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| 1 | Patterns of synonymous codon usage bias in chloroplast genomes of seed plants显示文摘Codon usage in chloroplast genome of six seed plants (Arabidopsis thaliana, Populus alba, Zea mays, Triticum aestivum, Pinus koraiensis and Cycas taitungensis) was analyzed to find general patterns of codon usage in chloroplast genomes of seed plants. The results show that chloroplast genomes of the six seed plants had similar codon usage patterns, with a strong bias towards a high representation of NNA and NNT codons. In chloroplast genomes of the six seed plants, the effective number of codons (ENC) for most genes was similar to that of the expected ENC based on the GC content at the third codon position, but several genes with low ENC values were laying below the expected curve. All of these data indicate that codon usage was dominated by a mutational bias in chloroplast genomes of seed plants and that selection appeared to be limited to a subset of genes and to only subtly affect codon us-age. Meantime, four, six, eight, nine, ten and 12 codons were defined as the optimal codons in chloroplast genomes of the six seed plants. | ZHOU Meng LONG Wei LI Xia | 2008 | Forestry Studies in China2008，10，4： | 30 |
| 2 | Characterization of drug responses of mini patient-derived xenografts in mice for predicting cancer patient clinical therapeutic response显示文摘Background:Patient-derived organoids and xenografts(PDXs)have emerged as powerful models in functional diag-nostics with high predictive power for anticancer drug response.However,limitations such as engraftment failure and time-consuming for establishing and expanding PDX models followed by testing drug efficacy,and inability to subject to systemic drug administration for ex vivo organoid culture hinder realistic and fast decision-making in selecting the right therapeutics in the clinic.The present study aimed to develop an advanced PDX model,namely MiniPDX,for rapidly testing drug efficacy to strengthen its value in personalized cancer treatment.Methods:We developed a rapid in vivo drug sensitivity assay,OncoVee®MiniPDX,for screening clinically relevant regimens for cancer.In this model,patient-derived tumor cells were arrayed within hollow fiber capsules,implanted subcutaneously into mice and cultured for 7 days.The cellular activity morphology and pharmacokinetics were systematically evaluated.MiniPDX performance(sensitivity,specificity,positive and negative predictive values)was examined using PDX as the reference.Drug responses were examined by tumor cell growth inhibition rate and tumor growth inhibition rate in PDX models and MiniPDX assays respectively.The results from MiniPDX were also used to evaluate its predictive power for clinical outcomes.Results:Morphological and histopathological features of tumor cells within the MiniPDX capsules matched those both in PDX models and in original tumors.Drug responses in the PDX tumor graft assays correlated well with those in the corresponding MiniPDX assays using 26 PDX models generated from patients,including 14 gastric cancer,10 lung cancer and 2 pancreatic cancer.The positive predictive value of MiniPDX was 92%,and the negative predictive value was 81%with a sensitivity of 80%and a specificity of 93%.Through expanding to clinical tumor samples,Min-iPDX assay showed potential of wide clinical application.Conclusions:Fast in vivo MiniPDX assay based on capsule implantation was developed-to assess drug responses of both PDX tumor grafts and clinical cancer specimens.The high correlation between drug responses of paired MiniPDX and PDX tumor graft assay,as well as translational data suggest that MiniPDX assay is an advanced tool for personalized cancer treatment. | Feifei Zhang Wenjie Wang Yuan Long Hui Liu Jijun Cheng Lin Guo Rongyu Li Chao Meng Shan Yu Qingchuan Zhao Shun Lu Lili Wang Haitao Wang Danyi Wen | 2018 | Cancer Communications2018，38，1： | 20 |
| 3 | ^(18)F-FDG uptake as a biologic factor predicting outcome in patients with resected non-small-cell lung cancer显示文摘背景 non-small-cell 肺癌症(NSCLC ) 的外科的治疗的结果仍然保持差。在许多病人, NSCLC 的生物行为不跟随一个明确的模式,并且不能精确地在治疗前被预言。正电子排放断层摄影术(宠物) 上的 18F-fluoro-2-deoxy-glucose (18F-FDG ) 举起与 NSCLC 的攻击性被联系。现在的学习在与回顾的分析用经历了完全的切除术和外科手术前的 FDG 宠物的 82 个病人做的 NSCLC.Methods A 预言通过手术对待的病人的结果集中了于 18F-FDG 举起的角色。最大值标准化了举起价值(SUVmax ) ,除了五个 clinicopathological 因素和三 biomolecular 因素,能可能影响幸存,与病人的复发和幸存为可能的协会被作比较,由比例的危险在 multivariate 分析建模的 univariate 分析和艇长的木头等级测试。在 SUVmax 和另外的因素之间的协会也被分析。有 SUVmax 的结果病人超过 11 与不到 11 在 univariate 分析的 SUVmax 有没有疾病的幸存和比病人短的全面幸存(P0.001, P=0.002 ) 。在 multivariate 分析, SUVmax (在 11 的 dichotomized ) 是为肿瘤复发的唯一的重要预言者。TNM 舞台和 SUVmax (在 11 的 dichotomized ) 是为全面幸存的独立预言者。有 p53 overexpression 的 SUVmax 的协会,增殖的房间把肿瘤的索引和 microvascular 密度标记的原子抗原(PCNA ) 在全部组是重要的。宠物上的结论 18F-FDG 举起可以被用来 noninvasively 在 vivo 估计 NSCLC 的生物攻击性,识别能得益于另外的治疗的有差的预后的通过手术对待的病人。 | ZHANG Zhen-jiang CHEN Jing-han MENG Long DU Jia-jun ZHANG Lin LIU Ying DAI Hong-hai | 2007 | Chinese Medical Journal2007，，2： | 17 |
| 4 | 银白杨叶绿体基因组密码子用法分析(英文)显示文摘通过计算银白杨叶绿体基因组中各基因的ENc值、RSCU值、CAI值和GC3s的含量,分析银白杨叶绿体基因组密码子用法,并采用目前普遍使用的多变量统计分析方法(对应分析)和ENc.plot方法探讨了若干重要因子对银白杨叶绿体基因组密码子用法的效应。对应分析结果显示在影响最大的第一条向量轴上,基因的坐标位置与GC3s(r=349)极显著相关,而与该基因的表达水平(CAI)无显著相关性,但是在第二、三向量轴上基因的坐标位置与该基因的表达水平(CAI)呈极显著相关(r=-0.348和r=0.602,),说明碱基突变是影响密码子发挥作用的主要因素,而少数基因密码子用法受到翻译选择的作用;ENC-plot分析结果也证明了这一点。图2表2参34。 | ZHOU Meng LONG Wei LI Xia | 2008 | Journal of Forestry Research2008，19，4： | 17 |
| 5 | Gold nanorod-photosensitizer conjugate with extracellular pH-driven tumor targeting ability for photothermal/photodynamic therapy显示文摘氯 e6-pHLIP <候补选手class=“ a-plus-plus ”> ss -AuNRs,金使nanorod具有感光性结合包含 pH (低)有给予细胞外的 pH 的一张二硫化物契约的插入肽( pHLIP )( pH <候补选手class=“ a-plus-plus ”> e )-driven 肿瘤指向能力,成功地为光力学的 bimodal 和 photothermal 治疗被开发了。在这 bimodal 治疗,氯 e6 (Ce6 ) ,第二代的 photosensitizer (PS ) ,被用于光力学的治疗(太平洋夏季时间) 。金 nanorods (AuNRs ) 作为 Ce6 的 nanocarrier 和 quencher 为 photothermal 治疗(PTT ) 并且也被用作一个过高热代理人。pHLIPss 作为一根驾驶 pHe 的指向探针被设计在低 pH 在癌症房间提高 Ce6 和 AuNRs 的累积。在 Ce6-pHLIP < 潜水艇 class= “ a-plus-plus ” > ss -AuNRs, Ce6 接近并且由 AuNRs 熄灭了,引起小太平洋夏季时间效果。当暴露了到正常生理的 pH 时 7.4, Ce6-pHLIP < 潜水艇 class= “ a-plus-plus ” > ss -AuNRs 泛泛地与房间膜联系。然而,曾经暴露了到酸的 pH 6.2, pHLIP 活跃地插入到房间膜,和 conjugates 是进房间的 translocated。当这发生时, Ce6 由于二硫化物与 AuNRs 分开细胞内部的谷胱甘肽(GSH ) 引起的契约劈开,和汗衫氧在光之上为太平洋夏季时间被生产照耀。作为单个 PTT 代理人,另外, AuNRs 能由提高的浸透和保留(EPR ) 效果在肿瘤提高 PS 的累积。因此由我们的数据显示了当暴露了到酸的 pH 时, Ce6-pHLIP < 潜水艇 class= “ a-plus-plus ” > ss -AuNRs 能为癌症治疗完成 synergistic PTT/PDT bimodality。 | Nannan Wang Zilong Zhao Yifan Lv Huanhuan Fan Huarong Bai Hongmin Meng Yuqian Long Ting Fu Xiaobing Zhang Weihong Tan | 2014 | Nano Research2014，7，9： | 11 |
| 6 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 7 | Plasma microRNAs as potential new biomarkers for early detection of early gastric cancer显示文摘BACKGROUND Early gastric cancer(EGC), compared with advanced gastric cancer(AGC), has a higher 5-year survival rate. However, due to the lack of typical symptoms and the difficulty in diagnosing EGC, no effective biomarkers exist for the detection of EGC, and gastroscopy is the only detection method.AIM To provide new biomarkers with high specificity and sensitivity through analyzed the differentially expressed microRNAs(miRNAs) in EGC and AGC and compared them with those in benign gastritis(BG).METHODSWe examined the differentially expressed miRNAs in the plasma of 30 patients with EGC, AGC, and BG by miRNA chip analysis. Then, we analyzed and selected the significantly different miRNAs using bioinformatics. Reverse transcription quantitative real-time polymerase chain reaction(RT-qPCR)confirmed the relative transcription level of these miRNAs in another 122 patients, including patients with EGC, AGC, Helicobacter pylori(H. pylori)-negative gastritis(Control-1), and H. pylori-positive atrophic gastritis(Control-2).To establish a diagnostic model for the detection of plasma miRNA in EGC, we chose miRNAs that can be used to determine EGC and AGC from Control-1 and Control-2 and miRNAs in EGC from all other groups.RESULTS Among the expression profiles of the miRNA chips in the three groups in the discovery set, of 117 aberrantly expressed miRNAs, 30 confirmed target prediction, whereas 14 were included as potential miRNAs. The RT-qPCR results showed that 14 potential miRNAs expression profiles in the two groups exhibited no differences in terms of H. pylori-negative gastritis(Control-1) and H. pyloripositive atrophic gastritis(Control-2). Hence, these two groups were incorporated into the Control group. A combination of four types of miRNAs,miR-7641, miR-425-5 p, miR-1180-3 p and miR-122-5 p, were used to effectively distinguish the Cancer group(EGC + AGC) from the Control group [area under the curve(AUC) = 0.799, 95% confidence interval(CI): 0.691-0.908, P < 0.001].Additionally, miR-425-5 p, miR-24-3 p, miR-1180-3 p and miR-122-5 p were utilized to distinguish EGC from the Control group(AUC = 0.829, 95%CI: 0.657-1.000, P =0.001). Moreover, the miR-24-3 p expression level in EGC was lower than that in the AGC(AUC = 0.782, 95%CI: 0.571-0.993, P = 0.029), and the miR-4632-5 p expression level in EGC was significantly higher than that in AGC(AUC = 0.791,95%CI: 0.574-1.000, P = 0.024).CONCLUSION The differentially expressed circulatory plasma miR-425-5 p, miR-1180-3 p, miR-122-5 p, miR-24-3 p and miR-4632-5 p can be regarded as a new potential biomarker panel for the diagnosis of EGC. The prediction and early diagnosis of EGC can be considerably facilitated by combining gastroscopy with the use of these miRNA biomarkers, thereby optimizing the strategy for effective detection of EGC. Nevertheless, larger-scale human experiments are still required to confirm our findings. | Xiao-Liang Zhu Long-Fei Ren Hai-Ping Wang Zhong-Tian Bai Lei Zhang Wen-Bo Meng Ke-Xiang Zhu Fang-Hui Ding Long Miao Jun Yan Yan-Ping Wang Yu-Qin Liu Wen-Ce Zhou Xun Li | 2019 | World Journal of Gastroenterology2019，25，13： | 11 |
| 8 | BRAFV600E mutation is not a positive predictor for distant metastasis in sporadic papillary thyroid carcinoma显示文摘 | JING Fan-jing LIANG Jun LIANG Zhi-yong MENG Chao LONG Wen LI Xiao-yi LIN Yan-song | 2013 | Chinese Medical Journal2013，，16： | 11 |
| 9 | Noninvasive Ultrasound Deep Brain Stimulation for the Treatment of Parkinson’s Disease Model Mouse显示文摘Modulating basal ganglia circuitry is of great signifcance in the improvement of motor function in Parkinson’s disease(PD).Here,for the frst time,we demonstrate that noninvasive ultrasound deep brain stimulation(UDBS)of the subthalamic nucleus(STN)or the globus pallidus(GP)improves motor behavior in a subacute mouse model of PD induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP).Immunohistochemical c-Fos protein expression confrms that there is a relatively high level of c-Fos expression in the STN-UDBS and GP-UDBS group compared with sham group(both p<0.05).Furthermore,STN-UDBS or GPUDBS signifcantly increases the latency to fall in the rotarod test on day 9(p<0.05)and decreases the time spent climbing down a vertical rod in the pole test on day 12(p<0.05).Moreover,our results reveal that STN-UDBS or GP-UDBS protects the dopamine(DA)neurons from MPTP neurotoxicity by downregulating Bax(p<0.001),upregulating Bcl-2(p<0.01),blocking cytochrome c(Cyt C)release from mitochondria(p<0.05),and reducing cleaved-caspase 3 activity(p<0.01)in the ipsilateral substantia nigra(SN).Additionally,the safety of ultrasound stimulation is characterized by hematoxylin and eosin(HE)and Nissl staining;no hemorrhage or tissue damage is detected.Tese data demonstrate that UDBS enables modulation of STN or GP neural activity and leads to neuroprotection in PD mice,potentially serving as a noninvasive strategy for the clinical treatment of PD. | Hui Zhou Lili Niu Long Meng Zhengrong Lin Junjie Zou Xiangxiang Xia Xiaowei Huang Wei Zhou Tianyuan Bian Hairong Zheng | 2019 | Research2019，，1： | 9 |
| 10 | Emergent Endoscopic Retrograde Cholangiopancreatography with Placement of Biliary Double Stents to Salvage Endoscopic Retrograde Cholangiopancreatography-lnduced Stapfer's Type Ⅱ Perforation显示文摘 | Ping Yue Wen-Bo Meng Joseph W Leung Lei Zhang Xiao-Liang Zhu Hui Zhang Hai-Ping Wang Zheng-Feng Wang Ke-Xiang Zhu Long Miao Wen-Ce Zhou Xun Li | 2018 | Chinese Medical Journal2018，，19： | 7 |
| 11 | The role of ^(11)C-choline positron emission tomography-computed tomography and videomediastinoscopy in the evaluation of diseases of middle mediastinum显示文摘Background Middle mediastinal masses comprise a wide variety of tumors but may also reflect lymphadenopathy, and thus remain an interesting diagnostic challenge. We performed positron emission tomography (PET) of mediastinal masses in order to evaluate the ability of PET to predict the malignancy of these tumors. We compared histologic findings, videomediastinoscopy, computed tomography (CT), and PET-CT in patients with mediastinal disease. Methods Thirty-two patients were evaluated with CT, PET-CT and videomediastionoscopy, and all studies were performed within four weeks in each patient. 11C-choline as a PET tracer was used to visualize masses. PET data were evaluated using the standardized uptake value (SUV) and were compared with pathologic data. Results There were 13 men and 19 women aged from 21 to 74 (mean 45.2) years. Among the patients with mediastinal diseases, sarcoidosis was diagnosed in 12 patients, tuberculosis in 5 patients, lymphoma in 5 patients, and noncaseating granulomata without classical 'sarcoid' finding in 3 patients. N2 or N3 nodal metastasis was revealed in 6 of 7 patients who had non-small cell lung cancer or suspected lung cancer, and one was negative (the pathological diagnosis was reactive hyperplasia). The accuracies for correctly diagnosing mediastinal masses for CT, PET-CT and videomediastinoscopy were 38% (12/32), 63% (20/32), and 91% (29/32) respectively. The diagnostic accuracy of videomediastinoscopy was superior to that of PET-CT (χ2=11.130,P<0.001). The SUVs were similar among these diseases. On the other hand, if the diagnostic classification was benign vs malignancy, the accuracies for CT, PET-CT and videomediastinoscopy were 53% (17/32), 75% (24/32), 100% (32/32) respectively. The diagnostic accuracy of videomediastinoscopy was superior to that of PET-CT (χ2=22.042, P<0.001). The SUV of malignant lesions (6.9, 3.2-9.8; n=11) appeared to be higher than that of benign lesions (4.9, 2.9-8.3; n=21), however, this difference was not statistically significant (P=0.054). Conclusions To diagnose lesions located in the middle mediastinum, videomediastinoscopy possesses the highest diagnostic accuracy, and therefore remains the gold standard. PET-CT is valuable for differential diagnosis of benign vs malignant lesions, CT alone or PET alone (SUV) may provide misdiagnosis in a substantial proportion of patients with mediastinal masses. | LIU Qi PENG Zhong-min LIU Qing-wei YAO Shu-zhan ZHANG Lin MENG Long CHEN Jing-han | 2006 | Chinese Medical Journal2006，，8： | 7 |
| 12 | Simulated Sensitivity of Ozone Generation to Precursors in Beijing during a High O_(3) Episode显示文摘This study uses the WRF-Chem model combined with the empirical kinetic modeling method(EKMA curve)to study the compound pollution event in Beijing that happened in 13−23 May 2017.Sensitivity tests are conducted to analyze ozone sensitivity to its precursors,and to develop emission reduction measures.The results suggest that the model can accurately simulate the compound pollution process of photochemistry and haze.When VOCs and NOx were reduced by the same proportion,the effect of O_(3)reduction at peak time was more obvious,and the effect during daytime was more significant than at night.The degree of change in ozone was peak time>daytime average.When reducing or increasing the ratio of precursors by 25%at the same time,the effect of reducing 25%VOCs on the average ozone concentration reduction was most significant.The degree of change in ozone decreased with increasing altitude,the location of the ozone maximum change shifted westward,and its range narrowed.As the altitude increases,the VOCs-limited zone decreases,VOCs sensitivity decreases,NOx sensitivity increases.The controlled area changed from near-surface VOCs-limited to high-altitude NOx-limited.Upon examining the EKMA curve,we have found that suburban and urban are sensitive to VOCs.The sensitivity tests indicate that when VOCs in suburban are reduced about 60%,the O_(3)-1h concentration could reach the standard,and when VOCs of the urban decreased by about 50%,the O_(3)-1h concentration could reach the standard.Thus,these findings could provide references for the control of compound air pollution in Beijing. | Meng CUI Xingqin AN Li XING Guohui LI Guiqian TANG Jianjun HE Xin LONG Shuman ZHAO | 2021 | Advances in Atmospheric Sciences2021，38，7： | 7 |
| 13 | Design and Analysis of Gecko-like Robot显示文摘Gecko-like robot(Geckobot),an important branch of bionic robotics,is a robot that simulates gecko's capacity to climb walls and ceilings.The work environment of the traditional wall-climbing robot is greatly limited as the moving structure and adsorption principle of the robot have nothing to do with the real gecko.However,the adsorption principle and moving mode of the real gecko can provide a new way to break through the restrictions of the traditional wall-climbing robot.Inspired by the moving mechanism of geckos, this paper develops the Geckobot with motile body.Two types of Geckobots are addressed:one with compliant flat bar as the body,and the other with prismatic joint as the body.The compliant body not only resembles the moving mode of the real gecko body,but also simplifies the Geckobot's structure.The prismatic joint body is used to adapt the change of body length in ground-to-wall transition. The gait planning on the plane and the transition between perpendicular intersectional planes is discussed,with an emphasis on the analysis of the kinematics degree of freedom(DOF) and body posture.Central pattern generator(CPG) neural network is realized in LabVIEW and utilized to control Geckobot's movement.The CPG scheme in Lab VIEW is given,and how CPG is used to control Geckobot to turn or move forward is explored.Simulations are conducted in ADAMS to verify the feasibility of the structure design and gait planning and to acquire some parameters for practical Geckobot development.The experiment with Geckobot-Ⅰand Geckobot-Ⅱon their crawling capacity on the plane and the ground-to-wall transition finds that the robot can complete the crawling movement and ground-to-wall transition,verifying the feasibility of the structure design,gait planning and the CPG motion control.The Geckobot structure design approach,gait planning and the CPG motion control presented would be useful for the research on wall-climbing robots. | MENG Cai WANG Tianmiao GUAN Shengguo ZHANG Long WANG Jing LI Xiaohu | 2011 | Chinese Journal of Mechanical Engineering2011，24，2： | 6 |
| 14 | Comparative genomic and transcriptomic analyses uncover the molecular basis of high nitrogen-use efficiency in the wheat cultivar Kenong 9204显示文摘Studying the regulatory mechanisms that drive nitrogen-use efficiency(NUE)in crops is important for sustainable agriculture and environmental protection.In this study,we generated a high-quality genome assembly for the high-NUE wheat cultivar Kenong 9204 and systematically analyzed genes related to nitrogen uptake and metabolism.By comparative analyses,we found that the high-affinity nitrate transporter gene family had expanded in Triticeae.Further studies showed that subsequent functional differentiation endowed the expanded family members with saline inducibility,providing a genetic basis for improving the adaptability of wheat to nitrogen deficiency in various habitats.To explore the genetic and molecular mechanisms of high NUE,we compared genomic and transcriptomic data from the high-NUE cultivar Kenong 9204(KN9204)and the low-NUE cultivar Jing 411 and quantified their nitrogen accumulation under high-and low-nitrogen conditions.Compared with Jing 411,KN9204 absorbed significantly more nitrogen at the reproductive stage after shooting and accumulated it in the shoots and seeds.Transcriptome data analysis revealed that nitrogen deficiency clearly suppressed the expression of genes related to cell division in the young spike of Jing 411,whereas this suppression of gene expression was much lower in KN9204.In addition,KN9204 maintained relatively high expression of NPF genes for a longer time than Jing 411 during seed maturity.Physiological and transcriptome data revealed that KN9204 was more tolerant of nitrogen deficiency than Jing 411,especially at the reproductive stage.The high NUE of KN9204 is an integrated effect controlled at different levels.Taken together,our data provide new insights into the molecular mechanisms of NUE and important gene resources for improving wheat cultivars with a higher NUE trait. | Xiaoli Shi Fa Cui Xinyin Han Yilin He Long Zhao Na Zhang Hao Zhang Haidong Zhu Zhexin Liu Bin Ma Shusong Zheng Wei Zhang Jiajia Liu Xiaoli Fan Yaoqi Si Shuiquan Tian Jianqing Niu Huilan Wu Xuemei Liu Zhuo Chen Deyuan Meng Xiaoyan Wang Liqiang Song Lijing Sun Jie Han Hui Zhao Jun Ji Zhiguo Wang Xiaoyu He Ruilin Li Xuebin Chi Chengzhi Liang Beifang Niu Jun Xiao Junming Li Hong-Qing Ling | 2022 | Molecular Plant2022，15，9： | 6 |
| 15 | Pioglitazone ameliorates memory deficits in streptozotocin-induced diabetic mice by reducing brain 13-amyloid through PPARy activation显示文摘 | Li-ping LIU Tian-hua YAN Li-ying JIANG Wei HU Meng HU Chao WANG Qian ZHANG Yan LONG Jiang-qing WANG Yong-qi LI Mei HU Hao HONG | 2013 | Acta Pharmacologica Sinica2013，34，4： | 6 |
| 16 | Sequential analysis of dimethyl sulfur compounds in seawater显示文摘为暗淡乙醇硫的化合物,包括的 dimethylsulfide (数据管理系统) , dimethylsulfoniopropionate (DMSP ) 和 dimethylsulfoxide (DMSO ) 的决心的一个顺序的方法,在海水,样品被开发了。在 25 mL 样品的数据管理系统的 2.5 pmol 的检测极限,相应于 0.10 nmol/L,被完成。为暗淡乙醇硫的化合物的恢复在范围 68.6 78.3% 。为数据管理系统, DMSP 和 DMSO 决心的相对标准偏差(R.S.D.s ) 分别地是 3.0, 5.4 和 7.4% 。 | Meng Li Dong Xing Yuan Quan Long Li Xiao Ying Jin | 2007 | Chinese Chemical Letters2007，18，1： | 6 |
| 17 | Effect of TiO_2@SiO_2 nanoparticles on the mechanical and UV-resistance properties of polyphenylene sulfide fibers显示文摘In order to avoid the inherent photo-catalysis and aggregation of TiO2 in PPS, TiO2 nanoparticles were coated with SiO2 layers, which were chosen as the UV absorbent to improve the UV stability of polyphenylene sul fi de(PPS) fi ber. The PPS–TiO2@SiO2 nanocomposites fi bers were prepared via melt spinning, and the nanocomposites fi bers displayed different crystallization behaviors on variation of the diameters of TiO2@SiO2 nanoparticles, as con fi rmed by Differential Scanning Calorimetry(DSC). The spinnability, breaking strength and UV-resistance properties of PPS nanocomposites fi bers, as measured by homemade melt spinning machine, Xenon-lamp Weather Resistance Test Chamber and Yarn Tensile Tester, manifested the dependence on the diameters. The addition of nanoparticles with the diameter of 25 nm improved the spinnability and the mechanical performance of PPS most, which is attributed to the heterogeneous nucleation effect of nanoparticles. The UVresistance properties of the PPS nanocomposites were improved by the addition of TiO2@SiO2 nanoparticles. After aging for 180 h, PPS nanocomposites fi ber still maintained a high strength. | Zexu Hu Lili Li Bin Sun Si Meng Long Chen Meifang Zhu | 2015 | Progress in Natural Science:Materials International2015，25，4： | 5 |
| 18 | Concept Design and Coupled Dynamic Response Analysis on 6-MW Spar-Type Floating Offshore Wind Turbine显示文摘Tower,Spar platform and mooring system are designed in the project based on a given 6-MW wind turbine.Under wind-induced only,wave-induced only and combined wind and wave induced loads,dynamic response is analyzed for a 6-MW Spar-type floating offshore wind turbine(FOWT) under operating conditions and parked conditions respectively.Comparison with a platform-fixed system(land-based system) of a 6-MW wind turbine is carried out as well.Results demonstrate that the maximal out-of-plane deflection of the blade of a Spar-type system is 3.1% larger than that of a land-based system;the maximum response value of the nacelle acceleration is 215% larger for all the designed load cases being considered;the ultimate tower base fore-aft bending moment of the Spar-type system is92% larger than that of the land-based system in all of the Design Load Cases(DLCs) being considered;the fluctuations of the mooring tension is mainly wave-induced,and the safety factor of the mooring tension is adequate for the 6-MW FOWT.The results can provide relevant modifications to the initial design for the Spar-type system,the detailed design and model basin test of the 6-MW Spar-type system. | MENG Long ZHOU Tao HE Yan-ping ZHAO Yong-sheng LIU Ya-dong | 2017 | China Ocean Engineering2017，31，5： | 5 |
| 19 | Clinical significance of different periampullary diverticulum classifications for endoscopic retrograde cholangiopancreatography cannulation显示文摘BACKGROUND Different types of periampullary diverticulum(PAD) may differentially affect the success of endoscopic retrograde cholangiopancreatography(ERCP) cannulation,but the clinical significance of the two current PAD classifications for cannulation is limited.AIM To verify the clinical value of our newly proposed PAD classification.METHODS A new PAD classification(Li-Tanaka classification) was proposed at our center.All PAD patients with native papillae who underwent ERCP from January 2012 to December 2017 were classified according to three classification systems, and the effects of various types of PAD on ERCP cannulation were compared.RESULTS A total of 3564 patients with native papillae were enrolled, including 967(27.13%)PAD patients and 2597(72.87%) non-PAD patients. In the Li-Tanaka classification, type Ⅰ PAD patients exhibited the highest difficult cannulation rate(23.1%, P = 0.01), and type Ⅱ and Ⅳ patients had the highest cannulation success rates(99.4% in type Ⅱ and 99.3% in type Ⅳ, P < 0.001). In a multivariableadjusted logistic model, the overall successful cannulation rate in PAD patients was higher than that in non-PAD patients [odds ratio(OR) = 1.87, 95% confidence interval(CI): 1.04-3037, P = 0.037]. In addition, compared to the non-PAD group,the difficulty of cannulation in the type Ⅰ PAD group according to the Li-Tanaka classification was greater(OR = 2.04, 95%CI: 1.13-3.68, P = 0.004), and the successful cannulation rate was lower(OR = 0.27, 95%CI: 0.11-0.66, P < 0.001),while it was higher in the type Ⅱ PAD group(OR = 4.44, 95%CI: 1.61-12.29, P <0.01).CONCLUSION Among the three PAD classifications, the Li-Tanaka classification has an obvious clinical advantage for ERCP cannulation, and it is helpful for evaluating potentially difficult and successful cannulation cases among different types of PAD patients. | Ping Yue Ke-Xiang Zhu Hai-Ping Wang Wen-Bo Meng Jian-Kang Liu Lei Zhang Xiao-Liang Zhu Hui Zhang Long Miao Zheng-Feng Wang Wen-Ce Zhou Azumi Suzuki Kiyohito Tanaka Xun Li | 2020 | World Journal of Gastroenterology2020，26，19： | 5 |
| 20 | Investigation of straightforward impedance eduction method on single-degree-of-freedom acoustic liners显示文摘In order to address the current aircraft noise problem, the knowledge of impedance of acoustic liners subjected to high-intensity sound and grazing flow is of crucial importance to the design of high-efficiency acoustic nacelles. To this end, the present study is twofold. Firstly, the StraightForward impedance eduction Method(SFM) is evaluated by the strategy that the impedance of a liner specimen is firstly experimentally educed on a flow duct using the SFM, and then its accuracy is checked by comparing the numerical prediction with the measured wall sound pressure of the flow duct. Secondly, the effects of grazing flow and high-intensity sound on the impedance behavior of two single-layer liners are investigated based on comparisons between educed impedance and predictions by three impedance models. The performance of the SFM is validated by showing that the educed impedance leads to excellent agreement between the simulation and the measured wall sound pressure for different grazing flow Mach numbers and Sound Pressure Levels(SPLs) and over a frequency range from 3000 Hz down to 500 Hz. The grazing flow effect generally has the tendency that the acoustic resistance exhibits a slight decrease before it increases linearly with an increase in Mach,predicted successfully by the sound-vortex interaction theoretical model and the Kooi semi-empirical impedance model. However, the Goodrich semi-empirical impedance model gives only a simple linear relation of acoustic resistance starting from Mach zero. Additionally, when the SPL increases from 110 to 140 d B in the present investigation, the acoustic resistance exhibits a significant increase at all frequencies in the absence of flow; however, the resistance decreases slightly under a grazing flow of Mach 0.117. It indicates that the SPL effect can be greatly inhibited when flow is present,and the grazing flow effect can be reduced partly as well at a relatively high SPL. | Xianghai QIU Bo XIN Long WU Yang MENG Xiaodong JING | 2018 | Chinese Journal of Aeronautics2018，31，12： | 5 |
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