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| 1 | 微粒化非诺贝特治疗高脂血症疗效和耐受性显示文摘上海市多中心、开放性、自身比较,观察微粒化非诺贝特200mg,每晚一次,治疗131例高脂血症病人4~8周的疗效和耐受性。男性76例,女性55例,平均年龄56.2±9.73岁,所属高血脂类型:Ⅱa型26例,Ⅱb型53例,Ⅳ型52例。治疗8周之后,Ⅱa和Ⅱb型患者血清总胆固醇明显降低(平均降低20%,P<0.01),Ⅱb和Ⅳ型患者血清甘油三酯明显降低(平均降低60%~63%,P<0.01),未出现严重不良反应,结论:微粒化非诺贝特特别适用于治疗Ⅱb和Ⅳ型高脂血症患者。4例合并有高尿酸血症者,治疗8周后,血尿酸平均降低59%。 | Zhu Junren, Han Qingqin. Zhongshan Hospital, Shanghai Medical University, Shanghai 100032 Shanghai multicenter clinical study group ) | 1997 | 中华心血管病杂志1997，25，3： | 16 |
| 2 | CDH1 germline mutation in hereditary gastric carcinoma显示文摘This paper provides a bird's-eye view both in preclinical and clinical aspects of E-cadherin germline gene (CDH1) in gastric cancer patients and their families. E-cadherin, a product of CDH1 gene, belonging to the functionally related trans-membrane glycoprotein family, is responsible for the Ca^2+-dependent cell-cell adhesion mechanism and contributes to dissociation followed by acquisition of cell motility, which usually occurs in the first step of cancer irwasion and metastasis. CDH1 gene germline mutation is common in many types of carcinoma, and occurs very frequent in hereditary gastric carcinoma (HGC) patients and their families. Recently, more and more researches support that E-cadherin plays an important role in the differentiation, growth and invasion of HGC. So it is of great value to clarify its mechanisms both for understanding HGC pathogenesis and for clinical therapy, especially in China, where there are a high risk population of gastric cancer and a high HGC incidence rate. In this paper, recent researches on CDH1 gene mutation, especially its role in tumor genesis and progress of HGC, are reviewed, and advances in evaluation of its mutation status for HGC diagnosis, therapy and prognosis, are also discussed briefly. | Hal-DanWang JunRen LianZhang | 2004 | World Journal of Gastroenterology2004，10，21： | 6 |
| 3 | Small guanine nucleotide-binding protein Rho and myocardial function显示文摘RhoA and Rho-kinase (ROCK) participate in a wide variety of cell signal functions such as cell growth, smooth and cardiac muscle contraction, cytoskeleton rearrangement, cell migration and proliferation. In vascular smooth muscle cells, RhoA and ROCK play an important role in Ca^2+ sensitization and regulate vascular smooth muscle tone. In the heart, RhoA and ROCK mediate hypertrophic response leading to cardiac hypertrophy. Recent cellular and molecular biology studies using ROCK inhibitors such as Y-27632 and fasudil have indicated a pivotal role of the RhoA-ROCK cascade in many aspects of cardiovascular function such as cardiac hypertrophy and ventricular remodeling following myocardial infarction. Inhibition of the RhoA-ROCK signaling pathway may be a suitable target for a number of cardiovascular diseases including hypertension, atherosclerosis, diabetes and hypertrophic heart failure. This review focuses on the current understanding of the RhoA-ROCK signal pathway in heart diseases and discusses the use of ROCK inhibitors as therapeutic agents for heart diseases ranging from hypertensive cardiomyopathy to heart failure. | JunREN CindyXFANG | 2005 | Acta Pharmacologica Sinica2005，26，3： | 6 |
| 4 | Global analysis of lysine succinylation in patchouli plant leaves显示文摘Lysine succinylation is a novel,naturally occurring posttranslational modification(PTM)in living organisms.Global lysine succinylation identification has been performed at the proteomic level in various species;however,the study of lysine succinylation in plant species is relatively limited.Patchouli plant(P.cablin(Blanco)Benth.,Lamiaceae)is a globally important industrial plant and medicinal herb.In the present study,lysine succinylome analysis was carried out in patchouli plants to determine the potential regulatory role of lysine succinylation in patchouli growth,development,and physiology.The global succinylation sites and proteins in patchouli plants were screened with an immunoprecipitation affinity enrichment technique and advanced mass spectrometry-based proteomics.Several bioinformatic analyses,such as function classification and enrichment,subcellular location predication,metabolic pathway enrichment and protein−protein interaction networking,were conducted to characterize the functions of the identified sites and proteins.In total,1097 succinylation sites in 493 proteins were detected in patchouli plants,among which 466 succinylation sites in 241 proteins were repeatedly identified within three independent experiments.The functional characterization of these proteins indicated that the tricarboxylic acid(TCA)cycle,oxidative phosphorylation,photosynthesis processes,and amino acid biosynthesis may be regulated by lysine succinylation.In addition,these succinylated proteins showed a wide subcellular location distribution,although the chloroplast and cytoplasm were the top two preferred cellular components.Our study suggested the important role of lysine succinylation in patchouli plant physiology and biology and could serve as a useful reference for succinylation studies in other medicinal plants. | Xiaobing Wang Xiuzhen Chen Junren Li Xuanxuan Zhou Yanting Liu Liting Zhong Yun Tang Hai Zheng Jiyun Liu Ruoting Zhan Likai Chen | 2019 | Horticulture Research2019，6，1： | 2 |
| 5 | Attractive electron-electron interaction induced by geometric phase in a Bloch band显示文摘Attractive interaction between electrons(or neutral fermions)is responsible for superconductivity(or superfluidity).In condensed matter systems,attractive interaction is usually induced by the boson-exchange mechanism[1].Indeed,in the celebrated Bardeen-Cooper-Schreiffer(BCS)theory,electrons develop attractive interaction by exchanging phonons[2].Subsequent studies show that other collective excitations such as charge density waves[3]and spin fluctuations[4]can also induce attractive interaction.The bosonexchange mechanism,together with the concept of Cooperpair,is considered to be the cornerstone of the modern theory of superconductivity. | JunRen Shi Qian Niu | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，2： | 1 |
| 6 | Comparison of the blood pressure-lowering effects and tolerability of Losartan-and Amlodipine-based regimens in patients with isolated systolic hypertension显示文摘 | VOLPE M JUNREN Z MAXWELL T | 2003 | Clin Ther2003，25，5： | 1 |
| 7 | VLCA: vision-language aligning model with cross-modal attention for bilingual remote sensing image captioning显示文摘In the field of satellite imagery, remote sensing image captioning(RSIC) is a hot topic with the challenge of overfitting and difficulty of image and text alignment. To address these issues, this paper proposes a vision-language aligning paradigm for RSIC to jointly represent vision and language. First, a new RSIC dataset DIOR-Captions is built for augmenting object detection in optical remote(DIOR) sensing images dataset with manually annotated Chinese and English contents. Second, a Vision-Language aligning model with Cross-modal Attention(VLCA) is presented to generate accurate and abundant bilingual descriptions for remote sensing images. Third, a crossmodal learning network is introduced to address the problem of visual-lingual alignment. Notably, VLCA is also applied to end-toend Chinese captions generation by using the pre-training language model of Chinese. The experiments are carried out with various baselines to validate VLCA on the proposed dataset. The results demonstrate that the proposed algorithm is more descriptive and informative than existing algorithms in producing captions. | WEI Tingting YUAN Weilin LUO Junren ZHANG Wanpeng LU Lina | 2023 | Journal of Systems Engineering and Electronics2023，34，1： | 1 |
| 8 | Failure Mechanisms of Tunnels in Weak Rock with Interbedded Structures 显示文摘 | HSU S C CHIANG S S LAI Junren | 2004 | International Journal of Rock Mechanics and Mining Sciences2004，41，3： | 1 |
| 9 | Synthesis and characterization of a dewatering reagent: cationic polyacrylamide (P(AM–DMC–DAC)) for activated sludge dewatering treatment显示文摘 | Junren Zhu Huaili Zheng Zhenzhen Jiang Zhi Zhang Liwei Liu Yongjun Sun Tiroyaone Tshukudu | 2013 | Desalination and Water Treatment2013，，13： | 1 |
| 10 | Miocene Jiali faulting and its implications for Tibetan tectonic evolution显示文摘 | Lee Haoyang Chung Sunlin Wang Junren | 2003 | EPSL2003，205，： | 1 |
| 11 | Identification of the heat shock protein 70 (HLHsp70) in Haemaphysalis longicornis显示文摘 | Zhancheng Tian Guangyuan Liu Liyan Zhang Hong Yin Hui Wang Junren Xie Ping Zhang Jin Luo | 2011 | Veterinary Parasitology2011，，2： | 1 |
| 12 | Separation of lysozyme from chicken egg white using ultrafiltration显示文摘 | WAN Yinhua LU Junren CUI Zhanfeng | 2006 | Separation and Purification Technology2006，48，2： | 1 |
| 13 | Contrasting Confucian Virtue Ethics and Maclntyre's Aristotelian Virtue Theory显示文摘在一篇关于“儒家与亚里士多德主义者关于美德的会话”的文章中,麦金泰尔对儒家与亚里士多德美德理论之间的问题做出了一种“亚里士多德式的阐释”。本文则力图提供一种儒家的美德伦理阐释,而非对亚里士多德主义的美德理论做儒家式的阐释(与麦金泰尔的做法相对),并由此尝试对“儒家与亚里士多德美德理论之间的问题”做出一种儒家式的回答。讨论的问题主要涉及两个方面:个人与人伦:美德主体的概念视差;“成就”与“成人”:美德评价的标准视差。 | Wan Junren | 2003 | Social Sciences in China2003，24，2： | 1 |
| 14 | Surgery for perforated colorectal malignancy in an Asian population: an institution’s experience over 5?years显示文摘 | Ker-Kan Tan Choon-Chiet Hong Junren Zhang Jody Zhiyang Liu Richard Sim | 2010 | International Journal of Colorectal Disease2010，，8： | 1 |
| 15 | Optimization of Base-catalyzed Biodiesel Production from waste frying oil显示文摘 | Zhao Yun Xu Xinmiao Zheng Junren Li Zequn | | 0，，： | 1 |
| 16 | Research on High-Efficiency Cyclone Separators and Their Optimum Design显示文摘ResearchonHighEficiencyCycloneSeparatorsandTheirOptimumDesignShiMingxian,JinYouhai,WuXiaolin,ChenJianyi,LiuJunren(UnitedRese... | Shi Mingxian, Jin Youhai, Wu Xiaolin, Chen Jianyi, Liu Junren (United Research Institute of Applied Chemistry and Chemical Engineering, University of Petroleum, Beijing 100083) | 1997 | 石油学报(石油加工)1997，13，S1： | 1 |
| 17 | Construction and expression of recombined human AFP eukaryotic expression vector显示文摘AIM: To construct a recombined human AFP eukaryotic expression vector for the purpose of gene therapy and target therapy of hepatocellular carcinoma (HCC).METHODS: The full length AFP-cDNA of prokaryotic vector was digested, and subcloned to the multi-clony sites of the eukaryotic vector. The constructed vector was confirmed by enzymes digestion and electrophoresis, and the product expressed was detected by electrochemiluminescence and immunofluorescence methods.RESULTS: The full length AFP-cDNA successfully cloned to the eukaryotic vector through electrophoresis, 0.9723 IU/ml AFP antigen was detected in the supernatant of AFPCHO by electrochemiluminescence method. Compared with the control groups, the differences were significant (P<0.05).AFP antigen molecule was observed in the plasma of AFPCHO by immunofluorescence staining.CONCLUSION: The recombined human AFP eukaryotic expression vector can express in CHO cell line. It provides experimental data for gene therapy and target therapy of hepatocellular carcinoma. | Li-WangZhang JunRen AiangZhang Hong-MeiZhang BinJin Bo-RongPan Xiao-MingSi Yan-JunZhang Zhong-HuaWang Yang-LinPan | 2003 | World Journal of Gastroenterology2003，9，7： | 1 |
| 18 | Quantum ac transport through coupled quantum dots显示文摘 | Ma Zhongshui Shi Junren Xie X C | 2000 | Phys Rev B2000，62，15： | 1 |
| 19 | Ribosome biogenesis protein Urb1 acts downstream of mTOR complex 1 to modulate digestive organ development in zebrafish显示文摘Ribosome biogenesis is essential for the cell growth and division. Disruptions in ribosome biogenesis result in developmental defects and a group of diseases, known as ribosomopathies. Here, we report a mutation in zebrafish urb1, which encodes an essential ribosome biogenesis protein. The urb1 cq31 mutant exhibits hypoplastic digestive organs, which is caused by impaired cell proliferation with the differentiation of digestive organ progenitors unaffected. Knockdown of mtor or raptor leads to similar hypoplastic phenotypes and reduced expression of urb1 in the digestive organs. Overexpression of Urb1 results in overgrowth of digestive organs, and can efficiently rescue the hypoplastic liver and pancreas in the mtor and raptor morphants. Reduced syntheses of free ribosomal subunits and impaired assembly of polysomes are observed in the urb1 mutant as well as in the mtor and raptor morphants, which can be rescued by the Urb1 overexpression. These data demonstrate that Urb1 plays an important role in governing ribosome biogenesis and protein synthesis downstream of mammalian/mechanistic target of rapamycin complex 1(mTORC1), thus regulating the development of digestive organs. Our study indicates the requirement of hyperactive protein synthesis for the digestive organ development. | Jia He Yun Yang Junren Zhang Jinzi Chen Xiangyong Wei Jianbo He Lingfei Luo | 2017 | Journal of Genetics and Genomics2017，44，12： | 1 |
| 20 | Competition between weak localization and antilocalization in topological surface states显示文摘 | Lu Haizhou Shi Junren Shen Shunqing | | 0，，： | 1 |
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