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5篇 您的检索式:作者名="Annette Nicke"
    题名 作者 年代 出处 被引量
1Characterization of the Expression of the ATP-Gated P2X7 Receptor Following Status Epilepticus and during Epilepsy Using a P2X7-EGFP Reporter Mouse显示文摘Mounting evidence suggests that the ATP-gated P2X7 receptor contributes to increased hyperexcitability in the brain.While increased expression of P2X7 in the hippocampus and cortex following status epilepticus and during epilepsy has been repeatedly demonstrated,the cell type-specific expression of P2X7 and its expression in extra-hippocampal brain structures remains incompletely explored.In this study,P2X7 expression was visualized by using a transgenic mouse model overexpressing P2X7 fused to the fluorescent protein EGFP.The results showed increased P2X7-EGFP expression after status epilepticus induced by intra-amygdala kainic acid and during epilepsy in different brain regions including the hippocampus,cortex,striatum,thalamus and cerebellum,and this was most evident in microglia and oligodendrocytes.Colocalization of P2X7-EGFP with cell type-specific markers was not detected in neurons or astrocytes.These data suggest that P2X7 activation is a common pathological hallmark across different brain structures,possibly contributing to brain inflammation and neurodegeneration following acute seizures and during epilepsy.James Morgan Mariana Alves Giorgia Conte Aida Menendez-Mendez Laura de Diego-Garcia Gioacchino de Leo Edward Beamer Jonathon Smith Annette Nicke Tobias Engel 2020Neuroscience Bulletin2020,36,11:3
2Molecular and functional properties of P2X receptors—recent progress and persisting challenges显示文摘Karina Kaczmarek-Hájek éva L?rinczi Ralf Hausmann Annette Nicke 2012Purinergic Signalling2012,,3:1
3Correlation between symptoms of pain and peritoneal fluid inflammatory cytokine concentrations in endometriosis显示文摘Bonny S Nick B Annette K 2009Gynecol Endocrino12009,25,:1
4WHO guidance on the prevention of viral hepatitis B and C among people who inject drugs显示文摘Nick Walsh Annette Verster Michelle Rodolph Elie A. Akl 2014International Journal of Drug Policy2014,,:1
5Molecular and functional properties of P2X receptors—recent progress and persisting challenges显示文摘Karina Kaczmarek-Hájek éva L?rinczi Ralf Hausmann Annette Nicke 2012Purinergic Signalling2012,,3:1
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