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| 1 | Driving gene-engineered T cell immunotherapy of cancer显示文摘妄想的抗原受体(汽车) 设计基因的 T 房间治疗保持潜力与终末期癌在病人的生活有有意义的差别。为十年,癌症治疗基于生物物理的参数,与到 debulk 的外科的切除术,由放射和化疗列在后面指向很快成长的肿瘤房间,当时主要 sparing 静止正常纸巾。一突破与 allogeneic 骨头髓发生了与白血病为病人移植,它提供了一有时药品治疗。为稳固的肿瘤的采纳房间治疗的地与发现被建立渗入肿瘤的淋巴细胞能与变形黑瘤被扩展并且使用到对待和甚至痊愈病人。肿瘤特定的 T 房间受体(TCR ) 被识别并且设计了进耐心的外部血淋巴细胞,它也被发现治疗肿瘤。然而,这些被耐心的 HLA 限制限制。紧随来汽车的产生,把抗体的优美识别与一个 T 房间的受动器功能相结合。为与先进 B 房间恶意的多重表格对待病人的指向 CD19 的汽车的来临取得了大成功,与多达 95% 反应率。然而,到稳固的肿瘤的适用的汽车治疗刚开始了,但是已经,某些因素被弄明白:肿瘤目标具有最大的重要性让临床医生不做伤害;并且稳固的肿瘤与 hematologic 相比对汽车治疗不同地作出回应。这里,我们考察临床的设计基因的 T 房间免疫疗法,它的成功,挑战,和未来的状态。 | Laura A Johnson Carl H June | 2017 | Cell Research2017，27，1： | 37 |
| 2 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 3 | Thompson CB: The B7 and CD28 receptor families显示文摘 | June C H Bluestone J A Nadler L M | 1994 | Immunol Today1994，15，7： | 1 |
| 4 | Dynamic model- ing of large - scale mageto theological damper systems for civil engineering applications 显示文摘 | Yang G Q Spencer B F June H J | 2004 | Journal of Engineering Mechanics2004，130，9： | 1 |
| 5 | Adaptive Hopfield Neural Networks for Economic Load Dispatch 显示文摘 | Lee K Y Sode-Yome A June H P | 1998 | Power Systems IEEE Transactions on1998，13，2： | 1 |
| 6 | Osteop rotegerin inhibits ar- tery calcigtication induced by warfarin and by vitamin D 显示文摘 | Price P A June H H Buekley J R | 2001 | Arte- rioseler Thromb Vasc Biol2001，21，10： | 1 |
| 7 | Osteoprotegerin inhibits artery calcification induced by warfarin and by vitamin D 显示文摘 | Price P A June H H Buckley J R | 2001 | Arterioscler 3hromb Vasc Biol2001，21，10： | 1 |
| 8 | Considerations for the clinical applicationof chimeric antigen receptor T cells: observations froma recombinant DNA Advisory Committee Symposiumheld June 15,2010 显示文摘 | Ertl H C Zaia J? Rosenberg S A June C H Dotti G Kahn J | 2011 | Cancer Res2011，71，： | 1 |
| 9 | Adoptive T cell transfer for cancer immunotherapy in the era of synthetic biology显示文摘 | Kalos M June C H | 2013 | Immunity2013，39，1： | 1 |
| 10 | Osteoprotegerin inhibits artery calcification induced by warfarin and by vitamin D显示文摘 | June H Buckley J | 2001 | Arterioscler Thromb Vasc Biol2001，21，10： | 1 |
| 11 | Antibiotic resistance in triclosan tolerant fecal coliforms isolated from surface waters near wastewater treatment plant outflows显示文摘 | June H M James D S | 2013 | Ecotoxicology En?vironment Safafety2013，88，1： | 1 |
| 12 | Engineering lympho- cyte subsets: tools, trials and tribulations显示文摘 | June C H Blazar B R Riley J L | 2009 | Nature Re- views Immunology2009，9，10： | 1 |
| 13 | Expression of Distinct Self-Incompatibility Specificities in Arabidopsis thaliana显示文摘 | Boggs Nathan A Dwyer Kathleen G Shah Paurush McCulloch Amanda A Bechsgaard Jesper Schierup Mikkel H Nasrallah Mikhail E Nasrallah June B | 2009 | Genetics2009，，4： | 1 |
| 14 | Clinical perspec- tives for regulatory T cells in transplantation tolerance 显示文摘 | HIPPEN K L RILEY J L JUNE C H | 2011 | Semin Immunol2011，23，6： | 1 |
| 15 | simultaneous measurement of strain and temperature using a single fiber Bragg grating written in an erbium:ytterbium-doped fiber显示文摘 | June J Nam H Lee J H | 2000 | Appl Opt2000，39，7： | 1 |
| 16 | Adoptive T cell transfer for cancer immunotherapy in the era of synthetic biology 显示文摘 | Kalos M June C H | 2013 | Immunity2013，39，1： | 1 |
| 17 | Sensitivity and speicificity of PCR for detection of Mycobacterium tuberculosis: a blind comparison study among seven laboratories 显示文摘 | NOORDHOEK G T KOLK A H B JUNE G | 1994 | Journal of Clinical Microbiology1994，32，2： | 1 |
| 18 | Clinical application of expanded CD4 + 25 + cells显示文摘 | June C H Blazar B R | 2006 | Semi Immunol2006，18，2： | 1 |
| 19 | Simultaneous Measurement of Strain and Temperature Using a Single Fiber Bragg Grating with Erbium-Doped Fiber Amplifier显示文摘 | June J Nam H Lee J H | 1999 | Appl Opt1999，38，1： | 1 |
| 20 | Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia显示文摘 | Porter DL Levine BL June C H | 2011 | N Engl J Med2011，365，： | 1 |
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