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| 1 | The Origin and Tectonic Significance of the Volcanic Rocks of the Yeba Formation in the Gangdese Magmatic Belt, South Tibet显示文摘Zircon U-Pb geochronology, Hf isotope and whole-rock geochemistry were performed on the tuffs of the Yeba Formation in the Gangdese magmatic belt, South Tibet. The results are used to detail the age, source nature and tectonic processes that led to the formation of the Gangdese belt. Dating results indicate that the rhyolitic-andesitic tuffs were formed at 174–170 Ma. Positive and variable zircon ε_(Hf)(t) values of the rhyolitic tuffs reveal that the source was dominated by juvenile material, however, experienced crustal contamination. The basaltic tuffs have low HREEs, high contents of compatible elements(V and Cr) and no Eu anomaly. In contrast, the rhyolitic-andesitic tuffs show low compatible trace elements, depletion in Eu but enrichment in incompatible elements(Rb, Zr and Hf). According to the discrimination diagrams of P_2O_5-SiO_2 and Th-Rb, the rhyolitic-andesitic tuffs show a close affinity to Ⅰ-type granitoids. Moreover, these tuffs are marked by significant depletion in Nb, Ta and Ti, plotted in calc-alkaline field, and with the andesitic-rhyolitic tuffs falling into an active continental margin setting. We suggest that these tuffs of the Yeba Formation were probably generated in an active continental margin above the northward subduction of the Neo-Tethyan oceanic lithosphere. | Xuxuan Ma Zhiqin Xu Xijie Chen Joseph G.Meert Zhenyu He Fenghua Liang Yuanku Meng Shiwei Ma | 2017 | Journal of Earth Science2017，28，2： | 20 |
| 2 | Connexin 43 hemichannels protect bone loss during estrogen deficiency显示文摘Estrogen deficiency in postmenopausal women is a major cause of bone loss,resulting in osteopenia,osteoporosis,and a high risk for bone fracture.Connexin 43 (Cx43) hemichannels (HCs) in osteocytes play an important role in osteocyte viability,bone formation,and remodeling.We showed here that estrogen deficiency reduced Cx43 expression and HC function.To determine if functional HCs protect osteocytes and bone loss during estrogen deficiency,we adopted an ovariectomy model in wild-type (WT) and two transgenic Cx43 mice:R76W (dominant-negative mutant inhibiting only gap junction channels) and Cx43 Δ130–136 (dominant-negative mutant compromising both gap junction channels and HCs).The bone mineral density (BMD),bone structure,and histomorphometric changes of cortical and trabecular bones after ovariectomy were investigated.Our results showed that the Δ130–136 transgenic cohort had greatly decreased vertebral trabecular bone mass compared to WT and R76W mice,associated with a significant increase in the number of apoptotic osteocyte and empty lacunae.Moreover,osteoclast surfaces in trabecular and cortical bones were increased after ovariectomy in the R76W and WT mice,respectively,but not in Δ130–136 mice.These data demonstrate that impairment of Cx43 HCs in osteocytes accelerates vertebral trabecular bone loss and increase in osteocyte apoptosis,and further suggest that Cx43 HCs in osteocytes protect trabecular bone against catabolic effects due to estrogen deficiency. | Liang Ma Rui Hua Yi Tian Hongyun Cheng Roberto Jose Fajardo Joseph J. Pearson Teja Guda Daniel Brian Shropshire Sumin Gu Jean X. Jiang | 2019 | Bone Research2019，7，2： | 11 |
| 3 | A new prognostic histopathologic classification of nasopharyngeal carcinoma显示文摘Background:The current World Health Organization(WHO) classification of nasopharyngeal carcinoma(NPC) con?veys little prognostic information.This study aimed to propose an NPC histopathologic classification that can poten?tially be used to predict prognosis and treatment response.Methods:We initially developed a histopathologic classification based on the morphologic traits and cell differentia?tion of tumors of 2716 NPC patients who were identified at Sun Yat?sen University Cancer Center(SYSUCC)(training cohort).Then,the proposed classification was applied to 1702 patients(retrospective validation cohort) from hospitals outside SYSUCC and 1613 patients(prospective validation cohort) from SYSUCC.The efficacy of radiochemotherapy and radiotherapy modalities was compared between the proposed subtypes.We used Cox proportional hazards models to estimate hazard ratios(HRs) with 95% confidence intervals(CI) for overall survival(OS).Results:The 5?year OS rates for all NPC patients who were diagnosed with epithelial carcinoma(EC;3708 patients),mixed sarcomatoid?epithelial carcinoma(MSEC;1247 patients),sarcomatoid carcinoma(SC;823 patients),and squamous cell carcinoma(SCC;253 patients) were 79.4%,70.5%,59.6%,and 42.6%,respectively(P < 0.001).In mul?tivariate models,patients with MSEC had a shorter OS than patients with EC(HR = 1.44,95% CI = 1.27–1.62),SC(HR = 2.00,95% CI = 1.76–2.28),or SCC(HR = 4.23,95% CI = 3.34–5.38).Radiochemotherapy significantly improved survival compared with radiotherapy alone for patients with EC(HR 49–0.75),and possibly for those with SCC(HR = 0.67,95% CI = 0.56–0.80),MSEC(HR = 0.58,95% CI = 0..74–1.28).= 0.63;95% CI = 0.40–0.98),but not for patients with SC(HR = 0.97,95% CI = 0Conclusions:The proposed classification offers more information for the prediction of NPC prognosis compared with the WHO classification and might be a valuable tool to guide treatment decisions for subtypes that are associ?ated with a poor prognosis. | Hai-Yun Wang Yih-Leong Chang Ka-Fai To Jacqueline S.G.Hwang Hai-Qiang Mai Yan-Fen Feng Ellen T.Chang Chen-Ping Wang Michael Koon Ming Kam Shie-Lee Cheah Ming Lee Li Gao Hui-Zhong Zhang Jie-Hua He Hao Jiang Pei-Qing Ma Xiao-Dong Zhu Liang Zeng Chun-Yan Chen Gang Chen Ma-Yan Huang Sha Fu Qiong Shao An-Jia Han Hai-Gang Li Chun-Kui Shao Pei-Yu Huang Chao-Nan Qian Tai-Xiang Lu Jin-Tian Li Weimin Ye Ingemar Ernberg Ho Keung Ng Joseph T.S.Wee Yi-Xin Zeng Hans-Olov Adami Anthony T.C.Chan Jian-Yong Shao | 2016 | Chinese Journal of Cancer2016，35，6： | 10 |
| 4 | Molecular phylogeny and divergence time of Trachypithecus: with implications for the taxonomy of T. phayrei显示文摘 | Kai HE Naiqing HU Joseph D.ORKIN Daw Thida NYEIN Chi MA Wen XIAO Pengfei FAN Xuelong JIANG | 2012 | Zoological Research2012，33，6： | 5 |
| 5 | Effect of Tangnaikang on TGF-β_1-induced transdifferentiation of human renal tubular epithelial HK-2 cells显示文摘OBJECTIVE: To explore the function of Tangnaikang (TNK) in the prevention and treatment of renal interstitial fibrosis through transdifferentiation of the human renal tubular epithelial cell line HK-2 induced by transforming growth factor-β1(TGF-β1).METHODS: HK-2 cells cultured in dulbecco's modified eagle medium/F12 (1∶1) with 10% fetal calf serum were divided into six groups: blank control group, TGF-β1 group (TGF-β1 10 ng/mL), serum control group (TGF-β1 10 ng/mL+10% serum), treatment group 1 (TGF-β1 10 ng/mL+ 5% TNK serum),treatment group 2 (TGF-β1 10 ng/mL+10% TNK serum), and treatment group 3 (TGF-β1 10 ng/mL+20% TNK serum). Cell proliferation was detected by 4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Expression of α-smooth muscle actin (α-SMA) and E-cadherin were observed by immunohistochemical assay. The contents of collagen Ⅰ (Col Ⅰ), collagen Ⅲ (Col Ⅲ), and fibronectin (FN) in the culture medium supernatant were detected by ELISA.RESULTS: E-cadherin was expressed and α-SMA was not expressed in normal HK-2 cells. In HK-2 cells cultured with TGF-β1,α-SMA expression significantly increased, HK-2 cells significantly proliferated, and secretion of Col Ⅰ, Col Ⅲ, and FN significantly increased compared with the blank control group (all P<0.05). In the HK-2 cells cultured with TGF-β1 and TNK serum, the expression of α-SMA significantly decreased, the expression of E-cadherin significantly increased, and the cell proliferation and the secretion of Col Ⅰ, Col Ⅲ and FN were significantly inhibited compared with the TGF-β1 group (all P<0.05).CONCLUSION: TNK can inhibit cell proliferation and reduce secretion of Col Ⅰ, Col Ⅲ, and FN.This indicates that TNK can inhibit transdifferentiation of human renal tubular epithelial cells induced by TGF-β1, with the effect of preventing and treating renal interstitial fibrosis. | Lixia Yang Xinhuan Ma Tao Cheng Tonghua Liu Lili Wu Wen Sun Margetts Peter Joseph | 2013 | Journal of Traditional Chinese Medicine2013，33，3： | 5 |
| 6 | Bupivacaine causes cytotoxicity in mouse C2C12 myoblast cells: involvement of ERK and Akt signaling pathways显示文摘 | Joseph M MAURICE Yan GAN Fan-xin MA Yong-chang CHANG Michael HIBNER Yao HUANG | 2010 | Acta Pharmacologica Sinica2010，31，4： | 5 |
| 7 | Plant Programmed Cell Death Caused by an Autoactive Form of Prf Is Suppressed by Co-Expression of the Prf LRR Domain显示文摘在西红柿, NBARC-LRR 抵抗(R) 蛋白质 Prf 与 Pto 或分 kinase 在音乐会行动对 Pseudomonas syringae pv 决定免疫。西红柿(Pst ) 。发信号的调停 Prf 的防卫被二顺序无关的藏匿 Pst 的受动器蛋白质, AvrPto 和 AvrPtoB 的识别开始,由西红柿 Pto 或分。Prf 检测这些相互作用并且激活发信号包括与 Pst 生长的拘捕被联系的局部性的规划细胞死亡(PCD ) 导致宿主防卫回答。当短暂地在 Nicotiana benthamiana 的叶子表示了时,我们发现有在在在 NBARC 领域的 IHD 主题(isoleucine-histidine-aspartic 酸) 的 D1416 的单个氨基酸替换的 Prf 变体引起受动器无关的 PCD,建议 D1416 起在 Prf 的激活的一个重要作用。Prf (NPrf ) 和 LRR 领域的 N 终端区域为发信号的这 autoactive Prf 房间死亡被要求但是为 PrfD1416V 蛋白质的累积非必需。显著地, Prf LRR 然而并非 NPrf 的合作表示与 PrfD1416V, AvrPto/Pto, AvrPtoB/Pto, Pto (PtoY207D ) 的一种 autoactive 形式,或分完全压制 PCD。然而, Prf LRR 不防碍 PCD 由 Rpi-blb1D475V 引起了,表明事件的不同 R 调停蛋白质的 PCD,或由 MAPKKK 的 overexpression 引起了, Prf 下游地行动的蛋白质。而且,我们发现当与 Prf LRR 领域共同表示时, PrfD1416V 蛋白质是不能的在植物房间积累,多半向房间死亡解释抑制。为 PrfD1416V 的导致 LRR 的降级的机制是未知的,但是可以在 Prf 或到独立 LRR 的绑定的 intramolecular 相互作用包含干扰到为 Prf 稳定性被需要的另外的主机蛋白质。 | Xinran Du Min Miao Xinrong Ma Yongsheng Liu Joseph C. Kuhl Gregory B. Martin Fangming Xiao | 2012 | Molecular Plant2012，5，5： | 4 |
| 8 | Nanoseparation-lnspired Manipulation of the Synthesis of CdS Nanorods显示文摘 | Xiaoming Sun Xiuju Ma Lu Bai Junfeng Liu Zheng Chang David G. Evans Xue Duan Jiaou Wang Joseph F. Chiang | 2011 | Nano Research2011，4，2： | 2 |
| 9 | The Tomato Hybrid Proline-rich Protein regulates the abscission zone competence to respond to ethylene signals显示文摘The Tomato Hybrid Proline-rich Protein(THyPRP)gene was specifically expressed in the tomato(Solanum lycopersicum)flower abscission zone(FAZ),and its stable antisense silencing under the control of an abscission zone(AZ)-specific promoter,Tomato Abscission Polygalacturonase4,significantly inhibited tomato pedicel abscission following flower removal.For understanding the THyPRP role in regulating pedicel abscission,a transcriptomic analysis of the FAZ of THyPRP-silenced plants was performed,using a newly developed AZ-specific tomato microarray chip.Decreased expression of THyPRP in the silenced plants was already observed before abscission induction,resulting in FAZ-specific altered gene expression of transcription factors,epigenetic modifiers,post-translational regulators,and transporters.Our data demonstrate that the effect of THyPRP silencing on pedicel abscission was not mediated by its effect on auxin balance,but by decreased ethylene biosynthesis and response.Additionally,THyPRP silencing revealed new players,which were demonstrated for the first time to be involved in regulating pedicel abscission processes.These include:gibberellin perception,Ca2+-Calmodulin signaling,Serpins and Small Ubiquitin-related Modifier proteins involved in post-translational modifications,Synthaxin and SNARE-like proteins,which participate in exocytosis,a process necessary for cell separation.These changes,occurring in the silenced plants early after flower removal,inhibited and/or delayed the acquisition of the competence of the FAZ cells to respond to ethylene signaling.Our results suggest that THyPRP acts as a master regulator of flower abscission in tomato,predominantly by playing a role in the regulation of the FAZ cell competence to respond to ethylene signals. | Srivignesh Sundaresan Sonia Philosoph-Hadas Chao Ma Cai-Zhong Jiang Joseph Riov Raja Mugasimangalam Betina Kochanek Shoshana Salim Michael SReid Shimon Meir | 2018 | Horticulture Research2018，5，1： | 2 |
| 10 | Risk factors for lower urinary tract symptoms in a population - based sample of African - American Men显示文摘 | Joseph MA Harlow SD Wei JT | 2003 | Am J Epidemiol2003，157，10： | 1 |
| 11 | Subretinal sur- gery for juxafoveal cboroidal neovascularization 显示文摘 | Joseph DP Uemura A Thomas MA | 2003 | Retina2003，23，4： | 1 |
| 12 | Measuring drug concen- trations using pulsatile microdialysis: theory and method develop-merit in vitro 显示文摘 | Kabir MA Taft DR Joseph CK | 2005 | Int J Pharm2005，293，12： | 1 |
| 13 | Surgical resection endometriosis after prior hysterectomy 显示文摘 | Finan MA Kwark JA Joseph GF | 1997 | La State Med Soc1997，14，： | 1 |
| 14 | Slug is a downstream mediator of transforming growth factor-betal- induced matrix metalloproteinase-9 expression and invasion of oral cancer cells显示文摘 | Joseph M J Dangi-Garimella S Shields MA | 2009 | J Cell Biochem2009，108，3： | 1 |
| 15 | Risk factors for lower urinary tract symptoms in a population-based sample of African-American men显示文摘 | JOSEPH MA HARLOW SD WEI JT | 2003 | Am J Epidemiol2003，157，13： | 1 |
| 16 | Mechanical systems hazard estimation using condition monitoring显示文摘 | Yong Sun Lin Ma Joseph Mathew | 2004 | Mechanical Systems and Signal Processing2004，，： | 1 |
| 17 | Failure analysis of engineering systems with preventive main- tenance and failure interactions显示文摘 | SUN Yong MA Lin MATHEW Joseph | 2009 | Computers & In- dustrial Engineering2009，57，2： | 1 |
| 18 | CBF2-DBEB1C is a negative regulator of CBF1-DREB1B and CBF3-DREB1A expression and plays a central role in stress tolerance in Arabidopsis显示文摘 | Fernando N Jose MA Joseph R | 2004 | Proc Natl Acad Sci USA2004，101，11： | 1 |
| 19 | Synthesis of multiple Pseudomonas aeruginosa biofilm matrix exopolysaccharides is post‐transcriptionally regulated显示文摘 | Luyan Ma Juan Wang Shiwei Wang Erin M. Anderson Joseph S. Lam Matthew R. Parsek Daniel J. Wozniak | 2012 | Environmental Microbiology2012，，8： | 1 |
| 20 | Increased cox-2 expression in human vaginal epithelial cells exposed to nonoxynol-9, a vaginal contraceptive microbicide that failed to protect women from HIV-1 infection显示文摘 | Zalengkaya IA Cerocchi OG Joseph T Donaghay MA | 2011 | Am J Reprod Immunol2011，65，2： | 1 |
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