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| 1 | Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing显示文摘Hepatocellular 癌(HCC ) 是癌症实质词法,基因并且 phenotypic 差异。然而,我们不理解在 intratumor 异质和肿瘤的联系词法 / 组织学的特征之间的关系。用介绍 96 个肿瘤房间(30-36 各个) 和 15 个正常的肝房间(5 各个) 的单个房间的整个染色体的定序,与联系 HBV 的 HCC 从三个男病人收集了,我们证实拷贝数字变化在 hepatocarcinogenesis 早发生,但是此后在整个肿瘤仍然保持相对稳定前进。重要地,我们证明特定的 HCC 能具有 monoclonal 或 polyclonal 起源。有汇合的 multinodular 形态学的肿瘤是典型 polyclonal 肿瘤并且显示最高的 intratumor 异质。除了 mutational 和拷贝数字侧面,我们把了用导出 HBV 的外国 genomic 标记的 HCC 的同种细胞的起源。在 monoclonal HCC,所有肿瘤单身者房间展出一样的 HBV 集成,显示 HBV 集成是一个早司机事件并且在肿瘤前进期间仍然保持极其稳定。另外,我们的结果显示那两个都转移,迟了的传播并且早播种当模特儿,在 HCC 有一个角色前进。尤其是,开始的克隆传播的早 intrahepatic 导致同步 multifocal 肿瘤的形成。同时,我们在 HCC 识别了潜在的司机基因 ZNF717,它展出变化的高频率在单个房间并且人口铺平,,通过调整 IL-6/STAT3 小径行动的肿瘤 suppressor。这些调查结果热点多重不同肿瘤在 HCC 的进化机制,它为特定的处理策略建议需要。 | Meng Duan, Shu Zhang, Zhichao Wang, Jieyi Shi, Longzi Liu, Xiaoying Wang, Aiwu Ke, Jian Zhou, Jia Fan, Qiang Gao Junfeng Hao, Chong Li Sijia Cui Daniel L Worthley Ya Cao Ruibin Xi Xiaoming Zhang Jian Zhou, Jia Fan Qiang Gao | 2018 | Cell Research2018，28，3： | 21 |
| 2 | High-pressure granulite from Western Kunlun,northwestern China:Its metamorphic evolution,zircon SHRIMP U-Pb ages and tectonic implication显示文摘High-pressure mafic granulites occurring as lenticular bodies within garnet-amphibolites in Kangxiwar Fault have been first reported in this paper. The P-T conditions of two metamorphic stages were ob-tained using calibrated geothermal barometers and ThermoCalc Program. The peak metamorphic con-dition of these high-pressure granulites is about 760―820℃,1.0―1.2 GPa and the retrograde meta-morphic condition is about 620―720℃,0.7―0.8 GPa. The petrological studies show that they have a near-isobaric cooling P-T path which suggests that the Western Kunlun underwent initial crustal thickening,subsequent exhumation and cooling. The SHRIMP zircon U-Pb dating gives two groups of ages for high-pressure granulites. One is 177±6 Ma which is obtained from the rim of the zircon. We consider this age should be the metamorphic age. And the other is 456±30 Ma which is obtained from the core of the zircon and should be the protolith age. The formation of these high-pressure granulites in western Kunlun is closely correlated with the evolution of the Paleo-Tethys and has important im-plications for the research on Tethys and Paleo-Asian tectonic zone. | QU JunFeng ZHANG LiFei AI YongLiang L Zeng WANG JianPing ZHOU Hui WANG ShiYan | 2007 | Science China Earth Sciences2007，50，7： | 7 |
| 3 | Evaluating inter-continental transport of fine aerosols:method-ology, global aerosol distribution and optical depth显示文摘 | Junfeng Liu Denise L Mauzerall | 2009 | Atmospheric Environment2009，43，28： | 1 |
| 4 | A Universal Model of Stress Sensitive Coefficient in Low Permeability Reservoir显示文摘 | Junfeng Y Renjing L Huiqing L | 2011 | Procedia Engineering2011，，12： | 1 |
| 5 | Impacts of21st century climate change on global air pollution-related premature mortality显示文摘 | Fang Yuanyuan Mauzerall Denise L Liu Junfeng | 2013 | Climatic Change2013，121，2： | 1 |
| 6 | Atmospheric particulate mercury concentration and its dry deposition flux in Changchun City, China显示文摘 | FENGMAN F QICHAO W JUNFENG L | 2001 | The Science of the Total Environment2001，281，： | 1 |
| 7 | Assessment of sustainable energy potential of nonplantation biomass resources in China显示文摘 | Junfeng L Runqing H Yanqin S | 2005 | Biomass and Bioenergy2005，29，3： | 1 |
| 8 | Environmental health in China: progress towards clean air and safe water显示文摘 | Junfeng Zhang Denise L Mauzerall Tong Zhu Song Liang Majid Ezzati Justin V Remais | 2010 | The Lancet . 2010 (9720)2010，，9720： | 1 |
| 9 | Magnetic susceptibility as a proxy for rainfall:Worldwide data from tropical and temperate climate显示文摘 | Balsam W L Ellwood B B Ji Junfeng | | 0，，19： | 1 |
| 10 | Meta-analysis of randomized controlled trials on laparoscopic gastrectomy vs open gastrectomy for distal gastric cancer显示文摘 | Junfeng S Jun L Jianwei W | 2012 | Hepato Gastroenterol2012，59，118： | 1 |
| 11 | Efficacy of Qifu Lizhong enema prescription(芪附理中灌肠方)on intestinal mucosal tight junction function modulation of ulcerative colitis rat model显示文摘OBJECTIVE:To investigate the efficacy and mechanism of Qifu Lizhong enema prescription(芪附理中灌肠方,QFLZ)on intervening ulcerative colitis(UC)rat model with TCM spleen and kidney Yang insufficiency syndrome METHODS:Seventy-two male Sprague-Dawley rats were randomly assigned to six groups:normal model,mesalazine,and QFLZ high,medium,and low dose groups,each with 12 rats.After 3 d of adaptation feeding,all groups except the normal group were induced using rhubarb decoction in combination with trinitrobenzene sulfonic acid(TNBS)/55%ethanol to establish a UC rat model.Following successful modeling,the normal and model groups received daily saline enema,while the Chinese medicine and Western medicine groups received daily QFLZ and Mesalazine enema for 2 weeks respectively.The disease activity index score,hematoxylin and eosin staining,immunohistochemistry,and Western blotting were used to determine the expression of claudin 1,claudin 2,zonula occludens-1protein(ZO-1),and F-actin proteins in each rat colon tissue following treatment.RESULTS:QFLZ significantly alleviated the structural disorganization in the form of epithelial glands in the intestinal mucosa of rats with UC and retarded the progression of the disease.The intestinal mucosal epithelial cells of UC rats showed decreased expression of claudin 1,ZO-1,F-actin(P<0.05),claudin 2 appeared elevated(P<0.05),which resulted in impaired TJ.Treatment with QFLZ resulted in elevated expression of claudin 1(P<0.05),ZO-1(P<0.05)and F-actin(P<0.05)and decreased expression of claudin 2(P<0.05),which allowed for repair of the intestinal mucosal TJ,which in turn served as a treatment for UC.CONCLUSIONS:The mechanism of repairing TJ function and repairing the intestinal mucosal barrier by QFLZ may be associated with up-regulation of claudin 1,ZO-1,and F-actin levels,and down-regulation of claudin 2 expression level. | CHENG Jing Lü Shangbin ZHANG Yi HU Shuangyuan WEI Pengfei ZHOU Wenhua SHI Junfeng | 2023 | Journal of Traditional Chinese Medicine2023，43，2： | 1 |
| 12 | A New Approach to Investigate Real Flow Stress in Micro-Extrusion显示文摘 | Junfeng L Feng L Jinfeng Z | 2012 | Transac tions of Nonferrous Metals Society of China2012，22，2： | 1 |
| 13 | Relationship between illite crystallinity and temperature in active geothermal systems of New Zealand 显示文摘 | Ji Junfeng Browne P R L | 2000 | Clays and Minerals2000，48，1： | 1 |
| 14 | Secreted microRNAs: a new form of intercellular communication 显示文摘 | Xi C Hongwei L Junfeng Z | 2012 | Trends Cell Biol2012，22，3： | 1 |
| 15 | Evaluating intercontinental trans - port of fine aerosols: (2) Global heahh impact 显示文摘 | Junfeng Liu Denise L Mauzerall | 2009 | Atmospheric Environment2009，43，28： | 1 |
| 16 | Solidification of low - level - radioactive resins in ASC -zeolite blends显示文摘 | Junfeng L Gang Z Jianlong W | 2005 | Nuclear Engineering and Design2005，235，7： | 1 |
| 17 | Relationship between Illite Crystallinity and Temperature in Active Geothermal System of New Zealand显示文摘 | Ji Junfeng Browne P R L | 2000 | Clay and Clay Minerals2000，48，1： | 1 |
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