6,和 TNF 生产。Mlkl 缺乏保护老鼠免受导致天蓝色的尖锐胰腺炎的伤害,坏死相关的疾病,但是没在 polymicrobial 上有效果腐败导致吃惊的动物死亡。我们的结果在 necroptosis 为 Mlkl 的角色提供基因证据。 | Jianfeng Wu Zhe Huang Junming Ren Zhirong Zhang Peng He Yangxin Li Jianhui Ma Wanze Chen Yingying Zhang Xiaojuan Zhou Zhentao Yang Su-Qin Wu Lanfen Chen Jiahuai Han | 2013 | Cell Research2013，23，8： | 35 |
| 3 | Wheat genomic study for genetic improvement of traits in China显示文摘Bread wheat(Triticum aestivum L.)is a major crop that feeds 40%of the world’s population.Over the past several decades,advances in genomics have led to tremendous achievements in understanding the origin and domestication of wheat,and the genetic basis of agronomically important traits,which promote the breeding of elite varieties.In this review,we focus on progress that has been made in genomic research and genetic improvement of traits such as grain yield,end-use traits,flowering regulation,nutrient use efficiency,and biotic and abiotic stress responses,and various breeding strategies that contributed mainly by Chinese scientists.Functional genomic research in wheat is entering a new era with the availability of multiple reference wheat genome assemblies and the development of cutting-edge technologies such as precise genome editing tools,highthroughput phenotyping platforms,sequencing-based cloning strategies,high-efficiency genetic transformation systems,and speed-breeding facilities.These insights will further extend our understanding of the molecular mechanisms and regulatory networks underlying agronomic traits and facilitate the breeding process,ultimately contributing to more sustainable agriculture in China and throughout the world. | Jun Xiao Bao Liu Yingyin Yao Zifeng Guo Haiyan Jia Lingrang Kong Aimin Zhang Wujun Ma Zhongfu Ni Shengbao Xu Fei Lu Yuannian Jiao Wuyun Yang Xuelei Lin Silong Sun Zefu Lu Lifeng Gao Guangyao Zhao Shuanghe Cao Qian Chen Kunpu Zhang Mengcheng Wang Meng Wang Zhaorong Hu Weilong Guo Guoqiang Li Xin Ma Junming Li Fangpu Han Xiangdong Fu Zhengqiang Ma Daowen Wang Xueyong Zhang Hong-Qing Ling Guangmin Xia Yiping Tong Zhiyong Liu Zhonghu He Jizeng Jia Kang Chong | 2022 | Science China(Life Sciences)2022，65，9： | 9 |
| 4 | Comparative genomic and transcriptomic analyses uncover the molecular basis of high nitrogen-use efficiency in the wheat cultivar Kenong 9204显示文摘Studying the regulatory mechanisms that drive nitrogen-use efficiency(NUE)in crops is important for sustainable agriculture and environmental protection.In this study,we generated a high-quality genome assembly for the high-NUE wheat cultivar Kenong 9204 and systematically analyzed genes related to nitrogen uptake and metabolism.By comparative analyses,we found that the high-affinity nitrate transporter gene family had expanded in Triticeae.Further studies showed that subsequent functional differentiation endowed the expanded family members with saline inducibility,providing a genetic basis for improving the adaptability of wheat to nitrogen deficiency in various habitats.To explore the genetic and molecular mechanisms of high NUE,we compared genomic and transcriptomic data from the high-NUE cultivar Kenong 9204(KN9204)and the low-NUE cultivar Jing 411 and quantified their nitrogen accumulation under high-and low-nitrogen conditions.Compared with Jing 411,KN9204 absorbed significantly more nitrogen at the reproductive stage after shooting and accumulated it in the shoots and seeds.Transcriptome data analysis revealed that nitrogen deficiency clearly suppressed the expression of genes related to cell division in the young spike of Jing 411,whereas this suppression of gene expression was much lower in KN9204.In addition,KN9204 maintained relatively high expression of NPF genes for a longer time than Jing 411 during seed maturity.Physiological and transcriptome data revealed that KN9204 was more tolerant of nitrogen deficiency than Jing 411,especially at the reproductive stage.The high NUE of KN9204 is an integrated effect controlled at different levels.Taken together,our data provide new insights into the molecular mechanisms of NUE and important gene resources for improving wheat cultivars with a higher NUE trait. | Xiaoli Shi Fa Cui Xinyin Han Yilin He Long Zhao Na Zhang Hao Zhang Haidong Zhu Zhexin Liu Bin Ma Shusong Zheng Wei Zhang Jiajia Liu Xiaoli Fan Yaoqi Si Shuiquan Tian Jianqing Niu Huilan Wu Xuemei Liu Zhuo Chen Deyuan Meng Xiaoyan Wang Liqiang Song Lijing Sun Jie Han Hui Zhao Jun Ji Zhiguo Wang Xiaoyu He Ruilin Li Xuebin Chi Chengzhi Liang Beifang Niu Jun Xiao Junming Li Hong-Qing Ling | 2022 | Molecular Plant2022，15，9： | 6 |
| 5 | Combined deficiency of SLAMF8 and SLAMF9 prevents endotoxin-induced liver inflammation by downregulating TLR4 expression on macrophages显示文摘Classical signaling lymphocyte activating molecule(SLAM)family receptors are abundant within many types of immune cells,whereas the nonclassical SLAM family receptors SLAMF8 and SLAMF9,which uniquely lack cytoplasmic signaling motifs,are highly expressed by myeloid cells.Due to the potential redundancy,whether these two receptors regulate macrophage function remains largely unknown.Here,we show that SLAMF8 and SLAMF9 co-regulate macrophage-mediated liver inflammation.To overcome the redundancy,we generated mice that simultaneously lacked SLAMF8 and SLAMF9 using CRISPR-Cas9 technology.Although macrophage differentiation was not altered by the combined deficiency of SLAMF8 and SLAMF9,the loss of these two receptors significantly protected against lipopolysaccharide(LPS)-induced liver injury.SLAMF8 and SLAMF9 double-deficient mice had a prolonged survival rate and less infiltration of inflammatory cells.The depletion of macrophages using clodronate liposomes abolished the effects of SLAMF8 and SLAMF9 deficiencies on LPS-induced liver injury,which demonstrates that these receptors are required for macrophage activation following LPS challenge.Moreover,the deficiency of SLAMF8 and SLAMF9 suppressed the secretion of inflammatory cytokines by downregulating the expression of Toll-like receptor-4(TLR4),a receptor that specifically binds LPS,which led to decreased mitogen-activated protein kinases(MAPK)signaling activation.Notably,combined injections of truncated extracellular SLAMF8 and SLAMF9 proteins significantly alleviated LPS-induced liver injury.Thus,our findings provide insights into the role of SLAMF8 and SLAMF9 in endotoxin-induced liver injury and suggest that SLAMF8 and SLAMF9 are potential therapeutic targets for acute hepatic injury. | Xiaokang Zeng Guangao Liu Wanwen Peng Junming He Chenxu Cai Wei Xiong Shasha Chen Meixiang Yang Zhongjun Dong | 2020 | Cellular & Molecular Immunology2020，17，2： | 5 |
| 6 | MicroRNA Expression Signature and Antisense-Mediated Depletion Reveal an Essential Role of MicroRNA in Vascular Neointimal Lesion Formation显示文摘 | Ruirui Ji Yunhui Cheng Junming Yue Jian Yang Xiaojun Liu He Chen David B. Dean Chunxiang Zhang | 2007 | Circulation Research2007，，11： | 4 |
| 7 | Trace elements and rare earth elements in wet deposition of Lijiang,Mt.Yulong region,southeastern edge of the Tibetan Plateau显示文摘In order to investigate the compositions and wet deposition fluxes of trace elements and rare earth elements(REEs) in the precipitation of the southeastern edge of the Tibetan Plateau, 38 precipitation samples were collected from March to August in 2012 in an urban site of Lijiang city in the Mt. Yulong region. The concentrations of most trace elements and REEs were higher during the non-monsoon season than during the monsoon season,indicating that the lower concentrations of trace elements and REEs observed during monsoon had been influenced by the dilution effect of increased precipitation. The concentrations of trace elements in the precipitation of Lijiang city were slightly higher than those observed in remote sites of the Tibetan Plateau but much lower than those observed in the metropolises of China, indicating that the atmospheric environment of Lijiang city was less influenced by anthropogenic emissions, and, as a consequence, the air quality was still relatively good. However, the results of enrichment factor and principal component analysis revealed that some anthropogenic activities(e.g., the increasing traffic emissions from the rapid development of tourism) were most likely important contributors to trace elements, while the regional/local crustal sources rather than anthropogenic activities were the predominant contributors to the REEs in the wet deposition of Lijiang city. Our study was relevant not only for assessing the current status of the atmospheric environment in the Mt. Yulong region, but also for specific management actions to be implemented for the control of atmospheric inputs and the health of the environment for the future. | Junming Guo Shichang Kang Jie Huang Mika Sillanpaa Hewen Niu Xuejun Sun Yuanqing He Shijing Wang Lekhendra Tripathee | 2017 | Journal of Environmental Sciences2017，29，2： | 3 |
| 8 | Changes in compressed neurons from dogs with acute and severe cauda equina constrictions following intrathecal injection of brain-derived neurotrophic factor-conjugated polymer nanoparticles显示文摘This study established a dog model of acute multiple cauda equina constriction by experimental constriction injury (48 hours) of the lumbosacral central processes in dorsal root ganglia neurons. The repair effect of intrathecal injection of brain-derived neurotrophic factor with 15 mg encapsulated biodegradable poly(lactide-co-glycolide) nanoparticles on this injury was then analyzed. Dorsal root ganglion cells (L7) of all experimental dogs were analyzed using hematoxylin-eosin staining and immunohistochemistry at 1, 2 and 4 weeks following model induction. Intrathecal injection of brain-derived neurotrophic factor can relieve degeneration and inflammation, and elevate the expression of brain-derived neurotrophic factor in sensory neurons of compressed dorsal root ganglion. Simultaneously, intrathecal injection of brain-derived neurotrophic factor obviously improved neurological function in the dog model of acute multiple cauda equina constriction. Results verified that sustained intraspinal delivery of brain-derived neurotrophic factor encapsulated in biodegradable nanoparticles promoted the repair of histomorphology and function of neurons within the dorsal root ganglia in dogs with acute and severe cauda equina syndrome. | Junming Tan Jiangang Shi Guodong Shi Yanling Liu Xiaohong Liu Chaoyang Wang Dechun Chen Shunming Xing Lianbing Shen Lianshun Jia Xiaojian Ye Hailong He Jiashun Li | 2013 | Neural Regeneration Research2013，8，3： | 2 |
| 9 | Carbon as a hard template for nano material catalysts显示文摘As one of the naturally abundant elements,carbon can present in different molecular structures(allotropes) and thus lead to various physical/chemical properties of carbon-based materials which have found wide applications in a variety of fields including electrochemistry,optical,adsorption and catalysis,etc.On the other hand,its different allotropes also endow carbon-based materials with various morphostructures,which have been recently explored to prepare oxides and zeolites/zeotypes with tailored structures.In this review,we mainly summarize the recent advances in using carbon materials as hard templates to synthesize structural materials.Specifically,we focus on the development in the synthetic strategies,such as endotemplating,exotemplating approaches and using carbon materials as chemical reagents for the synthesis of metal carbides or nitrides,with an emphasis laid on the control of morphostructure.Meanwhile,the applications of the obtained materials will be highlighted,especially,in the field of heterogeneous catalysis where enhanced performances have been achieved with the materials derived from carbon-templated methods. | Kake Zhu Junming Sun He Zhang Jun Liu YongWang | 2012 | Journal of Natural Gas Chemistry2012，21，3： | 2 |
| 10 | Synthesis and characterization of MoS2/Fe@Fe3O4 nanocomposites exhibiting enhanced microwave absorption performance at normal and oblique incidences显示文摘Herein,we attempted to prepare MoS2/Fe@Fe3O4 nanocomposites capable of strongly absorbing broadband incident electromagnetic(EM)radiation and probed the effects of their composition on complex permittivity and permeability at 2-18 GHz.Calculations of normal-incidence reflection losses(RLs)based on EM parameters revealed that the Fe@Fe3O4 to MoS2 mass ratio strongly influenced the absorption peak intensity and bandwidth.Specifically,an RL peak of-31.8 dB@l5.3 GHz and a bandwidth(RL<-lOdB)of4.8 GHz(13.2-18 GHz)were achieved at a thickness of 1.52 mm and a Fe@Fe3O4 to M0S2 mass ratio of 60:40.Further,RL and bandwidth were investigated for oblique incidence,in which case two kinds of EM waves(TE-electric field perpendicular to plane of incidence;TM-electric field in the plane of incidence)were considered.The absorption peaks of TE and TM waves did not exceed-2 0 dB when the incidence angle increased to 3 0,and the bandwidth(R L<-10 dB)reached 4.2 GHz(TE wave)and 4.0 GHz(TM wave)when this angle was further increased to 40.0°and 50.4,respectively.Finally,the mechanism of microwave absorption was discussed in detail. | Peng Wang Junming Zhang Guowu Wang Benfang Duan Donglin He Tao Wang Fashen Li | 2019 | Journal of Materials Science & Technology2019，35，9： | 2 |
| 11 | The Cureumin Analog EF24 Targets NF-kB and miR-21, and Has Potent Anticancer Activity In Vitro and In Vivo显示文摘 | Chuan He Yang Junming Yue MieheUe Sims | 2013 | PLoS One2013，8，71： | 1 |
| 12 | Convective heat transfer in the laminar-turbulent transition region of molten salt in annular passage显示文摘 | Lu Jianfeng He Shiquan Liang Junming | 2013 | Experimental Thermal Fluid Sci2013，51，： | 1 |
| 13 | 显示文摘 | TIAN Ruijun SUN Junming ZHANG He YE Mingliang XIE Chuanhui DONG Jin HU Jiwei MA Ding BAO Xinhe ZOU Hanfa | 2006 | Electrophoresis2006，27，4： | 1 |
| 14 | Unusual mesoporous SBA-15 with parallel channels running along the short axis 显示文摘 | Zhang He Sun Junming Ma Ding | 2004 | Journal of American Chemical Society2004，126，24： | 1 |
| 15 | Toward monodispersed silver nanopartieles with unusual thermal stability显示文摘 | SUN Junming MA Ding ZHANG He | 2006 | Journal of the American Chemical Society2006，128，15： | 1 |
| 16 | Carbon-supported bimetallic Pd–Fe catalysts for vapor-phase hydrodeoxygenation of guaiacol显示文摘 | Junming Sun Ayman M. Karim He Zhang Libor Kovarik Xiaohong Shari Li Alyssa J. Hensley Jean-Sabin McEwen Yong Wang | 2013 | Journal of Catalysis2013，，： | 1 |
| 17 | Survival after radical cystectomy for bladder cancer:Multicenter comparison between minimally invasive and open approaches显示文摘Objective:To investigate oncological outcomes in patients with bladder cancer who underwent minimally invasive radical cystectomy(MIRC)or open radical cystectomy(ORC).Methods:We identified patients with bladder cancer who underwent radical cystectomy(RC)in 13 centers of the Chinese Bladder Cancer Consortium(CBCC).Perioperative outcomes were compared between MIRC and ORC.The influence of surgical approaches on overall survival(OS)and cancer-specific survival(CSS)in the entire study group and subgroups classified according to pathologic stage or lymph node(LN)status was assessed with the log-rank test.Multivariable Cox proportional hazard models were used to evaluate the association among OS,CSS and risk factors of interest.Results:Of 2098 patients who underwent RC,1243 patients underwent MIRC(1087 laparoscopic RC and 156 robotic-assisted RC,respectively),while 855 patients underwent ORC.No significant differences were noted in positive surgical margin rate and 90-day postoperative mortality rate.MIRC was associated with less estimated blood loss,more LN yield,higher rate of neobladder diversion,longer operative time,and longer length of hospital stay.There was no significant difference in OS and CSS according to surgical approaches(pZ0.653,and 0.816,respectively).Subgroup analysis revealed that OS and CSS were not significantly different regardless of the status of extravesical involvement or LN involvement.Multivariable Cox regression analyses showed that the surgical approach was not a significant predictor of OS and CSS.Conclusions:Our study showed that MIRC was comparable to conventional ORC in terms of OS and CSS. | Weibin Xie Junming Bi Qiang Wei Ping Han Dongkui Song Lei Shi Dingwei Ye Yijun Shen Xin Gou Weiyang He Shaogang Wang Zheng Liu Jinhai Fan Kaijie Wu Zhiwen Chen Xiaozhou Zhou Chuize Kong Yang Liu Chunxiao Liu Abai Xu Baiye Jin Guanghou Fu Wei Xue Haige Chen Tiejun Pan Zhong Tu Tianxin Lin Jian Huang | 2020 | Asian Journal of Urology2020，7，3： | 1 |
| 18 | Macro-Mesoporous Silicas Complex and the Carbon Replica显示文摘 | Sun Junming Ma Ding Zhang He | 2007 | Microporous Mesoporous Mater2007，100，13： | 1 |
| 19 | MicroRNAs Are Aberrantly Expressed in Hypertrophic Heart显示文摘 | Yunhui Cheng Ruirui Ji Junming Yue Jian Yang Xiaojun Liu He Chen David B. Dean Chunxiang Zhang | 2007 | The American Journal of Pathology2007，，6： | 1 |
| 20 | Electrochemical performances of NiO/Ni2N nanocomposite thin film as anode material for lithium ion batteries显示文摘Despite the high specific capacities,the practical application of transition metal oxides as the lithium ion battery(LIB)anode is hindered by their low cycling stability,severe polarization,low initial coulombic efficiency,etc.Here,we report the synthesis of the NiO/Ni2N nanocomposite thin film by reactive magnetron sputtering with a Ni metal target in an atmosphere of 1 vol.% O2 and 99 vol.%N2.The existence of homogeneously dispersed nano Ni2N phase not only improves charge transfer kinetics,but also contributes to the one-off formation of a stable solid electrolyte interphase(SEI).In comparison with the NiO electrode,the NiO/Ni2N electrode exhibits significantly enhanced cycling stability with retention rate of 98.8%(85.6%for the NiO electrode)after 50 cycles,initial coulombic efficiency of 76.6%(65.0%for the NiO electrode)and rate capability with 515.3 mA·h·g^−1(340.1 mA·h·g^−1 for the NiO electrode)at 1.6 A·g^−1. | Yanlin JIA Zhiyuan MA Zhicheng LI Zhenli HE Junming SHAO Hong ZHANG | 2019 | Frontiers of Materials Science2019，13，4： | 1 |
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