|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Punicalagin ameliorates collagen-induced arthritis by downregulating M1 macrophage and pyroptosis via NF-κB signaling pathway显示文摘Rheumatoid arthritis(RA)is a chronic inflammatory disease that eventually leads to disability.Inflammatory cell infiltration,severe joint breaking and systemic bone loss are the main clinical symptoms.In this study,we established a collagen-induced arthritis(CIA)model and found a large number of M1 macrophages and pyroptosis,which are important sources of proinflammatory cytokines.Punicalagin(PUN)is an active substance extracted from pomegranate peel.We found that it inhibited joint inflammation,cartilage damage and systemic bone destruction in CIA mice.PUN effectively alleviated the high expression of inflammatory cytokines in synovial tissue in vivo.PUN treatment shifted macrophages from the M1 phenotype to the M2 phenotype after stimulation with lipopolysaccharide(LPS)and interferon(IFN)-γ.The expression of inducible nitric oxide synthase(i NOS)and other proinflammatory cytokines released by M1 macrophages was decreased in the PUN treatment group.However,simultaneously,the expression of markers of anti-inflammatory M2 macrophages,such as arginase(Arg)-1 and interleukin(IL)-10,was increased.In addition,PUN treatment attenuated pyroptosis by downregulating the expression of NLRP3 and caspase-1,thereby preventing inflammatory cell death resulting from the release of IL-1βand IL-18.Mechanistically,PUN inhibited the activation of receptor activators of the nuclear factor-κB(NF-κB)signaling pathway,which contributes to M1 polarization and pyroptosis of macrophages.We concluded that PUN ameliorated pathological inflammation by inhibiting M1 phenotype polarization and pyroptosis and has great potential as a therapeutic treatment for human RA. | Gaoran Ge Jiaxiang Bai Qing Wang Xiaolong Liang Huaqiang Tao Hao Chen Minggang Wei Junjie Niu Huilin Yang Yaozeng Xu Yuefeng Hao Yi Xue Dechun Geng | 2022 | Science China(Life Sciences)2022，65，3： | 14 |
| 2 | Noninvasive Ultrasound Deep Brain Stimulation for the Treatment of Parkinson’s Disease Model Mouse显示文摘Modulating basal ganglia circuitry is of great signifcance in the improvement of motor function in Parkinson’s disease(PD).Here,for the frst time,we demonstrate that noninvasive ultrasound deep brain stimulation(UDBS)of the subthalamic nucleus(STN)or the globus pallidus(GP)improves motor behavior in a subacute mouse model of PD induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP).Immunohistochemical c-Fos protein expression confrms that there is a relatively high level of c-Fos expression in the STN-UDBS and GP-UDBS group compared with sham group(both p<0.05).Furthermore,STN-UDBS or GPUDBS signifcantly increases the latency to fall in the rotarod test on day 9(p<0.05)and decreases the time spent climbing down a vertical rod in the pole test on day 12(p<0.05).Moreover,our results reveal that STN-UDBS or GP-UDBS protects the dopamine(DA)neurons from MPTP neurotoxicity by downregulating Bax(p<0.001),upregulating Bcl-2(p<0.01),blocking cytochrome c(Cyt C)release from mitochondria(p<0.05),and reducing cleaved-caspase 3 activity(p<0.01)in the ipsilateral substantia nigra(SN).Additionally,the safety of ultrasound stimulation is characterized by hematoxylin and eosin(HE)and Nissl staining;no hemorrhage or tissue damage is detected.Tese data demonstrate that UDBS enables modulation of STN or GP neural activity and leads to neuroprotection in PD mice,potentially serving as a noninvasive strategy for the clinical treatment of PD. | Hui Zhou Lili Niu Long Meng Zhengrong Lin Junjie Zou Xiangxiang Xia Xiaowei Huang Wei Zhou Tianyuan Bian Hairong Zheng | 2019 | Research2019，，1： | 9 |
| 3 | Whole-genome sequencing provides insights into the genetic diversity and domestication of bitter gourd(Momordica spp.)显示文摘Bitter gourd(Momordica charantia)is a popular cultivated vegetable in Asian and African countries.To reveal the characteristics of the genomic structure,evolutionary trajectory,and genetic basis underlying the domestication of bitter gourd,we performed whole-genome sequencing of the cultivar Dali-11 and the wild small-fruited line TR and resequencing of 187 bitter gourd germplasms from 16 countries.The major gene clusters(Bi clusters)for the biosynthesis of cucurbitane triterpenoids,which confer a bitter taste,are highly conserved in cucumber,melon,and watermelon.Comparative analysis among cucurbit genomes revealed that the Bi cluster involved in cucurbitane triterpenoid biosynthesis is absent in bitter gourd.Phylogenetic analysis revealed that the TR group,including 21 bitter gourd germplasms,may belong to a new species or subspecies independent from M.charantia.Furthermore,we found that the remaining 166 M.charantia germplasms are geographically differentiated,and we identified 710,412,and 290 candidate domestication genes in the South Asia,Southeast Asia,and China populations,respectively.This study provides new insights into bitter gourd genetic diversity and domestication and will facilitate the future genomics-enabled improvement of bitter gourd. | Junjie Cui Yan Yang Shaobo Luo Le Wang Rukui Huang Qingfang Wen Xiaoxia Han Nansheng Miao Jiaowen Cheng Ziji Liu Changyuan Zhang Chengcheng Feng Haisheng Zhu Jianwen Su Xinjian Wan Fang Hu Yu Niu Xiaoming Zheng Yulan Yang Dai Shan Zhensheng Dong Weiming He Narinder P.S.Dhillon Kailin Hu | 2020 | Horticulture Research2020，7，1： | 7 |
| 4 | Chronology of the Holocene loess-paleosol section and its deposition and pedogenesis on the south of Chinese Loess Plateau显示文摘为 polymineral 标明日期有细密纹理的黄土的光学地刺激的光(OSL ) 取样,在中国黄土高原的南方上的 Laoguantai (LGT ) 节镇定,被申请做单人赛除得尽再生剂量(SAR ) 协议。‘ D | JIA Yaofeng HUANG Chunchang PANG Jiangli NIU Junjie | 2008 | Journal of Geographical Sciences2008，18，4： | 3 |
| 5 | Long-term clinical observation of patients with acute and chronic complete spinal cord injury after transplantation of Neuro Regen scaffold显示文摘Spinal cord injury(SCI)often results in an inhibitory environment at the injury site.In our previous studies,transplantation of a scaffold combined with stem cells was proven to induce neural regeneration in animal models of complete SCI.Based on these preclinical studies,collagen scaffolds loaded with the patients’own bone marrow mononuclear cells or human umbilical cord mesenchymal stem cells were transplanted into SCI patients.Fifteen patients with acute complete SCI and 51 patients with chronic complete SCI were enrolled and followed up for 2 to 5 years.No serious adverse events related to functional scaffold transplantation were observed.Among the patients with acute SCI,five patients achieved expansion of their sensory positions and six patients recovered sensation in the bowel or bladder.Additionally,four patients regained voluntary walking ability accompanied by reconnection of neural signal transduction.Among patients with chronic SCI,16 patients achieved expansion of their sensation level and 30 patients experienced enhanced reflexive defecation sensation or increased skin sweating below the injury site.Nearly half of the patients with chronic cervical SCI developed enhanced finger activity.These long-term follow-up results suggest that functional scaffold transplantation may represent a feasible treatment for patients with complete SCI. | Fengwu Tang Jiaguang Tang Yannan Zhao Jiaojiao Zhang Zhifeng Xiao Bing Chen Guang Han Na Yin Xianfeng Jiang Changyu Zhao Shixiang Cheng Ziqiang Wang Yumei Chen Qiaoling Chen Keran Song Zhiwei Zhang Junjie Niu Lingjun Wang Qin Shi Liang Chen Huilin Yang Shuxun Hou Sai Zhang Jianwu Dai | 2022 | Science China(Life Sciences)2022，65，5： | 3 |
| 6 | Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness显示文摘Tonic signaling of chimeric antigen receptor(CAR),i.e.,the spontaneous CAR activation in the absence of tumor antigen stimulation,is considered to be a pivotal event controlling CAR-T efficacy.However,the molecular mechanism underlying the spontaneous CAR signals remains elusive.Here,we unveil that positively charged patches(PCPs)on the surface of the CAR antigenbinding domain mediate CAR clustering and result in CAR tonic signaling.For CARs with high tonic signaling(e.g.,GD2.CAR and CSPG4.CAR),reducing PCPs on CARs or boosting ionic strength in the culture medium during ex vivo CAR-T cell expansion minimizes spontaneous CAR activation and alleviates CAR-T cell exhaustion.In contrast,introducing PCPs into the CAR with weak tonic signaling,such as CD19.CAR,results in improved in vivo persistence and superior antitumor function.These results demonstrate that CAR tonic signaling is induced and maintained by PCP-mediated CAR clustering.Notably,the mutations we generated to alter the PCPs maintain the antigen-binding affinity and specificity of the CAR.Therefore,our findings suggest that the rational tuning of PCPs to optimize tonic signaling and in vivo fitness of CAR-T cells is a promising design strategy for the nextgeneration CAR. | Jian Chen Shizhen Qiu Wentao Li Kun Wang Yu Zhang Han Yang Baichuan Liu Guangfei Li Li Li Min Chen Junjie Lan Jiahua Niu Peijie He Lei Cheng Gaofeng Fan Xin Liu Xianmin Song Chenqi Xu Haitao Wu Haopeng Wang | 2023 | Cell Research2023，33，5： | 2 |
| 7 | Noninvasive Ultrasound Stimulation of Ventral Tegmental Area Induces Reanimation from General Anaesthesia in Mice显示文摘Evidence in animals suggests that deep brain stimulation or optogenetics can be used for recovery from disorders of consciousness(DOC).However,these treatments require invasive procedures.This report presents a noninvasive strategy to stimulate central nervous system neurons selectively for recovery from DOC in mice.Through the delivery of ultrasound energy to the ventral tegmental area,mice were aroused from an unconscious,anaesthetized state in this study,and this process was controlled by adjusting the ultrasound parameters.The mice in the sham group under isoflurane-induced,continuous,steady-state general anaesthesia did not regain their righting reflex.On insonation,the emergence time from inhaled isoflurane anaesthesia decreased(sham.13.63±0.53 min,ultrasound.1.5±0.19 min,p<0.001).Further,the induction time(sham.12.0±0.6 min,ultrasound.17.88±0.64 min,p<0.001)and the concentration for 50%of the maximal effect(EC50)of isoflurane(sham.0.6%,ultrasound.0.7%)increased.In addition,ultrasound stimulation reduced the recovery time in mice with traumatic brain injury(sham.30.38±1.9 min,ultrasound.7.38±1.02 min,p<0.01).This noninvasive strategy could be used on demand to promote emergence from DOC and may be a potential treatment for such disorders. | Tianyuan Bian Wen Meng Meihong Qiu Zhigang Zhong Zhengrong Lin Junjie Zou Yibo Wang Xiaowei Huang Lisheng Xu Tifei Yuan Zhili Huang Lili Niu Long Meng Hairong Zheng | 2021 | Research2021，，1： | 2 |
| 8 | Preparation and characterization of carbon pillared clay material显示文摘Carbon pillared clay material was prepared from montmorillonite modified by C19H42BrN and C10H16ClN. SEM, FT-IR, XRD, N2 adsorption-desorption, thermal-gravimetric analysis and differential scanning calorimetry were employed to characterize the pore structure and test the effect of surfactant. The results show that organic modifier combines with montmorillonite particles by covalent bond and ion embedded. The microstructure of carbon pillared material looks like needle slice. The most probable pore size distribution is about 1.7 nm. The clay material slice mainly consists of two-dimensional aperture supported by a carbonization pillar. The high-temperature stability of carbon pillared clay is im- proved. | ZHANG ZengZhi YANG ChunWei NIU JunJie | 2009 | Science China(Technological Sciences)2009，52，1： | 2 |
| 9 | Orbital-regulated interfacial electronic coupling endows Ni3N with superior catalytic surface for hydrogen evolution reaction显示文摘The interstitial structure and weak Ni-N interaction of Ni3N lead to high unoccupied d orbital energy and unsuitable orbital orientation,which consequently results in weak orbital coupling with H2O and slow water dissociation kinetics for alkaline hydrogen evolution catalysis.Herein,we successfully lower the unoccupied d orbital energy of Ni3N to strengthen the interfacial electronic coupling by employing the strong electron pulling capability of oxygen dopants.The prepared O-Ni3N catalyst delivers an overpotential of 55 mV at 10 mA cm−2,very close to the commercial Pt/C.Refined structural characterization indicates the oxygen incorporation can decrease the electron densities around the Ni sites.Moreover,density functional theory calculation further proves the oxygen incorporation can create more unoccupied orbitals with lower energy and superior orientation for water adsorption and dissociation.The concept of orbital-regulated interfacial electronic coupling could offer a unique approach for the rational design of hydrogen evolution catalysts and beyond. | Yanyan Fang Da Sun Shuwen Niu Jinyan Cai Yipeng Zang Yishang Wu Linqin Zhu Yufang Xie Yun Liu Zixuan Zhu Amirabbas Mosallanezhad Di Niu Zheng Lu Junjie Shi Xiaojing Liu Dewei Rao Gongming Wang Yitai Qian | 2020 | Science China Chemistry2020，63，11： | 1 |
| 10 | Influence of the structure of carbon onions on their electrochemical performance in supercapacitor electrodes显示文摘 | John K. McDonough Andrey I. Frolov Volker Presser Junjie Niu Christopher H. Miller Teresa Ubieto Maxim V. Fedorov Yury Gogotsi | 2011 | Carbon2011，，9： | 1 |
| 11 | Dual interfacial engineering for efficient Cs_(2)AgBiBr_(6) based solar cells显示文摘The emerging lead-free halide double perovskite solar cells have attracted widespread attentions due to their long-term stability and non-toxicity, but suffer from the low device performance. One efficiencylimiting factor is the improper contacts between the halide double perovskite and anode/cathode electrodes. Here, we improve the efficiency and stability of the bismuth-halide double perovskite based solar cells by a synergistic interface design for both electron and hole transport layers(ETL/HTL). The results show that the modification of the TiO_2 ETL with a thin hydrophobic C60 layer and replacement of the lithium-doped small molecule HTL with an un-doped conjugated polymer lead to higher surface quality of perovskite film and better energy-level alignment at the contacts. As a result, the optimized device shows reduced trap density, suppressed charge recombination and enhanced charge extraction, leading to an increase of 69% in device efficiency. In addition, the device also exhibits superior stability in ambient environment, heat stress and light bias after interface optimization. This work provides an efficient strategy for the device optimization of the emerging lead-free perovskite solar cells. | Tao Luo Yalan Zhang Xiaoming Chang Junjie Fang Tianqi Niu Jing Lu Yuanyuan Fan Zicheng Ding Kui Zhao Shengzhong(Frank)Liu | 2021 | Journal of Energy Chemistry2021，30，2： | 1 |
| 12 | Infrared spectra of silicon nanowires显示文摘 | NIU Junjie J YANG Deren SHA Jian | 2007 | Materials Letters2007，61，： | 1 |
| 13 | Synthesis of superhydrophobic silicon oxide nanowires surface on silicon wafer显示文摘 | NIU Junjie WANG Jiannong XU Qianfeng | 2009 | Journal of Nanoscience and Nanoteehnology2009，9，3： | 1 |
| 14 | Silicon nanowires fabricatedby thermal evaporation of silicon monoxide显示文摘 | NIU JUNJIE SHA JIAN YANG DEREN | 2004 | Physica E2004，23，： | 1 |
| 15 | Sulfide-assisted growth of silicon nano-wires by thermal evaporation of sulfur powders显示文摘 | NIU Junjie SHA Jian YANG Deren | 2004 | Physica E2004，24，： | 1 |
| 16 | Temperature dependence of the first- order Raman scattering in silicon nanowires 显示文摘 | Junjie Niu Jian Sha DerenYang | 2006 | Script Materialia2006，55，： | 1 |
| 17 | Bio-clickable mussel-inspired peptides improve titanium-based material osseointegration synergistically with immunopolarization-regulation显示文摘Upon the osteoporotic condition,sluggish osteogenesis,excessive bone resorption,and chronic inflammation make the osseointegration of bioinert titanium(Ti)implants with surrounding bone tissues difficult,often lead to prosthesis loosening,bone collapse,and implant failure.In this study,we firstly designed clickable mussel-inspired peptides(DOPA-N3)and grafted them onto the surfaces of Ti materials through robust catechol-TiO2 coordinative interactions.Then,two dibenzylcyclooctyne(DBCO)-capped bioactive peptides RGD and BMP-2 bioactive domain(BMP-2)were clicked onto the DOPA-N3-coated Ti material surfaces via bio-orthogonal reaction.We characterized the surface morphology and biocompatibility of the Ti substrates and optimized the osteogenic capacity of Ti surfaces through adjusting the ideal ratios of BMP-2/RGD at 3:1.In vitro,the dual-functionalized Ti substrates exhibited excellent promotion on adhesion and osteogenesis of mesenchymal stem cells(MSCs),and conspicuous immunopolarization-regulation to shift macrophages to alternative(M2)phenotypes and inhibit inflammation,as well as enhancement of osseointegration and mechanical stability in osteoporotic rats.In summary,our biomimetic surface modification strategy by bio-orthogonal reaction provided a convenient and feasible method to resolve the bioinertia and clinical complications of Ti-based implants,which was conducive to the long-term success of Ti implants,especially in the osteoporotic or inflammatory conditions. | Jie Sun Yingkang Huang Huan Zhao Junjie Niu Xuwei Ling Can Zhu Lin Wang Huilin Yang Zhilu Yang Guoqing Pan Qin Shi | 2022 | Bioactive Materials2022，7，3： | 0 |
| 18 | Mission segment division of the whole aeroengine loading spectrum based on flight actions显示文摘This paper studies on a division method of the whole aeroengine loading spectrum flight mission segment and rotor speed mission segment,which is based on the actual flight actions and related to the flight operations of aeroengine and is suitable for the variable-speed aeroengines such as turbojet and turbofan.Through the research,the aeroengine loading spectrum operation-related mission segments can be divided,which can provide important data basis for the life research on the structures which are sensitive to flight maneuver(such as the main shaft,large gearbox and installation section),lay a foundation for the simulation,compilation and prediction of the whole aeroengine loading spectrum.Firstly,based on the summary of basic flight actions in actual flight,the division of flight mission segment was realized by programming.Moreover,the aeroengine rotor speed mission segments,associated with flight actions and missions,were divided based on the flight mission segment division results.Besides,the efficiency and accuracy of the mission segment division results were verified by adopting measured loading spectrum data.Finally,the characteristics of speed mission segment division results were compared and analyzed in tables and figures.The comparison results show that the characteristics of similar speed mission segments are similar,while the characteristics of different speed mission segments are different.And the shapes of similar mission segments vary to the change of flight actions and operations,which can reflect the operation-related feature of the segments. | Yu JIN Zhigang SUN Yingdong SONG Xin LIN Xuming NIU Junjie DING | 2022 | Chinese Journal of Aeronautics2022，35，2： | 0 |
| 19 | 'At last in'the physiological roles of the tubular ER network显示文摘In eukaryotic cells,the endoplasmic reticulum(ER)forms a continuous network of tubules and sheets.ER membranes are inter-connected by a class of dynamin-like GTPases termed atlastins(ATLs).Deletion or mutation of ATLs results in long and unbranched ER tubules in cells.Mutations in ATL1 in humans have been linked to the neurodegenerative disease hereditary spastic paraplegia.The basis of ATL-mediated membrane fusion has been studied extensively,but specific functions of ATL remain unclear.In this review,we summarize ER-related cellular processes that directly or indirectly involve ATL,including membrane trafficking,lipid metabolism,autophagy,microtubule dynamics,pathogen infections,calcium signaling,and protein homeostasis.These findings provide important clues for deciphering the physiological roles of the tubular ER network. | Li Lü Liling Niu Junjie Hu | 2020 | Biophysics Reports2020，6，4： | 0 |
| 20 | @重庆@世界·外国领馆、涉外机构及企业代表对话重庆国际化营商环境建设显示文摘6月1日,市政府外办、市商务委联合举办@重庆@世界·外国领馆、涉外机构及企业代表对话重庆国际化营商环境活动,邀请意大利、菲律宾、日本、缅甸、加拿大、乌拉圭、荷兰、英国、匈牙利、韩国、白俄罗斯、澳大利亚、奥地利等13国驻渝蓉总领事馆代表,越南工贸部驻重庆贸易促进办公室等7家外国商协会代表,英国怡和、丹麦嘉士伯等外资企业代表,以及外籍专家代表参加,召开了外国领馆、涉外机构及企业代表对话重庆国际化营商环境座谈会,着力优化重庆国际化营商环境,提升外籍人士在渝工作生活便捷度、舒适度。 | 无 Liu Junjie Niu Kexin Chen Jiaqi | 2023 | 重庆与世界2023，，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员