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| 1 | Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4显示文摘最近的尖铁 glycoprotein (S) 鉴别中东呼吸症候群 coronavirus (MERS-CoV ) 指向细胞的受体, dipeptidyl peptidase 4 (DPP4 ) 。顺序比较和当模特儿的分析在病毒的尖铁上揭示了一个通常认为的受体绑定领域(RBD ) ,它调停这个相互作用。我们报导 3.0 Å MERS-CoV RBD 的决定水晶结构跳了到人的 DPP4 的细胞外的领域。我们的结果证明 MERS-CoV RBD 由一个核心和受体绑定子域组成。受体绑定子域与 DPP4 β 交往;推进器然而并非它的内在的 hydrolase 领域。MERS-CoV RBD 和相关 SARS-CoV RBD 分享他们的核心子域的结构的类似的高度,但是在受体绑定子域是尤其是分叉的。Mutagenesis 研究在为到 DPP4 和入口的病毒的绑定是批评的进目标房间的受体绑定子域识别了几关键残余。在在 MERS-CoV RBD 和 DPP4 之间的接口的原子细节提供病毒和受体相互作用的结构的理解,它能对 MERS-CoV 感染指导治疗学和疫苗的开发。 | Nianshuang Wang Xuanling Shi Liwei Jiang Senyan Zhang Dongli Wang Pei Tong Dongxing Guo Lili Fu Ye Cui Xi Liu Kelly C Arledge Ying-Hua Chen Linqi Zhang Xinquan Wang | 2013 | Cell Research2013，23，8： | 26 |
| 2 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 3 | Use of secondary preventive medications in patients with atherosclerotic disease in urban China: a cross-sectional study of 16 860 patients显示文摘 | LI Jing CHEN Yi-ping LI Xi Jane Armitage FENG Fang LIU Jia-min GAO Yan ZHANG Hai-bo ZHANG Dan HUNDEI Wuhan-bilige CHEN Zheng-ming CHEN Fang Jemma C Hopewell Elsa Valdes-Marquez Martin Landray JIANG Li-xin | 2012 | Chinese Medical Journal2012，，24： | 10 |
| 4 | Effect of Temperature on the Synthesis of SiC Coating on Carbon Fibers by the Reaction of SiO with the Deposited Pyrolytic Carbon Layer显示文摘The influence of reaction temperature on the preparation of SiC coating on carbon fibers by the reaction of silicon monoxide with the deposited pyrolytic carbon (PyC) layer has been discussed.With rising reaction temperature,the thickness of SiC layer increases and the SiC grain is coarsening.The apparent activation energy for the synthesis of SiC layer is about 103.3 kJ/mol.The oxidation resistance of carbon fiber can be improved by the SiC/PyC layers significantly.The initial oxidation temperature of the SiC/PyC coated carbon fiber is about 300℃ higher than that of the uncoated carbon fiber.The oxidation of the SiC/PyC coated carbon fiber is owing to the diffusion of oxygen through the cracks generated by the mismatch of thermal expansion. | Hejun Li,Haibo Ouyang,Lehua Qi,Yulei Zhang,Zhengjia Li and Jianfeng Wei C/C Composites Research Center,Key Laboratory of Ultrahigh Temperature Composites,Northwestern Polytechnical University,Xi an 710072,China | 2010 | Journal of Materials Science & Technology2010，26，3： | 5 |
| 5 | Oxidation Protective C/SiC/Si-SiC Multilayer Coating for Carbon/Carbon Composites Applying at 1873 K显示文摘A C/SiC/Si-SiC multilayer coating for protecting carbon/carbon(C/C) composites against oxidation was prepared by slurry and pack cementation.X-ray diffraction(XRD) and energy dispersive spectroscopy(EDS) analysis showed that the inner coating obtained from the slurry and pack cementation was a C/SiC gradient layer acting as bonding layer,and the exterior coating formed in the second pack cementation was a Si-SiC double phase coating.Oxidation tests at 1873 K in air showed that the coating exhibited excellent oxidation protective ability and thermal shock resistance.The coating could effectively protect C/C composites from oxidation at 1873 K in air for 170 h and undergo the thermal cycling between 1873 K and room temperature for 8 cycles.The weight loss of the coated C/C composites is due to the formation of cracks and holes in the coating and the volatilization of SiO2 glass at high temperature. | Yulei Zhang,Hejun Li,Xinfa Qiang and Kezhi Li C/C Composites Research Center,State Key Laboratory of Solidification Processing,Northwestern Polytechnical University,Xi an 710072,China | 2010 | Journal of Materials Science & Technology2010，26，12： | 4 |
| 6 | Friction anisotropy dependence on lattice orientation of graphene显示文摘The observation of friction anisotropy on graphene by friction measurement at atomic scale has been reported in this paper.Atomic-scale friction measurement revealed friction anisotropy with a periodicity of 60°,which is consistent with the hexagonal periodicity of the graphene.Both experiments and theory show that the value of the friction force is related to the graphene lattice orientation,and the friction force along armchair orientation is also larger than the one along zigzag orientation.These results will play a critical role in the use of graphene to manufacture nanoscale devices. | ZHANG Yu LIU LianQing XI Ning WANG YueChao DONG ZaiLi WEJINYA Uchechukwu C | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，4： | 4 |
| 7 | ZrO_2 strengthened NiAl/Cr(Mo,Hf) composite fabricated by powder metallurgy | L.Y. Sheng a,b, J.T. Guo c, T.F. Xi a,b, B.C. Zhang c, H.Q. Ye c a PKU-HKUST ShenZhen-Hong Kong Institution, Shenzhen 518057, China b College of Engineering, Peking University, Beijing 100871, China c Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China | 2012 | Progress in Natural Science:Materials International2012，22，3： | 3 |
| 8 | Formulation development and bioavailability evaluation of a self nanoemulsified drug delivery system of oleanolie acid 显示文摘 | Xi J Chang Q Chan C K | 2009 | AAPS Pharm Sci Tech2009，10，1： | 1 |
| 9 | Delay-dependent robust H∞ performance for uncertain linear state-delayed systems显示文摘 | de Souza C E LI Xi | 1999 | Automatica1999，35，9： | 1 |
| 10 | Real time 3D shape in spection system of aulOlnOtivc paris based on Mruc tured light pattern 显示文摘 | Xu J Xi N Zhang C | 2011 | Optics and Laser Technology2011，43，1： | 1 |
| 11 | Evidence that wakefulness and REM sleep are controlled by a GABAergic pontine mechanism 显示文摘 | XI M C MORALES F R CHASE M H | 1999 | J Neurophysiol1999，82，4： | 1 |
| 12 | Association of GLUT4 gene variants with HbA1c level in Japanese men 显示文摘 | Xi C Miyaki K Ikeda S | 2012 | Endocr J2012，59，8： | 1 |
| 13 | Auslander-Reiten correspondence for tilting pairs显示文摘 | Wei J Q Xi C C | | 0，，： | 1 |
| 14 | Contralateral neuropathology in dorsal root ganglia in a rat model of noncompressive disc herniation显示文摘 | Li Y Xi C Niu M | 2011 | Neurosci lett2011，493，12： | 1 |
| 15 | Adsorption of antimony( Ⅲ ) and antimony( V ) on bentonite : Kinetics, thermodynamics and anion competition显示文摘 | Xi J He M Lin C | 2011 | Micro- chemical Journal2011，97，1： | 1 |
| 16 | Isolation of a strain of Acidithiobacillus caldus and its role in bioleaching of chalcopyrite显示文摘 | ZHOU Q G BO F BO Z H XI L JIAN G FEI L F HUA C X | 2007 | World Journal of Microbiology and Biotechnology2007，23，9： | 1 |
| 17 | Electron cyclotron wave current startup for ohmic discharges on the CT-6B tokamak 显示文摘 | Yao XI Jiang D Feng c | 2000 | Plasma Science IEEE Transactions on2000，28，1： | 1 |
| 18 | Sildenafil induces delayed preconditioning through inducible nitric oxide synthasedependent pathway in mouse heart显示文摘 | Salloum F Yin C Xi L | 2003 | Circ Res2003，92，6： | 1 |
| 19 | High hydraulic pressure to extraction flavonoids from propolis显示文摘 | Zhang S Q Xi J Wang C Z | 2005 | J Chem Technol Biotechnol2005，80，5： | 1 |
| 20 | The protective effects of ambroxol on radiation lung injury and influence on production of trans- forming growth factor betal and tumor necrosis factor alpha 显示文摘 | Xia DH Xi L Xv C | 2010 | Med Onco12010，27，3： | 1 |
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