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| 1 | 利用双源CT和MRI量化评估心脏移植接受者左室功能和心肌质量的临床初探显示文摘本研究的目的是对双源CT和MRI评价所得的心脏移植接受者的左室功能和心肌质量进行对比。对12例接受心脏移植的病人分别行双源CT和MRI检查。 | G.Bastarrika M.Arraiza C.N.De Cecco S.Mastrobuoni M.Ubilla G.Rábago 陈玥瑶 | 2008 | 国际医学放射学杂志2008，31，A06： | 13 |
| 2 | Efficient RT-QuIC seeding activity for α-synuclein in olfactory mucosa samples of patients with Parkinson’s disease and multiple system atrophy显示文摘Background:Parkinson’s disease(PD)is a neurodegenerative disorder whose diagnosis is often challenging because symptoms may overlap with neurodegenerative parkinsonisms.PD is characterized by intraneuronal accumulation of abnormalα-synuclein in brainstem while neurodegenerative parkinsonisms might be associated with accumulation of eitherα-synuclein,as in the case of Multiple System Atrophy(MSA)or tau,as in the case of Corticobasal Degeneration(CBD)and Progressive Supranuclear Palsy(PSP),in other disease-specific brain regions.Definite diagnosis of all these diseases can be formulated only neuropathologically by detection and localization ofα-synuclein or tau aggregates in the brain.Compelling evidence suggests that trace-amount of these proteins can appear in peripheral tissues,including receptor neurons of the olfactory mucosa(OM).Methods:We have set and standardized the experimental conditions to extend the ultrasensitive Real Time Quaking Induced Conversion(RT-QuIC)assay for OM analysis.In particular,by using human recombinantα-synuclein as substrate of reaction,we have assessed the ability of OM collected from patients with clinical diagnoses of PD and MSA to induceα-synuclein aggregation,and compared their seeding ability to that of OM samples collected from patients with clinical diagnoses of CBD and PSP.Results:Our results showed that a significant percentage of MSA and PD samples inducedα-synuclein aggregation with high efficiency,but also few samples of patients with the clinical diagnosis of CBD and PSP caused the same effect.Notably,the final RT-QuIC aggregates obtained from MSA and PD samples owned peculiar biochemical and morphological features potentially enabling their discrimination.Conclusions:Our study provide the proof-of-concept that olfactory mucosa samples collected from patients with PD and MSA possess important seeding activities forα-synuclein.Additional studies are required for(i)estimating sensitivity and specificity of the technique and for(ii)evaluating its application for the diagnosis of PD and neurodegenerative parkinsonisms.RT-QuIC analyses of OM and cerebrospinal fluid(CSF)can be combined with the aim of increasing the overall diagnostic accuracy of these diseases,especially in the early stages. | Chiara Maria Giulia De Luca Antonio Emanuele Elia Sara Maria Portaleone Federico Angelo Cazzaniga Martina Rossi Edoardo Bistaffa Elena De Cecco Joanna Narkiewicz Giulia Salzano Olga Carletta Luigi Romito Grazia Devigili Paola Soliveri Pietro Tiraboschi Giuseppe Legname Fabrizio Tagliavini Roberto Eleopra Giorgio Giaccone Fabio Moda | 2019 | Translational Neurodegeneration2019，8，1： | 5 |
| 3 | Combined Liver Transplantation and Gastric Sleeve Resection for Patients With Medically Complicated Obesity and End‐Stage Liver Disease显示文摘 | J. K. Heimbach K. D. S. Watt J. J. Poterucha N. Francisco Ziller S. D. Cecco M. R. Charlton J. E. Hay R. H. Wiesner W. Sanchez C. B. Rosen J. M. Swain | 2012 | American Journal of Transplantation2012，，2： | 3 |
| 4 | The genomics of desmoplastic small round cell tumor reveals the deregulation of genes related to DNA damage response, epithelial-mesenchymal transition, and immune response显示文摘Background:Desmoplastic small round cell tumor(DSRCT)is a rare,aggressive,and poorly investigated simple sarcoma with a low frequency of genetic deregulation other than an Ewing sarcoma RNA binding protein 1(EWSR1)-Wilm’s tumor suppressor(WT1)translocation.We used whole-exome sequencing to interrogate six consecutive pretreated DSRCTs whose gene expression was previously investigated.Methods:DNA libraries were prepared from formalin-fixed,paraffin-embedded archival tissue specimens following the Agilent SureSelectXT2 target enrichment protocol and sequenced on Illumina NextSeq 500.Raw sequence data were aligned to the reference genome with Burrows-Wheeler Aligner algorithm.Somatic mutations and copy number alterations(CNAs)were identified using MuTect2 and EXCAVATOR2,respectively.Biological functions associated with altered genes were investigated through Ingenuity Pathway Analysis(IPA)software.Results:A total of 137 unique somatic mutations were identified:133 mutated genes were case-specific,and 2 were mutated in two cases but in different positions.Among the 135 mutated genes,27%were related to two biological categories:DNA damage-response(DDR)network that was also identified through IPA and mesenchymal-epithelial reverse transition(MErT)/epithelial-mesenchymal transition(EMT)already demonstrated to be relevant in DSRCT.The mutated genes in the DDR network were involved in various steps of transcription and particularly affected pre-mRNA.Half of these genes encoded RNA-binding proteins or DNA/RNA-binding proteins,which were recently rec-ognized as a new class of DDR players.CNAs in genes/gene families,involved in MErT/EMT and DDR,were recurrent across patients and mostly segregated in the MErT/EMT category.In addition,recurrent gains of regions in chromosome 1 involving many MErT/EMT gene families and loss of one arm or the entire chromosome 6 affecting relevant immune-regulatory genes were recorded.Conclusions:The emerging picture is an extreme inter-tumor heterogeneity,characterized by the concurrent deregulation of the DDR and MErT/EMT dynamic and plastic programs that could favour genomic instability and explain the refractory DSRCT profile. | Andrea Devecchi Loris De Cecco Matteo Dugo Donata Penso Gianpaolo Dagrada Silvia Brich Silvia Stacchiotti Marialuisa Sensi Silvana Canevari Silvana Pilotti | 2018 | Cancer Communications2018，38，1： | 2 |
| 5 | Perforation rate in CT colonography: a systematic review of the literature and meta-analysis显示文摘 | Davide Bellini Marco Rengo Carlo Nicola Cecco Franco Iafrate Cesare Hassan Andrea Laghi | 2014 | European Radiology2014，，7： | 2 |
| 6 | Limits of predictive models using microarray data for breast cancer clinical treatment outcome显示文摘 | Reid JF Lusa L De Cecco L | | 0，，： | 1 |
| 7 | TLR9 agonists oppositely modulate DN repair genes in tumor versus immune cells and enhance chemotherapy effects显示文摘 | Sommariva M De Cecco L De Cesare M | 2011 | Cancer Res2011，71，20： | 1 |
| 8 | Contrast-induced acute kidney injury : definition, epidemiology, and outcome显示文摘 | Meinel F G De Cecco C N Schoepf U J | 2014 | Biomed Res Int2014，2014，85： | 1 |
| 9 | mTOR pathway and mTOR inhibitors as agents for cancer therapy显示文摘 | Baldo P Cecco S Giacomin E et at | 2008 | Curr Cancer Drug Targets2008，8，8： | 1 |
| 10 | miR-199a-3p displays tumor suppressor functions in papillary thyroid carcinoma显示文摘 | MINNA E ROMEO P DE CECCO L | 2014 | Oncotarget2014，5，9： | 1 |
| 11 | lmmonohistochemical expression d E-cadherin and -catenin in feline mammary tuinour$ 显示文摘 | ZappuUi V De Cecco S Trez D | | Comp Pathot0，147，23： | 1 |
| 12 | Limits of predictive models us- ing microarray data for breast cancer clinical treatment outcome显示文摘 | ReidJF Lusa L De Cecco L | 2005 | J Natl Cancer Inst2005，97，12： | 1 |
| 13 | miRNA control of apoptotic programs: focus on ovarian cancer显示文摘 | MEZZANZANICA D CANEVARI S CECCO L D | 2011 | Expert Rev Mol Diagn2011，11，3： | 1 |
| 14 | Feasibility of prospectively ECG-triggered high-pitch coronary CT angiography with 30 mL iodinated contrast agent at 70 kVp: initial experience显示文摘 | Long Jiang Zhang Li Qi Jing Wang Chun Xiang Tang Chang Sheng Zhou Xue Man Ji James V. Spearman Carlo Nicola Cecco Felix G. Meinel U. Joseph Schoepf Guang Ming Lu | 2014 | European Radiology2014，，： | 1 |
| 15 | Procedure for immunocytochemical detection of P16INK4A antigen in thin-layer,liquid-based specimens显示文摘 | Bibbo M Klump W J De Cecco J | 2002 | Acta Cytol2002，46，1： | 1 |
| 16 | Dual energy CT (DECT) of the liver: conventional versus virtual unenhanced images 显示文摘 | De Cecco CN Buffa V Fedeli S | 2010 | Eur Radiol2010，20，12： | 1 |
| 17 | mTOR pathway and mTOR inhibitors as agents for cancer therapy显示文摘 | Baldo P Cecco S Giacomin E | 2008 | Cnrr Cancer Drug Targets2008，8，8： | 1 |
| 18 | MicroRNAsignature of malignant mesothelioma with potential diagnos-tic and prognostic implications显示文摘 | Busacca S Germano S De Cecco L | 2010 | Am J Respir Cell Mol Biol2010，42，3： | 1 |
| 19 | Dual energy CT (DECT) of the liver conventional versus virtual unenhanced images显示文摘 | De Cecco C N Buffa V Fedeli S | 2010 | Eur Radiol2010，20，12： | 1 |
| 20 | The biological basis of medical treatment of endometriosis显示文摘 | Venturini PL $emino A De Cecco L | 1995 | Gynecol Endocrinol1995，9，5： | 1 |
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