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| 1 | FoxO3a and disease progression显示文摘The Forkhead box O(FoxO) family has recently been highlighted as an important transcriptional regulator of crucial proteins associated with the many diverse functions of cells. So far, FoxO1, FoxO3 a, FoxO4 and FoxO6 proteins have been identified in humans. Although each FoxO family member has its own role, unlike the other FoxO families, FoxO3 a has been extensively studied because of its rather unique and pivotal regulation of cell proliferation, apoptosis, metabolism, stress management and longevity. FoxO3 a alteration is closely linked to the progression of several types of cancers, fibrosis and other types of diseases. In this review, we will examine the function of FoxO3 a in disease progression and also explore FoxO3a's regulatory mechanisms. We will also discuss FoxO3 a as a potential target for the treatment of several types of disease. | Richard Seonghun Nho Polla Hergert | 2014 | World Journal of Biological Chemistry2014，5，3： | 28 |
| 2 | Road-Frequen- cy Adaptive Control for Semi-Active Suspension Systems显示文摘 | Nguyen Le Hoa Hong Keum-Shik Park Seonghun | 2010 | Inter- national Journal of Control Automation and System2010，8，5： | 1 |
| 3 | Sequential aeid-/alkali-pretreatment of empty palm fruit bunch fiber 显示文摘 | Kim Seonghun Park Jang Min Seo Jeong-Woo | 2012 | Bioresource Technology2012，109，109： | 1 |
| 4 | Plasma B-type natriuretic peptide level can predict myocardial tissue perfusion in patients undergoing primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction显示文摘 | Suk Min Seo Seonghun Kim Kiyuk Chang Jinsoo Min Tae Hoon Kim Yoon Seok Koh Hun Jun Park Woo Seung Shin Jong Min Lee Pum-Joon Kim Wook-Sung Chung Ki-Bae Seung | 2011 | Coronary Artery Disease2011，，： | 1 |
| 5 | Integrated modeling and analysis of dynamics for electric vehicle powertrains 显示文摘 | GWANGMIN PARK SEONGHUN LEE SUNGHO JIN | 2014 | Expert Systems with Application2014，41，5： | 1 |
| 6 | Correlation of microstructure with the wear resistance and fracture toughness of hardfacing alloys reinforced with complex carbides显示文摘 | Choo Seonghun Kim Changkyu Euh Kwang | 2000 | Metallurgical and Materials Transactions A: Physical Metallurgy and Materials Science2000，31，12： | 1 |
| 7 | Interactive effect of dietary vitamin E and inorganic mercury on growth performance and bioaccumulation of mercury in juvenile olive flounder, Paralichthys olivaceus treated with mercuric chloride显示文摘A 6-week feeding trial was carried out to evaluate the effects of dietary vitamin E(DL-a-tocopheryl acetate, TA) on growth and mercury(Hg) accumulation in juvenile olive flounder(Paralichthys olivaceus)treated with mercuric chloride(HgCl_2). Vitamin E and HgCl_2 were added to the semi-purified basal diet.Six semi-purified diets in a 2 × 3 factorial design were formulated to contain 2 levels of Hg(0 or 20 mg HgCl_2/kg diet) and 3 levels of vitamin E(0, 100, or 200 mg TA/kg diet). Experimental fish(n = 360,9.99 ± 0.15 g) were randomly allocated into 30-L tanks at a density of 20 fish per tank with 3 replicates in each treatment and were fed twice a day. At the end of the feeding trial, dietary Hg depressed the growth performances in terms of weight gain(WG), specific growth rate(SGR), feed efficiency(FE) and protein efficiency ratio(PER) in fish, while fish fed the diets supplemented with vitamin E showed significant growth improvement in both presence and absence of HgCl_2 in the diets(P < 0.05). Survival rate was not affected in fish fed the experimental diets. Whole body compositions of fish such as lipid and moisture contents were influenced by dietary vitamin E supplementation. Total Hg contents of muscle, liver and kidney tissues were significantly reduced in fish fed diets supplemented with vitamin E(P< 0.05), while the two-way ANOVA showed that increasing Hg concentration has resulted in a reduction in vitamin E.Whole body fatty acids of fish like eicosapentaenoic acid(EPA) and docosahexaenoic acid(DHA) contents were decreased by dietary Hg. However, supplementation of dietary vitamin E improved the a-linolenic acid(ALA) and EPA contents in fish. Our results suggest that dietary supplementation of vitamin E has potential effects on growth improvement and ameliorating inorganic Hg bioaccumulation in juvenile olive flounder. | Mohammad Moniruzzaman Jun-Ho Lee Jin-Hyeok Lee Seonghun Won Jim H.Damusaru Sungchul C.Bai | 2017 | Animal Nutrition2017，，3： | 1 |
| 8 | Oxidative stress in Cohen diabetic rat model by high-sucrose, low-copper diet: inducing pancreatic damage and diabetes显示文摘 | Seonghun Ryu Asher Ornoy Amram Samuni Sarah Zangen Ron Kohen | 2008 | Metabolism2008，，9： | 1 |
| 9 | Production of 3-hydroxypropionic acid through propionaldehyde dehydrogenase PduP mediated biosynthetic pathway in Klebsiella pneumoniae显示文摘 | Lian Hua Luo Chul Ho Kim Sun-Yeon Heo Baek-Rock Oh Won-Kyung Hong Seonghun Kim Dae-Hyuk Kim Jeong-Woo Seo | 2011 | Bioresource Technology2011，，1： | 1 |
| 10 | The neurovascular unit-on-a-chip:modeling ischemic stroke to stem cell therapy显示文摘The neurovascular unit and stem cell therapy in ischemic stroke:Ischemic stroke,accounts for approximately 85% of all stroke incidents and is a major global health burden.It is the leading cause of disability and death worldwide,posing immense societal and economic challenges due to the long-term care required for stro ke survivors and the significant healthcare costs associated with its treatment and management(Amarenco et al.,2009). | Seonghun Kim Minjun Kim Gerald A.Grant Wonjae Lee | 2024 | Neural Regeneration Research2024，19，7： | 0 |
| 11 | Kinematic Analysis of the Neck and Upper Extremities During Walking in Healthy Young Adults显示文摘 | Kwon Son Junghong Park Seonghun Park | 2011 | Journal of Bionic Engineering2011，8，3： | 0 |
| 12 | Effect of twine thickness on size-selectivity of driftnet for the yellow croaker Larimichthys polyactis in southwestern Sea of Korea显示文摘In order to determine the effect of twine thickness on the size-selectivity of the driftnet used for the yellow croaker, size-selectivity tests were conducted with three different twine thicknesses(monofi lament diameters of 0.279 mm(number's method; No. 3), 0.321 mm(No. 4), and 0.360 mm(No. 5)) of driftnets for the yellow croaker in the seas around Chooja-do, Jeju Islands. The selectivity curve was estimated by using Kitahara's method. In order to determine the physical properties of the twine used in the experimental fi shing nets, we measured the breaking load, elongation, and stiffness under both dry and wet conditions. In terms of physical properties, the thinnest twine(No. 3) had the strongest breaking strength per unit cross-sectional area, along with good elongation and excellent fl exibility. The thickest twine(No. 5) had the lowest fl exibility. In terms of selectivity, the net of No. 3 twine showed the broadest selection range and, thus, a relatively low selectivity compared with the other nets, while the less fl exible net of No. 5 twine showed the narrowest selectivity range and high selectivity. In addition, it was found that a thicker twine resulted in a smaller haul of small fi sh. Therefore, it can be inferred that the thickness of the twine affects the size of the catch and selectivity, and thus the size composition of the catch as well. | Seonghun KIM Jihyun LIM Kyounghoon LEE Seongwook PARK | 2016 | Chinese Journal of Oceanology and Limnology2016，34，6： | 0 |
| 13 | Propagating acoustic waves on a culture substrate regulate the directional collective cell migration显示文摘Collective cell migration plays a critical role in physiological and pathological processes such as development,wound healing,and metastasis.Numerous studies have demonstrated how various types of chemical,mechanical,and electrical cues dictate the collective migratory behaviors of cells.Although an acoustic cue can be advantageous because of its noninvasiveness and biocompatibility,cell migration in response to acoustic stimulation remains poorly understood.In this study,we developed a device that is able to apply surface acoustic waves to a cell culture substrate and investigated the effect of propagating acoustic waves on collective cell migration.The migration distance estimated at various wave intensities revealed that unidirectional cell migration was enhanced at a critical wave intensity and that it was suppressed as the intensity was further increased.The increased migration might be attributable to cell orientation alignment along the direction of the propagating wave,as characterized by nucleus shape.Thicker actin bundles indicative of a high traction force were observed in cells subjected to propagating acoustic waves at the critical intensity.Our device and technique can be useful for regulating cellular functions associated with cell migration. | Chikahiro Imashiro Byungjun Kang Yunam Lee Youn-Hoo Hwang Seonghun Im Dae-Eun Kim Kenjiro Takemura Hyungsuk Lee | 2021 | Microsystems & Nanoengineering2021，7，6： | 0 |
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