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| 1 | Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies treated with anticancer therapy显示文摘Hepatitis due to hepatitis B virus(HBV) reactivation can be severe and potentially fatal, but is preventable. HBV reactivation is most commonly reported in patients receiving cancer chemotherapy, especially rituximabcontaining therapy for hematological malignancies and those receiving stem cell transplantation. All patients with hematological malignancies receiving anticancer therapy should be screened for active or resolved HBV infection by blood tests for hepatitis B surface antigen(HBs Ag) and antibody to hepatitis B core antigen(antiHBc). Patients found to be positive for HBs Ag should be given prophylactic antiviral therapy to prevent HBV reactivation. For patients with resolved HBV infection, no standard strategy has yet been established to prevent HBV reactivation. There are usually two options. One is pre-emptive therapy guided by serial HBV DNA monitoring, whereby antiviral therapy is given as soon as HBV DNA becomes detectable. However, there is little evidence regarding the optimal interval and period of monitoring. An alternative approach is prophylactic antiviral therapy, especially for patients receiving highrisk therapy such as rituximab, newer generation of anti-CD20 monoclonal antibody, obinutuzumab or hematopoietic stem cell transplantation. This strategy may effectively prevent HBV reactivation and avoid the inconvenience of repeated HBV DNA monitoring. Entecavir or tenofovir are preferred over lamivudine as prophylactic therapy. Although there is no well-defined guideline on the optimal duration of prophylactic therapy, there is growing evidence to recommend continuing prophylactic antiviral therapy for at least 12 mo after cessation of chemotherapy, and even longer for those who receive rituximab or who had high serum HBV DNA levels before the start of immunosuppressive therapy. Many novel agents have recently become available for the treatment of hematological malignancies, and these agents may be associated with HBV reactivation. Although there is currently limited evidence to guide the optimal preventive measures, we recommend antiviral prophylaxis in HBs Ag-positive patients receiving novel treatments, especially the Bruton tyrosine kinase inhibitors and the phosphatidylinositol 3-kinase inhibitors, which are B-cell receptor signaling modulators and reduce proliferation of malignant B-cells. Further studies are needed to clarify the risk of HBV reactivation with these agents and the best prophylactic strategy in the era of targeted therapy for hematological malignancies. | Man Fai Law Rita Ho Carmen KM Cheung Lydia HP Tam Karen Ma Kent CY So Bonaventure Ip Jacqueline So Jennifer Lai Joyce Ng Tommy HC Tam | 2016 | World Journal of Gastroenterology2016，22，28： | 10 |
| 2 | 改良DBL法测定稻米中的赖氨酸含量显示文摘 | 王红梅 刘巧泉 Joyce W C Ma Samuel S M Sun | 2002 | 扬州大学学报(农业与生命科学版)2002，23，4： | 5 |
| 3 | High dose bicalutamide for androgen independent prostate cancer:effect of prior hormonal therapy显示文摘 | Joyce R Fenton MA Rode P | 1998 | J Urol1998，159，1： | 1 |
| 4 | High dose bicalutamide for androgen independent prostate cancer: effect of prior hormonal therapy 显示文摘 | Joyce R Fenton MA Rode P | 1998 | JUrol1998，159，1： | 1 |
| 5 | Vaccinationwith peptide mimetics of the gp41 prehairpin fusionintermediate yields neutralizing antisera against HIV-1isolates 显示文摘 | Bianchi E Joyce JG Miller MD Liang XP Finotto MA McKenna P Citron MA Hepler RW Hrin R Nahas D Wu CW Montefiori D Shiver JW Kim PS | 2010 | Proc Natl Acad Sci USA2010，107，10： | 1 |
| 6 | Antipsychotic medication prescriibing trends in children and adolescents显示文摘 | Joyce NH Fallon CK Deborah MA | 2012 | J Pediatric Health Care2012，26，2： | 1 |
| 7 | Expression and association analyses of promoter variants of the neurogenic gene HES6, a candidate gene for mood disorder susceptibility and antidepressant response显示文摘 | Glubb DM Joyce PR Kennedy MA | 2009 | Neurosci Lett2009，460，： | 1 |
| 8 | Activity-based protein profiling identifies a host enzyme, carboxylesterase 1, which is differentially active during hepatitis C virus replication 显示文摘 | Blais DR Lyn RK Joyce MA | 2010 | The Journal of Biological Chemistry2010，285，25： | 1 |
| 9 | An investigation of the digital discrimination of neutrons and γ rays with organic scintillation detectors using an artificial neural network显示文摘 | G. Liu M.D. Aspinall X. Ma M.J. Joyce | 2009 | and Methods in Physics Research, A2009，，3： | 1 |
| 10 | Expression and association analyses of promoter variants of the neurogenic gene HES3,a candidate gene for mood disorder susceptibility and antidepressant response显示文摘 | Glubb DM Joyce PR Kennedy MA | 2011 | Neurosci Lett2011，460，： | 1 |
| 11 | Zinc finger proteins designed to specifically target duck hepatitis B virus covalently closed circular DNA inhibit viral transcription in tissue culture显示文摘 | Zimmerman KA Fischer KP Joyce MA Tyrrell DL | | Journal of Virology0，，： | 1 |
| 12 | A digital method for the discrimination of neutrons and γrays with organic scintillation detectors using frequency gradient analysis显示文摘 | LIU G F JOYCE M J MA X D | 2010 | IEEE Trans Nucl Sci2010，57，3： | 1 |
| 13 | Expression of the uterine Mx protein in cyclic and pregnant cows,gilts,and mares显示文摘 | Hicks BA Etter SJ Carnahan KG Joyce MM Assiri AA Carling SJ Kodali K Johnson GA Hansen TR Mirando MA Woods GL Vandervall DK Ott TL | | 0，，06： | 1 |
| 14 | No evidence of increased adverse drug reactions in cytochrome P450 CYP2D6 poor metabolizers treated with fluoxetine or nortriptyline显示文摘 | Mulder RT Joyce PR Luty SE Kennedy MA | 2004 | Hum Psychopharmacol2004，19，1： | 1 |
| 15 | Rapid and comprehensive determination of cytochrome P450 CYP2D6 poor metabolizer genotypes by multiplex polymerase chain reaction显示文摘 | Roberts R Joyce P Kennedy MA | 2000 | Hum Mutat2000，16，1： | 1 |
| 16 | High-dose bicalutamide for androgen independent prostate cancer: Effect of prior hormonal therapy显示文摘 | Joyce R Fenton MA Rode P | 1998 | J Urol1998，159，1： | 1 |
| 17 | Seasonal distribution of bromophenols in selected Hong Kong seafood 显示文摘 | Chung H Y Joyce Ma W C Kim J S | 2003 | J Agric Food Chem2003，51，23： | 1 |
| 18 | Zinc finger proteins designed to specifically target duck hepatitis B viruscovalently closed circular DNA inhibit viral transcription in tissue culture 显示文摘 | Zimmerman KA Fischer KP Joyce MA et ol | 2008 | J Virol2008，82，16： | 1 |
| 19 | High dose bicalutamide for androgen independent prostate cancer:effect of prior hormonal therapy显示文摘 | Joyce R Fenton MA Rode P | 1997 | J Urol1997，159，1： | 1 |
| 20 | HCV induces oxidative and ER stress,and sensitize infected cells to apoptosis in SCID/Alb-uPA mice显示文摘 | Joyce MA Walters KA Lamb SE | | 0，，02： | 1 |
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