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| 1 | 赖氨酸琥珀酰化修饰与疾病的研究进展显示文摘赖氨酸琥珀酰化修饰是一种新型蛋白质翻译后修饰,在组蛋白中被发现,普遍存在于所有原核和真核生命体的细胞质和细胞核中,参与并调控几乎所有生命体的生物过程,与疾病密切相关。本文综述了赖氨酸琥珀酰化的特点、修饰位点的分布以及主要影响因素,归纳了SIRT5调控琥珀酰化参与疾病发生发展的多种代谢途径,为进一步探索疾病的发病机制提供基础。 | 蒙婷 徐丹 李争 荆晶 李风森 | 2021 | 中国医药科学2021，11，23： | 1 |
| 2 | Comprehensive analysis of the gut microbiome and posttranslational modifications elucidates the route involved in microbiota-host interactions显示文摘The gut microbiome interacts with the host to maintain body homeostasis,with gut microbial dysbiosis implicated in many diseases.However,the underlying mechanisms of gut microbe regulation of host behavior and brain functions remain unclear.This study aimed to elucidate the influence of gut microbiota on brain functions via post-translational modification mechanisms in the presence or absence of bacteria without any stimulation.We conducted succinylome analysis of hippocampal proteins in germ-free(GF)and specific pathogen-free(SPF)mice and metagenomic analysis of feces from SPF mice.These results were integrated with previously reported hippocampal acetylome and phosphorylome data from the same batch of mice.Subsequent bioinformatics analyses revealed 584 succinylation sites on 455 proteins,including 54 up-regulated succinylation sites on 91 proteins and 99 down-regulated sites on 51 proteins in the GF mice compared to the SPF mice.We constructed a panoramic map of gut microbiota-regulated succinylation,acetylation,and phosphorylation,and identified cross-talk and relative independence between the different types of post-translational modifications in modulating complicated intracellular pathways.Pearson correlation analysis indicated that 13 taxa,predominantly belonging to the Bacteroidetes phylum,were correlated with the biological functions of post-translational modifications.Positive correlations between these taxa and succinylation and negative correlations between these taxa and acetylation were identified in the modulation of intracellular pathways.This study highlights the hippocampal physiological changes induced by the absence of gut microbiota,and proteomic quantification of succinylation,phosphorylation,and acetylation,contributing to our understanding of the role of the gut microbiome in brain function and behavioral phenotypes. | Hai-Yang Wang Lan-Xiang Liu Xue-Yi Chen Yang-Dong Zhang Wen-Xia Li Wen-Wen Li Lian Wang Xiao-Long Mo Hong Wei Ping Ji Peng Xie | 2024 | Zoological Research2024，45，1： | 0 |
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