|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Retrospective analysis of extra-gastrointestinal stromal tumors显示文摘AIM:To investigate the clinicopathologic features of patients with extra-gastrointestinal stromal tumors(EGISTs)in South Korea.METHODS:A total of 51 patients with an EGIST were identified.The clinicopathologic features,including sex,age,location,tumor size,histology,mitotic rate,immunohistochemical features,genetic status and survival data,were analyzed.RESULTS:The median age was 55 years(range:29-80years),and male:female ratio was 1:1.04.The most common site was in the mesentery(n=15)followed by the retroperitoneum(n=13)and omentum(n=8).The median tumor size was 9.0 cm(range:2.6-30.0cm)and the median mitotic rate was 5.0/50HPF.(1/50-185/50).KIT was analyzed in 16,which revealed 10cases with wild-type KIT and 6 cases with an exon 11mutation.Among 51 patients,31 patients had undergone surgery,and 10 had unresectable disease and had taken palliative imatinib,which resulted in 22.7 mo of progression-free survival.Of the patients who had undergone surgery,18 did not take adjuvant imatinib,and 8 of these were categorized as'high risk'according to the risk criteria.However,the relapse-free survival was not different(P=0.157)between two groups.CONCLUSION:Because the biologic behaviors of GISTs differ according to the location of the tumor,a more stratified strategy is required for managing EGISTs including incorporation of molecular features. | Jun Ho Yi Byeong-Bae Park Jung Hun Kang In Gyu Hwang Dong Bok Shin Sun Jin Sym Hee Kyung Ahn Soon Il Lee Do Hyoung Lim Keon Woo Park Young-Woong Won Sung Hee Lim Se Hoon Park | 2015 | World Journal of Gastroenterology2015，21，6： | 9 |
| 2 | Glehnia fittoralis Extract Promotes Neurogenesis in the Hippocampal Dentate Gyrus of the Adult Mouse through Increasing Expressions of Brain-Derived Neurotrophic Factor and Tropomyosin-Related Kinase B显示文摘 | Joon Ha Park Bich Na Shin Ji Hyeon Ahn Jeong Hwi Cho Tae-Kyeong Lee Jae-Chul Lee Yong Hwan Jeon II Jun Kang Ki-Yeon Yoo In Koo Hwang Choong Hyun Lee Yoo Hun Noh Sung-Su Kim Moo-Ho Won Jong Dai Kim | 2018 | Chinese Medical Journal2018，，6： | 6 |
| 3 | Thioredoxin Reductase Type C (NTRC) Orchestrates Enhanced Thermotolerance to Arabidopsis by Its Redox-Dependent Holdase Chaperone Function显示文摘Genevestigator 分析为 NADPH-thioredoxin reductase 显示了抄本感应的热吃惊,在光的类型 C (NTRC ) 。这里,我们在 Arabidopsis 显示出 NTRC 的 overexpression | Ho Byoung Chae Jeong Chan Moon Mi Rim Shin Yong Hun Chi Young Jun Jung Sun Yong Lee Ganesh M. Nawkar Hyun Suk Jung Jae Kyung Hyun Woe Yeon Kim Chang Ho Kang Dae-Jin Yun Kyun Oh Lee Sang Yeol Lee | 2013 | Molecular Plant2013，6，2： | 5 |
| 4 | Efficacy and safety of ecabet sodium on functional dyspepsia:A prospective,double-blinded,randomized,multi-center controlled trial显示文摘瞄准:在减轻机能性消化不良的症状比较 ecabet 钠和 cimetidine。方法:我们执行了一个多中心,未来,使随机化,双 blinded 控制了试用在病人把 ecabet 钠和 cimetidine 的临床的功效与机能性消化不良作比较。二 -- 有完成 Rome-II 标准的消化不良的症状的 172 个病人从 7 个中心被注册。在学习组(115 个病人) , 1.5 g ecabet 钠一天被给两次。在控制组(121 个病人) , 400 mg cimetidine 一天被给两次。生命的质量的症状和参数在基线被分析,在开始治疗以后的 3, 14,和 28 d。结果:二 -- 136 个病人完成了临床的试用。在治疗的 4 wk 以后,在有消化不良的症状的病人的改进的率不在二个组之间是不同的(77.4% 在 ecabet 组织,分别地, 79.3% 在 cimetidine 组织 P >
0.05 ) 。同样,征兆的改进的率不在 3 d 和 14 d 是不同的。生命的质量的参数没在两个组在学习时期期间显著地变化。在两个组没有临床上重要的不利事件。结论:在有机能性消化不良的病人, ecabet 钠与 cimetidine 有类似的临床的功效。 | Jun Haeng Lee Jae J Kim Ki-Baik Hahm Dong Ho Lee Nayoung Kim Sung Kook Kim Jong Jae Park Seok Reyol Choi Jong Hun Lee Soo Teik Lee Eun Hyun Lee Jong Chul Rhee | 2006 | World Journal of Gastroenterology2006，12，17： | 3 |
| 5 | Ultrafast photonic PCR显示文摘Nucleic acid amplification and quantification via polymerase chain reaction(PCR)is one of the most sensitive and powerful tools for clinical laboratories,precision medicine,personalized medicine,agricultural science,forensic science and environmental science.Ultrafast multiplex PCR,characterized by low power consumption,compact size and simple operation,is ideal for timely diagnosis at the point-of-care(POC).Although several fast/ultrafast PCR methods have been proposed,the use of a simple and robust PCR thermal cycler remains challenging for POC testing.Here,we present an ultrafast photonic PCR method using plasmonic photothermal light-to-heat conversion via photon–electron–phonon coupling.We demonstrate an efficient photonic heat converter using a thin gold(Au)film due to its plasmon-assisted high optical absorption(approximately 65%at 450 nm,the peak wavelength of heat source light-emitting diodes(LEDs)).The plasmon-excited Au film is capable of rapidly heating the surrounding solution to over 150℃ within 3 min.Using this method,ultrafast thermal cycling(30 cycles;heating and cooling rate of 12.7960.93℃ s^(-1) and 6.660.29℃ s^(-1),respectively)from 55℃(temperature of annealing)to 95℃(temperature of denaturation)is accomplished within 5 min.Using photonic PCR thermal cycles,we demonstrate here successful nucleic acid(λ-DNA)amplification.Our simple,robust and low cost approach to ultrafast PCR using an efficient photonic-based heating procedure could be generally integrated into a variety of devices or procedures,including on-chip thermal lysis and heating for isothermal amplifications. | Jun Ho Son Byungrae Cho SoonGweon Hong Sang Hun Lee Ori Hoxha Amanda J Haack Luke P Lee | 2015 | Light(Science & Applications)2015，4，1： | 2 |
| 6 | Comparative clinical study of conjunctival toxicities of newer generation fluoroquinolones without the influence of preservatives显示文摘AIM: To compare the conjunctival epithelial toxicities of three newer-generation fluoroquinolones without preservatives.·METHODS: In a prospective, randomized, double blind comparative study, 47 eyes of 47 patients with a primary pterygium were enrolled, and divided randomly into three groups(levofloxacin 0.5%, gatifloxacin 0.3%, and moxifloxacin 0.5%). After pterygium surgery with the same conjunctival autograft technique, each patient maintained a regimen with a randomly assigned fluoroquinolone eye drop. Patients were examined every other day after surgery until the epithelium had completely healed. Photos were taken and used to measure the area of residual epithelial defects.Conjunctival healing time and speed(initial defect area/healing time(mm^2/d) compared in each group using Kruskal-Wallis tests.· RESULTS: There were no significant differences in mean age, gender, and conjunctival defect size of the donor site between these groups. However, the mean of conjunctival healing time and speed were statistically different in each group. The mean of conjunctival epithelial healing time was 8.93 ±2.69d(levofloxacin group), 10.31±2.96d(gatifloxacin group), and 13.50±4.10d(moxifloxacin group), P =0.006. The mean conjuctival epithelial healing speed was 6.18±1.39 mm^2/d(levofloxacin group), 5.52 ±1.68 mm^2/d(gatifloxacin group), and 4.40 ±1.30 mm^2/d(moxifloxacin group), P =0.003.·CONCLUSION: Without the influence of preservatives,levofloxacin and gatifloxacin might be less toxic to the regeneration of conjunctival epithelial cells and cause a faster conjunctival wound healing relative to moxifloxacin. | Han Sang Park Jun Hun Lee Hong Kyun Kim | 2015 | International Journal of Ophthalmology(English edition)2015，8，6： | 2 |
| 7 | Enzyme-amplified SERS immunoassay with Ag-Au bimetallic SERS hot spots显示文摘Surface-enhanced Raman scattering(SERS)enables rapid detection of single molecules with high specificity.However,quantitative and sensitive SERS analysis has been a challenge due to the lack of reliable SERS-active materials.In this study,we developed a quantitative SERS-based immunoassay using enzyme-guided Ag growth on Raman labeling compound(RLC)-immobilized gold nanoparticle(Au NP)-assembled silica NPs(SiO2@Au-RLC@Ag).The enzyme amplified Ag+reduction as well as Ag growth on the RLC-immobilized Au NP-assembled silica NPs(SiO2@Au-RLC),which resulted in a significant increase in SERS signal.In the presence of target antigens such as immunoglobulinG(IgG)or prostate-specific antigen(PSA),Ab1-Antigen-Ab2 immune complex with alkaline phosphatase triggered an enzyme-catalyzed reaction to convert 2-phospho-L-ascorbic acid(2-phospho-L-AA)to ascorbic acid(AA).As produced AA reduced Ag+to Ag,forming an Ag hot spot on the surface of SiO2@Au-RLC,which enhanced the SERS signal of SiO2@Au-RLC@Ag in a solution with a target antigen concentration.The plasmonic immunoassay for IgG detection showed a high linearity of SERS intensity in the range of 0.6 to 9.0 ng/mL with a detection limit(LOD)of 0.09 ng/mL,while an LOD of 0.006 ng/mL was obtained for PSA.The results indicate that the sensitivity of our novel SERS-based immunoassay is higher than that of conventional enzyme-based colorimetric immunoassays. | Xuan-Hung Pham Eunil Hahm Tae Han Kim Hyung-Mo Kim Sang Hun Lee Sang Chul Lee Homan Kang Ho-Young Lee Dae Hong Jeong Hak Soo Choi Bong-Hyun Jun | 2020 | Nano Research2020，13，12： | 2 |
| 8 | Pretreatment of rice straw with combined process using dilute sulfuric acid and aqueous ammonia显示文摘 | SUNG BONG KIM SANG JUN LEE JU HUN LEE | 2013 | Biotechnology for Biofuels2013，6，： | 1 |
| 9 | Pathogenesis of cerebral microbleeds: In vivo imaging of amyloid and subcortical ischemic small vessel disease in 226 individuals with cognitive impairment显示文摘 | Jae‐Hyun Park Sang Won Seo Changsoo Kim Geon Ha Kim Hyun Jin Noh Sung Tae Kim Ki‐Chang Kwak Uicheul Yoon Jong Min Lee Jong Weon Lee Ji Soo Shin Chi Hun Kim Young Noh Hanna Cho Hee Jin Kim Cindy W. Yoon Seung Jun Oh Jae Seung Kim Yearn Seong Choe Kyung‐Han | 2013 | Ann Neurol2013，，5： | 1 |
| 10 | Enhanced third-harmonic generation by manipulating the twist angle of bilayer graphene显示文摘Twisted bilayer graphene(tBLG)has received substantial attention in various research fields due to its unconventional physical properties originating from Moire superlattices.The electronic band structure in tBLG modified by interlayer interactions enables the emergence of low-energy van Hove singularities in the density of states,allowing the observation of intriguing features such as increased optical conductivity and photocurrent at visible or near-infrared wavelengths.Here,we show that the third-order optical nonlinearity can be considerably modified depending on the stacking angle in tBLG.The third-harmonic generation(THG)efficiency is found to significantly increase when the energy gap at the van Hove singularity matches the three-photon resonance of incident light.Further study on electrically tuneable optical nonlinearity reveals that the gate-controlled THG enhancement varies with the twist angle in tBLG,resulting in a THG enhanced up to 60 times compared to neutral monolayer graphene.Our results prove that the twist angle opens up a new way to control and increase the optical nonlinearity.of tBLG,,suggesting rotation-induced tuneable nonlinear optics in stacked two-dimensional material systems. | Seongju Ha Nam Hun Park Hyeonkyeong Kim Jiseon Shin Jungseok Choi Sungmin Park Ji-Yun Moon Kwanbyung Chae Jeil Jung Jae-Hyun Lee Youngdong Yoo Ji-Yong Park Kwang Jun Ahn Dong-Il Yeom | 2021 | Light(Science & Applications)2021，10，2： | 1 |
| 11 | Iron overload accelerates bone loss in healthy postmenopausal women and middle‐aged men: A 3‐year retrospective longitudinal study显示文摘 | Beom‐Jun Kim Seong Hee Ahn Sung Jin Bae Eun Hee Kim Seung‐Hun Lee Hong‐Kyu Kim Jae Won Choe Jung‐Min Koh Ghi Su Kim | 2012 | J Bone Miner Res2012，，： | 1 |
| 12 | Development of metal-based electrodes for non-aqueous redox flow batteries显示文摘 | Kim Jae Hun Kim Ki Jae Park Min Sik Lee Nam Jin Hwang Uk Kim Hansu Kim Young Jun | 2011 | Electrochemistry Communications2011，13，9： | 1 |
| 13 | Effects of Ginkgo biloba extracts with mirodenafil on the relaxation of corpus cavernosal smooth muscle and the potassium channel activity of corporal smooth muscle cells显示文摘在这研究,我们调查了白果树 biloba 摘录(GBE ) 和 phosphodiesterase 类型的联合的效果 5 (PDE-5 ) 阴茎海绵体和下士的钾隧道活动的肌肉发达的音调上的禁止者弄平肌肉房间。从雄的新西兰白兔子的阴茎海绵体的脱衣为等轴的紧张研究在器官洗澡被装。在有 1 × 的收缩以后; 10 −5 mol l −1 新肾上素, GBE (0.01-1 mg ml −1) 和 mirodenafil (0.01-100 nmol l −1) 一起被增加进机关洗澡。在 electrophysiological 研究,整个房间的水流被常规补丁夹钳技术在人的阴茎海绵体的有教养的光滑的肌肉房间记录。阴茎海绵体以一种剂量依赖者方式响应 GBE 被放松(从 0.64 % ± 8.35 %在 0.01 mg ml −1 到 52.28 % ± 11.42 %在 1 mg ml −1) 。在有 0.03 的预告的处理以后; GBE 的 mg ml −1 , mirodenafil 的弛缓的效果根本被增加集中。在 tetraethylammonium (茶) 以后(1 mmol l −1) 管理,增加的效果被禁止(P< 0.01 ) 。GBE 的细胞外的管理增加了在一个剂量依赖者的外面的水流塑造的整个房间的 K + 。外面的水流的增加被 1 禁止; mmol l −1 茶。这些结果建议 GBE 能甚至在最低限度地有效的剂量增加 mirodenafil 的弛缓的力量。通过钾隧道的 K + 流动可能是涉及这 synergistic 松驰的机制之一。 | Jung Jun Kim Deok Hyun Han Soo Hyun Lim Tae Hun Kim Mee Ree Chae Kyung Jin Chung Sung Chul Kam Ju-Hong Jeon Jong Kwan Parks Sung Won Lee | 2011 | Asian Journal of Andrology2011，13，5： | 1 |
| 14 | Reliability Assessment Approach Using Failure Mode Analysis in Machining Center显示文摘 | Kim Bong Suk Lee Soo Hun Kim Jong Soo Song Jun Yeob | 2006 | Key Engineering Materials2006，，321： | 1 |
| 15 | Overexpression of Jazf1 reduces body weight gain and regulates lipid metabolism in high fat diet显示文摘 | Woo Young Jang Ki Beom Bae Sung Hyun Kim Dong Hun Yu Hei Jung Kim Young Rae Ji Seo Jin Park Jun Koo Yi Nari Kim Si Jun Park Min-Cheol Kang Ja In Jeong Sang-Joon Park Sang Gyu Lee Inkyu Lee Myoung Ok Kim Zae Young Ryoo | 2013 | Biochemical and Biophysical Research Communications2013，，： | 1 |
| 16 | Plasma B-type natriuretic peptide level can predict myocardial tissue perfusion in patients undergoing primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction显示文摘 | Suk Min Seo Seonghun Kim Kiyuk Chang Jinsoo Min Tae Hoon Kim Yoon Seok Koh Hun Jun Park Woo Seung Shin Jong Min Lee Pum-Joon Kim Wook-Sung Chung Ki-Bae Seung | 2011 | Coronary Artery Disease2011，，： | 1 |
| 17 | Hemodynamics‐compliant reconstruction of the right hepatic vein for adult living donor liver transplantation with a right liver graft显示文摘 | Shin Hwang Tae‐Yong Ha Chul‐Soo Ahn Deok‐Bog Moon Gi‐Won Song Ki‐Hun Kim Dong‐Hwan Jung Gil‐Chun Park Kyu‐Bo Sung Gi‐Young Ko Kyoung Won Kim Byungchul Cho Jung‐Man Namgoong Sung‐Won Jung Sam‐Youl Yoon Chun‐Soo Park Yo‐Han Park Hyeong‐Woo Park Hyo‐Jun Lee | 2012 | Liver Transpl2012，，7： | 1 |
| 18 | Induction of pacemaker currents by DA-9701, a prokinetic agent, in interstitial cells of Cajal from murine small intestine显示文摘 | Seok Choi Jeong June Choi Jae Yeoul Jun Jae Woong Koh Sang Hun Kim Dong Hee Kim Myoung-Yun Pyo Sangzin Choi Jin Pub Son Inki Lee Miwon Son Mirim Jin | 2009 | Molecules and Cells2009，，3： | 1 |
| 19 | Usability of ringed polytetrafluoroethylene grafts for middle hepatic vein reconstruction during living donor liver transplantation显示文摘 | Shin Hwang Dong‐Hwan Jung Tae‐Yong Ha Chul‐Soo Ahn Deok‐Bog Moon Ki‐Hun Kim Gi‐Won Song Gil‐Chun Park Sung‐Won Jung Sam‐Youl Yoon Jung‐Man Namgoong Chun‐Soo Park Yo‐Han Park Hyeong‐Woo Park Hyo‐Jun Lee Sung‐Gyu Lee | 2012 | Liver Transpl2012，，8： | 1 |
| 20 | The effect of initial serum neuron - specific enolase level on clinical outcome in acute carotid artery territory infarction显示文摘 | Oh Seung Hun Lee Jin Goo Na Sang Jun | 2002 | Yonsei Med J2002，43，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员